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CY1107059T1 - Υδατικη διασπορα που περιεχει σταθερα νανοσωματιδια μιας αδιαλυτης στο νερο δραστικης ουσιας κι ενα εκδοχο οπως τα τριγλυκεριδια μεσης αλυσιδας (mct) - Google Patents

Υδατικη διασπορα που περιεχει σταθερα νανοσωματιδια μιας αδιαλυτης στο νερο δραστικης ουσιας κι ενα εκδοχο οπως τα τριγλυκεριδια μεσης αλυσιδας (mct)

Info

Publication number
CY1107059T1
CY1107059T1 CY20071101106T CY071101106T CY1107059T1 CY 1107059 T1 CY1107059 T1 CY 1107059T1 CY 20071101106 T CY20071101106 T CY 20071101106T CY 071101106 T CY071101106 T CY 071101106T CY 1107059 T1 CY1107059 T1 CY 1107059T1
Authority
CY
Cyprus
Prior art keywords
water
insoluble
triglycerides
excipient
active substance
Prior art date
Application number
CY20071101106T
Other languages
English (en)
Inventor
Pia Margaretha Cecilia Skantze
Tommy Urban Skantze
Corswant Lars Christian Von
Schantz Anna Elisabeth Fysi Zzackrisson
Per Lennart Lindfors
Ulf Olsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0119081A external-priority patent/GB0119081D0/en
Priority claimed from GB0212463A external-priority patent/GB0212463D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1107059T1 publication Critical patent/CY1107059T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Dental Preparations (AREA)

Abstract

Μία διαδικασία για την παρασκευή μίας σταθερής διασποράς στερεών σωματιδίων, σ' ένα υδατικό περιβάλλον που περιέχει συνδυασμένα (α) ένα πρώτο διάλυμα που περιέχει μία ουσιαστικά αδιάλυτη στο νερό ουσία, έναν αναμίξιμο με νερό οργανικό διαλύτη κι έναν αναστολέα με (β) μία υδατική φάση που περιέχει νερό και προαιρετικά ένα σταθεροποιητή, οπότε καθιζάνουν τα στερεά σωματίδια που περιέχουν τον αναστολέα και την ουσιαστικά αδιάλυτη στο νερό ουσία˙ και προαιρετικά αφαίρεση του αναμίξιμου με το νερό οργανικού διαλύτη. όπου ο αναστολέας είναι μία μη πολυμερική υδροφοβική οργανική ένωση όπως ορίζεται στην περιγραφή. Η διαδικασία δίδει μία διασπορά στερεών σωματιδίων σ' ένα υδατικό περιβάλλον, τα οποία σωματίδια επιδεικνύουν μειωμένη ή ουσιαστικά καθόλου ανάπτυξη σωματιδίων που να προκαλείται από την ωρίμανση Ostwald.
CY20071101106T 2001-08-06 2007-08-28 Υδατικη διασπορα που περιεχει σταθερα νανοσωματιδια μιας αδιαλυτης στο νερο δραστικης ουσιας κι ενα εκδοχο οπως τα τριγλυκεριδια μεσης αλυσιδας (mct) CY1107059T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0119081A GB0119081D0 (en) 2001-08-06 2001-08-06 Process
GB0212463A GB0212463D0 (en) 2002-05-30 2002-05-30 Process
EP02745697A EP1416917B1 (en) 2001-08-06 2002-08-01 Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)

Publications (1)

Publication Number Publication Date
CY1107059T1 true CY1107059T1 (el) 2012-10-24

Family

ID=26246405

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101106T CY1107059T1 (el) 2001-08-06 2007-08-28 Υδατικη διασπορα που περιεχει σταθερα νανοσωματιδια μιας αδιαλυτης στο νερο δραστικης ουσιας κι ενα εκδοχο οπως τα τριγλυκεριδια μεσης αλυσιδας (mct)

Country Status (20)

Country Link
US (1) US20050009908A1 (el)
EP (1) EP1416917B1 (el)
JP (1) JP4714412B2 (el)
KR (1) KR100914113B1 (el)
CN (1) CN1254233C (el)
AT (1) ATE365537T1 (el)
AU (1) AU2002317409B2 (el)
BR (1) BR0211705A (el)
CA (1) CA2456180C (el)
CY (1) CY1107059T1 (el)
DE (1) DE60220923T2 (el)
DK (1) DK1416917T3 (el)
ES (1) ES2287293T3 (el)
HK (1) HK1064048A1 (el)
IL (2) IL160103A0 (el)
MX (1) MXPA04001071A (el)
NO (1) NO20040484L (el)
NZ (1) NZ530916A (el)
PT (1) PT1416917E (el)
WO (1) WO2003013472A1 (el)

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CN101998851A (zh) * 2008-02-08 2011-03-30 帕纳德制药公司 吡铂和西妥昔单抗治疗结直肠癌的用途
BRPI1004808B1 (pt) * 2010-10-27 2020-09-29 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Composições baseadas em nanopartículas de própolis, processos de obtenção e uso
CN109999013A (zh) 2012-02-29 2019-07-12 普马特里克斯营业公司 可吸入干粉剂
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
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Also Published As

Publication number Publication date
DK1416917T3 (da) 2007-09-17
PT1416917E (pt) 2007-08-16
ATE365537T1 (de) 2007-07-15
EP1416917B1 (en) 2007-06-27
JP2005500362A (ja) 2005-01-06
CN1254233C (zh) 2006-05-03
NO20040484L (no) 2004-03-31
IL160103A0 (en) 2004-06-20
KR20040025739A (ko) 2004-03-25
HK1064048A1 (en) 2005-01-21
KR100914113B1 (ko) 2009-08-27
CA2456180A1 (en) 2003-02-20
CN1564677A (zh) 2005-01-12
MXPA04001071A (es) 2004-05-20
DE60220923D1 (de) 2007-08-09
DE60220923T2 (de) 2008-03-06
NZ530916A (en) 2005-07-29
CA2456180C (en) 2011-10-11
BR0211705A (pt) 2004-09-28
IL160103A (en) 2008-11-26
WO2003013472A1 (en) 2003-02-20
AU2002317409B2 (en) 2007-06-21
ES2287293T3 (es) 2007-12-16
EP1416917A1 (en) 2004-05-12
JP4714412B2 (ja) 2011-06-29
US20050009908A1 (en) 2005-01-13

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