CN210810980U - Skin imaging equipment in ultra-wide range - Google Patents
Skin imaging equipment in ultra-wide range Download PDFInfo
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- CN210810980U CN210810980U CN201921222493.8U CN201921222493U CN210810980U CN 210810980 U CN210810980 U CN 210810980U CN 201921222493 U CN201921222493 U CN 201921222493U CN 210810980 U CN210810980 U CN 210810980U
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Abstract
The utility model discloses a skin imaging device with an ultra-wide range, which comprises a light source, an optical fiber coupler, a reference arm device, a sample arm device, a spectrometer device and a computer processing terminal; the reference arm device comprises a first collimating lens and a reflecting mirror, and the first collimating lens is connected with the reflecting mirror through light; sample arm device includes second collimating lens, two-dimentional galvanometer scanning system and first focusing lens, the spectrum appearance device includes and connects third collimating lens, grating, triangular prism, second focusing lens and image acquisition module through light, light source, first collimating lens, second collimating lens and third collimating lens all with fiber coupler passes through fiber connection. The utility model discloses skin imaging equipment carries out formation of image on a large scale in real time to the skin that awaits measuring, and spectral resolution through improving the spectrum appearance device increases the imaging range in the direction of depth.
Description
Technical Field
The utility model relates to an OCT imaging technology field, more specifically say and relate to a skin imaging device of super wide range.
Background
The skin is the first large organ of the human body and is a very important organ of the human body. Optical Coherence Tomography (OCT) is a transverse imaging technology based on the principle of low coherent light interference, and has wide application prospect in clinical diagnosis of human skin diseases due to the advantages of high resolution, real-time property, non-contact property and the like. Such as skin cancer (such as basal cell carcinoma), nevus flammeus, and skin vascular diseases.
However, SDOCT has certain limitations in the application of skin. In the SDOCT system, interference signals of the sample arm and the reference arm are received by a spectrometer, the spectral resolution of the spectrometer is constrained by grating light splitting capability and the size of a camera pixel, and the spectral resolution determines the imaging range of the system. The imaging depth of the traditional spectrometer can reach about 3 mm. The system sensitivity decays continuously as the depth increases, and when the imaging depth reaches 2mm, the system sensitivity decays by about 12dB, which is shown by the image quality decreasing with depth. However, the thickness of human skin ranges from 0.5 mm to 4mm, blood vessels are located in the dermis and below the dermis, and the imaging of the conventional OCT system cannot well meet the requirements of skin structure imaging or skin blood vessel imaging. Therefore, it is necessary to develop a skin imaging device with an ultra-wide angle, and how to increase the imaging range in the depth direction, i.e. how to improve the spectral resolution of the spectrometer, and how to enlarge the imaging, needs to be solved.
In the prior art, the patent of "optical coherence tomography skin diagnosis equipment for real-time imaging" with application number CN200910076054.5 can realize real-time rapid imaging of skin at various places of a human body, and the patent of "device and system for detecting and positioning vascular skin diseases and working method" with application number CN201711340695.8 realizes consistent scanning positions before and after the patent is realized, and has high detection stability, but both the patent and the patent aim at small-range imaging and do not improve the detection depth.
SUMMERY OF THE UTILITY MODEL
The utility model discloses the technical problem that the type will be solved is: the imaging range of the existing OCT imaging system in the imaging depth direction is small.
The utility model provides a skin imaging equipment of super wide range increases the imaging range in the imaging depth direction through improving spectral resolution.
The utility model provides a solution of its technical problem is:
an ultra-wide range skin imaging device, comprising: the device comprises a light source, an optical fiber coupler, a reference arm device, a sample arm device, a spectrometer device and a computer processing terminal; the reference arm device comprises a first collimating lens and a reflecting mirror, and the first collimating lens is connected with the reflecting mirror through light;
the sample arm device comprises a second collimating lens, a two-dimensional galvanometer scanning system and a first focusing lens, emergent light of the second collimating lens is deflected by the two-dimensional galvanometer scanning system and then enters the first focusing lens, and emergent light of the first focusing lens enters the skin to be detected;
the spectrometer device comprises a third collimating lens, a grating, a triangular prism, a second focusing lens and an image acquisition module which are connected through light rays, emergent light of the third collimating lens sequentially penetrates through the grating and the triangular prism, and the emergent light of the triangular prism penetrates through the second focusing lens and then enters the image acquisition module;
the light source, the first collimating lens, the second collimating lens and the third collimating lens are all connected with the optical fiber coupler through optical fibers, and the image acquisition module and the two-dimensional galvanometer scanning system are all electrically connected with the computer processing terminal.
