Nothing Special   »   [go: up one dir, main page]

CY1115001T1 - Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a - Google Patents

Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a

Info

Publication number
CY1115001T1
CY1115001T1 CY20141100233T CY141100233T CY1115001T1 CY 1115001 T1 CY1115001 T1 CY 1115001T1 CY 20141100233 T CY20141100233 T CY 20141100233T CY 141100233 T CY141100233 T CY 141100233T CY 1115001 T1 CY1115001 T1 CY 1115001T1
Authority
CY
Cyprus
Prior art keywords
subject
compound
provides
formula
effective amount
Prior art date
Application number
CY20141100233T
Other languages
English (en)
Inventor
Andreas Ritzén
Jan Kehler
Morten Langgård
Jacob Nielsen
John Paul Kilburn
Mohamed M Farah
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1115001T1 publication Critical patent/CY1115001T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αυτή κατευθύνεται προς ενώσεις, που είναι αναστολείς ενζύμου PDE10A. Η εφεύρεση παρέχει μια φαρμακευτική σύνθεση που περιέχει μια θεραπευτικώς αποτελεσματική ποσότητα μιας ένωσης της εφεύρεσης κι έναν φαρμακευτικώς αποδεκτό φορέα. Η παρούσα εφεύρεση επίσης παρέχει μεθόδους για την παρασκευή των ενώσεων του τύπου (I). Η παρούσα εφεύρεση περαιτέρω παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από μια νευροεκφυλιστική διαταραχή που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I). Η παρούσα εφεύρεση επίσης παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από εξάρτηση από φάρμακο που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I). Η παρούσα εφεύρεση επίσης παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από ψυχιατρική διαταραχή που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I).
CY20141100233T 2008-06-20 2014-03-28 Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a CY1115001T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200800855 2008-06-20
DKPA200900402 2009-03-24
DKPA200900519 2009-04-22
EP09765461.0A EP2318394B1 (en) 2008-06-20 2009-06-19 Novel phenylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number Publication Date
CY1115001T1 true CY1115001T1 (el) 2016-12-14

Family

ID=40902594

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100233T CY1115001T1 (el) 2008-06-20 2014-03-28 Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a

Country Status (28)

