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CY1108104T1 - (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος - Google Patents

(4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος

Info

Publication number
CY1108104T1
CY1108104T1 CY20081100232T CY081100232T CY1108104T1 CY 1108104 T1 CY1108104 T1 CY 1108104T1 CY 20081100232 T CY20081100232 T CY 20081100232T CY 081100232 T CY081100232 T CY 081100232T CY 1108104 T1 CY1108104 T1 CY 1108104T1
Authority
CY
Cyprus
Prior art keywords
disease
morpholin
methoxy
amide
hydroxy
Prior art date
Application number
CY20081100232T
Other languages
English (en)
Inventor
Alexander Flohr
Jean-Luc Moreau
Sonia Maria Poli
Claus Riemer
Lucinda Steward
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34967309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108104(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1108104T1 publication Critical patent/CY1108104T1/el

Links

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με την ένωση του τύπου (I): η οποία είναι το (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο)-αμίδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικού οξέος και με φαρμακευτικώς αποδεκτά άλατα προσθήκης οξέος αυτού. Έχει βρεθεί ότι η ένωση είναι χρήσιμη για την θεραπευτική αντιμετώπιση ή πρόληψη της νόσου Alzheimer, της νόσου Parkinson, της νόσου Huntington, της νευροπροστασίας, της σχιζοφρένειας, του άγχους, του πόνου, των προβλημάτων αναπνοής, της κατάθλιψης, της ADHD (διαταραχή ελλειμματικής προσοχής με υπερκινητικότητα), του εθισμού σε αμφεταμίνες, κοκαΐνη, οπιοειδή, αιθανόλη, νικοτίνη, κανναβινοειδή ή για την θεραπευτική αντιμετώπιση του άσθματος, αλλεργικών αντιδράσεων, υποξίας, ισχαιμίας, παροξυσμού, κατάχρησης ουσιών, ή για τη χρήση ως μυοχαλαρωτικών, αντιψυχωσικών, αντιεπιληπτικών, σπασμολυτικών και καρδιοπροστατευτικών παραγόντων.
CY20081100232T 2004-05-24 2008-02-28 (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος CY1108104T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102262 2004-05-24
EP05741185A EP1753760B1 (en) 2004-05-24 2005-05-17 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Publications (1)

Publication Number Publication Date
CY1108104T1 true CY1108104T1 (el) 2014-02-12

Family

ID=34967309

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100232T CY1108104T1 (el) 2004-05-24 2008-02-28 (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος

Country Status (39)

Country Link
US (1) US7368446B2 (el)
EP (1) EP1753760B1 (el)
JP (1) JP4668265B2 (el)
CN (1) CN1956983B (el)
AR (1) AR048973A1 (el)
AT (1) ATE382619T1 (el)
AU (1) AU2005247567B2 (el)
BR (1) BRPI0511543B1 (el)
CA (1) CA2567703C (el)
CR (1) CR8703A (el)
CY (1) CY1108104T1 (el)
DE (1) DE602005004142T2 (el)
DK (1) DK1753760T3 (el)
DO (1) DOP2005000091A (el)
EA (1) EA011279B1 (el)
EC (1) ECSP067018A (el)
ES (1) ES2297710T3 (el)
GT (1) GT200500124A (el)
HK (1) HK1105199A1 (el)
HN (1) HN2005000238A (el)
HR (1) HRP20080027T3 (el)
IL (1) IL179364A (el)
MA (1) MA28601B1 (el)
MX (1) MXPA06013417A (el)
MY (1) MY140011A (el)
NO (1) NO336939B1 (el)
NZ (1) NZ550763A (el)
PA (1) PA8633901A1 (el)
PE (1) PE20060274A1 (el)
PL (1) PL1753760T3 (el)
PT (1) PT1753760E (el)
RS (1) RS50574B (el)
SI (1) SI1753760T1 (el)
SV (1) SV2006002125A (el)
TN (1) TNSN06371A1 (el)
TW (1) TWI358297B (el)
UA (1) UA87142C2 (el)
WO (1) WO2005116026A1 (el)
ZA (1) ZA200609136B (el)

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AU2013251079B2 (en) * 2012-04-20 2017-03-23 Ucb Pharma S.A. Methods for treating Parkinson's disease
JP2018517785A (ja) * 2015-06-19 2018-07-05 バイオティー セラピーズ インコーポレイテッド 制御放出トザデナント製剤
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WO2019141096A1 (zh) * 2018-01-19 2019-07-25 四川科伦博泰生物医药股份有限公司 取代脲类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
NO20065732L (no) 2006-12-22
JP2008500295A (ja) 2008-01-10
IL179364A (en) 2013-01-31
US7368446B2 (en) 2008-05-06
SV2006002125A (es) 2006-02-15
DK1753760T3 (da) 2008-04-14
ZA200609136B (en) 2008-07-30
CA2567703A1 (en) 2005-12-08
CN1956983A (zh) 2007-05-02
CR8703A (es) 2007-10-04
PT1753760E (pt) 2008-02-12
HN2005000238A (es) 2008-07-14
CA2567703C (en) 2013-03-05
GT200500124A (es) 2005-12-26
SI1753760T1 (sl) 2008-04-30
CN1956983B (zh) 2010-05-26
EA011279B1 (ru) 2009-02-27
HK1105199A1 (en) 2008-02-06
BRPI0511543A (pt) 2008-01-02
HRP20080027T3 (en) 2008-05-31
UA87142C2 (en) 2009-06-25
MXPA06013417A (es) 2007-01-23
ATE382619T1 (de) 2008-01-15
NO336939B1 (no) 2015-11-30
AR048973A1 (es) 2006-06-14
EA200602048A1 (ru) 2007-06-29
TWI358297B (en) 2012-02-21
AU2005247567B2 (en) 2010-09-02
PL1753760T3 (pl) 2008-06-30
RS50574B (sr) 2010-05-07
IL179364A0 (en) 2007-03-08
BRPI0511543B1 (pt) 2022-05-10
ECSP067018A (es) 2006-12-29
WO2005116026A1 (en) 2005-12-08
DE602005004142T2 (de) 2009-01-02
AU2005247567A1 (en) 2005-12-08
TNSN06371A1 (fr) 2008-02-22
DE602005004142D1 (de) 2008-02-14
MY140011A (en) 2009-11-30
TW200612937A (en) 2006-05-01
JP4668265B2 (ja) 2011-04-13
MA28601B1 (fr) 2007-05-02
NZ550763A (en) 2010-07-30
EP1753760B1 (en) 2008-01-02
ES2297710T3 (es) 2008-05-01
US20050261289A1 (en) 2005-11-24
PA8633901A1 (es) 2006-05-16
EP1753760A1 (en) 2007-02-21
PE20060274A1 (es) 2006-04-14
DOP2005000091A (es) 2005-06-29

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