CN210394226U

CN210394226U - 6-APA recovery unit in 6-APA mother liquor

Info

Publication number: CN210394226U
Application number: CN201920866005.0U
Authority: CN
Inventors: 王绪民
Original assignee: Henan Green Garden Pharmaceutical Co Ltd
Current assignee: Henan Green Garden Pharmaceutical Co Ltd
Priority date: 2019-06-11
Filing date: 2019-06-11
Publication date: 2020-04-24
Anticipated expiration: 2029-06-11

Abstract

The utility model discloses a 6-APA mother liquor retrieves technical field's a 6-APA recovery unit in 6-APA mother liquor aims at solving and how to retrieve 6-APA's technical problem from 6-APA mother liquor, and the device includes mother liquor jar, vacuum distillation equipment, surge tank, primary filtration equipment, receive filter membrane concentrator, crystallizer and secondary filter equipment that connect gradually by the pipeline, there is alkali lye to add the case the feed liquor end of surge tank through the pipe connection, secondary filter equipment's flowing back end links to each other with the mother liquor jar through mother liquor backflow pipeline. The utility model provides a decompression distillation plant can detach the menstruum in the mother liquor, prevents the menstruum to the destruction of receiving the filter membrane in subsequent handling, and the impurity particle in the mother liquor can be detached to first filtration equipment, receives the filter membrane concentrator and can make 6-APA in the mother liquor obtain the concentration to crystallization in the crystallizer is appeared, and 6-APA of non-crystallization gets into the mother liquor jar along with the concentrate and retrieves once more.

Description

6-APA recovery unit in 6-APA mother liquor

Technical Field

The utility model relates to a 6-APA mother liquor retrieves technical field, concretely relates to 6-APA recovery unit in 6-APA mother liquor.

Background

6-Aminopenicillanic acid (6-Aminopenicillanic acid) is commonly called side chain-free penicillin, is called 6-APA for short, is white flaky crystal, is a mother nucleus of penicillin, is an important intermediate for preparing various semi-synthetic penicillins, and has wide application range.

In industrial production, 6-APA is generally prepared by cracking penicillin G salt under the action of penicillin acylase at present, and the waste liquid after the cracking liquid is crystallized still contains about 0.3 percent (mass fraction) of 6-APA, a small amount of styrene, penicillin raw materials and trace other impurities. 6-APA in the crystallization mother liquor still has high economic benefit, and if the 6-APA is directly discharged, the 6-APA in the discharged waste liquor not only causes resource economic waste, but also has certain influence on the environment.

Therefore, a 6-APA recovery device in 6-APA mother liquor is urgently needed in the market.

SUMMERY OF THE UTILITY MODEL

In view of the above, the present invention is directed to provide a device for recovering 6-APA from 6-APA mother liquor, so as to solve the technical problem of how to recover 6-APA from 6-APA mother liquor.

The utility model discloses the technical scheme who adopts does:

design a 6-APA recovery unit in 6-APA mother liquor, the device includes mother liquor jar, decompression distillation plant, surge tank, primary filtration equipment, receive filter membrane concentrator, crystallizer and secondary filter equipment that connect gradually by the pipeline, there is alkali lye to add the case the feed liquor end of surge tank through the pipe connection, secondary filter equipment's flowing back end links to each other with the mother liquor jar through mother liquor backflow pipeline.

Preferably, be equipped with rabbling mechanism and PH detection mechanism in the regulation jar.

Preferably, the primary filtering device is an ultrafiltration membrane filtering device.

Preferably, the device also comprises a sedimentation tank, and a sewage discharge pipe and a recovery pipe are arranged between the primary filtering equipment and the sedimentation tank.

Preferably, a heat exchanger is arranged on a pipeline between the reduced pressure distillation equipment and the adjusting tank.

Compared with the prior art, the utility model has the advantages that:

the utility model provides a decompression distillation plant can detach the menstruum in the mother liquor, prevents the menstruum to the destruction of receiving the filter membrane in subsequent handling, and the impurity particle in the mother liquor can be detached to first filtration equipment, receives the filter membrane concentrator and can make 6-APA in the mother liquor obtain the concentration to crystallization in the crystallizer is appeared, and 6-APA of non-crystallization gets into the mother liquor jar along with the concentrate and retrieves once more.

