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CY1112655T1 - Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις - Google Patents

Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις

Info

Publication number
CY1112655T1
CY1112655T1 CY20121100161T CY121100161T CY1112655T1 CY 1112655 T1 CY1112655 T1 CY 1112655T1 CY 20121100161 T CY20121100161 T CY 20121100161T CY 121100161 T CY121100161 T CY 121100161T CY 1112655 T1 CY1112655 T1 CY 1112655T1
Authority
CY
Cyprus
Prior art keywords
polypeptides
well
relates
preparation
cells
Prior art date
Application number
CY20121100161T
Other languages
English (en)
Inventor
Michel Morre
Brigitte Assouline
Iann Rance
Anne Gregoire
Corinne Breque
Original Assignee
Cytheris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytheris filed Critical Cytheris
Publication of CY1112655T1 publication Critical patent/CY1112655T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε νέα και βελτιωμένα πολυπεπτίδια ιντερλευκίνης-7, καθώς επίσης συνθέσεις που περιλαμβάνουν αυτά, παρασκευή αυτών και χρήσεις αυτών. Η εφεύρεση ειδικότερα αφορά σε υπεργλυκοζυλιωμένα ΙL-7 πολυπεπτίδια που έχουν βελτιωμένες ιδιότητες, καθώς επίσης τη βιομηχανική κατασκευή αυτών και θεραπευτικές χρήσεις αυτών. Η εφεύρεση επίσης αποκαλύπτει νέα πολυπεπτίδια IL-7 που έχουν τροποποιημένες αλληλουχίες αμινοξέος που περιέχουν τεχνητώς δημιουργούμενη θέση(-εις) γλυκοζυλίωσης, καθώς επίσης αντίστοιχα μόρια νουκλεϊνικού οξέος, φορείς και ανασυνδυασμένα κύτταρα ξενιστές. Η εφεύρεση επίσης αφορά στη χρήση τέτοιων πολυπεπτιδίων, κυττάρων ή νουκλεϊνικών οξέων για θεραπευτική ή προληπτική θεραπεία υποκειμένων θηλαστικών, συμπεριλαμβανομένων ανθρώπινων υποκειμένων.
CY20121100161T 2005-07-20 2012-02-16 Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις CY1112655T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291556A EP1746161A1 (en) 2005-07-20 2005-07-20 Glycosylated IL-7, preparation and uses
EP06795556A EP1904635B1 (en) 2005-07-20 2006-07-19 Glycosylated il-7, preparation and uses

Publications (1)

Publication Number Publication Date
CY1112655T1 true CY1112655T1 (el) 2016-02-10

Family

ID=35385570

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100161T CY1112655T1 (el) 2005-07-20 2012-02-16 Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις

Country Status (20)

Country Link
US (3) US7708985B2 (el)
EP (2) EP1746161A1 (el)
JP (2) JP5685363B2 (el)
CN (2) CN105647939A (el)
AT (1) ATE542901T1 (el)
AU (1) AU2006271315B2 (el)
CA (2) CA2615562C (el)
CY (1) CY1112655T1 (el)
DK (1) DK1904635T3 (el)
EA (1) EA012802B1 (el)
ES (1) ES2379732T3 (el)
HK (1) HK1115154A1 (el)
IL (1) IL188480A0 (el)
NO (1) NO344802B1 (el)
NZ (1) NZ564907A (el)
PL (1) PL1904635T3 (el)
PT (1) PT1904635E (el)
SI (1) SI1904635T1 (el)
WO (1) WO2007010401A2 (el)
ZA (1) ZA200800533B (el)

