CY1115001T1 - Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a - Google Patents
Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10aInfo
- Publication number
- CY1115001T1 CY1115001T1 CY20141100233T CY141100233T CY1115001T1 CY 1115001 T1 CY1115001 T1 CY 1115001T1 CY 20141100233 T CY20141100233 T CY 20141100233T CY 141100233 T CY141100233 T CY 141100233T CY 1115001 T1 CY1115001 T1 CY 1115001T1
- Authority
- CY
- Cyprus
- Prior art keywords
- subject
- compound
- provides
- formula
- effective amount
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η εφεύρεση αυτή κατευθύνεται προς ενώσεις, που είναι αναστολείς ενζύμου PDE10A. Η εφεύρεση παρέχει μια φαρμακευτική σύνθεση που περιέχει μια θεραπευτικώς αποτελεσματική ποσότητα μιας ένωσης της εφεύρεσης κι έναν φαρμακευτικώς αποδεκτό φορέα. Η παρούσα εφεύρεση επίσης παρέχει μεθόδους για την παρασκευή των ενώσεων του τύπου (I). Η παρούσα εφεύρεση περαιτέρω παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από μια νευροεκφυλιστική διαταραχή που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I). Η παρούσα εφεύρεση επίσης παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από εξάρτηση από φάρμακο που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I). Η παρούσα εφεύρεση επίσης παρέχει μια μέθοδο θεραπείας ενός ατόμου που πάσχει από ψυχιατρική διαταραχή που περιλαμβάνει χορήγηση στο άτομο μιας θεραπευτικώς αποτελεσματικής ποσότητας μιας ένωσης του τύπου (I).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200800855 | 2008-06-20 | ||
DKPA200900402 | 2009-03-24 | ||
DKPA200900519 | 2009-04-22 | ||
EP09765461.0A EP2318394B1 (en) | 2008-06-20 | 2009-06-19 | Novel phenylimidazole derivatives as pde10a enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115001T1 true CY1115001T1 (el) | 2016-12-14 |
Family
ID=40902594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100233T CY1115001T1 (el) | 2008-06-20 | 2014-03-28 | Νεα παραγωγα φαινυλιμιδαζολιου ως αναστολεις ενζυμου pde10a |
Country Status (28)
Country | Link |
---|---|
US (1) | US8841297B2 (el) |
EP (1) | EP2318394B1 (el) |
JP (1) | JP5930714B2 (el) |
KR (3) | KR102025487B1 (el) |
CN (2) | CN102124002B (el) |
AR (1) | AR072199A1 (el) |
AU (1) | AU2009259209B2 (el) |
BR (1) | BRPI0915383B8 (el) |
CA (1) | CA2728335C (el) |
CL (2) | CL2010001467A1 (el) |
CO (1) | CO6321263A2 (el) |
CY (1) | CY1115001T1 (el) |
DK (1) | DK2318394T3 (el) |
EA (2) | EA018880B1 (el) |
ES (1) | ES2456349T3 (el) |
HK (1) | HK1159632A1 (el) |
HR (1) | HRP20140232T1 (el) |
IL (1) | IL209834A (el) |
MX (1) | MX2010014136A (el) |
MY (1) | MY152949A (el) |
NZ (1) | NZ589926A (el) |
PL (1) | PL2318394T3 (el) |
PT (1) | PT2318394E (el) |
RS (2) | RS53226B (el) |
SI (1) | SI2318394T1 (el) |
TW (1) | TWI501965B (el) |
WO (1) | WO2009152825A1 (el) |
ZA (1) | ZA201100109B (el) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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UA102693C2 (ru) * | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TWI481607B (zh) * | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
JP5674828B2 (ja) | 2010-03-12 | 2015-02-25 | オメロス コーポレーション | Pde10インヒビターならびに関連する組成物および方法 |
US8410117B2 (en) * | 2010-03-26 | 2013-04-02 | Hoffmann-La Roche Inc. | Imidazopyrimidine derivatives |
NZ705135A (en) | 2010-05-26 | 2017-10-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
TW201206935A (en) | 2010-07-16 | 2012-02-16 | Lundbeck & Co As H | Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor |
WO2012018909A1 (en) * | 2010-08-04 | 2012-02-09 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
EP2602255B1 (en) * | 2010-08-04 | 2017-04-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
ME02145B (me) * | 2010-11-10 | 2015-10-20 | H Lundbeck As | Radioobeleženi ligandi na bazi fenilimidazola |
JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
US8349824B2 (en) * | 2010-12-07 | 2013-01-08 | Hoffmann-La Roche Inc. | Triazolopyridine compounds |
JP6106603B2 (ja) | 2011-01-11 | 2017-04-05 | スノビオン プハルマセウトイカルス インコーポレイテッド | ヘテロアリール化合物及びその使用方法 |
US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
CN103476757A (zh) | 2011-02-18 | 2013-12-25 | 阿勒根公司 | 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物 |
WO2013005798A1 (ja) * | 2011-07-06 | 2013-01-10 | 持田製薬株式会社 | 新規含窒素複素環誘導体 |
WO2013045607A1 (en) | 2011-09-30 | 2013-04-04 | H. Lundbeck A/S | Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors |
WO2013050527A1 (en) | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
TWI570124B (zh) * | 2011-12-21 | 2017-02-11 | H 朗德貝克公司 | 作為pde10a酵素抑制劑的喹啉衍生物 |
WO2013127817A1 (en) | 2012-02-27 | 2013-09-06 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
WO2013178572A1 (en) * | 2012-05-30 | 2013-12-05 | F. Hoffmann-La Roche Ag | Triazolo compounds as pde10 inhibitors |
