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CO6710902A2 - Inhibidores de oxadiazol de la producción de leucotrienos - Google Patents

Inhibidores de oxadiazol de la producción de leucotrienos

Info

Publication number
CO6710902A2
CO6710902A2 CO13057875A CO13057875A CO6710902A2 CO 6710902 A2 CO6710902 A2 CO 6710902A2 CO 13057875 A CO13057875 A CO 13057875A CO 13057875 A CO13057875 A CO 13057875A CO 6710902 A2 CO6710902 A2 CO 6710902A2
Authority
CO
Colombia
Prior art keywords
compounds
leukotriene production
oxadiazole
inhibitors
oxadiazole inhibitors
Prior art date
Application number
CO13057875A
Other languages
English (en)
Inventor
Alessandra Bartolozzi
Todd Bosanac
Zhidong Chen
Lombaert Stephane De
Jonathon Alan Dines
John D Huber
Weimin Liu
Pui Leng Loke
Tina Marie Morwick
Alan Olague
Doris Riether
Heather Tye
Lifen Wu
Renee M Zindell
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44720163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6710902(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6710902A2 publication Critical patent/CO6710902A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I) y (lA):y sus sales farmacéuticamente aceptables, en donde R1- R5 son tal como se definen en la presente. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos, métodos de uso de estos compuestos en el tratamiento de diversas enfermedades y trastornos, procesos para preparar estos compuestos e intermediarios de utilidad en estos procesos.
CO13057875A 2010-09-23 2013-03-22 Inhibidores de oxadiazol de la producción de leucotrienos CO6710902A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38573310P 2010-09-23 2010-09-23
US201161533349P 2011-09-12 2011-09-12

Publications (1)

Publication Number Publication Date
CO6710902A2 true CO6710902A2 (es) 2013-07-15

Family

ID=44720163

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13057875A CO6710902A2 (es) 2010-09-23 2013-03-22 Inhibidores de oxadiazol de la producción de leucotrienos

Country Status (18)

Country Link
US (1) US8575201B2 (es)
EP (1) EP2619197B1 (es)
JP (1) JP5713511B2 (es)
KR (1) KR20130109122A (es)
CN (1) CN103261193A (es)
AU (1) AU2011305667A1 (es)
BR (1) BR112013008638A2 (es)
CA (1) CA2812449A1 (es)
CL (1) CL2013000788A1 (es)
CO (1) CO6710902A2 (es)
EA (1) EA201300389A1 (es)
EC (1) ECSP13012548A (es)
IN (1) IN2013DN02555A (es)
MX (1) MX2013003202A (es)
PE (1) PE20131398A1 (es)
SG (1) SG188604A1 (es)
WO (1) WO2012040139A1 (es)
ZA (1) ZA201301747B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580829B2 (en) * 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена
EP2619196B1 (en) * 2010-09-23 2015-09-16 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
US9079866B2 (en) * 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
PL2875736T3 (pl) 2013-11-26 2017-02-28 Citrage N-karbamoiloputrescyna do zwiększenia syntezy białka mięśni

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU780047B2 (en) 1999-08-06 2005-02-24 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
US20050054663A1 (en) * 2003-08-13 2005-03-10 Bennett Christina N. GSK-3 inhibitors
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
AU2005295646B2 (en) 2004-10-18 2008-11-20 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes as flap inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
WO2007120574A2 (en) 2006-04-11 2007-10-25 Merck & Co., Inc. Diaryl substituted alkanes
ATE540681T1 (de) 2006-06-26 2012-01-15 Amgen Inc Verfahren zur behandlung von atherosklerose
WO2008030369A1 (en) * 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5 -lipoxygenase activating protein ( flap)
US20100120784A1 (en) 2007-04-20 2010-05-13 Lachance Nicolas Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP2170065A4 (en) 2007-06-20 2011-11-23 Merck Sharp & Dohme DIPHENYL SUBSTITUTED ALKANES
JP2011500563A (ja) 2007-10-10 2011-01-06 メルク・シャープ・エンド・ドーム・コーポレイション ジフェニル置換されたシクロアルカン
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
US8598209B2 (en) * 2008-10-31 2013-12-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
CA2749893A1 (en) 2009-02-04 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
EP2568809A4 (en) 2010-05-12 2013-11-06 Univ Vanderbilt MGLUR4-SULFONATED HETEROCYCLIC ALLOSTERIC POTENTIALIZERS, COMPOSITIONS THEREFOR, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTION
SG187549A1 (en) * 2010-08-16 2013-03-28 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
US8580829B2 (en) * 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
EP2619196B1 (en) * 2010-09-23 2015-09-16 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена

Also Published As

Publication number Publication date
EP2619197A1 (en) 2013-07-31
CL2013000788A1 (es) 2013-06-28
JP5713511B2 (ja) 2015-05-07
ZA201301747B (en) 2014-08-27
EA201300389A1 (ru) 2013-09-30
US8575201B2 (en) 2013-11-05
IN2013DN02555A (es) 2015-08-07
AU2011305667A1 (en) 2013-03-21
PE20131398A1 (es) 2013-12-19
ECSP13012548A (es) 2013-06-28
WO2012040139A1 (en) 2012-03-29
EP2619197B1 (en) 2015-08-05
CA2812449A1 (en) 2012-03-29
KR20130109122A (ko) 2013-10-07
US20120295896A1 (en) 2012-11-22
MX2013003202A (es) 2013-04-24
CN103261193A (zh) 2013-08-21
BR112013008638A2 (pt) 2016-06-21
SG188604A1 (en) 2013-04-30
JP2013537909A (ja) 2013-10-07

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