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CR11106A - Inhibidores de cinasa p710 s6 - Google Patents

Inhibidores de cinasa p710 s6

Info

Publication number
CR11106A
CR11106A CR11106A CR11106A CR11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A CR 11106 A CR11106 A CR 11106A
Authority
CR
Costa Rica
Prior art keywords
kinase inhibitors
formula
methods
relates
present
Prior art date
Application number
CR11106A
Other languages
English (en)
Inventor
Dean Dally Robert
Huang Jianping
Joseph Sajan
Alan Shepherd Timothy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR11106A publication Critical patent/CR11106A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a inhibidores de cinasa p70 6 de la formula:formulaciones farmaceuticas que los comprenden, y metodos para su uso.
CR11106A 2007-05-11 2009-11-10 Inhibidores de cinasa p710 s6 CR11106A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
CR11106A true CR11106A (es) 2010-04-12

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11106A CR11106A (es) 2007-05-11 2009-11-10 Inhibidores de cinasa p710 s6

Country Status (34)

Country Link
US (2) US8093383B2 (es)
EP (1) EP2148880B1 (es)
JP (1) JP5503532B2 (es)
KR (1) KR101088219B1 (es)
CN (1) CN101679439B (es)
AR (1) AR066344A1 (es)
AU (1) AU2008251692B2 (es)
BR (1) BRPI0811212A2 (es)
CA (1) CA2687265C (es)
CL (1) CL2008001230A1 (es)
CO (1) CO6241109A2 (es)
CR (1) CR11106A (es)
DK (1) DK2148880T3 (es)
DO (1) DOP2009000257A (es)
EA (1) EA016445B1 (es)
EC (1) ECSP099721A (es)
ES (1) ES2483726T3 (es)
GT (1) GT200900292A (es)
HK (1) HK1140767A1 (es)
HR (1) HRP20140611T1 (es)
IL (1) IL201564A (es)
MA (1) MA31433B1 (es)
MX (1) MX2009012075A (es)
MY (1) MY154898A (es)
NZ (1) NZ580423A (es)
PE (1) PE20090887A1 (es)
PL (1) PL2148880T3 (es)
PT (1) PT2148880E (es)
RS (1) RS53451B (es)
SI (1) SI2148880T1 (es)
TN (1) TN2009000446A1 (es)
TW (1) TWI423805B (es)
UA (1) UA99284C2 (es)
WO (1) WO2008140947A1 (es)

