CN220125273U - Dry powder inhalation device - Google Patents

Abstract

The utility model relates to a dry powder inhalation device comprising: a body including a suction passage and a rail cavity; a storage bin movably connected to the rail cavity and including a plurality of storage channels; the premixing bin is positioned below the storage bin and provided with a premixing cavity, and the premixing cavity is provided with an air inlet hole; when the storage bin is at the non-suction position, the openings at the two ends of the storage channel are closed by the cavity walls of the guide rail cavity to form a cavity for sealing and storing quantitative dry powder; when the storage bin is driven by external force to move to the state that one storage channel is respectively communicated with the suction channel and the premixing cavity, dry powder in the storage channel falls into the premixing cavity, the dry powder is dispersed and mixed with air in the falling process, and then the dry powder is supplied through the suction channel; the cartridge is moved to switch different storage channels for dry powder supply. The dry powder inhalation device can meet the multi-dose requirements of users, and the efficiency of dry powder inhalation is improved by arranging the premixing bin.

Description

Dry powder inhalation device

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a dry powder inhalation device.

Background

Inhalation administration refers to a mode of administration that targets the drug directly to the lesion, which can improve efficacy and reduce side effects. Existing dry powder inhalation devices can be divided into single dose and multiple dose types according to dose, wherein the multiple dose types can be divided into a predetermined amount type and a reservoir type.

A single dose dry powder inhalation device is inconvenient to use because it can only be administered once, and a patient needs to carry multiple dry powder inhalation devices to meet the daily dose requirement. The dry powder inhalation device of the reservoir type needs to be provided with a metering structure to realize repeated and quantitative administration, and has high requirement on metering precision. The dry powder inhalation device of the predetermined amount mainly comprises a capsule type inhalation device, a user needs to fill capsules in the device before using the device, and the administration is carried out after the capsules are pierced when the device is used, so that the operation of the user is complicated, the use is inconvenient, and the hands can contact the capsules to be unfavorable for the sanitation of medicines.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, an object of the present utility model is to provide a dry powder inhalation device, which can improve the dry powder inhalation efficiency by providing a premixing bin below a storage bin and premixing dry powder and air a plurality of times before the dry powder inhalation.

Therefore, the utility model provides the following technical scheme.

The present utility model provides a dry powder inhalation device comprising:

a body including a suction passage and a rail cavity;

a storage bin movably connected to the rail cavity and including a plurality of storage channels disposed in spaced relation along the rail cavity;

the premixing bin is positioned below the storage bin and provided with a premixing cavity, the premixing cavity is provided with an air inlet hole, and the air inlet hole is communicated with the outside and is configured to not pass through dry powder;

when the storage bin is at an unabsorbed position, openings at two ends of the storage channel are closed by the cavity walls of the guide rail cavity to form a cavity for storing quantitative dry powder in a sealing manner;

when an external force drives the storage bin to move to the state that one storage channel is respectively communicated with the suction channel and the premixing cavity, dry powder in the storage channel falls into the premixing cavity, the dry powder is dispersed and mixed with air in the falling process, and then the dry powder is supplied through the suction channel; the cartridge is moved to switch different of the storage channels for dry powder supply.

Preferably, the main body is provided with a mounting hole, and the premixing bin is clamped in the mounting hole.

Preferably, the outer wall of the premixing bin is provided with a first limiting protrusion extending along the axial direction of the premixing bin, the hole wall of the mounting hole is provided with a first clamping groove, and the first limiting protrusion is clamped with the first clamping groove.

Preferably, the outer wall of the premixing bin is provided with a second limiting protrusion extending along the circumferential direction of the outer wall, the hole wall of the mounting hole is provided with a second clamping groove, and the second limiting protrusion is clamped with the second clamping groove.

Preferably, when the storage bin is at the suction position, central axes of the suction channel, the storage channel and the premixing cavity which are sequentially communicated are coincident.

Preferably, the suction channel comprises a channel inlet and a channel body, the cross-sectional dimension of the channel inlet being smaller than the cross-sectional dimension of the channel body.

