CY1116041T1 - Μεσα και μεθοδοι για τη θεραπευτικη αγωγη νεοπλασματικων νοσων - Google Patents
Μεσα και μεθοδοι για τη θεραπευτικη αγωγη νεοπλασματικων νοσωνInfo
- Publication number
- CY1116041T1 CY1116041T1 CY20151100194T CY151100194T CY1116041T1 CY 1116041 T1 CY1116041 T1 CY 1116041T1 CY 20151100194 T CY20151100194 T CY 20151100194T CY 151100194 T CY151100194 T CY 151100194T CY 1116041 T1 CY1116041 T1 CY 1116041T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- methods
- single chain
- antibody construct
- instruments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Εδώ παρέχονται φαρμακευτικά μέσα και μέθοδοι για την πρόληψη, θεραπευτική αγωγή ή βελτίωση ανώδυνου ή επιθετικού λεμφώματος Β-κυττάρων τύπου μη Hodgkin (Β NHL) και Β-κυτταρικής λευχαιμίας που περιλαμβάνουν τη χορήγηση μιας κατασκευής αμφιειδικού αντισώματος μονής αλυσίδας σε ένα υποκείμενο που χρήζει αυτής και τη χρησιμοποίηση της ρηθείσας κατασκευής αμφιειδικού αντισώματος μονής αλυσίδας για την παρασκευή μιας φαρμακευτικής σύνθεσης για την πρόληψη, θεραπευτική αγωγή ή βελτίωση ανώδυνου ή επιθετικού λεμφώματος Β-κυττάρων τύπου μη Hodgkin (Β NHL) και Β-κυτταρικής λευχαιμίας, διά της οποίας η ρηθείσα κατασκευή πρόκειται να χορηγηθεί επί τουλάχιστον 1 εβδομάδα σε καθορισμένες ημερήσιες δόσεις. Επιπλέον, η εφεύρεση αναφέρεται σε κιτία που περιλαμβάνουν μια κατασκευή αμφιειδικού αντισώματος μονής αλυσίδας που πρόκειται να χρησιμοποιηθεί σύμφωνα με την παρούσα εφεύρεση.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05027606 | 2005-12-16 | ||
| EP06004144 | 2006-03-01 | ||
| EP06818912.5A EP1976886B1 (en) | 2005-12-16 | 2006-11-29 | Means and methods for the treatment of tumorous diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116041T1 true CY1116041T1 (el) | 2017-01-25 |
Family
ID=37944802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100194T CY1116041T1 (el) | 2005-12-16 | 2015-02-25 | Μεσα και μεθοδοι για τη θεραπευτικη αγωγη νεοπλασματικων νοσων |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8007796B2 (el) |
| EP (1) | EP1976886B1 (el) |
| JP (2) | JP5442998B2 (el) |
| AU (1) | AU2006326727A1 (el) |
| CA (1) | CA2633594C (el) |
| CY (1) | CY1116041T1 (el) |
| DK (1) | DK1976886T3 (el) |
| ES (1) | ES2532124T3 (el) |
| HK (1) | HK1116202A1 (el) |
| HR (1) | HRP20150175T1 (el) |
| PL (1) | PL1976886T3 (el) |
| PT (1) | PT1976886E (el) |
| RS (1) | RS53905B1 (el) |
| RU (1) | RU2008129080A (el) |
| SI (1) | SI1976886T1 (el) |
| WO (1) | WO2007068354A1 (el) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2606081C (en) | 2005-04-26 | 2013-09-17 | Markus M. Heiss | Combination of the application of antibodies for immunostimulation together with glucocorticoids |
| RU2008129080A (ru) * | 2005-12-16 | 2010-01-27 | Микромет Аг (De) | Средства и способы лечения опухолевых заболеваний |
| JP5825756B2 (ja) | 2006-08-14 | 2015-12-02 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | Ｃｄ１９を標的とする最適化抗体 |
| ES2558434T3 (es) * | 2008-11-07 | 2016-02-04 | Amgen Research (Munich) Gmbh | Tratamiento de leucemia linfoblástica aguda |
| CN102209729B (zh) * | 2008-11-07 | 2016-05-25 | 安进研发（慕尼黑）股份有限公司 | 小儿急性淋巴细胞白血病的治疗方法 |
| EP2493503B2 (en) * | 2009-10-27 | 2021-01-20 | Amgen Research (Munich) GmbH | Dosage regimen for administering a cd19xcd3 bispecific antibody |
| US8796420B2 (en) | 2009-12-31 | 2014-08-05 | Avidbiotics Corp. | Non-natural MIC proteins |
| US8658765B2 (en) | 2009-12-31 | 2014-02-25 | Avidbiotics Corp. | Non-natural MIC proteins |
| KR101889995B1 (ko) * | 2010-10-27 | 2018-08-20 | 암젠 리서치 (뮌헨) 게엠베하 | Dlbcl의 치료 수단 및 방법 |
| DK2637670T4 (da) * | 2010-11-10 | 2024-03-25 | Amgen Res Munich Gmbh | Forebyggelse af uønskede hændelser forårsaget af specifikke cd3-bindingsdomæner |
| US9249217B2 (en) | 2010-12-03 | 2016-02-02 | Secretary, DHHS | Bispecific EGFRvIII x CD3 antibody engaging molecules |
| CN107303387A (zh) | 2011-04-28 | 2017-10-31 | 安进研发（慕尼黑）股份有限公司 | 用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案 |
| US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| US9486475B2 (en) | 2013-02-08 | 2016-11-08 | Amgen Research (Munich) Gmbh | PPS for the prevention of potential adverse effects caused by CD3 specific binding domains |
