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CY1114284T1 - Σουλφονυλοπυρρολες ως hdac αναστολεις - Google Patents

Σουλφονυλοπυρρολες ως hdac αναστολεις

Info

Publication number
CY1114284T1
CY1114284T1 CY20131100737T CY131100737T CY1114284T1 CY 1114284 T1 CY1114284 T1 CY 1114284T1 CY 20131100737 T CY20131100737 T CY 20131100737T CY 131100737 T CY131100737 T CY 131100737T CY 1114284 T1 CY1114284 T1 CY 1114284T1
Authority
CY
Cyprus
Prior art keywords
pyrols
hdac
sulfonyl
suspensions
compounds
Prior art date
Application number
CY20131100737T
Other languages
English (en)
Inventor
Thomas Maier
Thomas Beckers
Thomas Baer
Petra Gimmnich
Frank Dullweber
Matthias Vennemann
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of CY1114284T1 publication Critical patent/CY1114284T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
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  • Urology & Nephrology (AREA)
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  • Communicable Diseases (AREA)
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  • AIDS & HIV (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
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Abstract

Ενώσεις ενός ορισμένου τύπου (Ι), στις οποίες R1, R2, R3, R4, R5, R6 και R7 έχουν τις σημασίες οι οποίες υποδεικνύονται στην περιγραφή, είναι νέοι αποτελεσματικοί ΗDΑC αναστολείς.
CY20131100737T 2004-03-11 2013-08-28 Σουλφονυλοπυρρολες ως hdac αναστολεις CY1114284T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101003 2004-03-11
EP05716989.8A EP1725528B1 (en) 2004-03-11 2005-03-10 Sulphonylpyrroles as hdac inhibitors

Publications (1)

Publication Number Publication Date
CY1114284T1 true CY1114284T1 (el) 2016-08-31

Family

ID=34928899

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100737T CY1114284T1 (el) 2004-03-11 2013-08-28 Σουλφονυλοπυρρολες ως hdac αναστολεις

Country Status (26)

Country Link
US (5) US7842820B2 (el)
EP (2) EP1725528B1 (el)
JP (1) JP4856623B2 (el)
KR (1) KR101130556B1 (el)
CN (1) CN1926103B (el)
AR (1) AR048427A1 (el)
AU (1) AU2005221834B2 (el)
BR (1) BRPI0508464B8 (el)
CA (1) CA2558552C (el)
CY (1) CY1114284T1 (el)
DK (1) DK1725528T3 (el)
EA (1) EA012451B1 (el)
ES (1) ES2430371T3 (el)
HK (1) HK1102583A1 (el)
HR (1) HRP20130810T1 (el)
IL (1) IL177168A (el)
ME (1) ME02122B (el)
NO (1) NO337457B1 (el)
NZ (1) NZ549251A (el)
PL (1) PL1725528T3 (el)
PT (1) PT1725528E (el)
RS (1) RS52937B (el)
SI (1) SI1725528T1 (el)
TW (1) TWI353977B (el)
WO (1) WO2005087724A2 (el)
ZA (1) ZA200606315B (el)

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CN105801464B (zh) * 2014-12-29 2019-05-28 成都先导药物开发有限公司 吡咯酰胺类化合物及其制备方法与用途
KR20180130565A (ko) 2016-04-14 2018-12-07 4에스체 악티엔게젤샤프트 아시아 환자에서의 레스미노스타트의 의학적 적용
TW201912183A (zh) 2017-08-31 2019-04-01 德商４Ｓｃ製藥公司 Hdac抑制劑與抗代謝藥劑組合用於癌症治療
WO2019200238A1 (en) 2018-04-14 2019-10-17 Dynavax Technologies Corporation Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer
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TW202114659A (zh) 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合

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