Preferably, the channel inlet is elongated.

Preferably, the storage bin is located partially outside the rail cavity.

Preferably, the number of the storage channels is two.

Preferably, both sides of the storage bin are provided with limit lugs, both sides of the guide rail cavity are provided with limit grooves, and the limit lugs are matched with the limit grooves one by one so as to limit the suction positions of the corresponding storage channels.

The utility model has the following technical effects:

the utility model provides a dry powder inhalation device which comprises a main body, a storage bin and a premixing bin, wherein the dry powder inhalation device can meet the multi-dose requirement of a user, and the storage bin is driven to move by external force to trigger dry powder supply, so that the operation is simple and convenient. In addition, the dry powder inhalation device is provided with the premixing bin below the storage channel, and when the corresponding storage channel is triggered to supply dry powder, the dry powder in the storage channel falls into the premixing bin and then is supplied to a user through the inhalation channel. The dry powder in the storage channel falls into the premixing bin, so that the dry powder and the air are premixed for a plurality of times, the surface energy of the dry powder is increased, the suction of the dry powder is facilitated, the air flow speed required to be formed when a user inhales is reduced, and discomfort and waste caused by sudden increase of the flow of the dry powder due to instant pressure relief are avoided when the user just begins to inhale.

Drawings

Fig. 1 is a cross-sectional view of a dry powder inhalation device of the present utility model with a cartridge in an inhalation position;

FIG. 2 is a structural cross-sectional view of the body of the present utility model;

FIG. 3 is an enlarged view of FIG. 2 at A;

FIG. 4 is a cross-sectional view of the structure of the storage bin of the present utility model;

FIG. 5 is a top view of the storage bin of the present utility model;

fig. 6 is an exploded view of the structure of the dry powder inhalation device of the present utility model;

FIG. 7 is a top view of the premix cartridge of the present utility model;

FIG. 8 is a front view of the dry powder inhalation device with the storage bin of the present utility model in the unactuated position;

FIG. 9 is a partial cross-sectional view of the dry powder inhalation device with the cartridge of the present utility model in the unactuated position;

FIG. 10 is a partial cross-sectional view of the dry powder inhalation device upon primary dry powder supply according to the present utility model;

FIG. 11 is a partial cross-sectional view of a dry powder inhalation device upon secondary dry powder supply according to the present utility model;

fig. 12 is a schematic perspective view of a dry powder inhalation device according to the present utility model;

FIG. 13 is a three-dimensional finite element model of a dry powder inhalation device in a simulation experiment of the present utility model;

FIG. 14 is a three-dimensional finite element model of a dry powder inhalation device of an experimental set of the present utility model loaded with dry powder;

figure 15 is a three-dimensional finite element model of a dry powder inhalation device of a control group of the present utility model loaded with dry powder;

FIG. 16 is a graph showing the results of a dry powder inhalation simulation experiment of the experimental group of the present utility model;

fig. 17 shows the results of a dry powder inhalation simulation experiment of the control group according to the present utility model.

Description of the reference numerals

In the figure: 100. a dry powder inhalation device;

1. a main body; 11. a suction passage; 111. a channel inlet; 112. a channel body; 113. a channel outlet; 12. a guide rail cavity; 121. a limit groove; 13. a mounting hole; 131. a first clamping groove; 132. a second clamping groove; 133. a boss;

2. a storage bin; 21. a storage channel; 22. a limit bump; 221. a stop portion; 222. an inclined plane; 23. a hollowed-out part;

3. premixing bin; 31. a premix chamber; 311. an air inlet hole; 32. the first limiting protrusion; 33. the second limiting bulge;

200. and (5) dry powder.

Detailed Description

In order to make the technical scheme and the beneficial effects of the utility model more obvious and understandable, the following detailed description is given by way of example. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs.