As a further improvement of the technical scheme, the two-dimensional galvanometer scanning system is connected with the computer processing terminal through a data acquisition card.
As a further improvement of the technical scheme, the image acquisition module is connected with the computer processing terminal through an image acquisition card.
As a further improvement of the technical scheme, the image acquisition module is a linear array CCD camera.
As a further improvement of the above technical scheme, the light source is a light emitting diode with a wavelength of 1310 nm.
The utility model has the advantages that: the utility model discloses skin imaging equipment carries out formation of image on a large scale in real time to the skin that awaits measuring, and spectral resolution through improving the spectrum appearance device increases the imaging range in the direction of depth.
Drawings
In order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is clear that the described figures represent only some embodiments of the invention, not all embodiments, and that a person skilled in the art can also derive other designs and figures from these figures without inventive effort.
FIG. 1 is a schematic diagram of the apparatus of the embodiment;
FIG. 2 is a schematic diagram of a device scan path of an embodiment;
FIG. 3 is a flowchart illustrating the processing of the interfering optical signal by the computer processing terminal according to the embodiment.
Detailed Description
The conception, the specific structure, and the technical effects produced by the present invention will be clearly and completely described below with reference to the embodiments and the accompanying drawings, so as to fully understand the objects, the features, and the effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive labor based on the embodiments of the present invention all belong to the protection scope of the present invention. In addition, all the connection relations mentioned herein do not mean that the components are directly connected, but mean that a better connection structure can be formed by adding or reducing connection accessories according to the specific implementation situation. The utility model discloses each technical feature in the creation can the interactive combination under the prerequisite that does not contradict conflict each other.
Embodiment 1, referring to fig. 1, an ultra-wide range skin imaging device, comprising: a light source 100, a fiber coupler 200, a reference arm device 300, a sample arm device 400, a spectrometer device 500 and a computer processing terminal 600; the reference arm device 300 comprises a first collimating lens 301 and a reflecting mirror 302, wherein the first collimating lens 301 and the reflecting mirror 302 are connected through light;
the sample arm device 400 comprises a second collimating lens 401, a two-dimensional galvanometer scanning system 402 and a first focusing lens 403, emergent light of the second collimating lens 401 is deflected by the two-dimensional galvanometer scanning system 402 and then enters the first focusing lens 403, and emergent light of the first focusing lens 403 enters the skin 700 to be detected;
the spectrometer device 500 comprises a third collimating lens 501, a grating 502, a triangular prism 503, a second focusing lens 504 and an image collecting module 505 which are connected through light, emergent light of the third collimating lens 501 sequentially penetrates through the grating 502 and the triangular prism 503, and emergent light of the triangular prism 503 penetrates through the second focusing lens 504 and then enters the image collecting module 505;
the light source 100, the first collimating lens 301, the second collimating lens 401 and the third collimating lens 501 are all connected with the fiber coupler 200 through optical fibers, and the image acquisition module 505 and the two-dimensional galvanometer scanning system 402 are all electrically connected with the computer processing terminal 600.
The light beam emitted from the light source 100 enters the fiber coupler 200 and is split into a first light beam and a second light beam, the first light beam enters the reference arm device 300, the second light beam enters the sample arm device 400, and the splitting ratio of the fiber coupler 200 in this embodiment is 50: 50. The first light beam is collimated by the first collimating lens 301 and then emitted to the reflecting mirror 302, and the first light beam returns to the fiber coupler 200 along the original path under the action of the reflecting mirror 302.
Emergent light of a second light beam after being collimated by the second collimating lens 401 is emitted into the two-dimensional galvanometer scanning system 402, the emergent light of the two-dimensional galvanometer scanning system 402 is scanned along a preset scanning path after passing through the first focusing lens 403, the scanned light beam is scattered on the surface of the skin 700 to be detected, and scattered light enters the fiber coupler 200 after passing through the first focusing lens 403, the two-dimensional galvanometer scanning system 402 and the second collimating lens 401 in sequence.
The first light beam returning to the fiber coupler 200 interferes with the scattered light to generate an interference light signal, which includes image information of the skin 700 to be measured, and the fiber coupler 200 outputs the interference light signal to the spectrometer apparatus 500. The interference light signal is collimated through the third collimating lens 501, the emergent light of the third collimating lens 501 is split through the grating 502 and the triangular prism 503 in sequence, the split interference light signal enters the image acquisition module 505 after passing through the second focusing lens 504, and the image acquisition module 505 transmits the split interference light signal obtained by acquisition to the computer processing terminal 600.
