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CO5570696A2 - 1-amino-alquilciclohexanos insaturados como antagonistas de los receptores nmda, 5ht3 y nicotinico neuronal - Google Patents

1-amino-alquilciclohexanos insaturados como antagonistas de los receptores nmda, 5ht3 y nicotinico neuronal

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Publication number
CO5570696A2
CO5570696A2 CO04041831A CO04041831A CO5570696A2 CO 5570696 A2 CO5570696 A2 CO 5570696A2 CO 04041831 A CO04041831 A CO 04041831A CO 04041831 A CO04041831 A CO 04041831A CO 5570696 A2 CO5570696 A2 CO 5570696A2
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Colombia
Prior art keywords
linear
branched lower
group
branched
alkenyl
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Application number
CO04041831A
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English (en)
Inventor
Christopher Graham Raphael Parsons
Markus Henrich
Wojciech Dansyz
Ivars Kalvinsh
Valerjans Kauss
Aigars Jirgensons
Original Assignee
Merz Pharma Gmbh And Co Kgaa
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Application filed by Merz Pharma Gmbh And Co Kgaa filed Critical Merz Pharma Gmbh And Co Kgaa
Publication of CO5570696A2 publication Critical patent/CO5570696A2/es

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    • C—CHEMISTRY; METALLURGY
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    • C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
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    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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Abstract

1.- Un compuesto seleccionado entre los compuestos de fórmula I: donde:- R* es -(A)n-(CR1R2)m-NR3R4, - n + m = 0, 1, o 2, - A se selecciona entre el grupo que consiste en alquilo inferior lineal o ramificado (C1-C6), alquenilo inferior lineal o ramificado (C2-C6), y alquinilo inferior lineal o ramificado (C2-C6), - R1 y R2 se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, alquilo inferior lineal o ramificado (C1-C6), alquenilo inferior lineal o ramificado (C2-C6), y alquinilo inferior lineal o ramificado (C2-C6), - R3 y R4 se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, alquilo inferior lineal o ramificado (C1-C6), alquenilo inferior lineal o ramificado (C2-C6), y alquinilo inferior lineal o ramificado (C2-C6), o juntos forman alquileno (C2-C10) o alquenileno (C2-C10) o junto con el N forman un azacicloalcano o azacicloalqueno de 3-7 miembros opcionalmente sustituido por C1-6 alquilo y/o C2-6 alquenilo, - R5 se selecciona en forma independiente entre el grupo que consiste en alquilo inferior lineal o ramificado (C1-C6), alquenilo inferior lineal o ramificado (C2-C6), y alquinilo inferior lineal o ramificado (C2-C6), o R5 se combina con el carbono al cual se encuentra unido y un carbono adyacente para formar una unión doble, - Rp, Rq, Rr, y Rs se seleccionan en forma independiente entre el grupo que consiste en hidrógeno, alquilo inferior lineal o ramificado (C1-C6), alquenilo inferior lineal o ramificado (C2-C6), y alquinilo inferior lineal o ramificado (C2-C6), o Rp, Rq, Rr, y Rs en forma independiente se pueden combinar con el carbono al cual se encuentran unidos y un carbono adyacente para formar una unión doble, o Rp, Rq, Rr, y Rs en forma independiente pueden formar una unión doble con U o con Y al cual se encuentran unidos, ...
CO04041831A 2001-11-07 2004-05-06 1-amino-alquilciclohexanos insaturados como antagonistas de los receptores nmda, 5ht3 y nicotinico neuronal CO5570696A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35097401P 2001-11-07 2001-11-07
US33785801P 2001-11-08 2001-11-08

Publications (1)

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CO5570696A2 true CO5570696A2 (es) 2005-10-31

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ID=26990903

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CO04041831A CO5570696A2 (es) 2001-11-07 2004-05-06 1-amino-alquilciclohexanos insaturados como antagonistas de los receptores nmda, 5ht3 y nicotinico neuronal

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Country Link
US (1) US6828462B2 (es)
EP (1) EP1442008A1 (es)
JP (1) JP2005508381A (es)
KR (1) KR100655975B1 (es)
CN (1) CN100390131C (es)
AU (1) AU2002337389B2 (es)
CA (1) CA2465738C (es)
CO (1) CO5570696A2 (es)
EA (1) EA010177B1 (es)
GE (1) GEP20053714B (es)
HK (1) HK1075037A1 (es)
HU (1) HUP0402028A3 (es)
IL (1) IL161801A0 (es)
MX (1) MXPA04004412A (es)
NO (1) NO20042338L (es)
PL (1) PL370245A1 (es)
WO (1) WO2003040084A1 (es)

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TW593223B (en) * 2000-06-20 2004-06-21 Merz Pharma Gmbh & Co Kgaa 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists
EP1660058A2 (en) * 2003-07-28 2006-05-31 Merz Pharma GmbH & Co. KGaA The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity
AR046314A1 (es) * 2003-11-05 2005-11-30 Merz Pharma Gmbh & Co Kgaa Composiciones que comprenden ciclohexilaminas y aminoadamantanos
TW200531680A (en) * 2004-03-03 2005-10-01 Merz Pharma Gmbh & Co Kgaa Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease
CA2568445C (en) * 2004-06-17 2011-05-24 Merz Pharma Gmbh & Co. Kgaa Immediate release formulations of memantine oral dosage forms
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
US7893289B2 (en) * 2007-02-21 2011-02-22 Ssv Therapeutics, Inc. Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
MX2011001671A (es) 2008-08-12 2011-06-17 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad.
EA201691399A1 (ru) 2011-01-10 2016-10-31 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
US20150182546A1 (en) * 2013-03-15 2015-07-02 Mitochondrial Concepts Llc Therapeutic agent for enhancing mitochondrial function
WO2018129609A1 (en) * 2017-01-10 2018-07-19 Owen-Barry Pharmaceuticals Inc. Anticonvulsant compounds

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US4267366A (en) * 1977-12-14 1981-05-12 Scm Corporation Cyclic terpenoid amines, their preparation and uses
CZ293248B6 (cs) * 1997-06-30 2004-03-17 Merz Pharma Gmbh & Co. Kgaa 1-Aminocyklohexanový derivát a farmaceutická kompozice na jeho bázi
US6071966A (en) * 1997-06-30 2000-06-06 Merz + Co. Gmbh & Co. 1-amino-alkylcyclohexane NMDA receptor antagonists

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Publication number Publication date
US6828462B2 (en) 2004-12-07
KR100655975B1 (ko) 2006-12-08
MXPA04004412A (es) 2005-05-16
CA2465738C (en) 2009-01-20
HK1075037A1 (en) 2005-12-02
NO20042338L (no) 2004-07-21
HUP0402028A2 (hu) 2005-01-28
PL370245A1 (en) 2005-05-16
HUP0402028A3 (en) 2008-03-28
CA2465738A1 (en) 2003-05-15
WO2003040084A1 (en) 2003-05-15
CN100390131C (zh) 2008-05-28
EP1442008A1 (en) 2004-08-04
CN1602292A (zh) 2005-03-30
GEP20053714B (en) 2005-12-26
IL161801A0 (en) 2005-11-20
EA200400637A1 (ru) 2004-10-28
AU2002337389B2 (en) 2005-12-08
JP2005508381A (ja) 2005-03-31
KR20050044354A (ko) 2005-05-12
US20030166634A1 (en) 2003-09-04
EA010177B1 (ru) 2008-06-30

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