In the description of the present utility model, unless explicitly defined otherwise, terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., refer to an orientation or positional relationship based on that shown in the drawings, and are merely for convenience of simplifying the description of the present utility model, and do not indicate that the apparatus or element referred to must have a specific orientation, be constructed and operated in a specific orientation, i.e., are not to be construed as limiting the present utility model.

In the present utility model, the terms "first", "second" are used for descriptive purposes only and are not to be construed as relative importance of the features indicated or the number of technical features indicated. Thus, a feature defining "first", "second" may explicitly include at least one such feature. In the description of the present utility model, "plurality" means at least two; "plurality" means at least one; unless otherwise specifically defined.

In the present utility model, the terms "mounted," "connected," "secured," "disposed," and the like are to be construed broadly, unless otherwise specifically limited. For example, "connected" may be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, or can be communicated between two elements or the interaction relationship between the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present utility model, unless explicitly defined otherwise, a first feature "on", "above", "over" and "above", "below" or "under" a second feature may be that the first feature and the second feature are in direct contact, or that the first feature and the second feature are in indirect contact via an intermediary. Moreover, a first feature "above," "over" and "on" a second feature may be that the first feature is directly above or obliquely above the second feature, or simply indicates that the level of the first feature is higher than the level of the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the level of the first feature is less than the level of the second feature.

All references to "left", "right", "upper" and "lower" in this disclosure are made to the designations in fig. 1, 10 and 11.

The dry powder inhalation device of the present utility model will be described in detail with reference to fig. 1 to 17.

In the present embodiment, as shown in fig. 1, 6 and 8 to 12, the dry powder inhalation device 100 comprises a main body 1, a storage bin 2 and a pre-mixing bin 3, the main body 1 comprises an inhalation passage 11 and a guide rail cavity 12, the storage bin 2 is movably connected to the guide rail cavity 12 and the storage bin 2 comprises a plurality of storage passages 21, the storage passages 21 are arranged at intervals along the guide rail cavity 12, the pre-mixing bin 3 is positioned below the storage bin 2 and the pre-mixing bin 3 is provided with a pre-mixing chamber 31, the pre-mixing chamber 31 is provided with an air inlet hole 311, and the air inlet hole 311 is communicated with the outside and is configured to not be capable of passing through the dry powder 200.

As shown in fig. 1 and 4, the storage passage 21 is open at both ends, one of which is directed toward the suction passage 11 and the other of which is directed toward the premix chamber 31. As shown in fig. 8 and 9, when the storage bin 2 is in the non-inhaled position, the openings at both ends of the storage channel 21 are closed by the walls of the guide rail cavity 12, and at this time, the storage channel 21 and the walls of the guide rail cavity 12 together form a closed chamber for hermetically storing the quantitative dry powder 200, wherein each storage channel 21 is used for storing a single dose of dry powder.

As shown in fig. 10, when the external force drives the cartridge 2 to move to the state where one of the storage passages 21 is respectively communicated with the suction passage 11 and the premix chamber 31, the cartridge 2 is at the suction position, that is, the suction passage 11, the storage passage 21 and the premix chamber 31 are sequentially communicated to form a medicine supply passage. In the process that the storage channel 21 and the premixing cavity 31 are gradually communicated, the dry powder 200 in the storage channel 21 falls into the premixing cavity 31, so that the dry powder is displaced in space, and the dry powder is dispersed in the falling process, so that the original powder coagulation form of the dry powder can be dispersed, the powder is rearranged, and the contact area of the dry powder and air is increased. The user mouth holds the channel outlet 113 of the inhalation channel 11 to inhale dry powder, and the storage bin 2 moves to switch different storage channels 21 to supply dry powder, so as to meet the multi-dose requirement of the user, and the air inlet 311 is used for balancing the internal and external air pressure difference of the medicine supply channel.

As shown in fig. 11, when the next dry powder inhalation is performed, the external force drives the storage bin 2 to move to the other storage channel 21 to be respectively communicated with the inhalation channel 11 and the premixing cavity 31, so that the operation is simple, and the multi-dose requirement of a user is met.

