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CO4970733A1 - Tetrahidro prostaglandinas aromaticas c16-c20 sustituidas utiles como agonistas fp - Google Patents

Tetrahidro prostaglandinas aromaticas c16-c20 sustituidas utiles como agonistas fp

Info

Publication number
CO4970733A1
CO4970733A1 CO98051815A CO98051815A CO4970733A1 CO 4970733 A1 CO4970733 A1 CO 4970733A1 CO 98051815 A CO98051815 A CO 98051815A CO 98051815 A CO98051815 A CO 98051815A CO 4970733 A1 CO4970733 A1 CO 4970733A1
Authority
CO
Colombia
Prior art keywords
ring
aromatic
aliphatic ring
alkyl
heteroalkyl
Prior art date
Application number
CO98051815A
Other languages
English (en)
Inventor
Mitchell Anthony Delong
John August Wos
Jack S Amburgey Jr
De Biswanath
Yan Day George Hai
Soper David Lindsey
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO4970733A1 publication Critical patent/CO4970733A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con un compuesto quetiene la extructura: donde a) R1 es CO2 H, C(O)NHOH, CO2 R5 , CH2 OH, S(O)2 R5 , C(O)NHR5 , C(O)NHS(O)2 R5 o tetrazol; donde R5 es alquilo, heteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; b) R2 es H o alquilo inferior; c) X es NR6 R7 , OR8 , SR9 , S(O)R9 , ó S(O)2 R9 ; donde R6 , R7 y R8 son independientemente seleccionados del grupo consistente de H, acilo, alquilo, heteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; y donde R9 es alquilo, eteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; d) R3 y R4 son independientemente H, alquilo hidroxialquilo...; excepto que R3 y R4 no puedan ser simultáneamente hidrógeno; e) Z es anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo eteroaromático; y cualquier isómero óptico, diestereómero, enantiómero de la extructura anterior o una sal farmacéuticamente aceptable o amida biohidrolizable, éster o imida de ellos.
CO98051815A 1997-09-09 1998-09-09 Tetrahidro prostaglandinas aromaticas c16-c20 sustituidas utiles como agonistas fp CO4970733A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5825297P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
CO4970733A1 true CO4970733A1 (es) 2000-11-07

Family

ID=22015635

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98051815A CO4970733A1 (es) 1997-09-09 1998-09-09 Tetrahidro prostaglandinas aromaticas c16-c20 sustituidas utiles como agonistas fp

Country Status (24)

Country Link
US (1) US6048895A (es)
EP (1) EP1012137B1 (es)
JP (2) JP4619531B2 (es)
KR (1) KR20010023838A (es)
CN (1) CN1269784A (es)
AR (1) AR017078A1 (es)
AT (1) ATE227266T1 (es)
AU (1) AU731032B2 (es)
BR (1) BR9812631A (es)
CA (1) CA2303801C (es)
CO (1) CO4970733A1 (es)
DE (1) DE69809268T2 (es)
DK (1) DK1012137T3 (es)
HU (1) HUP0004427A3 (es)
ID (1) ID24845A (es)
IL (1) IL134840A0 (es)
NO (1) NO20001139L (es)
NZ (1) NZ503738A (es)
PE (1) PE123099A1 (es)
PL (1) PL339221A1 (es)
SK (1) SK3382000A3 (es)
TR (1) TR200000673T2 (es)
WO (1) WO1999012898A1 (es)
ZA (1) ZA988232B (es)

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US20100074857A1 (en) * 2008-09-23 2010-03-25 Pamela Lipkin Compositions and methods to treat epithelial-related conditions
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CN103864653A (zh) * 2012-12-10 2014-06-18 韩冰 一类降低眼压的化合物及其用途
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Also Published As

Publication number Publication date
CA2303801A1 (en) 1999-03-18
KR20010023838A (ko) 2001-03-26
US6048895A (en) 2000-04-11
DK1012137T3 (da) 2003-03-10
EP1012137A1 (en) 2000-06-28
JP2001515885A (ja) 2001-09-25
NO20001139D0 (no) 2000-03-06
HUP0004427A2 (hu) 2001-05-28
ZA988232B (en) 1999-03-09
JP2010254705A (ja) 2010-11-11
NO20001139L (no) 2000-05-04
DE69809268D1 (de) 2002-12-12
ID24845A (id) 2000-08-24
AR017078A1 (es) 2001-08-22
DE69809268T2 (de) 2003-08-28
AU9224098A (en) 1999-03-29
AU731032B2 (en) 2001-03-22
ATE227266T1 (de) 2002-11-15
HUP0004427A3 (en) 2001-09-28
SK3382000A3 (en) 2000-10-09
TR200000673T2 (tr) 2000-11-21
EP1012137B1 (en) 2002-11-06
WO1999012898A1 (en) 1999-03-18
CN1269784A (zh) 2000-10-11
JP5330324B2 (ja) 2013-10-30
CA2303801C (en) 2005-05-10
PL339221A1 (en) 2000-12-04
BR9812631A (pt) 2000-08-22
NZ503738A (en) 2001-05-25
JP4619531B2 (ja) 2011-01-26
PE123099A1 (es) 2000-02-02
IL134840A0 (en) 2001-05-20

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