KR20150021120A (ko) * | 2012-06-19 | 2015-02-27 | 선오비온 파마슈티컬스 인코포레이티드 | 헤테로아릴 화합물 및 이의 이용 방법 |
US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
WO2014100533A1 (en) | 2012-12-21 | 2014-06-26 | Bristol-Myers Squibb Company | NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 δ/ε INHIBITORS |
BR112015020302B1 (pt) * | 2013-02-27 | 2023-04-18 | Mochida Pharmaceutical Co., Ltd | Derivado de pirazol, composição farmacêutica e composto intermediário |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
AU2015249753B2 (en) | 2014-04-23 | 2019-10-10 | Dart Neuroscience (Cayman) Ltd. | Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as PDE2 inhibitors |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
PL408251A1 (pl) * | 2014-05-19 | 2015-11-23 | Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością | Skondensowane pochodne triazolu jako inhibitory fosfodiesterazy 10A |
US10239882B2 (en) | 2014-11-05 | 2019-03-26 | Dart Neuroscience (Cayman) Ltd. | Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors |
EP3285760A4 (en) | 2015-04-24 | 2018-09-26 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
WO2017079678A1 (en) | 2015-11-04 | 2017-05-11 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
BR112020013743A2 (pt) | 2018-11-06 | 2020-12-01 | H. Lundbeck A/S | hemiadipato de 5,8-dimetil-2-[2-(1-metil-4-fenil-1h-imidazol-2-il)-etil]-[1,2,4]triazolo[1,5-a]pirazina |
BR112020013820A2 (pt) | 2018-11-06 | 2021-06-01 | H. Lundbeck A/S | inibidores de pde10a para tratamento de sintomas negativos e comprometimentos cognitivos em um paciente sofrendo de esquizofrenia |
BR112020013697A2 (pt) | 2018-11-06 | 2020-12-01 | H. Lundbeck A/S | compostos para tratamento de sintomas negativos e comprometimentos cognitivos |
CN111100071A (zh) * | 2019-12-19 | 2020-05-05 | 西安近代化学研究所 | 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法 |
CN110981813A (zh) * | 2019-12-19 | 2020-04-10 | 西安近代化学研究所 | 一种2-氰基-5-芳基-1h-咪唑类化合物的合成方法 |
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CA2654394A1 (en) | 2006-06-26 | 2008-01-03 | Pfizer Products Inc. | Tricyclic heteroaryl compounds as pde10 inhibitors |
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EA201000201A1 (ru) | 2007-08-10 | 2010-12-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Азотсодержащие бициклические химические вещества для лечения вирусных инфекций |
UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
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2009
- 2009-06-15 TW TW098119876A patent/TWI501965B/zh not_active IP Right Cessation
- 2009-06-19 KR KR1020177034302A patent/KR102025487B1/ko active IP Right Grant
- 2009-06-19 BR BRPI0915383A patent/BRPI0915383B8/pt not_active IP Right Cessation
- 2009-06-19 MX MX2010014136A patent/MX2010014136A/es active IP Right Grant
- 2009-06-19 EP EP09765461.0A patent/EP2318394B1/en active Active
- 2009-06-19 CN CN200980132027.3A patent/CN102124002B/zh not_active Expired - Fee Related
- 2009-06-19 KR KR1020107028654A patent/KR101703938B1/ko active IP Right Grant
- 2009-06-19 SI SI200930879T patent/SI2318394T1/sl unknown
- 2009-06-19 DK DK09765461.0T patent/DK2318394T3/en active
- 2009-06-19 CA CA2728335A patent/CA2728335C/en not_active Expired - Fee Related
- 2009-06-19 WO PCT/DK2009/050134 patent/WO2009152825A1/en active Application Filing
- 2009-06-19 PT PT97654610T patent/PT2318394E/pt unknown
- 2009-06-19 AU AU2009259209A patent/AU2009259209B2/en not_active Ceased
- 2009-06-19 ES ES09765461.0T patent/ES2456349T3/es active Active
- 2009-06-19 AR ARP090102239A patent/AR072199A1/es active IP Right Grant
- 2009-06-19 RS RS20140135A patent/RS53226B/en unknown
- 2009-06-19 JP JP2011513878A patent/JP5930714B2/ja not_active Expired - Fee Related
- 2009-06-19 PL PL09765461T patent/PL2318394T3/pl unknown
- 2009-06-19 KR KR1020177002859A patent/KR20170016523A/ko not_active Application Discontinuation
- 2009-06-19 NZ NZ589926A patent/NZ589926A/en not_active IP Right Cessation
- 2009-06-19 MY MYPI20106011 patent/MY152949A/en unknown
- 2009-06-19 EA EA201170061A patent/EA018880B1/ru not_active IP Right Cessation
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2010
- 2010-06-17 US US13/378,405 patent/US8841297B2/en not_active Expired - Fee Related
- 2010-06-17 EA EA201270046A patent/EA021410B1/ru not_active IP Right Cessation
- 2010-06-17 RS RS20140700A patent/RS53704B1/en unknown
- 2010-06-17 CN CN201080037331.2A patent/CN102482262B/zh not_active Expired - Fee Related
- 2010-12-07 IL IL209834A patent/IL209834A/en active IP Right Grant
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- 2010-12-20 CO CO10159483A patent/CO6321263A2/es active IP Right Grant
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2011
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2012
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