It will be appreciated that the spacing between adjacent two of the storage channels 21 is greater than the maximum dimension of the inlet of the premix chamber 31 in the direction of extension of the rail chamber 12 to avoid that the storage channels 21 are in partial communication with the premix chamber 31 when the cartridge 2 is in the non-inhaled position, resulting in dry powder in the storage channels 21 falling into the premix chamber 31, thereby affecting the accuracy of the dose and the premixing effect of the dry powder with air.

It should be appreciated that the air inlet aperture 311 may be defined by defining the aperture of the air inlet aperture 311 or by providing a filter at the air inlet aperture 311 to enable the air inlet aperture 311 to pass gas but not dry powder.

By adopting the above technical scheme, the dry powder inhalation device 100 can meet the multi-dose requirement of users, and the dry powder supply can be triggered by driving the storage bin 2 to move through external force, so that the operation is simple and convenient. In addition, the dry powder inhalation device 100 sets the premixing bin 3 below the storage channel 21, when the corresponding storage channel 21 is triggered to supply dry powder, the dry powder in the storage channel 21 falls into the premixing bin 3 first and then is supplied to a user through the inhalation channel 11, wherein the dry powder and the air are premixed for a plurality of times through the process that the dry powder in the storage channel 21 falls into the premixing bin 3, the surface energy of the dry powder is increased, the inhalation of the dry powder is facilitated, the air flow speed required to be formed when the user inhales is reduced, and discomfort and waste caused by sudden increase of the dry powder flow caused by instant pressure relief when the user just begins to inhale are avoided.

In one embodiment, as shown in fig. 1, the inhalation channel 11, the storage channel 21 and the pre-mixing chamber 31 are sequentially distributed from top to bottom, so that, in use, a user holds one side of the dry powder inhalation device 100 and holds the channel outlet 113 of the inhalation channel 11 from top to bottom, which accords with the use habit of the user.

Further, as shown in fig. 2, the rail chamber 12 penetrates the main body 1, the rail chamber 12 partitions the suction passage 11 and the premix chamber 31, and the main body 1 has a simple structure and is convenient to assemble the cartridge 2.

In one embodiment, as shown in fig. 1 and 12, the inhalation passage 11 is circular or oval in cross-section to facilitate fitting to the mouth or nasal passages of a user.

In one embodiment, as shown in fig. 1 and 4, the storage bin 2 is provided with a hollowed-out portion 23 to reduce the dead weight, so that a user can easily carry the dry powder inhalation device 100.

In an embodiment, as shown in fig. 1 and 2, the main body 1 is provided with a mounting hole 13, the mounting hole 13 is a through hole, and the pre-mixing bin 3 is clamped in the mounting hole 13, so that the pre-mixing bin 3 is conveniently assembled and disassembled, and the main body 1 and the pre-mixing bin 3 are separately processed, so that the processing difficulty is reduced. Of course, the assembly structure of the main body 1 and the premix chamber 3 is not limited to this, and both may be integrally formed, so that the assembly process can be simplified.

Further, as shown in fig. 6 and 7, the outer wall of the premixing bin 3 is provided with a first limiting protrusion 32 extending along the axial direction of the premixing bin, as shown in fig. 3, the hole wall of the mounting hole 13 is provided with a first clamping groove 131, and the first limiting protrusion 32 is clamped with the first clamping groove 131 so as to limit the circumferential movement of the premixing bin 3.

Further, as shown in fig. 7, the outer wall of the premixing bin 3 is provided with a second limiting protrusion 33 extending along the circumferential direction of the outer wall, as shown in fig. 3, the hole wall of the mounting hole 13 is provided with a second clamping groove 132, and the second limiting protrusion 33 is clamped with the second clamping groove 132 so as to limit the axial movement of the premixing bin 3.

