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CO2019013008A2 - Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agonistas de glp-1 - Google Patents

Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agonistas de glp-1

Info

Publication number
CO2019013008A2
CO2019013008A2 CONC2019/0013008A CO2019013008A CO2019013008A2 CO 2019013008 A2 CO2019013008 A2 CO 2019013008A2 CO 2019013008 A CO2019013008 A CO 2019013008A CO 2019013008 A2 CO2019013008 A2 CO 2019013008A2
Authority
CO
Colombia
Prior art keywords
glp
combination
gipr
agonists
treat
Prior art date
Application number
CONC2019/0013008A
Other languages
English (en)
Inventor
Darren L Bates
Donghui Shi
David J Lloyd
Pavel Bondarenko
Mark L Michaels
Todd Hager
Xiaoshan Min
Aiko Umeda
Irwin Chen
Zhulun Wang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62904598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2019013008(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CO2019013008A2 publication Critical patent/CO2019013008A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan métodos para tratar enfermedades y trastornos metabólicos usando una proteína de unión a antígeno específica para el polipéptido GIPR. En diversas realizaciones, la enfermedad o trastorno metabólico es diabetes tipo 2, obesidad, dislipidemia, niveles elevados de glucosa, niveles elevados de insulina y nefropatía diabética. En ciertas realizaciones, la proteína de unión a antígeno se administra en combinación con un agonista del receptor GLP-1.
CONC2019/0013008A 2017-06-20 2019-11-20 Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agonistas de glp-1 CO2019013008A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762522559P 2017-06-20 2017-06-20
PCT/US2018/038638 WO2018237097A1 (en) 2017-06-20 2018-06-20 METHOD OF TREATING OR REDUCING METABOLIC DISORDERS USING GASTRIC INHIBITING PEPTIDE RECEPTOR BINDING PROTEINS (GIPR) IN ASSOCIATION WITH GLP-1 AGONISTS

Publications (1)

Publication Number Publication Date
CO2019013008A2 true CO2019013008A2 (es) 2020-01-17

Family

ID=62904598

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0013008A CO2019013008A2 (es) 2017-06-20 2019-11-20 Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agonistas de glp-1

Country Status (20)

Country Link
US (1) US20210087286A1 (es)
EP (1) EP3642239A1 (es)
JP (2) JP7237853B2 (es)
KR (1) KR20200019122A (es)
CN (1) CN110831969B (es)
AU (1) AU2018288854A1 (es)
BR (1) BR112019024410A2 (es)
CA (1) CA3062194A1 (es)
CL (1) CL2019003332A1 (es)
CO (1) CO2019013008A2 (es)
CR (1) CR20190532A (es)
EA (1) EA201992502A1 (es)
JO (1) JOP20190268A1 (es)
MA (1) MA49460A (es)
MX (1) MX2019013919A (es)
PE (1) PE20200013A1 (es)
PH (1) PH12019502603A1 (es)
SA (1) SA519410598B1 (es)
WO (1) WO2018237097A1 (es)
ZA (1) ZA201907259B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017112824A2 (en) 2015-12-23 2017-06-29 Amgen Inc. Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
CN112521501A (zh) * 2019-09-18 2021-03-19 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
EP4126046A4 (en) * 2020-03-30 2024-07-31 Crystal Bioscience Inc ANTI-GIPR ANTIBODIES AND METHODS OF USE THEREOF
CA3221655A1 (en) * 2021-06-09 2022-12-15 Swiftnovo Therapeutics Inc. Therapeutics and methods for treating or ameliorating metabolic disorders
WO2024051802A1 (zh) * 2022-09-08 2024-03-14 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与fgf21的融合蛋白，以及其药物组合物和应用
WO2024209050A1 (en) 2023-04-05 2024-10-10 Antag Therapeutics Aps Gip activity modulators and orthostatic intolerance

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Also Published As

Publication number Publication date
JOP20190268A1 (ar) 2019-11-20
BR112019024410A2 (pt) 2020-07-14
CL2019003332A1 (es) 2020-03-20
CA3062194A1 (en) 2018-12-27
CN110831969B (zh) 2024-06-21
MA49460A (fr) 2020-04-29
KR20200019122A (ko) 2020-02-21
US20210087286A1 (en) 2021-03-25
PE20200013A1 (es) 2020-01-06
JP7237853B2 (ja) 2023-03-13
CR20190532A (es) 2020-01-10
JP2023071835A (ja) 2023-05-23
CN110831969A (zh) 2020-02-21
ZA201907259B (en) 2021-08-25
SA519410598B1 (ar) 2023-02-19
JP2020524658A (ja) 2020-08-20
WO2018237097A1 (en) 2018-12-27
EA201992502A1 (ru) 2020-04-22
MX2019013919A (es) 2020-01-21
AU2018288854A1 (en) 2019-11-21
EP3642239A1 (en) 2020-04-29
PH12019502603A1 (en) 2020-07-13

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