Nothing Special   »   [go: up one dir, main page]

CO6761400A2 - Combinación de análogos de glucagón acilados con análogos de insulina - Google Patents

Combinación de análogos de glucagón acilados con análogos de insulina

Info

Publication number
CO6761400A2
CO6761400A2 CO13165262A CO13165262A CO6761400A2 CO 6761400 A2 CO6761400 A2 CO 6761400A2 CO 13165262 A CO13165262 A CO 13165262A CO 13165262 A CO13165262 A CO 13165262A CO 6761400 A2 CO6761400 A2 CO 6761400A2
Authority
CO
Colombia
Prior art keywords
combination
acylated glucagon
insulin analogues
glucagon analogs
acylated
Prior art date
Application number
CO13165262A
Other languages
English (en)
Inventor
Keld Fosgerau
Ditte Riber
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45607302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6761400(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of CO6761400A2 publication Critical patent/CO6761400A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención se refiere a procedimientos para tratar trastornos metabólicos, incluyendo diabetes, usando una combinación de un análogo de glucagón acilado y un análogo de insulina. La invención también presenta un kit que incluye un análogo de glucagón acilado y un análogo de insulina.
CO13165262A 2011-01-20 2013-07-11 Combinación de análogos de glucagón acilados con análogos de insulina CO6761400A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161434698P 2011-01-20 2011-01-20

Publications (1)

Publication Number Publication Date
CO6761400A2 true CO6761400A2 (es) 2013-09-30

Family

ID=45607302

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13165262A CO6761400A2 (es) 2011-01-20 2013-07-11 Combinación de análogos de glucagón acilados con análogos de insulina

Country Status (21)