Country Link
US (1) US8841297B2 (el)
EP (1) EP2318394B1 (el)
JP (1) JP5930714B2 (el)
KR (3) KR102025487B1 (el)
CN (2) CN102124002B (el)
AR (1) AR072199A1 (el)
AU (1) AU2009259209B2 (el)
BR (1) BRPI0915383B8 (el)
CA (1) CA2728335C (el)
CL (2) CL2010001467A1 (el)
CO (1) CO6321263A2 (el)
CY (1) CY1115001T1 (el)
DK (1) DK2318394T3 (el)
EA (2) EA018880B1 (el)
ES (1) ES2456349T3 (el)
HK (1) HK1159632A1 (el)
HR (1) HRP20140232T1 (el)
IL (1) IL209834A (el)
MX (1) MX2010014136A (el)
MY (1) MY152949A (el)
NZ (1) NZ589926A (el)
PL (1) PL2318394T3 (el)
PT (1) PT2318394E (el)
RS (2) RS53226B (el)
SI (1) SI2318394T1 (el)
TW (1) TWI501965B (el)
WO (1) WO2009152825A1 (el)
ZA (1) ZA201100109B (el)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA102693C2 (ru) * 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為pde10a酵素抑制劑的2-芳基咪唑衍生物
JP5674828B2 (ja) 2010-03-12 2015-02-25 オメロス コーポレーション Pde10インヒビターならびに関連する組成物および方法
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
NZ705135A (en) 2010-05-26 2017-10-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof
TW201215607A (en) 2010-07-02 2012-04-16 Lundbeck & Co As H Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
TW201206935A (en) 2010-07-16 2012-02-16 Lundbeck & Co As H Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
WO2012018909A1 (en) * 2010-08-04 2012-02-09 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
EP2602255B1 (en) * 2010-08-04 2017-04-26 Takeda Pharmaceutical Company Limited Fused heterocyclic ring compound
ME02145B (me) * 2010-11-10 2015-10-20 H Lundbeck As Radioobeleženi ligandi na bazi fenilimidazola
JO3089B1 (ar) * 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
US8349824B2 (en) * 2010-12-07 2013-01-08 Hoffmann-La Roche Inc. Triazolopyridine compounds
JP6106603B2 (ja) 2011-01-11 2017-04-05 スノビオン プハルマセウトイカルス インコーポレイテッド ヘテロアリール化合物及びその使用方法
US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
CN103476757A (zh) 2011-02-18 2013-12-25 阿勒根公司 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013045607A1 (en) 2011-09-30 2013-04-04 H. Lundbeck A/S Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
WO2013050527A1 (en) 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
TWI570124B (zh) * 2011-12-21 2017-02-11 H 朗德貝克公司 作為pde10a酵素抑制劑的喹啉衍生物
WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013178572A1 (en) * 2012-05-30 2013-12-05 F. Hoffmann-La Roche Ag Triazolo compounds as pde10 inhibitors
KR20150021120A (ko) * 2012-06-19 2015-02-27 선오비온 파마슈티컬스 인코포레이티드 헤테로아릴 화합물 및 이의 이용 방법
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
WO2014100533A1 (en) 2012-12-21 2014-06-26 Bristol-Myers Squibb Company NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 δ/ε INHIBITORS
BR112015020302B1 (pt) * 2013-02-27 2023-04-18 Mochida Pharmaceutical Co., Ltd Derivado de pirazol, composição farmacêutica e composto intermediário
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
AU2015249753B2 (en) 2014-04-23 2019-10-10 Dart Neuroscience (Cayman) Ltd. Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as PDE2 inhibitors
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
NZ630803A (en) 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
PL408251A1 (pl) * 2014-05-19 2015-11-23 Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością Skondensowane pochodne triazolu jako inhibitory fosfodiesterazy 10A
US10239882B2 (en) 2014-11-05 2019-03-26 Dart Neuroscience (Cayman) Ltd. Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
EP3285760A4 (en) 2015-04-24 2018-09-26 Omeros Corporation Pde10 inhibitors and related compositions and methods
WO2017079678A1 (en) 2015-11-04 2017-05-11 Omeros Corporation Solid state forms of a pde10 inhibitor
BR112020013743A2 (pt) 2018-11-06 2020-12-01 H. Lundbeck A/S hemiadipato de 5,8-dimetil-2-[2-(1-metil-4-fenil-1h-imidazol-2-il)-etil]-[1,2,4]triazolo[1,5-a]pirazina
BR112020013820A2 (pt) 2018-11-06 2021-06-01 H. Lundbeck A/S inibidores de pde10a para tratamento de sintomas negativos e comprometimentos cognitivos em um paciente sofrendo de esquizofrenia
BR112020013697A2 (pt) 2018-11-06 2020-12-01 H. Lundbeck A/S compostos para tratamento de sintomas negativos e comprometimentos cognitivos
CN111100071A (zh) * 2019-12-19 2020-05-05 西安近代化学研究所 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法
CN110981813A (zh) * 2019-12-19 2020-04-10 西安近代化学研究所 一种2-氰基-5-芳基-1h-咪唑类化合物的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036840A (en) 1972-06-07 1977-07-19 Icn Pharmaceuticals 2-Substituted-s-triazolo[1,5a]pyrimidines
DE10230605A1 (de) 2002-07-08 2004-01-29 Bayer Ag Substituierte Imidazotriazine
WO2005003129A1 (en) * 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolodihydroisoquinolines as pde10 inhibitors
JP2007523152A (ja) * 2004-02-18 2007-08-16 ファイザー・プロダクツ・インク キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体
US7368467B2 (en) 2004-03-08 2008-05-06 Wyeth Ion channel modulators
US20060183763A1 (en) * 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
NL2000397C2 (nl) * 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
CA2643963A1 (en) * 2006-02-21 2007-08-30 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
CA2654394A1 (en) 2006-06-26 2008-01-03 Pfizer Products Inc. Tricyclic heteroaryl compounds as pde10 inhibitors
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
EA201000201A1 (ru) 2007-08-10 2010-12-30 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Азотсодержащие бициклические химические вещества для лечения вирусных инфекций
UA102693C2 (ru) 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors

