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CO5540317A2 - Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales - Google Patents

Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales

Info

Publication number
CO5540317A2
CO5540317A2 CO03100165A CO03100165A CO5540317A2 CO 5540317 A2 CO5540317 A2 CO 5540317A2 CO 03100165 A CO03100165 A CO 03100165A CO 03100165 A CO03100165 A CO 03100165A CO 5540317 A2 CO5540317 A2 CO 5540317A2
Authority
CO
Colombia
Prior art keywords
benzamida
phenil
piperidin
anxiety
pain
Prior art date
Application number
CO03100165A
Other languages
English (en)
Inventor
William Brown
Andrew Griffin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5540317A2 publication Critical patent/CO5540317A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1.- Un compuesto de la fórmula I en donde,R1 es seleccionado de cualquiera de los siguientes compuestos:(i) fenilo(ii) piridinilo(iii) tienilo(iv) furanilo(v) imidazolilo (vi) triazolilo(vii) pirrolilo(viii) tiazolilo(ix) piridil-N-oxidoen donde cada anillo fenilo R1 y cada anillo heteroaromático R1 pueden independientemente sustituirse adicionalmente por 1, 2 o 3 sustituyentes seleccionados independientemente de alquilo C1-C6 ramificado o lineal, NO2, CF3, alcoxi C1-C6, cloro, flúor, bromo y yodo, así como las sales de los mismos.
CO03100165A 2001-05-18 2003-11-12 Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales CO5540317A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0101769A SE0101769D0 (sv) 2001-05-18 2001-05-18 Novel compounds

Publications (1)

Publication Number Publication Date
CO5540317A2 true CO5540317A2 (es) 2005-07-29

Family

ID=20284172

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03100165A CO5540317A2 (es) 2001-05-18 2003-11-12 Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales

Country Status (26)

Country Link
US (1) US7226933B2 (es)
EP (1) EP1395555B1 (es)
JP (1) JP2005508289A (es)
KR (1) KR20030094425A (es)
CN (1) CN1639123A (es)
AR (1) AR033758A1 (es)
AT (1) ATE313528T1 (es)
BG (1) BG108330A (es)
BR (1) BR0209670A (es)
CA (1) CA2446311A1 (es)
CO (1) CO5540317A2 (es)
CZ (1) CZ20033089A3 (es)
DE (1) DE60208192T2 (es)
EE (1) EE200300554A (es)
HU (1) HUP0401328A2 (es)
IL (1) IL158628A0 (es)
IS (1) IS7028A (es)
MX (1) MXPA03010440A (es)
NO (1) NO20035113D0 (es)
NZ (1) NZ529398A (es)
PL (1) PL366387A1 (es)
RU (1) RU2003131966A (es)
SE (1) SE0101769D0 (es)
SK (1) SK13912003A3 (es)
WO (1) WO2002094782A1 (es)
ZA (1) ZA200308631B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424395T1 (de) * 2002-03-13 2009-03-15 Janssen Pharmaceutica Nv Aminoderivate als histone-deacetylase-inhibitoren
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
NZ593444A (en) 2003-10-01 2012-12-21 Adolor Corp 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CA2662115A1 (en) * 2006-09-12 2008-03-20 Adolor Corporation Methods for enhancing cognitive function

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091096A (en) * 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
US4252812A (en) * 1977-05-23 1981-02-24 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
SE441448B (sv) 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
EP0181793B1 (fr) * 1984-10-16 1988-07-27 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
KR940003491B1 (ko) * 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
WO1999033806A1 (en) 1997-12-24 1999-07-08 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
CA2324418C (en) 1998-03-10 2010-02-02 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
AU2001241676A1 (en) * 2000-03-03 2001-09-17 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
WO2009028275A1 (ja) * 2007-08-28 2009-03-05 Konica Minolta Medical & Graphic, Inc. シンチレータパネル

Also Published As

Publication number Publication date
IS7028A (is) 2003-11-12
NZ529398A (en) 2005-08-26
US20040235897A1 (en) 2004-11-25
EE200300554A (et) 2004-02-16
HUP0401328A2 (hu) 2004-12-28
DE60208192D1 (de) 2006-01-26
RU2003131966A (ru) 2005-05-10
EP1395555B1 (en) 2005-12-21
PL366387A1 (en) 2005-01-24
KR20030094425A (ko) 2003-12-11
WO2002094782A1 (en) 2002-11-28
NO20035113D0 (no) 2003-11-17
US7226933B2 (en) 2007-06-05
ATE313528T1 (de) 2006-01-15
CN1639123A (zh) 2005-07-13
DE60208192T2 (de) 2006-07-13
MXPA03010440A (es) 2004-03-09
JP2005508289A (ja) 2005-03-31
CA2446311A1 (en) 2002-11-28
EP1395555A1 (en) 2004-03-10
AR033758A1 (es) 2004-01-07
IL158628A0 (en) 2004-05-12
CZ20033089A3 (en) 2004-06-16
BG108330A (bg) 2004-12-30
BR0209670A (pt) 2004-04-20
ZA200308631B (en) 2005-02-07
SE0101769D0 (sv) 2001-05-18
SK13912003A3 (sk) 2004-04-06

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Legal Events

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