| JO3529B1 (ar) | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| CN105813654B (zh) | 2013-10-11 | 2019-05-31 | 美国政府(由卫生和人类服务部的部长所代表) | Tem8抗体及其用途 |
| WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| PL3149480T3 (pl) | 2014-05-30 | 2019-06-28 | Amgen Research (Munich) Gmbh | Stratyfikacja ryzyka u pacjentów z ostrą białaczką limfoblastyczną z prekursorów b |
| US10160795B2 (en) | 2014-11-14 | 2018-12-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to Ebola virus glycoprotein and their use |
| FI3560953T3 (fi) | 2014-12-24 | 2024-03-21 | Autolus Ltd | Solu |
| SG11201705988UA (en) | 2015-02-24 | 2017-08-30 | Bioatla Llc | Conditionally active biological proteins |
| WO2016138160A1 (en) | 2015-02-24 | 2016-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use |
| EP3683233A1 (en) | 2015-03-20 | 2020-07-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to gp120 and their use |
| WO2017040344A2 (en) | 2015-08-28 | 2017-03-09 | Amunix Operating Inc. | Chimeric polypeptide assembly and methods of making and using the same |
| AU2016335750B2 (en) | 2015-10-07 | 2023-05-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | IL-7R-alpha specific antibodies for treating acute lymphoblastic leukemia |
| US11236152B2 (en) | 2015-11-03 | 2022-02-01 | The United States of America, as represented by the Sectetary, Department of Health and Human Services | Neutralizing antibodies to HIV-1 GP41 and their use |
| WO2017192589A1 (en) | 2016-05-02 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to influenza ha and their use and identification |
| AU2017290828A1 (en) | 2016-06-30 | 2019-01-24 | Virogin Biotech Canada Ltd | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| KR20190118172A (ko) | 2017-02-08 | 2019-10-17 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| WO2018148660A1 (en) | 2017-02-10 | 2018-08-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| AU2018220736B2 (en) | 2017-02-20 | 2024-10-24 | Dragonfly Therapeutics, Inc. | Proteins binding HER2, NKG2D and CD16 |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| US11976109B2 (en) | 2018-01-02 | 2024-05-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
| KR20200118080A (ko) | 2018-02-08 | 2020-10-14 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d 수용체를 표적화하는 항체 가변 도메인 |
| WO2019165122A1 (en) | 2018-02-21 | 2019-08-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| US20220089694A1 (en) | 2018-12-20 | 2022-03-24 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof |
| WO2020221792A1 (en) | 2019-04-30 | 2020-11-05 | Amgen Research (Munich) Gmbh | Means and methods of treating burkitt lymphoma or leukemia |
| WO2020227228A2 (en) | 2019-05-03 | 2020-11-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| US20230085439A1 (en) | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
| WO2021003297A1 (en) | 2019-07-02 | 2021-01-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind egfrviii and their use |
| EP4073114A4 (en) * | 2019-12-11 | 2024-04-17 | Cullinan Oncology, Inc. | ANTISERUM ALBUMIN ANTIBODIES |
| JP2023506017A (ja) * | 2019-12-11 | 2023-02-14 | カリナン オンコロジー インコーポレイテッド | 抗ｃｄ１９抗体および多重特異性結合タンパク質 |
| WO2021150824A1 (en) * | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
| JP2023517889A (ja) | 2020-03-10 | 2023-04-27 | マサチューセッツ インスティテュート オブ テクノロジー | ＮＰＭ１ｃ陽性がんの免疫療法のための組成物および方法 |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| WO2022132904A1 (en) | 2020-12-17 | 2022-06-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies targeting sars-cov-2 |
| JP2024506315A (ja) | 2021-02-09 | 2024-02-13 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ | コロナウイルスのスパイクタンパク質を標的とする抗体 |
| CN117396502A (zh) | 2021-02-09 | 2024-01-12 | 佐治亚大学研究基金会有限公司 | 针对肺炎球菌抗原的人类单克隆抗体 |
| AU2022345251A1 (en) | 2021-09-17 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies |
| IL314799A (en) | 2022-02-10 | 2024-10-01 | Us Health | Human monoclonal antibodies broadly targeting coronavirus |
