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CU20140061A7 - VACCINES AGAINST VIRUS INFLUENZA AND ITS USES - Google Patents

VACCINES AGAINST VIRUS INFLUENZA AND ITS USES

Info

Publication number
CU20140061A7
CU20140061A7 CU2014000061A CU20140061A CU20140061A7 CU 20140061 A7 CU20140061 A7 CU 20140061A7 CU 2014000061 A CU2014000061 A CU 2014000061A CU 20140061 A CU20140061 A CU 20140061A CU 20140061 A7 CU20140061 A7 CU 20140061A7
Authority
CU
Cuba
Prior art keywords
polypeptides
domain
influenza
vaccines against
influenza hemagglutinin
Prior art date
Application number
CU2014000061A
Other languages
Spanish (es)
Inventor
Jan Wilem Meijberg
Antonietta Impagliazzo
Ronald Vogels
Robert Heinz Edward Friesen
Philippe Alard
Stefan Loverix
Katarina Radoševic
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/073706 external-priority patent/WO2013079473A1/en
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of CU20140061A7 publication Critical patent/CU20140061A7/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Polipéptidos que comprenden polipéptidos del dominio de tallo de la hemaglutinina de la influenza, donde dichos polipéptidos comprenden (a) un dominio HA1 de la hemaglutinina de la influenza, que comprende un segmento del tallo N-terminal del HA1, unido covalentemente mediante una secuencia conectora de 0-50 aminoácidos a un segmento del tallo C-terminal del HA1, y (b) un dominio HA2 de la hemaglutinina de la influenza en el que se han mutado uno o más aminoácidos. También se proveen ácidos nucleicos que codifican dichos polipéptidos, composiciones que comprenden a los polipéptidos y/o a las moléculas de ácidos nucleicos; así como métodos para usarlos, en particular en la detección, la prevención y/o el tratamiento de la influenza.Polypeptides comprising polypeptides of the influenza hemagglutinin stem domain, wherein said polypeptides comprise (a) an HA1 domain of influenza hemagglutinin, which comprises a segment of the N-terminal stem of HA1, covalently linked by a linker sequence from 0-50 amino acids to a segment of the C-terminal stem of HA1, and (b) an HA2 domain of influenza hemagglutinin in which one or more amino acids have been mutated. Nucleic acids encoding said polypeptides, compositions comprising polypeptides and / or nucleic acid molecules are also provided; as well as methods to use them, in particular in the detection, prevention and / or treatment of influenza.

CU2014000061A 2011-11-28 2014-05-28 VACCINES AGAINST VIRUS INFLUENZA AND ITS USES CU20140061A7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161564086P 2011-11-28 2011-11-28
PCT/EP2012/073706 WO2013079473A1 (en) 2011-11-28 2012-11-27 Influenza virus vaccines and uses thereof

Publications (1)

Publication Number Publication Date
CU20140061A7 true CU20140061A7 (en) 2014-10-02

Family

ID=52395366

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2014000061A CU20140061A7 (en) 2011-11-28 2014-05-28 VACCINES AGAINST VIRUS INFLUENZA AND ITS USES

Country Status (1)

Country Link
CU (1) CU20140061A7 (en)

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