CN203224464U - Nuclear-magnetic-resonance device for biological medicines - Google Patents
Nuclear-magnetic-resonance device for biological medicines Download PDFInfo
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- CN203224464U CN203224464U CN 201320099056 CN201320099056U CN203224464U CN 203224464 U CN203224464 U CN 203224464U CN 201320099056 CN201320099056 CN 201320099056 CN 201320099056 U CN201320099056 U CN 201320099056U CN 203224464 U CN203224464 U CN 203224464U
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- 238000005481 NMR spectroscopy Methods 0.000 title claims abstract description 26
- 239000003814 drug Substances 0.000 title claims abstract description 10
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000005540 biological transmission Effects 0.000 claims abstract description 13
- 238000005452 bending Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 239000004809 Teflon Substances 0.000 claims description 3
- 229920006362 Teflon® Polymers 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000005672 electromagnetic field Effects 0.000 claims description 3
- 230000006698 induction Effects 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000009987 spinning Methods 0.000 abstract 1
- 238000012565 NMR experiment Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
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Abstract
The utility model discloses a nuclear-magnetic-resonance device for biological medicines. The nuclear-magnetic-resonance device comprises a frequency meter, a radio-frequency oscillator, a radio-frequency coil and a modulation receiver, wherein the radio-frequency coil is used for generating an alternating magnetic field according to pulse current of the radio-frequency oscillator and inducing and generating a sample feedback signal to the nuclear-spinning energy level of a representation sample; the radio-frequency coil comprises an even number of rectangular subcoils; a long edge at one side of one rectangular subcoil extends to form a first transmission line positioned at the axis, and a short edge adjacent to the long edge is folded and extends to form a second transmission line; the plurality of rectangular subcoils are connected in parallel and are arranged at equal intervals to form the radio-frequency coil; the modulation receiver is connected to the radio-frequency oscillator; a sample pipe is positioned on the axis of the radio-frequency coil, is positioned right below the radio-frequency coil, and is arranged on a rotor fixing piece; a first magnet and a second magnet are respectively positioned at the two sides of the sample pipe. The nuclear-magnetic-resonance device disclosed by the utility model has the advantages that the quality factor is high, the high-power excitation and the good radio-frequency magnetic-field distribution are realized, and the accuracy and the sensitivity of measurement are greatly improved; the stability of samples in rotation is enhanced, and the blocking rate in sample loading is also reduced.
Description
Technical field
The utility model relates to nuclear magnetic resonance spectroscopy device field, is specifically related to a kind of nuclear magnetic resonance device for biological medicine.
Background technology
In view of the widespread use of nuclear magnetic resonance technique in fundamental researchs such as chemistry, biology and clinical medicine, drug development, various high resolution NMR analytical technologies become the important tool in the Biochemical Research.Go for high-quality nmr spectrum, parameters such as the alternating temperature performance of nuclear magnetic resonance rotor adapter, rotational stabilization seem extremely important.Especially go for high-resolution nmr spectrum, need to use the bigger rotor adapter (200 to 200 ℃) of extent of alternating temperature and make sample rotation (greater than 20 rpm), need to guarantee sample tube stability when rotated this moment.Present common rotor adapter, correlation parameters such as the magnetic susceptibility of its material and mass distribution all do not satisfy the demand of using in than large-temperature range, and under high rotating speed, the less stable of rotor adapter, it is very complicated that feasible process of carrying out the high resolution NMR experiment becomes.
On the other hand, go for high-quality nmr spectrum, the load power of NMR RF coil, the parameters such as homogeneity of radio-frequency (RF) magnetic field seem extremely important.Especially go for high-resolution nmr spectrum, often need to use the higher radio-frequency coil (greater than 20kHz) of load power, just have higher requirement for geometric configuration and the space structure of radio-frequency coil this moment.Present common radio-frequency coil, as the solenoid type radio-frequency coil, and Hai Muhuozi type radio-frequency coil, the maximum intensity of the radio-frequency field that it can apply is 10 ~ 15kHz, do not satisfy the demand apply more high-power radio-frequency field, make that carrying out the high resolution NMR experiment becomes and be difficult to carry out.
Summary of the invention
The utility model provides a kind of nuclear magnetic resonance device for biological medicine, and this nuclear magnetic resonance spectroscopy device has higher quality factor, has realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly; And the stability when strengthening the sample rotation, thereby improved the accuracy of rotation and irrotational nuclear magnetic resonance data, the rate that gets stuck when this design has simultaneously also reduced last sample.
For achieving the above object, the technical solution adopted in the utility model is: a kind of nuclear magnetic resonance device for biological medicine comprises:
Frequency meter is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator, and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil comprises even number rectangle subcoil, first transmission line that back formation one is positioned at the axle center is extended on the long limit of one side of this rectangle subcoil, extend to form second transmission line after the adjacent minor face bending in long limit therewith, several rectangle subcoils are in parallel and uniformly-spaced arrange and form described radio-frequency coil;
Modulator receiver is connected to described radio-frequency oscillator, is used for extracting the sample feedback signal from radio-frequency oscillator;
The sample hose that is used for the carrying detected sample is positioned on the described radio-frequency coil axial line and is positioned under it, and this sample hose is installed on the rotor fixture;
First magnet and second magnet lay respectively at described sample hose both sides, and being used for provides static magnetic field to the sample in this sample hose.