In a preferred embodiment, the image capturing module 505 is connected to the computer processing terminal 600 via an image capturing card.
The interference light signal carries image information of the skin 700 to be detected, and the computer processing terminal 600 is connected with the image acquisition module 505 through an image acquisition card.
The computer processing terminal 600 performs fourier transform and background denoising on the received interference light signal containing the image information of the skin 700 to be detected, eliminates motion artifacts through a phase compensation algorithm to obtain artifact-removed images, calculates an image offset between adjacent artifact-removed images through a two-dimensional cross-correlation algorithm, calibrates the motion offset between the adjacent artifact-removed images, performs image matching, and finally performs image splicing by using an image splicing algorithm based on SURF to finally obtain an imaging image of the skin 700 to be detected.
The spectrometer device 500 comprises a third collimating lens 501, a grating 502, a triangular prism 503, a second focusing lens 504 and an image acquisition module 505, wherein the grating 502 and the triangular prism 503 are used as dispersion elements of the spectrometer device 500, the grating 502 performs light splitting according to a wavelength diffraction angle, the triangular prism 503 performs light splitting according to a wavelength refractive index, an interference light signal performs first-layer light splitting through the grating 502, and performs second-layer light splitting through the triangular prism 503, and the grating 502 and the triangular prism 503 are used as two dispersion elements to increase spectral resolution and convert a spectrum from a wavelength domain to a wavenumber domain, so that the imaging depth is increased, the precise calibration of the spectrum can be realized on a mechanical structure, a software algorithm is not needed, the image processing process is greatly simplified, and the device performance is improved.
The skin imaging equipment can realize the imaging depth of 6mm, and when the imaging depth reaches 2mm, the system sensitivity of the spectrometer device 500 only loses 6dB, thereby effectively ensuring the imaging image quality.
The two-dimensional galvanometer scanning system 402 is used for adjusting the direction of the light beam, and the two-dimensional galvanometer scanning system 402 is composed of an X-direction reflecting mirror and a Y-direction reflecting mirror, and performs scanning in the X direction and scanning in the Y direction respectively, wherein the X direction represents transverse scanning, and the Y direction represents longitudinal scanning. When the Y-direction scanning is 0, two-dimensional scanning, that is, cross-sectional imaging is realized, and when the Y-direction scanning is not 0, three-dimensional scanning, that is, three-dimensional imaging is realized. The two-dimensional galvanometer scanning system 402 is electrically connected with the computer processing terminal 600, and the computer processing terminal 600 controls the two-dimensional galvanometer scanning system 402 to adjust the scanning speed and the scanning path of the light beam.
Referring to fig. 2, in the scanning imaging process, 2 × 2mm imaging size is used as a primitive, the skin 700 to be measured is sequentially scanned in an S-shaped scanning sequence, adjacent scanning areas with 2 × 2mm as the primitive have an overlapping portion, scanning signals of a plurality of scanning areas are acquired after the preset scanning path is completed, and the image acquisition module 505 acquires interference light signals including the scanning signals of the scanning areas and transmits the interference light signals to the computer processing terminal 600.
Further, in a preferred embodiment, the two-dimensional galvanometer scanning system 402 is connected to the computer processing terminal 600 via a data acquisition card.
The computer processing terminal 600 scans the skin 700 to be measured by adjusting the angles of the X-direction mirror and the Y-direction mirror of the two-dimensional galvanometer scanning system 402. The computer processing terminal 600 transmits data signals to the two-dimensional galvanometer scanning system 402 through a data acquisition card.
Further as a preferred embodiment, the image acquisition module 505 is a line CCD camera.
Further, in a preferred embodiment, the light source 100 is a light emitting diode with a wavelength of 1310 nm. Since the absorption coefficient of 1310nm light in skin tissue is relatively small and the scattering coefficient is relatively high, it is suitable for skin imaging.