It should be understood that the main body 1 and the premix bin 3 may be fastened by a fastener after being fastened by the first limiting protrusion 32 and the first clamping groove 131 to be pre-positioned, may be fastened by a fastener after being fastened by the second limiting protrusion 33 and the second clamping groove 132 to be pre-positioned, and may be fastened by both the first limiting protrusion 32 and the first clamping groove 131 and the second limiting protrusion 33 and the second clamping groove 132 to be fastened axially and circumferentially.

Of course, the pre-positioning between the main body 1 and the pre-mixing bin 3 is not limited to the positioning mode of clamping, and may be performed by other structures such as a magnetic attraction structure.

In an embodiment, as shown in fig. 1 and 3, a boss 133 is formed at an end of the mounting hole 13 of the main body 1 facing the storage bin 2, when the premix bin 3 is assembled to the main body 1, the premix bin 3 is inserted from an end of the mounting hole 13 facing away from the storage bin 2, and the premix bin 3 is continuously pushed until an end surface of the premix bin 3 abuts against the boss 133, at this time, the premix bin 3 cannot be continuously pushed, and the problem that the assembly force is too large to cause the assembly of the premix bin 3 is not in place can be avoided.

In an embodiment, the mounting hole 13 of the main body 1 is cylindrical, and the contour of the outer surface of the pre-mixing chamber 3 is matched with the contour shape of the mounting hole 13 so as to facilitate assembly.

In an embodiment, when the storage bin 2 is at the suction position, central axes of the suction channel 11, the storage channel 21 and the premix chamber 31 which are sequentially communicated are coincident, and the three are opposite to each other in the axial direction, so that dry powder in the storage channel 21 smoothly falls into the premix chamber 31 and dry powder in the premix chamber 31 smoothly sequentially passes through the storage channel 21 and the suction channel 11 to be inhaled by a user.

In one embodiment, as shown in fig. 1, the suction channel 11 includes a channel inlet 111 and a channel body 112, and the cross-sectional size of the channel inlet 111 is smaller than that of the channel body 112, so that the flow rate of the dry powder at the channel inlet 111 can be increased.

Further, the channel inlet 111 is elongated, which is further advantageous for increasing the flow rate of the dry powder at the channel inlet 111.

In one embodiment, as shown in fig. 8, the bin 2 is partially located outside the rail cavity 12, facilitating manual grasping of the bin 2 by a user to push the bin 2 to move to replace a different storage channel 21 for dry powder supply.

Further, as shown in fig. 2 and 8, the middle part of the main body 1 is a narrowed section, the guide rail cavity 12 is disposed at the narrowed section, and when the storage bin 2 is assembled in the guide rail cavity 12 and the storage bin 2 is at the non-inhalation position, the outer contour of the storage bin 2 does not protrude or slightly protrudes from the outer contour of the main body 1, so that displacement caused by mistaken touching of the storage bin 2 during storage, transportation or carrying by a user can be avoided. Furthermore, since the middle portion of the main body 1 is a narrowed section, the storage bin 2 can be partially located outside the rail cavity 12, thereby facilitating the user's grip.

In one embodiment, as shown in fig. 1, 4 and 10, the number of storage channels 21 is two, so that the dry powder inhalation device 100 has two doses, and the dry powder inhalation device 100 is simple and compact in structure and convenient to carry.

Further, as shown in fig. 9, when the dry powder inhalation device 100 is in the unused state, the two storage channels 21 are symmetrically arranged on the storage bin 2 with respect to the axial direction of the premixing chamber 31, which is beneficial for stabilizing the gravity center of the dry powder inhalation device 100 on one hand, and facilitating the user to use the dry powder of two doses respectively by pushing the storage bin 2 forward and backward on the other hand.