Country Link
US (2) US20140011733A1 (es)
EP (1) EP2665487A1 (es)
JP (1) JP2014504597A (es)
KR (1) KR20140043709A (es)
CN (1) CN103491975B (es)
AR (1) AR085086A1 (es)
AU (1) AU2012208349A1 (es)
BR (1) BR112013018269A2 (es)
CA (1) CA2824397A1 (es)
CL (1) CL2013002085A1 (es)
CO (1) CO6761400A2 (es)
EA (1) EA201390796A1 (es)
MA (1) MA34913B1 (es)
MX (1) MX2013008005A (es)
PE (1) PE20140969A1 (es)
PH (1) PH12013501495A1 (es)
SG (1) SG192038A1 (es)
TN (1) TN2013000251A1 (es)
TW (1) TW201247702A (es)
UY (1) UY33872A (es)
WO (1) WO2012098462A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5635531B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
KR20110126592A (ko) 2008-12-15 2011-11-23 질랜드 파마 에이/에스 글루카곤 유사체
MX2011006313A (es) 2008-12-15 2011-09-27 Zealand Pharma As Analogos de glucagon.
WO2010070255A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
SI2454282T1 (sl) 2009-07-13 2015-06-30 Zealand Pharma A/S Acilirani glukagonski analogi
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
BR112012033225A2 (pt) 2010-06-24 2017-06-20 Zealand Pharma As análogos do glucagon
RU2017101333A (ru) 2011-09-23 2018-12-19 Ново Нордиск А/С Новые аналоги глюкагона
MX356641B (es) 2012-05-03 2018-06-07 Zealand Pharma As Compuestos agonistas dobles de gip-glp-1 y procedimientos.
US10442847B2 (en) 2012-07-23 2019-10-15 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
BR112015023071A2 (pt) * 2013-03-14 2017-07-18 Univ Indiana Res & Tech Corp conjugados de insulina-incretina
WO2014170496A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
US9988429B2 (en) * 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
EP3057984B1 (en) 2013-10-17 2018-07-11 Zealand Pharma A/S Acylated glucagon analogues
EA035466B9 (ru) 2013-11-06 2020-08-17 Зилэнд Фарма А/С Соединения и способы на основе двойного агониста гип и гпп-1
TR201902516T4 (tr) 2013-11-06 2019-03-21 Zealand Pharma As Glukagon-glp-1-gıp üçlü agonist bileşikleri.
AR098616A1 (es) 2013-12-18 2016-06-01 Lilly Co Eli Péptido para el tratamiento de hipoglicemia severa
CN105916877A (zh) 2014-01-20 2016-08-31 韩美药品株式会社 长效胰岛素及其用途
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
CN106536547A (zh) 2014-06-04 2017-03-22 诺和诺德股份有限公司 用于医疗用途的glp‑1/胰高血糖素受体共激动剂
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
EP3212218B1 (en) 2014-10-29 2021-06-30 Zealand Pharma A/S Gip agonist compounds and methods
DK3283507T3 (da) 2015-04-16 2020-01-02 Zealand Pharma As Acyleret glucagonanalog
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
BR102015031283A2 (pt) * 2015-12-14 2018-09-18 Univ Rio De Janeiro Bioconjugado de amilina humana ou de análogos de amilinanão agregantes, composição, métodos para a preparação deuma composição, para o tratamento de uma doença oucondição e para estabilizar um composto amilino-mimético, e,medicamento
US20190175744A1 (en) * 2016-03-18 2019-06-13 Merck Sharp & Dohme Corp. Insulin-incretin conjugates
EP3448417A4 (en) * 2016-04-26 2019-12-11 Merck Sharp & Dohme Corp. INSULIN Dimer incretin CONJUGATES
CN110546161B (zh) 2016-09-23 2024-01-26 韩美药品股份有限公司 对胰岛素受体具有降低的结合力的胰岛素类似物及其用途
CA3054899A1 (en) 2017-03-23 2018-09-27 Hanmi Pharm. Co., Ltd. Insulin analog complex with reduced affinity for insulin receptor and use thereof
CA3124340A1 (en) * 2018-12-21 2020-06-25 Hanmi Pharm. Co., Ltd. Pharmaceutical composition containing insulin and glucagon
EP4164675A4 (en) * 2020-06-11 2024-06-26 Abvance Therapeutics Inc. SYSTEMS, DEVICES, COMPOSITIONS, AND METHODS FOR TREATMENT OF DIABETES
JP2024543441A (ja) * 2021-11-19 2024-11-21 メッドシャイン ディスカバリー インコーポレイテッド ステープルペプチド及びその使用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
KR100310122B1 (ko) 1993-09-17 2002-04-24 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 아실화된인슐린
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5866538A (en) 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Glp―1誘導体
JP4405594B2 (ja) 1996-09-09 2010-01-27 ジーランド ファーマ アクティーゼルスカブ 改良型固相ペプチド合成及びかかる合成において利用するための試薬
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
ES2315226T3 (es) 1999-03-17 2009-04-01 Novo Nordisk A/S Metodo de acilacion de peptidos y proteinas.
AU2002346491A1 (en) 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
BR0215029A (pt) 2001-12-20 2005-12-20 Lilly Co Eli Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
BRPI0409600A (pt) 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
AU2006258841B2 (en) 2005-06-13 2012-05-03 Imperial Innovations Limited Oxyntomodulin analogues and their effects on feeding behaviour
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
AU2007221366B2 (en) 2006-02-22 2012-08-23 Msd Italia S.R.L. Oxyntomodulin derivatives
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
BRPI0807728A2 (pt) 2007-02-15 2012-04-17 Univ Indiana Res & Tech Corp co-agonistas de receptor glucagon/glp-1
JP5385266B2 (ja) 2007-06-15 2014-01-08 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
AU2008326324B9 (en) 2007-11-20 2012-11-15 Ambrx, Inc. Modified insulin polypeptides and their uses
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP2229407B1 (de) 2008-01-09 2016-11-16 Sanofi-Aventis Deutschland GmbH Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
NZ586589A (en) 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
KR20110021758A (ko) 2008-04-22 2011-03-04 케이스 웨스턴 리저브 유니버시티 이형체-특이적 인슐린 유사체
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
EP2307037A4 (en) * 2008-06-17 2011-08-03 Univ Indiana Res & Tech Corp GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
CN102123723B (zh) 2008-06-17 2016-05-25 印第安纳大学研究及科技有限公司 胰高血糖素/glp-1受体共激动剂
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
AU2009276346B2 (en) 2008-07-31 2014-07-03 Case Western Reserve University Halogen-stabilized insulin
WO2010070255A1 (en) * 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
JP5635531B2 (ja) * 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
MX2011006313A (es) * 2008-12-15 2011-09-27 Zealand Pharma As Analogos de glucagon.
KR20110126592A (ko) * 2008-12-15 2011-11-23 질랜드 파마 에이/에스 글루카곤 유사체
WO2010080606A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
CN101519446A (zh) 2009-03-31 2009-09-02 上海一就生物医药有限公司 一种重组人胰岛素及其类似物的制备方法
SI2454282T1 (sl) * 2009-07-13 2015-06-30 Zealand Pharma A/S Acilirani glukagonski analogi
AU2011247452B2 (en) * 2010-04-27 2016-03-17 Zealand Pharma A/S Peptide conjugates of GLP-1 receptor agonists and gastrin and their use
UY33462A (es) * 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon

