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CO6501153A2 - Inhibidores macrociclicos de serina proteasa - Google Patents

Inhibidores macrociclicos de serina proteasa

Info

Publication number
CO6501153A2
CO6501153A2 CO10110008A CO10110008A CO6501153A2 CO 6501153 A2 CO6501153 A2 CO 6501153A2 CO 10110008 A CO10110008 A CO 10110008A CO 10110008 A CO10110008 A CO 10110008A CO 6501153 A2 CO6501153 A2 CO 6501153A2
Authority
CO
Colombia
Prior art keywords
macrociclic
inhibitors
proteasa
serina
serina proteasa
Prior art date
Application number
CO10110008A
Other languages
English (en)
Inventor
Claude C Parsy
Francois-Rene Alexandre
Dominique Louis Nestor Ghislain Surleraux
Michel Derock
Frederic Leroy
Original Assignee
Idenix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Pharmaceuticals Inc filed Critical Idenix Pharmaceuticals Inc
Publication of CO6501153A2 publication Critical patent/CO6501153A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Aquí se proporcionan compuestos macro cíclicos inhibidores de serina proteasa, por ejemplo, de la Fórmula (I), composiciones farmacéuticas que comprenden los compuestos, y procesos para la preparación de los mismos. También se proporcionan los métodos para su uso, para el tratamiento de una infección por HCV en un hospedero en necesidad del mismo.
CO10110008A 2008-02-04 2010-09-06 Inhibidores macrociclicos de serina proteasa CO6501153A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2608608P 2008-02-04 2008-02-04
US8386708P 2008-07-25 2008-07-25

Publications (1)

Publication Number Publication Date
CO6501153A2 true CO6501153A2 (es) 2012-08-15

Family

ID=40568607

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10110008A CO6501153A2 (es) 2008-02-04 2010-09-06 Inhibidores macrociclicos de serina proteasa

Country Status (22)

Country Link
US (2) US8003659B2 (es)
EP (1) EP2250174B1 (es)
JP (1) JP5574982B2 (es)
KR (1) KR20100118991A (es)
CN (1) CN101977915B (es)
AR (1) AR070413A1 (es)
AU (1) AU2009210789B2 (es)
BR (1) BRPI0908021A2 (es)
CA (1) CA2712971A1 (es)
CO (1) CO6501153A2 (es)
CR (1) CR11618A (es)
EC (1) ECSP10010413A (es)
ES (1) ES2437147T3 (es)
HK (1) HK1144198A1 (es)
IL (1) IL207333A0 (es)
MX (1) MX2010008523A (es)
NI (1) NI201000136A (es)
NZ (1) NZ587133A (es)
RU (1) RU2490272C2 (es)
TW (1) TW200936131A (es)
WO (1) WO2009099596A2 (es)
ZA (1) ZA201005318B (es)

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US8003659B2 (en) 2011-08-23
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US20090202480A1 (en) 2009-08-13
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