Drawings

Fig. 1 is a schematic structural view of the present invention;

1 is mother liquor jar, 2 is the vacuum distillation equipment, 3 is the surge tank, 4 is first filtration equipment, 5 is for receiving filter membrane concentrator, 6 is the crystallizer, 7 is secondary filtration equipment, 8 is alkali lye and adds the case, 9 is mother liquor backflow pipeline, 10 is rabbling mechanism, 11 is PH detection mechanism, 12 is the sedimentation tank, 13 is the blow off pipe, 14 is the recovery tube, 15 is heat exchanger, 16 is the valve.

Detailed Description

The following embodiments are only intended to illustrate the present invention in detail, and do not limit the scope of the present invention in any way. The unit module components, structures, mechanisms, sensors and other devices referred to in the following examples are all conventional and commercially available products unless otherwise specified.

Example (b): as shown in figure 1, the device for recovering 6-APA in 6-APA mother liquor comprises a mother liquor tank 1, a reduced pressure distillation device 2, an adjusting tank 3, a primary filtering device 4, a nanofiltration membrane concentrating device 5, a crystallizing tank 6 and a secondary filtering device 7 which are sequentially connected through pipelines, wherein the liquid inlet end of the adjusting tank 3 is connected with an alkali liquor adding tank 8 through a pipeline, the liquid discharging end of the secondary filtering device 7 is connected with the mother liquor tank 1 through a mother liquor backflow pipeline 9, and the secondary filtering device 7 is common filtering equipment such as a security filter.

In this embodiment, the adjusting tank 3 is provided with a stirring mechanism 10 and a PH detection mechanism 11.

In this embodiment, the primary filtering apparatus 4 is an ultrafiltration membrane filtering apparatus.

In this embodiment, the device further comprises a sedimentation tank 12, and a sewage discharge pipe 14 and a recovery pipe 13 are arranged between the primary filtering device 4 and the sedimentation tank 12.

In this embodiment, a heat exchanger 15 is provided on a pipe between the vacuum distillation apparatus 2 and the adjustment tank 3.

The operation and use method of the recovery device is as follows:

the 6-APA mother liquor is subjected to solvent removal in the reduced pressure distillation equipment 2 to remove various solvents in the mother liquor and prevent the solvents from damaging the nanofiltration membrane in the subsequent process; the 6-APA mother liquor after the solvent is removed is cooled to about 10 ℃ in a heat exchanger 15, and enters an adjusting tank 3 together with the sodium hydroxide solution in an alkali liquor adding box 8, and the PH of the 6-APA mother liquor is adjusted to 6.5-7.0 under the stirring action of a stirring mechanism 10; the adjusted 6-APA mother liquor enters ultrafiltration membrane filtration equipment for primary filtration to remove impurity particles in the mother liquor, filter residues are discharged to a sedimentation tank 12 through a discharge pipe 14, and supernatant in the sedimentation tank 12 flows back to the ultrafiltration membrane filtration equipment through a recovery pipe 13; concentrating the ultrafiltered 6-APA mother liquor by a nanofiltration membrane concentration device 5, discharging the concentrated solution into a crystallization tank 6 for crystallization, filtering and separating out, and refluxing the filtered concentrated solution into a mother liquor tank 1 for recycling again through a mother liquor reflux pipeline 9.

Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and other modifications or equivalent replacements made by the technical solutions of the present invention by those of ordinary skill in the art should be covered within the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solutions of the present invention.

Claims

1. A6-APA recovery unit in 6-APA mother liquor, characterized by: include mother liquor jar, vacuum distillation equipment, adjusting tank, first filtration equipment, receive filter membrane concentrator, crystallizer and secondary filtration equipment that connect gradually by the pipeline, there is alkali lye to add the case the feed liquor end of adjusting tank through the pipe connection, secondary filtration equipment's flowing back end links to each other with the mother liquor jar through mother liquor backflow pipeline.

2. The apparatus for recovering 6-APA from 6-APA mother liquor according to claim 1, wherein: and a stirring mechanism and a PH detection mechanism are arranged in the adjusting tank.

3. The apparatus for recovering 6-APA from 6-APA mother liquor according to claim 1, wherein: the primary filtering equipment is ultrafiltration membrane filtering equipment.

4. The apparatus for recovering 6-APA from 6-APA mother liquor according to claim 1, wherein: the device also comprises a sedimentation tank, and a sewage discharge pipe and a recovery pipe are arranged between the primary filtering equipment and the sedimentation tank.

5. The apparatus for recovering 6-APA from 6-APA mother liquor according to claim 1, wherein: and a heat exchanger is arranged on a pipeline between the reduced pressure distillation equipment and the adjusting tank.