Also Published As

Publication number Publication date
MX2013008005A (es) 2013-08-21
CL2013002085A1 (es) 2013-12-06
US20160000883A1 (en) 2016-01-07
PE20140969A1 (es) 2014-07-24
MA34913B1 (fr) 2014-02-01
CN103491975B (zh) 2016-05-11
PH12013501495A1 (en) 2013-09-16
SG192038A1 (en) 2013-08-30
BR112013018269A2 (pt) 2017-06-06
CA2824397A1 (en) 2012-07-26
JP2014504597A (ja) 2014-02-24
EP2665487A1 (en) 2013-11-27
TW201247702A (en) 2012-12-01
TN2013000251A1 (en) 2014-11-10
US20140011733A1 (en) 2014-01-09
CN103491975A (zh) 2014-01-01
UY33872A (es) 2012-08-31
AR085086A1 (es) 2013-09-11
AU2012208349A1 (en) 2013-07-18
WO2012098462A1 (en) 2012-07-26
EA201390796A1 (ru) 2014-07-30
NZ612719A (en) 2015-05-29
KR20140043709A (ko) 2014-04-10

Similar Documents

Publication Publication Date Title
CO6761400A2 (es) Combinación de análogos de glucagón acilados con análogos de insulina
BR112014032990A2 (pt) seringa
UY34698A (es) Combinaciones farmacéuticas que comprenden un análogo de tionucleótidos
CL2016003075A1 (es) Composición para tratar diabetes, que contiene un conjugado de análogo de insulina de acción prolongada y un conjugado de péptido insulinotrópico de acción prolongada
BR112016009889A2 (pt) ?compostos agonistas duplos gip-glp-1 e métodos?
EA201691911A1 (ru) Быстродействующие композиции инсулина
ES2877502T8 (es) Uso del fitocannabinoide cannabidiol (CBD) en combinación con un fármaco antiepiléptico estándar (SAED) en el tratamiento de la epilepsia
EA201590058A1 (ru) Аналоги глюкагона
MX370264B (es) Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2.
MX356728B (es) Combinación farmacéutica para usar en el tratamiento de pacientes que padecen diabetes de tipo 2.
CL2015000976A1 (es) Compuestos de 2-fenil-5-heterociclil-tetrahidro-2h-piran-3-amina para uso en el tratamiento de diabetes y sus trastornos asociados.
CL2014003429A1 (es) Compuestos especificos derivados de indanosulfamida; composicion farmaceutica que los comprende, utiles en el tratamiento e la epilepsia.
WO2014153009A3 (en) Thiosaccharide mucolytic agents
CL2014002978A1 (es) Combinaciones farmacéuticas que contienen un inhibidor de 11-beta-hidroxiesteroide dehidrogenasa para el tratamiento de trastornos metabólicos
DK2550985T3 (da) Plungerstempelkit til medicinsprøjte
MX2016004325A (es) Nuevo derivado de un analogo de insulina.
CR20140473A (es) Compuestos de pirazol como inhibidores de sglt1
CO6920289A2 (es) Composición farmacéutica oftalmológica tópica que contiene regorafenib.
BR112013027403A2 (pt) composições que compreendem uma antimetabólito de glicose e selênio
BR112015006692A2 (pt) formulação de nanodispersão, método para administrar uma formulação de nanodispersão líquida de taxina livre de etanol em um indivíduo, e, kit.
UY34407A (es) Nuevos moduladores de trpv3
CO2017007007A2 (es) Análogos de calcitonina
AR100028A1 (es) Composiciones nutricionales que contienen ácido estearidónico
CL2014000991A1 (es) Metodo de tratamiento de una enferemedad autoinmune, que comprende adminsitrar un modulador o agonista del receptor s1p, util en esclerosis multiple; un kit.
BR112015017432A2 (pt) métodos para o tratamento de indicações cardiovasculares