Referring to fig. 3, the ultra-wide range skin imaging device further comprises an ultra-wide range skin imaging method, the method comprising:
the light beam emitted by the light source 100 is split into a first light beam and a second light beam by the fiber coupler 200, the first light beam enters the first collimating lens 301, and the second light beam enters the second collimating lens 401;
the first light beam passes through the first collimating lens 301 and then returns to the optical fiber coupler 200 in the original path under the action of the reflector 302; emergent light of a second light beam after penetrating through the second collimating lens 401 enters the two-dimensional galvanometer scanning system 402, the two-dimensional galvanometer scanning system 402 is used for adjusting the direction of the light beam, the emergent light of the two-dimensional galvanometer scanning system 402 passes through the first focusing lens 403 and then scans the skin 700 to be detected along a preset scanning path, the scanned light beam is scattered on the surface of the skin 700 to be detected, and the scattered light enters the fiber coupler 200 after passing through the first focusing lens 403, the two-dimensional galvanometer scanning system 402 and the second collimating lens 401 in sequence;
the first light beam returning to the optical fiber coupler 200 interferes with the scattered light to generate an interference light signal, the interference light signal includes image information of the skin 700 to be measured, the optical fiber coupler 200 outputs the interference light signal to a third collimating lens 501 for collimation, emergent light of the third collimating lens 501 is split by a grating 502 and a triangular prism 503 in sequence, and the split interference light signal enters an image acquisition module 505 after passing through a second focusing lens 504;
the two-dimensional galvanometer scanning system 402 is used for adjusting the direction of the light beam, and the two-dimensional galvanometer scanning system 402 is composed of an X-direction reflecting mirror and a Y-direction reflecting mirror, and performs scanning in the X direction and scanning in the Y direction respectively, wherein the X direction represents transverse scanning, and the Y direction represents longitudinal scanning. When the Y-direction scanning is 0, two-dimensional scanning, that is, cross-sectional imaging is realized, and when the Y-direction scanning is not 0, three-dimensional scanning, that is, three-dimensional imaging is realized. The two-dimensional galvanometer scanning system 402 is electrically connected with the computer processing terminal 600, and the computer processing terminal 600 controls the two-dimensional galvanometer scanning system 402 to adjust the scanning speed and the scanning path of the light beam.
Referring to fig. 2, in the scanning imaging process, 2 × 2mm imaging size is used as a primitive, the skin 700 to be measured is sequentially scanned in an S-shaped scanning sequence, adjacent scanning areas with 2 × 2mm as the primitive have an overlapping portion, scanning signals of a plurality of scanning areas are acquired after the preset scanning path is completed, and the image acquisition module 505 acquires interference light signals including the scanning signals of the scanning areas and transmits the interference light signals to the computer processing terminal 600.
Fourier transformation and background denoising are carried out on the interference light signals, and denoised images of a plurality of scanning areas in the scanning process are obtained;
eliminating the motion artifact of the de-noised image by adopting a phase compensation algorithm to obtain an artifact-removed image;
and carrying out image calibration and matching on the artifact-removed images by adopting a two-dimensional cross-correlation algorithm, and splicing the artifact-removed images which are calibrated and matched by utilizing an image splicing algorithm based on SURF to obtain imaging images.
Further, as a preferred embodiment, the process of fourier transforming and background denoising the interference light signal includes:
collecting the optical signal of the first light beam returned to the optical fiber coupler 200 as a background signal, performing fourier transform on the interference optical signal to obtain a block scanning image, subtracting the background signal from the block scanning image to obtain a de-noised image, and eliminating the influence of the background signal on the final imaging image of the skin 700 to be detected.
In the process of scanning the skin 700 to be detected, human tissue movement inevitably occurs, and in order to eliminate the motion artifact caused by the autonomous motion of the human body in the blood imaging, the motion artifact is extracted and eliminated by the histogram compensation map in the phase compensation algorithm.
Further as a preferred embodiment, the process of eliminating the motion artifact from the denoised image by using a phase compensation algorithm to obtain the denoised image includes:
performing histogram calculation on the phase of the denoised image, wherein the width dereferencing principle of the histogram is as follows:
h＝2IQm-1/3
wherein h is the width of the histogram, IQ is the phase-arranged quartile, and m is the total number of phases;
and obtaining phase values with the highest occurrence frequency from the adjacent histograms of the denoised images, wherein the phase values form motion artifact phases, extracting the motion artifact phases from the adjacent histograms of the denoised images, and subtracting the motion artifact phases from the adjacent histograms of the denoised images to obtain the denoised images.
Further, as a preferred embodiment, the process of performing image calibration and matching on the artifact-removed image by using a two-dimensional cross-correlation algorithm includes:
calculating the image offset between two adjacent artifact-removed images through a two-dimensional cross-correlation algorithm, wherein the correlation between the two adjacent artifact-removed images can be represented as follows:
wherein f is1(x1，y1)、f2(x2，y2) And respectively as a function of two adjacent artifact-removed images, wherein Δ x is the offset in the transverse direction, and Δ y is the offset in the axial direction, and the motion offset between the two adjacent artifact-removed images is calibrated to perform image matching. And according to the calculated motion offset between the two artifact-removed images, if the motion offset is negative, adding the motion offset to perform image matching, and if the motion offset is positive, subtracting the motion offset to perform image matching.