Further, as shown in fig. 5 and 6, the two sides of the storage bin 2 are provided with limiting protruding blocks 22, as shown in fig. 2, the two sides of the guide rail cavity 12 are provided with limiting grooves 121, the limiting protruding blocks 22 are matched with the limiting grooves 121 one by one to limit the suction position of the corresponding storage channel 21, namely, the two groups of limiting protruding blocks 22 and the limiting grooves 121 are used for limiting the movement track of the storage bin 2 in two opposite directions of the movement of the storage bin 2 respectively, and the limiting structure is simple and convenient to operate. Specifically, as shown in fig. 9, when the dry powder inhalation device 100 is in an unused state, the two storage channels 21 are respectively located at both sides in the radial direction of the inhalation channel 11, and as shown in fig. 10, when the storage bin 2 is pushed to the right, the storage bin 2 is stopped at a position where one of the storage channels 21 is respectively communicated with the inhalation channel 11 and the premix chamber 31 by the cooperation of one set of the limit lugs 22 and the limit groove 121, so as to trigger one dry powder supply. When the storage bin 2 is pushed leftwards in the next use process, as shown in fig. 11, the storage bin 2 stops at the position where the other storage channel 21 is respectively communicated with the suction channel 11 and the premixing cavity 31 through the cooperation of the limiting convex blocks 22 and the limiting grooves 121 of the other group, so as to trigger the second dry powder supply.

Further, as shown in fig. 5, one end of the limiting bump 22 forms a stop portion 221, and the stop portion 221 abuts against an abutment wall of the limiting groove 121 to achieve limiting. The other end of the limiting bump 22 is provided with a bevel 222, and the bevel 222 is used for reducing the friction force generated between the limiting bump 22 and the limiting groove 121 in the process that the limiting bump 22 moves towards the direction away from the abutting wall of the limiting groove 121. Further, the bevel 222 is planar or curved.

Of course, the limit structure of the motion track of the storage bin 2 is not limited to this, and the limit structure can also be limited by other limit structures which are convenient for releasing limit, such as a matched magnetic attraction structure.

According to journal (literature name "three-dimensional finite element reconstruction of upper respiratory tract and numerical simulation of flow field of human body", sun Xiuzhen, in the ease, liu Yingxi, in the description, zhang Jun, su Yingfeng, volume 19, 2 nd) it is disclosed that, for example, pulmonary administration, when administration, a drug enters into trachea, bronchi, peripheral small airways and alveoli through an inhalation device via oral throat, the total cross-sectional area of tube diameter increases stepwise, and the air flow velocity decreases stepwise, so that we need the drug to enter into the small airways entirely and adhere to the small airways. Therefore, it is necessary to increase the suction airflow rate, and the airflow rate at the inlet is preferably around 49 m/s.

Further, the small airway is an airway with the caliber smaller than 2mm, and is connected with the alveolar wall and the alveolar sac through multistage branches from the 8 th branch of the bronchial tree, and gradually tapers from 2mm to 0.35mm along with the increase of the branch.

The following verifies the simulation experiment aiming at the effect of the setting of the premixing bin, and the specific experimental conditions are as follows:

the model is subjected to finite element mesh division by utilizing Ansysfluentmesh software, the mesh units are polyhedral units, the number of divided model units is 94425, the number of nodes is 349717, the divided three-dimensional finite element model is shown in fig. 13, two ends of the dry powder inhalation device are communicated with the outside atmosphere, the inlet speed is applied to one inhalation end of the dry powder inhalation device, the other end of the dry powder inhalation device is a pressure outlet, the reference pressure is 0Pa relative to the atmospheric pressure, and the inner wall of the dry powder inhalation device is regarded as a non-sliding wall surface.

According to the "the medical data can know that the gas volume inhaled or exhaled by a normal person each time is Q=600-800 ml during calm breath and 15-25 times per minute" in page 130 of the paper "three-dimensional finite element reconstruction of the upper respiratory tract and flow field numerical simulation of human body" published in journal "space medicine and medical engineering" in 4 of 2006 by Sun Xiuzhen et al, the gas volume of breathing is 700ml, the breathing frequency is 20 times per minute, that is, the breathing period is T=3 s, and the time of one breath is 1.5s, which is taken as the parameter of the inlet boundary in the experiment.

