CO6331311A2 - Derivados de n-heterociclico-6-heterociclico-imidazo[1,2-alfa]piriidina-2-carboxamidas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de n-heterociclico-6-heterociclico-imidazo[1,2-alfa]piriidina-2-carboxamidas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6331311A2 CO6331311A2 CO10080869A CO10080869A CO6331311A2 CO 6331311 A2 CO6331311 A2 CO 6331311A2 CO 10080869 A CO10080869 A CO 10080869A CO 10080869 A CO10080869 A CO 10080869A CO 6331311 A2 CO6331311 A2 CO 6331311A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- alkoxy
- groups
- hydrogen atom
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Compuestos que responden a la fórmula (I):en la que:X representa un grupo heterocíclico sustituido opcionalmente con uno o varios grupos elegidos independientemente los unos de los otros entre los átomos o grupos siguientes: halógeno, alcoxi(C1-C6), alquilo(C1-C6), NRaRb, ciano, óxido, COOR8, pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios átomos de halógeno;R1 representa un átomo de hidrógeno, un átomo de halógeno, un grupo alcoxi(C1-C6), grupo alquilo(C2-C6), amino o NRaRb; pudiendo estar los grupos alquilo y alcoxi sustituidos opcionalmente con uno o varios átomos de halógeno, un grupo hidroxi, amino o grupo alcoxi(C1-C6);R2 representa un grupo heterocíclico, estando este grupo opcionalmente sustituido con uno o varios grupos seleccionados independientemente unos de los otros entre los átomos o grupos siguientes: hidroxi, alquilo(C1-C6), alcoxí(C1-C6), halógeno, ciano, NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, - NR9-CO-R10, estando los grupos alquilo(C1-C6) y alcoxi(C1-C6) opcionalmente sustituidos con uno o varios átomos de halógeno o grupos hidroxi, NRaRb, óxido;R3 representa un átomo de hidrógeno, un grupo alquilo(C1-C6), un grupo alcoxi(C1-C6) o un átomo de halógeno;R4 representa un átomo de hidrógeno, un grupo alquilo(C1-C4), un grupo alcoxi(C1-C4) o un átomo de flúor;R5 representa un átomo de hidrógeno, un grupo fenilo o un grupo alquilo(C1-C6);R6 y R7, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo(C1-C6) o forman con el átomo de nitrógeno que les lleva un ciclo de 4 a 7 eslabones incluyendo opcionalmente otro heteroátomo seleccionado de entre N, O o S;R8 representa un grupo alquilo(C1-C6);R9 y R10, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo(C1-C6);Ra y Rb representan, independientemente el uno del otro, un átomo de hidrógeno, un grupo alquilo(C1-C6) o forman con el átomo de nitrógeno al que están unidos un ciclo de 4 a 7 eslabones, que incluye opcionalmente otro heteroátomo elegido entre N, O o S;en forma de base o de sal de adición a un ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800006A FR2925904B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-HETEROCYCLIQUE-6-HETEROCYCLIQUE-IMIDAZO°1,2-a! PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6331311A2 true CO6331311A2 (es) | 2011-10-20 |
Family
ID=39768560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10080869A CO6331311A2 (es) | 2008-01-02 | 2010-07-02 | Derivados de n-heterociclico-6-heterociclico-imidazo[1,2-alfa]piriidina-2-carboxamidas su preparacion y su aplicacion en terapeutica |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20100317686A1 (es) |
| EP (1) | EP2225243B1 (es) |
| JP (1) | JP2011508762A (es) |
| KR (1) | KR20100103660A (es) |
| CN (1) | CN101959885A (es) |
| AR (1) | AR070075A1 (es) |
| AT (1) | ATE533767T1 (es) |
| AU (1) | AU2008351929A1 (es) |
| BR (1) | BRPI0821823A2 (es) |
| CA (1) | CA2710794A1 (es) |
| CL (1) | CL2008003929A1 (es) |
| CO (1) | CO6331311A2 (es) |