And after the adjacent artifact-removed images are subjected to image matching, splicing the artifact-removed images which are calibrated and matched by using an image splicing algorithm based on SURF to obtain an imaging image.
Image stitching is a SURF-based image stitching algorithm. Firstly, inputting two adjacent artifact-removed images with an overlapping area, wherein the width of the overlapping area is the best 0.1-0.3 mm, in the embodiment, the scanning speed and the scanning distance of the two-dimensional galvanometer scanning system 402 to the skin 700 to be detected are adjusted through the computer processing terminal 600, so that the width of the overlapping area between the adjacent artifact-removed images is 0.1mm, image calibration and matching are performed on the adjacent artifact-removed images through a two-dimensional cross-correlation algorithm, image feature points of the overlapping area between the adjacent artifact-removed images are extracted through a SURF feature matching algorithm, then the feature points of the adjacent artifact-removed images are fused, the adjacent artifact-removed images are mapped into a new blank image to form a spliced image, and finally, the imaging image is obtained.
And identifying and fusing image characteristic points of an overlapping area of all the acquired artifact-removed images based on an SURF image splicing algorithm, mapping the fused artifact-removed images to a new blank image to form a spliced image, and acquiring an imaging image of the skin 700 to be detected, so that the ultra-wide scanning atmosphere of the skin 700 to be detected is effectively acquired.
In this embodiment, the width of the overlapping region between adjacent artifact-removed images is 0.1mm, which can ensure the continuity of image stitching.
The utility model discloses skin imaging equipment carries out real-time formation of image on a large scale to the skin 700 that awaits measuring, and spectral resolution through improving spectrum appearance device 500 increases the imaging range on the direction of depth, obtains the image on a large scale through image mosaic algorithm.
While the preferred embodiments of the present invention have been described in detail, it will be understood by those skilled in the art that the invention is not limited to the details of the embodiments shown, but is capable of various modifications and substitutions without departing from the spirit of the invention.
Claims (5)
1. An ultra-wide range skin imaging device, comprising: the device comprises a light source, an optical fiber coupler, a reference arm device, a sample arm device, a spectrometer device and a computer processing terminal; the reference arm device comprises a first collimating lens and a reflecting mirror, and the first collimating lens is connected with the reflecting mirror through light;
the sample arm device comprises a second collimating lens, a two-dimensional galvanometer scanning system and a first focusing lens, emergent light of the second collimating lens is deflected by the two-dimensional galvanometer scanning system and then enters the first focusing lens, and emergent light of the first focusing lens enters the skin to be detected;
the spectrometer device comprises a third collimating lens, a grating, a triangular prism, a second focusing lens and an image acquisition module which are connected through light rays, emergent light of the third collimating lens sequentially penetrates through the grating and the triangular prism, and the emergent light of the triangular prism penetrates through the second focusing lens and then enters the image acquisition module;
the light source, the first collimating lens, the second collimating lens and the third collimating lens are all connected with the optical fiber coupler through optical fibers, and the image acquisition module and the two-dimensional galvanometer scanning system are all electrically connected with the computer processing terminal.
2. The ultra-wide range skin imaging device of claim 1, wherein said two-dimensional galvanometer scanning system is coupled to said computer processing terminal via a data acquisition card.
3. The ultra-wide range skin imaging device of claim 1, wherein said image acquisition module is connected to said computer processing terminal via an image acquisition card.
4. An ultra-wide range skin imaging device, as claimed in claim 1, wherein said image acquisition module is a line CCD camera.
5. The ultra-wide range skin imaging device of claim 1, wherein said light source is a light emitting diode with a wavelength of 1310 nm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292361A (en) * | 2019-07-30 | 2019-10-01 | 佛山科学技术学院 | A kind of dermal imaging apparatus and method for of super wide range |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292361A (en) * | 2019-07-30 | 2019-10-01 | 佛山科学技术学院 | A kind of dermal imaging apparatus and method for of super wide range |
| CN110292361B (en) * | 2019-07-30 | 2024-04-30 | 佛山科学技术学院 | Ultra-wide-range skin imaging device and method |
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Effective date of registration: 20210707 Address after: 528000 one of the fourth floor of Building 1, block 2, No. 117, Zhangcha 1st Road, Chancheng District, Foshan City, Guangdong Province Patentee after: GUANGDONG WEIREN MEDICAL TECHNOLOGY Co.,Ltd. Address before: No.33 Guangyun Road, Shishan town, Nanhai District, Foshan City, Guangdong Province Patentee before: FOSHAN University |