And determining the position of the dry powder in the initial state according to whether the premixing bin is arranged, wherein the premixing bin is arranged as an experimental group, the premixing bin is not arranged as a comparison group, and the difference between the experimental group and the comparison group is only that whether the premixing bin is arranged or not, and other structures and size parameters are the same. As shown in fig. 14, the dry powder of the experimental group was located in the upper part of the device; as shown in fig. 15, the dry powder initial position of the control group was accumulated at the bottom of the dry powder inhalation device.

The two models of the experimental group and the control group are respectively simulated, the airflow velocity at the inlet is 49m/s, the simulation result of the experimental group is shown in fig. 16, the dry powder of the experimental group needs about 0.3-0.4s to be basically absorbed, the simulation result of the control group is shown in fig. 17, and the dry powder of the control group needs about 0.8s to be absorbed.

As shown in FIG. 16, the inhalation efficiency of the experimental group was particularly remarkable in the initial stage (a 1-b 1) of dry powder inhalation during inhalation, and the time-consuming time was 0-0.014s, and the dry powder inhalation amount was about 40.37%; as shown in fig. 17, the control group took about 0.16s to inhale about 40.37% of the dry powder amount during inhalation, which was time-consuming and inefficient. As shown in fig. 16, the experimental group had a majority of dry powder inhalation amount completed in the section a1-c1 (main dry powder inhalation section) which was about 86.61% of the total dry powder, with about 0.326s, whereas the control group as shown in fig. 17 had a majority of dry powder inhalation amount completed in the section a2-c2, which was about 86.57% of the total dry powder, with about 0.77s, which was time-consuming and inefficient. The data of the experimental group and the control group can obviously show that the premixing bin is arranged to premix the extracted dry powder and the air for a plurality of times, so that the dry powder inhalation efficiency is obvious no matter in the initial stage or the main stage of the dry powder inhalation, and the dry powder inhalation is facilitated.

The inhalation efficiency of the dry powder inhalation device of the experimental group is particularly obvious in the section a1-b1, and the simulation result shows that the inhalation amount of the dry powder of the experimental group is about 40.37% in the stage a1-b1 (section a1-b 1) of 0-0.014s, compared with the inhalation amount of the dry powder of the control group a2-b2, the time required for inhaling about 40.37% of the dry powder is about 0.16s, and the average administration rate of the experimental group is obviously higher than the average rate of the dry powder of the control group a2-b 2. The dry powder inhalation amount in the experimental group is about 86.61% in the whole section of a1-c1, and about 0.326s in the time period, while the inhalation amount in the control group, section a2-c2, accounts for about 86.57% in the time period of about 0.77s, and the average inhalation rate is obviously smaller than that in the experimental group. As can be seen from comparison of the experimental group and the control group, the dry powder inhalation device provided by the utility model can be used for completing the inhalation procedure of the dry powder by using smaller inhalation amount, is beneficial to assisting the people with small lung capacity such as respiratory tract patients or young children, and meanwhile, has high inhalation efficiency, is beneficial to shortening the interval time of respiratory ventilation of patients, and shows the friendliness of the dry powder inhalation device.

In addition, the utility model has the remarkable advantages that the dry powder inhalation device has the function of moving the bin in the dry powder inhalation process, in the bin moving process, dry powder can fall into the premixing bin 3 from the storage bin 2 with the height difference, and the dry powder group is converted into kinetic energy due to gravitational potential energy, so that the dry powder particles form rebound, diffusion, splashing and other movements after colliding with the bin wall of the premixing bin 3 and collision among the dry powder particles, thereby being beneficial to improving the uniformity of dry powder concentration in the premixing bin, reducing the difficulty of dry powder inhalation and improving the effect of dry powder inhalation.

It should be understood that the three-dimensional finite element model used in the simulation experiment is used to simulate the effect of dry powder inhalation with or without the premix chamber, the structure and size of the three-dimensional finite element model need not be consistent with the dry powder inhalation device 100 in the above embodiment, and only the requirement that can be used to analyze the influence of the setting of the premix chamber on the dry powder inhalation efficiency needs to be met, that is, the structure of the three-dimensional finite element model of the experimental group and the three-dimensional finite element model of the control group are different only in whether the premix chamber is set, and the shape and size of other structures (including the inhalation channel, the storage chamber and the air inlet hole) are the same.