| WO2023192881A1 (en) | 2022-03-28 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| WO2024030829A1 (en) | 2022-08-01 | 2024-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind to the underside of influenza viral neuraminidase |
| WO2024054822A1 (en) | 2022-09-07 | 2024-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Engineered sars-cov-2 antibodies with increased neutralization breadth |
| WO2024064826A1 (en) | 2022-09-22 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use |
| WO2024137381A1 (en) | 2022-12-19 | 2024-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies for treating sars-cov-2 infection |
| WO2024138151A1 (en) | 2022-12-22 | 2024-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ebolavirus (sudan and zaire) antibodies from non-human primates and human vaccinees |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19725586C2 (de) * | 1997-06-17 | 1999-06-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper |
| TR200003087T2 (tr) * | 1998-04-21 | 2001-02-21 | Micromet Ag | Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları |
| TW200408407A (en) * | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
| AU2004257142A1 (en) * | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
| CA2522586C (en) * | 2003-05-31 | 2017-02-21 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| ZA200601699B (en) | 2003-10-16 | 2007-05-30 | Micromet Ag | Multispecific deimmunized CD3-binders |
| CA2606081C (en) | 2005-04-26 | 2013-09-17 | Markus M. Heiss | Combination of the application of antibodies for immunostimulation together with glucocorticoids |
| RU2008129080A (ru) * | 2005-12-16 | 2010-01-27 | Микромет Аг (De) | Средства и способы лечения опухолевых заболеваний |
| ES2558434T3 (es) * | 2008-11-07 | 2016-02-04 | Amgen Research (Munich) Gmbh | Tratamiento de leucemia linfoblástica aguda |
| CN114829401A (zh) * | 2019-09-27 | 2022-07-29 | 南京金斯瑞生物科技有限公司 | 抗vhh域抗体及其用途 |
-
2006
- 2006-11-29 RU RU2008129080/13A patent/RU2008129080A/ru not_active Application Discontinuation
- 2006-11-29 ES ES06818912.5T patent/ES2532124T3/es active Active
- 2006-11-29 SI SI200631893T patent/SI1976886T1/sl unknown
- 2006-11-29 EP EP06818912.5A patent/EP1976886B1/en active Active
- 2006-11-29 AU AU2006326727A patent/AU2006326727A1/en not_active Abandoned
- 2006-11-29 US US12/095,951 patent/US8007796B2/en active Active
- 2006-11-29 PL PL06818912T patent/PL1976886T3/pl unknown
- 2006-11-29 JP JP2008544796A patent/JP5442998B2/ja active Active
- 2006-11-29 CA CA2633594A patent/CA2633594C/en active Active
- 2006-11-29 RS RS20150179A patent/RS53905B1/en unknown
- 2006-11-29 WO PCT/EP2006/011466 patent/WO2007068354A1/en active Application Filing
- 2006-11-29 PT PT06818912T patent/PT1976886E/pt unknown
- 2006-11-29 DK DK06818912T patent/DK1976886T3/en active
-
2008
- 2008-10-24 HK HK08111723.3A patent/HK1116202A1/xx unknown
-
2011
- 2011-08-26 US US13/219,120 patent/US11154617B2/en active Active
-
2013
- 2013-09-26 JP JP2013200055A patent/JP5834056B2/ja active Active
-
2015
- 2015-02-16 HR HRP20150175TT patent/HRP20150175T1/hr unknown
- 2015-02-25 CY CY20151100194T patent/CY1116041T1/el unknown
-
2021
- 2021-09-21 US US17/480,504 patent/US20220088196A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2633594C (en) | 2021-10-26 |
| PT1976886E (pt) | 2015-03-09 |
| HK1116202A1 (en) | 2008-12-19 |
| WO2007068354A8 (en) | 2007-08-09 |
| DK1976886T3 (en) | 2015-03-02 |
| RS53905B1 (en) | 2015-08-31 |
| HRP20150175T1 (en) | 2015-03-27 |
| US20130095103A1 (en) | 2013-04-18 |
| US11154617B2 (en) | 2021-10-26 |
| JP5442998B2 (ja) | 2014-03-19 |
| ES2532124T3 (es) | 2015-03-24 |
| RU2008129080A (ru) | 2010-01-27 |
| AU2006326727A1 (en) | 2007-06-21 |
| PL1976886T3 (pl) | 2015-06-30 |
| WO2007068354A1 (en) | 2007-06-21 |
| JP2014028840A (ja) | 2014-02-13 |
| SI1976886T1 (sl) | 2015-03-31 |
| US8007796B2 (en) | 2011-08-30 |
| JP5834056B2 (ja) | 2015-12-16 |
| US20090291072A1 (en) | 2009-11-26 |
| CA2633594A1 (en) | 2007-06-21 |
| JP2009519257A (ja) | 2009-05-14 |
| EP1976886B1 (en) | 2014-12-17 |
| US20220088196A1 (en) | 2022-03-24 |
| EP1976886A1 (en) | 2008-10-08 |
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