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CY1113969T1 - Ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii - Google Patents

Ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii

Info

Publication number
CY1113969T1
CY1113969T1 CY20121101185T CY121101185T CY1113969T1 CY 1113969 T1 CY1113969 T1 CY 1113969T1 CY 20121101185 T CY20121101185 T CY 20121101185T CY 121101185 T CY121101185 T CY 121101185T CY 1113969 T1 CY1113969 T1 CY 1113969T1
Authority
CY
Cyprus
Prior art keywords
aluminum
factor viii
group
copperations
raffinose
Prior art date
Application number
CY20121101185T
Other languages
English (en)
Inventor
Marc Besman
Erik Bjornson
Feroz Jameel
Ramesh Kashi
Michael Pikal
Serguei Tchessalov
John Carpenter
Original Assignee
University Of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26944588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113969(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Of Connecticut filed Critical University Of Connecticut
Publication of CY1113969T1 publication Critical patent/CY1113969T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/829Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Σύνθεση Παράγοντα VIII που συνταγοποιείται χωρίς αλβουμίνη, περιλαμβάνουσα τα ακόλουθα έκδοχα συνταγοποίησης επιπλέον του Παράγοντα VIII: 4 % έως 10 % από έναν παράγοντα όγκου που επιλέγεται από την ομάδα που αποτελείται από μαννιτόλη, γλυκίνη και αλανίνη, 1 % έως 4 % από έναν σταθεροποιητικό παράγοντα που επιλέγεται από την ομάδα που αποτελείται από σακχαρόζη, τρεαλόζη, ραφινόζη και αργινίνη, 1 mM έως 5 mM άλατος ασβεστίου, 100 mM έως 300 mM NaCI και έναν ρυθμιστικό παράγοντα για διατήρηση pΗ περίπου μεταξύ 6 και 8. Εναλλακτικά, η συνταγοποίηση μπορεί να περιλαμβάνει 2 % έως 6 % υδροξυαιθυλ άμυλο, 1 % έως 4 % ενός σταθεροποιητικού παράγοντα που επιλέγεται από την ομάδα που αποτελείται από σακχαρόζη, τρεαλόζη, ραφινόζη και αργινίνη, 1 mM έως 5 mM άλατος ασβεστίου, 100 mM έως 300 mM NaCI και έναν ρυθμιστικό παράγοντα για διατήρηση pΗ περίπου μεταξύ 6 και 8.
CY20121101185T 1999-02-22 2012-12-04 Ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii CY1113969T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25527999A 1999-02-22 1999-02-22
US45275299A 1999-12-01 1999-12-01
EP09075396A EP2130554B1 (en) 1999-02-22 2000-02-22 Albumin-free factor VIII formulations

Publications (1)

Publication Number Publication Date
CY1113969T1 true CY1113969T1 (el) 2016-07-27

Family

ID=26944588

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071101050T CY1108030T1 (el) 1999-02-22 2007-08-07 Νεες ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii
CY20121101185T CY1113969T1 (el) 1999-02-22 2012-12-04 Ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20071101050T CY1108030T1 (el) 1999-02-22 2007-08-07 Νεες ανευ-αλβουμινης συνταγοποιησεις παραγοντα viii

Country Status (19)

Country Link
US (8) US6586573B1 (el)
EP (5) EP1154796B1 (el)
JP (9) JP5149470B2 (el)
CN (3) CN101683522B (el)
AT (1) ATE365052T1 (el)
AU (1) AU777972B2 (el)
BR (1) BR0008405B1 (el)
CA (4) CA2634674A1 (el)
CY (2) CY1108030T1 (el)
CZ (3) CZ300547B6 (el)
DE (1) DE60035260T2 (el)
DK (4) DK2130554T3 (el)
ES (4) ES2541470T3 (el)
HK (4) HK1106705A1 (el)
MX (1) MXPA01008515A (el)
PL (4) PL203893B1 (el)
PT (4) PT1154796E (el)
RU (1) RU2244556C2 (el)
WO (1) WO2000048635A1 (el)

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