CY1105735T1 - MODIFIED FACTOR VIII cDNA - Google Patents
MODIFIED FACTOR VIII cDNAInfo
- Publication number
- CY1105735T1 CY1105735T1 CY20061101541T CY061101541T CY1105735T1 CY 1105735 T1 CY1105735 T1 CY 1105735T1 CY 20061101541 T CY20061101541 T CY 20061101541T CY 061101541 T CY061101541 T CY 061101541T CY 1105735 T1 CY1105735 T1 CY 1105735T1
- Authority
- CY
- Cyprus
- Prior art keywords
- factor viii
- viii cdna
- modified factor
- cdna
- modified
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title abstract 6
- 239000002299 complementary DNA Substances 0.000 title abstract 5
- 108010054218 Factor VIII Proteins 0.000 abstract 5
- 102000001690 Factor VIII Human genes 0.000 abstract 5
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 1
- 108010076282 Factor IX Proteins 0.000 abstract 1
- 229960004222 factor ix Drugs 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Περιγράφεται τροποποιημένο cDNA παράγοντα VIII στο οποίο η Β-περιοχή του cDNA παράγοντα VIII φυσικού τύπου έχει εξαλειφθεί και κολοβωμένο ενδόνιο 1 παράγοντα IX έχει εντεθεί σε μία ή περισσότερες θέσεις του cDNA παράγοντα VIII. Αυτό το τροποποιημένο cDNA παράγοντα VIII μπορεί να χρησιμοποιηθεί για παραγωγή in vitro υψηλότερης απόδοσης του παράγοντα VIII όπως επίσης και ως φορέας μεταφοράς για γονιδιακή θεραπεία.A modified factor VIII cDNA is described in which the B-region of the wild-type factor VIII cDNA has been deleted and a truncated factor IX intron 1 has been inserted into one or more sites of the factor VIII cDNA. This modified factor VIII cDNA can be used for higher efficiency in vitro production of factor VIII as well as a delivery vector for gene therapy.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99104050A EP1038959A1 (en) | 1999-03-17 | 1999-03-17 | Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX |
| EP99107397A EP1048736A1 (en) | 1999-04-27 | 1999-04-27 | DNA-construct for the tissue specific expression of a blood coagulation factor |
| EP20000104677 EP1048726B1 (en) | 1999-04-27 | 2000-03-03 | Modified factor VIII cDNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105735T1 true CY1105735T1 (en) | 2010-12-22 |
Family
ID=90195461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101541T CY1105735T1 (en) | 1999-03-17 | 2006-10-25 | MODIFIED FACTOR VIII cDNA |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1105735T1 (en) |
-
2006
- 2006-10-25 CY CY20061101541T patent/CY1105735T1/en unknown
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