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AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
WO2010056574A1 (en) * 2008-11-11 2010-05-20 Eli Lilly And Company P70 s6 kinase inhibitor and mtor inhibitor combination therapy
AU2010214095B2 (en) 2009-02-11 2015-12-24 Merck Patent Gmbh Novel amino azaheterocyclic carboxamides
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CA2778291C (en) * 2009-10-23 2014-02-11 Eli Lilly And Company Akt inhibitors
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UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
CN103140484B (zh) 2010-07-29 2015-04-22 默克专利有限公司 环状胺氮杂杂环甲酰胺
KR101894116B1 (ko) 2010-11-24 2018-08-31 메르크 파텐트 게엠베하 퀴나졸린 카르복사미드 아제티딘
US9321760B2 (en) 2011-09-12 2016-04-26 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity
PT2755965T (pt) * 2011-09-12 2017-11-02 Merck Patent Gmbh Novas imidazol aminas como moduladores da atividade quinase
CN104981247A (zh) * 2012-09-06 2015-10-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
WO2014078637A1 (en) 2012-11-16 2014-05-22 Merck Patent Gmbh Novel heterocyclic derivatives as modulators of kinase activity
ES2656096T3 (es) 2012-11-16 2018-02-23 Merck Patent Gmbh Nuevos derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
MX2015006516A (es) 2012-11-29 2015-08-14 Merck Patent Gmbh Derivados de azaquinolin-carboxamida.
AR095202A1 (es) * 2013-03-11 2015-09-30 Merck Patent Gmbh Heterociclos como moduladores de la actividad quinasa
TWI631949B (zh) 2013-04-17 2018-08-11 標誌製藥公司 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法
JP6382949B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー 癌を治療するためのｔｏｒキナーゼ阻害剤及び５−置換キナゾリノン化合物を含む組合せ療法
TWI656875B (zh) 2013-04-17 2019-04-21 美商標誌製藥公司 藉二氫吡并吡治療癌症
CA2908957C (en) 2013-04-17 2021-05-18 Signal Pharmaceuticals, Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
CN105324381A (zh) 2013-04-17 2016-02-10 西格诺药品有限公司 有关1-乙基-7-(2-甲基-6-(1H-1,2,4-三唑-3-基)吡啶-3-基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法
JP6382945B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
KR20160002792A (ko) 2013-04-17 2016-01-08 시그날 파마소티칼 엘엘씨 암 치료용 tor 키나제 억제제 및 n-(3-(5-플루오로-2-(4-(2-메톡시에톡시)페닐아미노)피리미딘-4-일아미노)페닐)아크릴아미드를 포함하는 병용 요법
WO2014193912A1 (en) 2013-05-29 2014-12-04 Signal Pharmaceuticals, Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MX370540B (es) 2014-04-03 2019-12-17 Merck Patent Gmbh Combinaciones de amida de ácido 4-[(s) -2-azetidin-1-il-1-(4-cloro -3-trifluorometil - fenil) - etilamino] -quinazolin-8-carboxílico e inhibidores de her2 para usarse en el tratamiento de cáncer.
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US9512129B2 (en) 2014-04-16 2016-12-06 Signal Pharmaceuticals, Llc Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
WO2016040078A1 (en) * 2014-09-10 2016-03-17 Eli Lilly And Company Substituted phenyl imidazolyl piperidyl compounds as p70s6k1 inhibitors
WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
WO2018237114A1 (en) 2017-06-22 2018-12-27 Celgene Corporation TREATMENT OF HEPATOCELLULAR CARCINOMA CHARACTERIZED BY HEPATITIS B VIRUS INFECTION
MX2023005520A (es) 2020-11-16 2023-05-23 Merck Patent Gmbh Combinaciones de inhibidores de cinasa para tratamiento de cancer.

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NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
EP1750727A2 (en) * 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
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UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Also Published As

Publication number Publication date
AR066344A1 (es) 2009-08-12
PL2148880T3 (pl) 2014-10-31
AU2008251692B2 (en) 2012-10-11
KR20100005710A (ko) 2010-01-15
ES2483726T3 (es) 2014-08-07
HRP20140611T1 (hr) 2014-08-15
PT2148880E (pt) 2014-08-28
DK2148880T3 (da) 2014-06-16
HK1140767A1 (en) 2010-10-22
JP2010526814A (ja) 2010-08-05
JP5503532B2 (ja) 2014-05-28
IL201564A (en) 2014-08-31
CA2687265A1 (en) 2008-11-20
TW200848053A (en) 2008-12-16
PE20090887A1 (es) 2009-07-13
MX2009012075A (es) 2009-11-19
US8093383B2 (en) 2012-01-10
NZ580423A (en) 2012-02-24
GT200900292A (es) 2011-06-24
DOP2009000257A (es) 2010-03-31
BRPI0811212A2 (pt) 2014-10-29
US20120071490A1 (en) 2012-03-22
UA99284C2 (ru) 2012-08-10
EA200971051A1 (ru) 2010-06-30
TN2009000446A1 (en) 2011-03-31
MA31433B1 (fr) 2010-06-01
CN101679439A (zh) 2010-03-24
CO6241109A2 (es) 2011-01-20
CL2008001230A1 (es) 2009-05-22
IL201564A0 (en) 2010-05-31
CA2687265C (en) 2012-12-04
US20090163714A1 (en) 2009-06-25
MY154898A (en) 2015-08-28
WO2008140947A1 (en) 2008-11-20
EP2148880A1 (en) 2010-02-03
SI2148880T1 (sl) 2014-07-31
RS53451B (en) 2014-12-31
EP2148880B1 (en) 2014-05-28
CN101679439B (zh) 2013-09-11
EA016445B1 (ru) 2012-05-30
TWI423805B (zh) 2014-01-21
KR101088219B1 (ko) 2011-11-30
AU2008251692A1 (en) 2008-11-20
ECSP099721A (es) 2009-12-28

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