It should be understood that in the figures, a1, b1, c1, d1 represent four inhalation rate inflection points of the experimental group during dry powder inhalation, and likewise, in the figures, a2, b2, c2, d2 represent four inhalation rate inflection points of the control group during dry powder inhalation.

It should be understood that the above examples are illustrative and are not intended to encompass all possible implementations encompassed by the claims. Various modifications and changes may be made in the above embodiments without departing from the scope of the disclosure. Likewise, the individual features of the above embodiments can also be combined arbitrarily to form further embodiments of the utility model which may not be explicitly described. Therefore, the above examples merely represent several embodiments of the present utility model and do not limit the scope of protection of the patent of the present utility model.

Claims (10)

1. A dry powder inhalation device, characterized in that the dry powder inhalation device (100) comprises:

a main body (1) including a suction passage (11) and a rail chamber (12);

-a storage compartment (2) movably connected to the rail cavity (12) and comprising a plurality of storage channels (21), the plurality of storage channels (21) being arranged at intervals along the rail cavity (12);

the premixing bin (3) is positioned below the storage bin (2) and is provided with a premixing cavity (31), the premixing cavity (31) is provided with an air inlet hole (311), and the air inlet hole (311) is communicated with the outside and is configured to not pass through dry powder;

when the storage bin (2) is in an unabsorbed position, openings at two ends of the storage channel (21) are closed by the cavity wall of the guide rail cavity (12) to form a cavity for sealing and storing quantitative dry powder;

when an external force drives the storage bin (2) to move to one of the storage channels (21) to be respectively communicated with the suction channel (11) and the premixing cavity (31), dry powder in the storage channel (21) falls into the premixing cavity (31), and the dry powder is dispersed and mixed with air in the falling process and then is supplied to the dry powder through the suction channel (11); the storage bin (2) is supplied with dry powder by being moved to switch different storage channels (21).

2. A dry powder inhalation device according to claim 1 characterised in that the body (1) is provided with mounting holes (13) and the pre-mix cartridge (3) is snap-fitted into the mounting holes (13).

3. The dry powder inhalation device according to claim 2, wherein the outer wall of the premixing bin (3) is provided with a first limiting protrusion (32) extending along the axial direction of the premixing bin, the hole wall of the mounting hole (13) is provided with a first clamping groove (131), and the first limiting protrusion (32) is clamped with the first clamping groove (131).

4. A dry powder inhalation device according to claim 2 or 3, characterized in that the outer wall of the premixing bin (3) is provided with a second limiting protrusion (33) extending along the circumferential direction of the premixing bin, the hole wall of the mounting hole (13) is provided with a second clamping groove (132), and the second limiting protrusion (33) is clamped with the second clamping groove (132).

5. A dry powder inhalation device according to claim 1 characterised in that when the cartridge (2) is in the inhalation position, the central axes of the inhalation channel (11), the storage channel (21) and the premix chamber (31) which are in communication in sequence coincide.

6. A dry powder inhalation device according to claim 1 characterised in that the inhalation channel (11) comprises a channel inlet (111) and a channel body (112), the cross-sectional dimension of the channel inlet (111) being smaller than the cross-sectional dimension of the channel body (112).

7. A dry powder inhalation device according to claim 6 characterised in that the channel inlet (111) is elongate.

8. A dry powder inhalation device according to claim 1 characterised in that the storage bin (2) is located partly outside the rail cavity (12).

9. A dry powder inhalation device according to claim 1 characterised in that the number of storage channels (21) is two.

10. The dry powder inhalation device according to claim 9, wherein both sides of the storage bin (2) are provided with limit lugs (22), both sides of the guide rail cavity (12) are provided with limit grooves (121), and the limit lugs (22) are matched with the limit grooves (121) one by one so as to limit the inhalation position of the corresponding storage channel (21).