| EA (1) | EA201070818A1 (es) |
| FR (1) | FR2925904B1 (es) |
| IL (1) | IL206672A0 (es) |
| MA (1) | MA32058B1 (es) |
| MX (1) | MX2010007352A (es) |
| PA (1) | PA8810201A1 (es) |
| PE (1) | PE20091531A1 (es) |
| TW (1) | TW200936133A (es) |
| UY (1) | UY31590A1 (es) |
| WO (1) | WO2009106751A2 (es) |
| ZA (1) | ZA201004646B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| WO2012147890A1 (ja) * | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004103991A1 (fr) * | 2003-05-20 | 2004-12-02 | 'chemical Diversity Research Institute', Ltd. | Piperidines 2-substituees, bibliotheque focalisee et composition pharmaceutique |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| EP1849465A4 (en) * | 2005-02-18 | 2008-12-24 | Takeda Pharmaceutical | AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR |
| ES2400287T3 (es) * | 2005-03-14 | 2013-04-08 | High Point Pharmaceuticals, Llc | Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa |
| TW200800997A (en) * | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
-
2008
- 2008-01-02 FR FR0800006A patent/FR2925904B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810201A patent/PA8810201A1/es unknown
- 2008-12-30 CL CL2008003929A patent/CL2008003929A1/es unknown
- 2008-12-30 PE PE2008002194A patent/PE20091531A1/es not_active Application Discontinuation
- 2008-12-30 AR ARP080105780A patent/AR070075A1/es unknown
- 2008-12-30 UY UY31590A patent/UY31590A1/es not_active Application Discontinuation
- 2008-12-31 JP JP2010541087A patent/JP2011508762A/ja not_active Withdrawn
- 2008-12-31 EP EP08872982A patent/EP2225243B1/fr active Active
- 2008-12-31 WO PCT/FR2008/001838 patent/WO2009106751A2/fr active Application Filing
- 2008-12-31 EA EA201070818A patent/EA201070818A1/ru unknown
- 2008-12-31 MX MX2010007352A patent/MX2010007352A/es active IP Right Grant
- 2008-12-31 CN CN2008801277673A patent/CN101959885A/zh active Pending
- 2008-12-31 AT AT08872982T patent/ATE533767T1/de active
- 2008-12-31 TW TW097151696A patent/TW200936133A/zh unknown
- 2008-12-31 BR BRPI0821823-4A patent/BRPI0821823A2/pt not_active IP Right Cessation
- 2008-12-31 AU AU2008351929A patent/AU2008351929A1/en not_active Abandoned
- 2008-12-31 CA CA2710794A patent/CA2710794A1/fr not_active Abandoned
- 2008-12-31 KR KR1020107017145A patent/KR20100103660A/ko not_active Application Discontinuation
-
2010
- 2010-06-28 IL IL206672A patent/IL206672A0/en unknown
- 2010-07-01 US US12/828,376 patent/US20100317686A1/en not_active Abandoned
- 2010-07-01 ZA ZA2010/04646A patent/ZA201004646B/en unknown
- 2010-07-02 CO CO10080869A patent/CO6331311A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33056A patent/MA32058B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091531A1 (es) | 2009-10-29 |
| FR2925904B1 (fr) | 2010-01-01 |
| KR20100103660A (ko) | 2010-09-27 |
| MA32058B1 (fr) | 2011-02-01 |
| EA201070818A1 (ru) | 2011-02-28 |
| ATE533767T1 (de) | 2011-12-15 |
| FR2925904A1 (fr) | 2009-07-03 |
| EP2225243A2 (fr) | 2010-09-08 |
| CN101959885A (zh) | 2011-01-26 |
| ZA201004646B (en) | 2011-09-28 |
| EP2225243B1 (fr) | 2011-11-16 |
| CL2008003929A1 (es) | 2010-01-22 |
| UY31590A1 (es) | 2009-08-03 |
| IL206672A0 (en) | 2010-12-30 |
| MX2010007352A (es) | 2010-08-18 |
| CA2710794A1 (fr) | 2009-09-03 |
| TW200936133A (en) | 2009-09-01 |
| US20100317686A1 (en) | 2010-12-16 |
| WO2009106751A2 (fr) | 2009-09-03 |
| PA8810201A1 (es) | 2009-08-26 |
| WO2009106751A3 (fr) | 2010-02-25 |
| AU2008351929A1 (en) | 2009-09-03 |
| BRPI0821823A2 (pt) | 2015-06-16 |
| AR070075A1 (es) | 2010-03-10 |
| JP2011508762A (ja) | 2011-03-17 |
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