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CY1109404T1 - Μεθοδος δια την παρασκευη προϊοντων στεροειδους ορμονης. η οποια περιλαμβανει παραγοντα σταθεροποιησεως εις μη-κρυσταλλικην μορφη - Google Patents

Μεθοδος δια την παρασκευη προϊοντων στεροειδους ορμονης. η οποια περιλαμβανει παραγοντα σταθεροποιησεως εις μη-κρυσταλλικην μορφη

Info

Publication number
CY1109404T1
CY1109404T1 CY20091101002T CY091101002T CY1109404T1 CY 1109404 T1 CY1109404 T1 CY 1109404T1 CY 20091101002 T CY20091101002 T CY 20091101002T CY 091101002 T CY091101002 T CY 091101002T CY 1109404 T1 CY1109404 T1 CY 1109404T1
Authority
CY
Cyprus
Prior art keywords
crystal form
products
includes stabilization
hormone
steroid products
Prior art date
Application number
CY20091101002T
Other languages
English (en)
Inventor
Thomas Schultz
Bradley A Clark
Angela Falzone
Original Assignee
Ortho-Mcneil-Janssen Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil-Janssen Pharmaceuticals, Inc. filed Critical Ortho-Mcneil-Janssen Pharmaceuticals, Inc.
Publication of CY1109404T1 publication Critical patent/CY1109404T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεσις αναφέρεται εις προϊόντα στεροειδούς ορμόνης, όπως από του στόματος αντισυλληπτικά προϊόντα, τα οποία περιλαμβάνουν τουλάχιστον ένα στεροειδές δραστικόν συστατικόν εν αναμίξει μετ'εκδόχου και τα οποία έχουν βελτιωμένας ιδιότητας διαλύσεως και ταχύτητος απελευθερώσεως. Η εφεύρεσις αναφέρεται εις μεθόδους δια παρασκευήν τοιούτων προϊόντων στεροειδούς ορμόνης, ένθα μίγμα της ορμόνης και του εκδόχου υποβάλλεται εις επαρκήν μηχανικήν ενέργεια προς διαμόρφωσιν κονιώδους μίγματος (μίγματος κόνεως) εις το οποίον η ορμόνη σταθεροποιείται υπό του εκδόχου εις ουσιωδώς μη-κρυσταλλικήν μορφή.
CY20091101002T 2000-12-14 2009-09-24 Μεθοδος δια την παρασκευη προϊοντων στεροειδους ορμονης. η οποια περιλαμβανει παραγοντα σταθεροποιησεως εις μη-κρυσταλλικην μορφη CY1109404T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25566900P 2000-12-14 2000-12-14
EP05076805A EP1591121B1 (en) 2000-12-14 2001-12-13 Process for preparing steroid hormone products comprising a stabilizing agent in non-crystalline form

Publications (1)

Publication Number Publication Date
CY1109404T1 true CY1109404T1 (el) 2014-07-02

Family

ID=22969374

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101002T CY1109404T1 (el) 2000-12-14 2009-09-24 Μεθοδος δια την παρασκευη προϊοντων στεροειδους ορμονης. η οποια περιλαμβανει παραγοντα σταθεροποιησεως εις μη-κρυσταλλικην μορφη

Country Status (31)

Country Link
US (4) US7867990B2 (el)
EP (2) EP1361881B1 (el)
KR (1) KR100899032B1 (el)
CN (1) CN1290507C (el)
AT (2) ATE307591T1 (el)
AU (2) AU2002227421B2 (el)
BG (1) BG66178B1 (el)
BR (1) BRPI0116793B8 (el)
CA (1) CA2431521E (el)
CR (1) CR7022A (el)
CY (1) CY1109404T1 (el)
CZ (1) CZ306435B6 (el)
DE (2) DE60139087D1 (el)
DK (2) DK1591121T3 (el)
EC (1) ECSP034654A (el)
EE (1) EE05358B1 (el)
ES (2) ES2253451T3 (el)
HK (2) HK1057174A1 (el)
HU (1) HU230400B1 (el)
IL (2) IL156423A0 (el)
ME (1) ME00339B (el)
MX (1) MXPA03005339A (el)
NO (2) NO334341B1 (el)
NZ (1) NZ526517A (el)
PT (1) PT1591121E (el)
RS (1) RS50414B (el)
RU (1) RU2286155C2 (el)
SK (1) SK288222B6 (el)
UA (1) UA77404C2 (el)
WO (1) WO2002047693A2 (el)
ZA (1) ZA200305342B (el)

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Also Published As

Publication number Publication date
ATE434439T1 (de) 2009-07-15
US20140309204A1 (en) 2014-10-16
US20110046099A1 (en) 2011-02-24
EP1591121B1 (en) 2009-06-24
EP1361881B1 (en) 2005-10-26
CZ20031896A3 (en) 2004-03-17
SK8802003A3 (en) 2004-04-06
CN1489468A (zh) 2004-04-14
CN1290507C (zh) 2006-12-20
DE60114467D1 (de) 2005-12-01
CR7022A (es) 2009-02-23
BRPI0116793B1 (pt) 2015-06-23
DK1361881T3 (da) 2006-02-20
CA2431521C (en) 2010-03-16
AU2002227421B2 (en) 2007-08-23
US20020173669A1 (en) 2002-11-21
DE60114467T2 (de) 2006-07-20
EP1591121A1 (en) 2005-11-02
MXPA03005339A (es) 2004-03-26
UA77404C2 (en) 2006-12-15
ATE307591T1 (de) 2005-11-15
EP1361881A2 (en) 2003-11-19
BG107958A (bg) 2004-11-30
EE200300229A (et) 2003-08-15
YU47903A (sh) 2006-08-17
WO2002047693A3 (en) 2002-11-07
NO334341B1 (no) 2014-02-10
HK1083457A1 (en) 2006-07-07
ES2327538T3 (es) 2009-10-30
US20110046095A1 (en) 2011-02-24
ES2253451T3 (es) 2006-06-01
ME00339B (me) 2011-05-10
SK288222B6 (sk) 2014-09-04
HU230400B1 (hu) 2016-04-28
RU2286155C2 (ru) 2006-10-27
RS50414B (sr) 2009-12-31
NO20032708L (no) 2003-07-04
HUP0400646A2 (hu) 2004-06-28
NZ526517A (en) 2005-09-30
EE05358B1 (et) 2010-12-15
ZA200305342B (en) 2004-10-11
ECSP034654A (es) 2003-07-25
HK1057174A1 (en) 2004-03-19
CZ306435B6 (cs) 2017-01-25
CA2431521E (en) 2013-04-16
CA2431521A1 (en) 2002-06-20
IL156423A0 (en) 2004-01-04
WO2002047693A2 (en) 2002-06-20
US7867990B2 (en) 2011-01-11
NO20032708D0 (no) 2003-06-13
IL156423A (en) 2010-04-29
AU2742102A (en) 2002-06-24
NO20131334L (no) 2003-07-04
MEP48808A (en) 2011-02-10
BR0116793A (pt) 2004-01-27
KR100899032B1 (ko) 2009-05-21
DE60139087D1 (de) 2009-08-06
HUP0400646A3 (en) 2012-08-28
DK1591121T3 (da) 2009-10-05
PT1591121E (pt) 2009-07-20
KR20030061856A (ko) 2003-07-22
BRPI0116793B8 (pt) 2021-05-25
BG66178B1 (bg) 2011-11-30
RU2003121240A (ru) 2005-02-10

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