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CO4700298A1 - Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica - Google Patents

Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica

Info

Publication number
CO4700298A1
CO4700298A1 CO95062144A CO95062144A CO4700298A1 CO 4700298 A1 CO4700298 A1 CO 4700298A1 CO 95062144 A CO95062144 A CO 95062144A CO 95062144 A CO95062144 A CO 95062144A CO 4700298 A1 CO4700298 A1 CO 4700298A1
Authority
CO
Colombia
Prior art keywords
group
carbon atoms
phenylisokinolein
therapeutics
derivatives
Prior art date
Application number
CO95062144A
Other languages
English (en)
Inventor
Mireille Sevrin
Benoit Marabout
Jacques Froissant
Catherine Guinot
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of CO4700298A1 publication Critical patent/CO4700298A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Compuesto que responde a la fórmula general (I):en la cualX representa un átomo de hidrógeno, un átomo de halógeno, un grupo trifluorometilo, un grupo alquilo con 1 a 3 átomos de carbono o bien uno o dos grupos alcoxi con 1 a 3 átomos de carbono, Y representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo con 1 a 3 átomos de carbono o bien un grupo alcoxi con 1 a 3 átomos de carbono. R1 representa un grupo alquilo con 1 a 4 átomos de carbono y R representa un grupo hidroxi, un grupo metoxi, un grupo etoxi, o bien un grupo de la fórmula general NR2 R3 en la cual R2 y R3 representan cada cual un átomo de hidrógeno o un grupo alquilo con 1 a 4 átomos de carbono.
CO95062144A 1994-12-29 1995-12-28 Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica CO4700298A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415837A FR2728900B1 (fr) 1994-12-29 1994-12-29 Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO4700298A1 true CO4700298A1 (es) 1998-12-29

Family

ID=9470390

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95062144A CO4700298A1 (es) 1994-12-29 1995-12-28 Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica

Country Status (22)

Country Link
US (1) US5665733A (es)
EP (1) EP0719764B1 (es)
JP (1) JPH08239365A (es)
KR (1) KR960022472A (es)
CN (1) CN1131150A (es)
AR (1) AR002016A1 (es)
AT (1) ATE172966T1 (es)
AU (1) AU698595B2 (es)
BR (1) BR9506106A (es)
CA (1) CA2166234A1 (es)
CO (1) CO4700298A1 (es)
CZ (1) CZ348995A3 (es)
DE (1) DE69505780D1 (es)
FI (1) FI956298A (es)
FR (1) FR2728900B1 (es)
HU (1) HU215394B (es)
IL (1) IL116590A0 (es)
NO (1) NO955326L (es)
NZ (1) NZ280765A (es)
PL (1) PL312079A1 (es)
SK (1) SK165795A3 (es)
ZA (1) ZA9511046B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2750427B1 (fr) * 1996-06-28 1998-08-07 Synthelabo Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
FR2772758B1 (fr) * 1997-12-22 2000-02-04 Synthelabo Derives de 1-oxo-1,2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique
ATE496893T1 (de) * 2002-12-20 2011-02-15 X Ceptor Therapeutics Inc Isochinolinonderivate und deren verwendung als medikamente
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1886996A1 (en) * 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
EP2064185B1 (en) * 2006-08-10 2011-06-08 Ferrer Internacional, S.A. 1h-quinolin-4-one compounds, with affinity for the gaba receptor, processes, uses and compositions
WO2010083436A1 (en) 2009-01-15 2010-07-22 Rutgers, The State University Of New Jersey Benzo [c] phenanthridines as antimicrobial agents
US20120059026A1 (en) * 2009-04-30 2012-03-08 University Of Medicine And Dentistry Of New Jersey Antimicrobial agents
FR2956816B1 (fr) * 2010-03-01 2012-05-18 Univ Joseph Fourier Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
CA2810162A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
US9102617B2 (en) 2010-06-25 2015-08-11 Rutgers, The State University Of New Jersey Antimicrobial agents
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
EP2828245A1 (en) 2012-03-21 2015-01-28 Rutgers, The State University of New Jersey Antimicrobial agents
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2017147316A1 (en) 2016-02-25 2017-08-31 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CA3058183A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates
TW202202495A (zh) * 2020-03-26 2022-01-16 匈牙利商羅特格登公司 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物
EP4126858A1 (en) * 2020-03-26 2023-02-08 Richter Gedeon Nyrt. Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators

Also Published As

Publication number Publication date
CA2166234A1 (en) 1996-06-30
HUT74187A (en) 1996-11-28
KR960022472A (ko) 1996-07-18
AU698595B2 (en) 1998-11-05
FI956298A (fi) 1996-06-30
AR002016A1 (es) 1998-01-07
CZ348995A3 (en) 1996-07-17
EP0719764A1 (fr) 1996-07-03
HU9503848D0 (en) 1996-02-28
PL312079A1 (en) 1996-07-08
SK165795A3 (en) 1996-07-03
CN1131150A (zh) 1996-09-18
IL116590A0 (en) 1996-03-31
NO955326D0 (no) 1995-12-28
BR9506106A (pt) 1997-12-23
ZA9511046B (en) 1996-07-11
DE69505780D1 (de) 1998-12-10
HU215394B (hu) 1998-12-28
NO955326L (no) 1996-07-01
FR2728900B1 (fr) 1997-01-31
JPH08239365A (ja) 1996-09-17
NZ280765A (en) 1996-08-27
FR2728900A1 (fr) 1996-07-05
EP0719764B1 (fr) 1998-11-04
ATE172966T1 (de) 1998-11-15
US5665733A (en) 1997-09-09
AU4071295A (en) 1996-07-04
FI956298A0 (fi) 1995-12-28

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