CO2018006300A2 - Derivados de 4-amino-2- (1h-pirazolo[3,4-b]piridin-3-il) -6-oxo-6,7-dihidro-5h-pirrolo [2,3-d] pirimidina y los respectivos (1h-indazol-3-il) derivados como moduladores cgmp para el tratamiento de enfermedades cardiovasculares - Google Patents
Derivados de 4-amino-2- (1h-pirazolo[3,4-b]piridin-3-il) -6-oxo-6,7-dihidro-5h-pirrolo [2,3-d] pirimidina y los respectivos (1h-indazol-3-il) derivados como moduladores cgmp para el tratamiento de enfermedades cardiovascularesInfo
- Publication number
- CO2018006300A2 CO2018006300A2 CONC2018/0006300A CO2018006300A CO2018006300A2 CO 2018006300 A2 CO2018006300 A2 CO 2018006300A2 CO 2018006300 A CO2018006300 A CO 2018006300A CO 2018006300 A2 CO2018006300 A2 CO 2018006300A2
- Authority
- CO
- Colombia
- Prior art keywords
- derivatives
- treatment
- indazol
- pyrazolo
- pyrrolo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona compuestos de la Fórmula (I) (I) o una sal farmacéuticamente aceptable de los mismos, en la que X, Y, Z, R1, R2, R4, Ra y los subíndices m, p y q son tal como se describen en el presente documento. Los compuestos o sus sales farmacéuticamente aceptables pueden modular la producción corporal de guanosín monofosfato cíclico ("GMPc") y son generalmente adecuados para el tratamiento y la prevención de enfermedades que están asociadas con un equilibrio de GMPc perturbado. La invención también proporciona composiciones farmacéuticas que comprenden compuestos de Fórmula (I) o sales farmacéuticamente aceptables de los mismos. La invención también se refiere a procedimientos para el uso de los compuestos o sus sales farmacéuticamente aceptables en el tratamiento y la prevención de las enfermedades mencionadas anteriormente y para la preparación de productos farmacéuticos para este fin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2015/098251 WO2017107052A1 (en) | 2015-12-22 | 2015-12-22 | Soluble guanylate cyclase stimulators |
| PCT/US2016/067654 WO2017112617A1 (en) | 2015-12-22 | 2016-12-20 | 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018006300A2 true CO2018006300A2 (es) | 2018-07-10 |
Family
ID=57758775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0006300A CO2018006300A2 (es) | 2015-12-22 | 2018-06-18 | Derivados de 4-amino-2- (1h-pirazolo[3,4-b]piridin-3-il) -6-oxo-6,7-dihidro-5h-pirrolo [2,3-d] pirimidina y los respectivos (1h-indazol-3-il) derivados como moduladores cgmp para el tratamiento de enfermedades cardiovasculares |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US10030027B2 (es) |
| EP (1) | EP3394067B1 (es) |
| JP (1) | JP6454448B2 (es) |
| KR (1) | KR102191312B1 (es) |
| CN (1) | CN108738320B (es) |
| AR (1) | AR107154A1 (es) |
| AU (1) | AU2016377364B2 (es) |
| BR (1) | BR112018012579B8 (es) |
| CA (1) | CA3009193C (es) |
| CL (1) | CL2018001671A1 (es) |
| CO (1) | CO2018006300A2 (es) |
| CR (1) | CR20180330A (es) |
| CY (1) | CY1123173T1 (es) |
| DK (1) | DK3394067T3 (es) |
| DO (1) | DOP2018000153A (es) |
| EA (1) | EA036445B1 (es) |
| EC (1) | ECSP18054606A (es) |
| ES (1) | ES2794654T3 (es) |
| HK (1) | HK1255028A1 (es) |
| HR (1) | HRP20200857T1 (es) |
| HU (1) | HUE049941T2 (es) |
| IL (1) | IL260020B (es) |
| LT (1) | LT3394067T (es) |
| ME (1) | ME03748B (es) |
| MX (2) | MX2018007728A (es) |
| MY (1) | MY194021A (es) |
| NI (1) | NI201800069A (es) |
| PE (1) | PE20181802A1 (es) |
| PH (1) | PH12018501342A1 (es) |
| PL (1) | PL3394067T3 (es) |
| PT (1) | PT3394067T (es) |
| RS (1) | RS60344B1 (es) |
| SG (1) | SG11201805272XA (es) |
| SI (1) | SI3394067T1 (es) |
| SV (1) | SV2018005715A (es) |
| TN (1) | TN2018000219A1 (es) |
| TW (1) | TWI724079B (es) |
| UA (1) | UA122264C2 (es) |
| WO (2) | WO2017107052A1 (es) |
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| US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SG10202004618TA (en) | 2015-11-19 | 2020-06-29 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MD3394033T2 (ro) | 2015-12-22 | 2021-04-30 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| US20170320875A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2017197555A1 (en) | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
| EP3458063A4 (en) | 2016-05-18 | 2020-02-26 | Merck Sharp & Dohme Corp. | METHODS OF USING TRIAZOLO-PYRAZINYL-SOLUBLE GUANYLATE CYCLASE ACTIVATORS FOR FIBROTIC DISORDERS |
| WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA47120A (fr) | 2016-12-22 | 2021-04-28 | Incyte Corp | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
| TWI798192B (zh) | 2016-12-22 | 2023-04-11 | 美商英塞特公司 | 免疫調節劑化合物及使用方法 |
| UA126394C2 (uk) | 2016-12-22 | 2022-09-28 | Інсайт Корпорейшн | Похідні бензоксазолу як імуномодулятори |
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| CN112135824B (zh) | 2018-03-30 | 2024-11-05 | 因赛特公司 | 作为免疫调节剂的杂环化合物 |
| US20210052528A1 (en) | 2018-04-30 | 2021-02-25 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| MD3790877T2 (ro) | 2018-05-11 | 2023-08-31 | Incyte Corp | Derivați de tetrahidro-imidazo[4,5-c]piridină în calitate de imunomodulatori PD-L1 |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| JP2022544189A (ja) | 2019-08-09 | 2022-10-17 | インサイト・コーポレイション | Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩 |
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