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EP2821078B1 (en) 2006-09-28 2016-09-21 Merck Sharp & Dohme Corp. Pegylated il-10 for use in treating lymphoma
CL2007003411A1 (es) * 2006-11-28 2008-07-04 Centelion Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu
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WO2012058726A1 (en) 2010-11-05 2012-05-10 Transbio Ltd Markers of endothelial progenitor cells and uses thereof
EP2649094B1 (en) 2010-12-10 2016-04-27 University of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
ES2568755T3 (es) 2011-08-03 2016-05-04 Cytheris Inmunoterapia para VHC
WO2014172392A1 (en) 2013-04-18 2014-10-23 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
ES2688206T3 (es) 2013-06-17 2018-10-31 Armo Biosciences, Inc. Procedimiento de evaluación de la identidad y la estabilidad de proteínas
EP3068425B1 (en) 2013-11-11 2021-01-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN104725484B (zh) * 2013-12-19 2018-03-13 中国科学院微生物研究所 一种糖基化多肽及其制备方法和其应用
US20180028593A1 (en) 2014-03-21 2018-02-01 Boreal Invest Terminal nanofiltration of solubilized protein compositions for removal of immunogenic aggregates
WO2015187295A2 (en) 2014-06-02 2015-12-10 Armo Biosciences, Inc. Methods of lowering serum cholesterol
CA2963995A1 (en) 2014-10-22 2016-04-28 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN104372021A (zh) * 2014-11-05 2015-02-25 太仓思源生物医药有限公司 人白细胞介素-2蛋白质的制备方法
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN107847583A (zh) 2015-05-28 2018-03-27 阿尔莫生物科技股份有限公司 用于治疗癌症的聚乙二醇化白细胞介素‑10
JP2018518955A (ja) * 2015-06-11 2018-07-19 ジェネクシン・インコーポレイテッドＧｅｎｅｘｉｎｅ， Ｉｎｃ． 改変されたインターロイキン−７タンパク質およびその使用
CA3002741A1 (en) 2015-10-23 2017-04-27 Apogenix Ag Single-chain gitr-receptor agonist proteins
KR102386735B1 (ko) 2015-11-06 2022-04-14 주식회사 제넥신 변형된 인터루킨-7 융합 단백질의 제형
US11708399B2 (en) 2015-12-04 2023-07-25 Genexine, Inc. Pharmaceutical composition comprising immunoglobulin Fc-fused interleukin-7 fusion protein for preventing or treating human papillomavirus-caused diseases
CN108697764A (zh) 2015-12-04 2018-10-23 格纳西尼有限公司 含有免疫球蛋白fc融合白细胞介素-7融合蛋白的用于预防或治疗流感病毒感染的药物组合物
CN106317226B (zh) * 2016-08-19 2017-09-05 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
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Also Published As

Publication number Publication date
EA012802B1 (ru) 2009-12-30
US8034327B2 (en) 2011-10-11
US8153114B2 (en) 2012-04-10
US7708985B2 (en) 2010-05-04
JP2009501543A (ja) 2009-01-22
NO344802B1 (no) 2020-05-04
PL1904635T3 (pl) 2012-07-31
US20100196312A1 (en) 2010-08-05
IL188480A0 (en) 2008-04-13
EP1904635A2 (en) 2008-04-02
US20080206190A1 (en) 2008-08-28
DK1904635T3 (da) 2012-02-27
SI1904635T1 (sl) 2012-10-30
US20120016104A1 (en) 2012-01-19
WO2007010401A2 (en) 2007-01-25
EP1904635B1 (en) 2012-01-25
ATE542901T1 (de) 2012-02-15
EP1746161A1 (en) 2007-01-24
CA2859145C (en) 2018-11-27
CN101228275A (zh) 2008-07-23
EA200800368A1 (ru) 2008-06-30
JP5685363B2 (ja) 2015-03-18
CA2859145A1 (en) 2007-01-25
CA2615562A1 (en) 2007-01-25
CN105647939A (zh) 2016-06-08
PT1904635E (pt) 2012-03-06
ES2379732T3 (es) 2012-05-03
CA2615562C (en) 2014-11-04
CN101228275B (zh) 2016-02-24
AU2006271315A1 (en) 2007-01-25
NO20080045L (no) 2008-04-21
NZ564907A (en) 2011-09-30
HK1115154A1 (en) 2008-11-21
ZA200800533B (en) 2008-12-31
AU2006271315B2 (en) 2011-08-11
JP2015057392A (ja) 2015-03-26
BRPI0613747A2 (pt) 2011-02-08
WO2007010401A3 (en) 2007-04-19

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