Also Published As

Publication number Publication date
PT2318394E (pt) 2014-04-03
AU2009259209B2 (en) 2013-08-01
JP5930714B2 (ja) 2016-06-08
CN102124002B (zh) 2014-06-25
CA2728335A1 (en) 2009-12-23
IL209834A (en) 2014-02-27
ZA201100109B (en) 2012-03-28
CA2728335C (en) 2016-05-24
MX2010014136A (es) 2011-01-21
KR20170134781A (ko) 2017-12-06
CO6321263A2 (es) 2011-09-20
BRPI0915383B1 (pt) 2020-09-15
AR072199A1 (es) 2010-08-11
HK1159632A1 (en) 2012-08-03
MY152949A (en) 2014-12-15
CN102124002A (zh) 2011-07-13
RS53704B1 (en) 2015-04-30
TWI501965B (zh) 2015-10-01
RS53226B (en) 2014-08-29
EA021410B1 (ru) 2015-06-30
CL2010001467A1 (es) 2011-08-05
CN102482262A (zh) 2012-05-30
KR20110020845A (ko) 2011-03-03
EA201270046A1 (ru) 2012-05-30
US8841297B2 (en) 2014-09-23
KR20170016523A (ko) 2017-02-13
NZ589926A (en) 2011-09-30
ES2456349T3 (es) 2014-04-22
CN102482262B (zh) 2014-06-25
HRP20140232T1 (hr) 2014-04-11
KR101703938B1 (ko) 2017-02-07
BRPI0915383B8 (pt) 2021-05-25
SI2318394T1 (sl) 2014-07-31
BRPI0915383A2 (pt) 2015-11-03
EP2318394A1 (en) 2011-05-11
DK2318394T3 (en) 2014-03-24
EA201170061A1 (ru) 2011-08-30
KR102025487B1 (ko) 2019-09-25
PL2318394T3 (pl) 2014-09-30
AU2009259209A1 (en) 2009-12-23
CL2011003205A1 (es) 2012-06-22
US20120190685A1 (en) 2012-07-26
EA018880B1 (ru) 2013-11-29
IL209834A0 (en) 2011-02-28
JP2011524381A (ja) 2011-09-01
WO2009152825A1 (en) 2009-12-23
TW201000481A (en) 2010-01-01
EP2318394B1 (en) 2014-01-22

Similar Documents

Publication Publication Date Title
CY1115001T1 (el) Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a
CY1115843T1 (el) Ετεροαρωματικες ενωσεις φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a
CY1115278T1 (el) Παραγωγα 2-αρυλιμιδαζολης ως αναστολεις του ενζυμου ρdε10α
UA102693C2 (ru) Производные фенилимидазола как ингибиторы фермента pde10a
EA201290517A1 (ru) Гетероароматические арилтриазольные производные в качестве ингибиторов фермента pde10a
IN2015DN02829A (el)
EA201390741A1 (ru) Производные имидазола в качестве ингибиторов фермента pde10a
ECSP14015609A (es) Inhibidores de pde9 con estructura básica de imidazotriazinona
CY1116689T1 (el) Παραγωγα ιμιδαζολης ως αναστολεις του ενζυμου pde10a
MX336915B (es) Derivados de imidazol como inhibidores de la enzima pde10a.
TN2013000200A1 (en) Imidazole derivatives as pde 10a enzyme inhibitors