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CY1118606T1 - Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων - Google Patents

Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων

Info

Publication number
CY1118606T1
CY1118606T1 CY20161101282T CY161101282T CY1118606T1 CY 1118606 T1 CY1118606 T1 CY 1118606T1 CY 20161101282 T CY20161101282 T CY 20161101282T CY 161101282 T CY161101282 T CY 161101282T CY 1118606 T1 CY1118606 T1 CY 1118606T1
Authority
CY
Cyprus
Prior art keywords
protein
antigens
mining
production against
generation production
Prior art date
Application number
CY20161101282T
Other languages
English (en)
Inventor
Mariagrazia Pizza
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0223741A external-priority patent/GB0223741D0/en
Priority claimed from GB0305831A external-priority patent/GB0305831D0/en
Priority claimed from GB0309115A external-priority patent/GB0309115D0/en
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1118606T1 publication Critical patent/CY1118606T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ένας μικρός αριθμός καθορισμένων αντιγόνων μπορούν να προσφέρουν ευρεία προστασία έναντι μόλυνσης από μηνιγγιόκοκκο, και η εφεύρεση προσφέρει μια σύνθεση η οποία, μετά από χορήγηση σε ένα άτομο, μπορεί να προκαλέσει απόκριση αντισωμάτων στο άτομο αυτό, όπου η απόκριση αντισωμάτων είναι βακτηριοκτόνος έναντι δύο ή τριών υπερμολυσματικών σειρών Α4, ΕΤ 5 και της σειράς 3 του Ν.meningitidis οροομάδας Β. Αντί να αποτελείται από ένα μοναδικό αντιγόνο, η σύνθεση περιέχει ένα μίγμα από 10 ή λιγότερα καθαρισμένα αντιγόνα, και δεν πρέπει να περιλαμβάνει πολύπλοκα ή ακαθόριστα μίγματα αντιγόνων όπως κυστίδια εξωτερικής μεμβράνης. Πέντε πρωτεϊνικά αντιγόνα χρησιμοποιούνται ιδιαίτερα: (1) μια πρωτεΐνη «NadA»• (2) μια πρωτεΐνη «741»• (3) μια πρωτεΐνη «936»• (4) μια πρωτεΐνη «953»• και (5) μια πρωτεΐνη «297». Συγκεκριμένα θραύσματα της «NadA» παρέχονται.
CY20161101282T 2002-10-11 2016-12-13 Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων CY1118606T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0223741A GB0223741D0 (en) 2002-10-11 2002-10-11 Composition with five meningococcal antigens
GB0305831A GB0305831D0 (en) 2003-03-13 2003-03-13 Broad protection meningococcal vaccines
GB0309115A GB0309115D0 (en) 2003-04-22 2003-04-22 Broad protection meningococcal vaccines
EP03758486A EP1549338B1 (en) 2002-10-11 2003-10-02 Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
EP10181277.4A EP2351579B1 (en) 2002-10-11 2003-10-02 Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages

Publications (1)

Publication Number Publication Date
CY1118606T1 true CY1118606T1 (el) 2017-07-12

Family

ID=32096623

Family Applications (4)

Application Number Title Priority Date Filing Date
CY20111100292T CY1111341T1 (el) 2002-10-11 2011-03-15 Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων
CY2013026C CY2013026I1 (el) 2002-10-11 2013-07-03 Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων
CY20161101282T CY1118606T1 (el) 2002-10-11 2016-12-13 Πολυπεπτιδικα εμβολια για ευρεια παραγωγη εναντι υπερμολυσματικων μηνιγγιοκοκκιkων σειρων
CY20201100227T CY1122869T1 (el) 2002-10-11 2020-03-16 Πολυπεπτιδικα εμβολια για ευρεια προστασια εναντι υπερλοιμογονων μηνιγγιτιδοκοκκικων γενεαλογικων σειρων

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20111100292T CY1111341T1 (el) 2002-10-11 2011-03-15 Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων
CY2013026C CY2013026I1 (el) 2002-10-11 2013-07-03 Πολυπεπτιδιου-εμβολια για ευρεια προστασια εναντι υπερ-λοιμογονων μηνιγγιοκοκκικων γενεαλογικων σειρων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20201100227T CY1122869T1 (el) 2002-10-11 2020-03-16 Πολυπεπτιδικα εμβολια για ευρεια προστασια εναντι υπερλοιμογονων μηνιγγιτιδοκοκκικων γενεαλογικων σειρων

Country Status (22)

Country Link
US (2) US8663656B2 (el)
EP (3) EP2351579B1 (el)
JP (4) JP4697706B2 (el)
CN (1) CN1809380B (el)
AT (1) ATE492288T1 (el)
AU (1) AU2003274511B2 (el)
BE (1) BE2013C042I2 (el)
BR (1) BRPI0315228A8 (el)
CA (1) CA2501812C (el)
CY (4) CY1111341T1 (el)
DE (1) DE60335477D1 (el)
DK (3) DK2353608T3 (el)
ES (2) ES2608048T3 (el)
FR (1) FR13C0040I2 (el)
HU (3) HUE031886T2 (el)
LU (1) LU92241I2 (el)
MX (1) MXPA05003863A (el)
NL (1) NL300604I2 (el)
NZ (1) NZ562998A (el)
PT (3) PT2351579T (el)
SI (3) SI2353608T1 (el)
WO (1) WO2004032958A1 (el)

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