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CY1121246T1 - Συζευγμα αντισωματος αντι-trop2-φαρμακου - Google Patents

Συζευγμα αντισωματος αντι-trop2-φαρμακου

Info

Publication number
CY1121246T1
CY1121246T1 CY20191100002T CY191100002T CY1121246T1 CY 1121246 T1 CY1121246 T1 CY 1121246T1 CY 20191100002 T CY20191100002 T CY 20191100002T CY 191100002 T CY191100002 T CY 191100002T CY 1121246 T1 CY1121246 T1 CY 1121246T1
Authority
CY
Cyprus
Prior art keywords
trop2
tumor
conject
antibody
drug antibody
Prior art date
Application number
CY20191100002T
Other languages
English (en)
Inventor
Toshinori Agatsuma
Shu Takahashi
Jun Hasegawa
Daisuke Okajima
Hirofumi Hamada
Miki Yamaguchi
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53477995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121246(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1121246T1 publication Critical patent/CY1121246T1/el

Links

Classifications

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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract

Ο σκοπός της παρούσας εφεύρεσης είναι να παρασχεθεί ένα φάρμακο κατά των όγκων που να υπερέχει σε επίδραση κατά των όγκων και ασφάλεια, και που να έχει εξαιρετική θεραπευτική επίδραση. Παρέχεται ένα σύζευγμα αντισώματος φαρμάκου που χαρακτηρίζεται από το γεγονός ότι μία ένωση κατά των όγκων που αναπαρίσταται από έναν χημικό τύπο και αντίσωμα αντι-ΤROP2 συνδέονται μέσω ενός συνδέτη που έχει μια δομή που αναπαρίσταται από τον χημικό τύπο -L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)- (όπου το αντίσωμα αντι-ΤRΟΡ2 δεσμεύεται με το L1 τερματικό και η ένωση κατά των όγκων δεσμεύεται με την ομάδα καρβοξυλίου της οντότητας (CH2)n2-C(=O)-χρησιμοποιώντας το άτομο αζώτου της αμινομάδας στη θέση 1 ως το σημείο δέσμευσης).
CY20191100002T 2013-12-25 2019-01-02 Συζευγμα αντισωματος αντι-trop2-φαρμακου CY1121246T1 (el)

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