Further improvement project in the technique scheme is as follows:
1. in the such scheme, described several second transmission line other end bendings connect by a closed loop coil.
2. in the such scheme, the magnetic field intensity of described first magnet and second magnet is 1 ~ 1.2 tesla.
3. in the such scheme, described rectangle subcoil number is 6, and the adjacent rectangle subcoil is spaced apart 60 degree
4. in the such scheme, described scapus, tighten solid, fastener and cap body material are teflon down.
Because technique scheme is used, the utility model compared with prior art has following advantage and effect:
1. the utility model nuclear magnetic resonance device, it is applicable to transmitting and receiving of pulse signal, can be used for the research of high resolution NMR experiment; This apparatus structure is tight, has higher quality factor, and the radio-frequency power that can carry is 30kHz, and the uniformity coefficient of radio-frequency (RF) magnetic field is 4.6%.Realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly.
2. adopted six groups of leads in the utility model nuclear magnetic resonance device, compared with the Helmholtz coils that is made of two groups of leads with the solenoid type coil that traditional one group of lead constitutes, structure is meticulousr, can realize more complicated radio-frequency field.
3. coil device of the present utility model has been realized high power, has six subcoils in a coil, and total radio-frequency power is distributed to six subcoils.Under the constant situation of each subcoil peak power, improved general power, therefore improved the resolution of imaging.
4. coil device of the present utility model has improved the uniformity coefficient of radio-frequency (RF) magnetic field, six subcoils have been adopted, utilize its radio-frequency (RF) magnetic field separately in the mutual compensation at space overlap place, improved the spatial uniformity in single coil magnetic field, improved the Distribution of Magnetic Field of single coil.
5. coil device of the present utility model is easy for installation, can directly be used for replacing original coil, and need not change other hardware, compare with traditional coil, this coil has had very big variation in shape, based on the change of shape, in conjunction with above-mentioned explanation, this coil has following characteristics: (1) has improved the radio-frequency power of coil; (2) improved the uniformity of magnetic field of coil; (3) easy to install and use.
Description of drawings
Accompanying drawing 1 is the utility model magnetic nuclear resonance analyzer principle schematic;
Accompanying drawing 2 is rectangle subcoil structural representation in the utility model radio-frequency coil;
Accompanying drawing 4 is the utility model radio-frequency coil structure synoptic diagram.
In the above accompanying drawing: 1, frequency meter; 2, radio-frequency oscillator; 3, radio-frequency coil; 4, modulator receiver; 5, sample hose; 6, rotor fixture; 7, rectangle subcoil; 8, grow the limit; 9, first transmission line; 10, minor face; 11, second transmission line; 12, first magnet; 13, second magnet; 14, closed loop coil.
Embodiment
Below in conjunction with drawings and Examples the utility model is further described:
Embodiment: a kind of nuclear magnetic resonance device for biological medicine shown in accompanying drawing 1 ~ 4, comprising:
Frequency meter 1 is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator 2 produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil 3, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator 2, and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil 3 comprises even number rectangle subcoil 7, first transmission line 9 that back formation one is positioned at the axle center is extended on the long limit 8 of one side of this rectangle subcoil 7, extend to form second transmission line 11 after adjacent minor face 10 bendings in long limit 8 therewith, several rectangle subcoils 7 are in parallel and uniformly-spaced arrange and form described radio-frequency coil 3;
Modulator receiver 4 is connected to described radio-frequency oscillator 2, is used for extracting the sample feedback signal from radio-frequency oscillator 2;
The sample hose 5 that is used for the carrying detected sample is positioned on described radio-frequency coil 3 axial lines and is positioned under it, and this sample hose is installed on the rotor fixture 6;
First magnet 12 and second magnet 13 lay respectively at described sample hose 5 both sides, and being used for provides static magnetic field to the sample in this sample hose 5.
Above-mentioned several second transmission line, 11 other end bendings connect by a closed loop coil 14; Above-mentioned rectangle subcoil number is 6, and the adjacent rectangle subcoil is spaced apart 60 degree.
The magnetic field intensity of above-mentioned first magnet 12 and second magnet 13 is 1 ~ 1.2 tesla; Above-mentioned rotor fixture 6 materials are teflon.
When adopting above-mentioned nuclear magnetic resonance device for biological medicine, it is applicable to transmitting and receiving of pulse signal, can be used for the research of high resolution NMR experiment; This apparatus structure is tight, has higher quality factor, and the radio-frequency power that can carry is 30kHz, and the uniformity coefficient of radio-frequency (RF) magnetic field is 4.6%.Realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly; Secondly, adopted six groups of leads in the nuclear magnetic resonance device, compared with the Helmholtz coils that is made of two groups of leads with the solenoid type coil that traditional one group of lead constitutes, structure is meticulousr, can realize more complicated radio-frequency field; Again, coil device has been realized high power.Have six subcoils in a coil, total radio-frequency power is distributed to six subcoils.Under the constant situation of each subcoil peak power, improved general power, therefore improved the resolution of imaging; Again, nuclear magnetic resonance device has improved the uniformity coefficient of radio-frequency (RF) magnetic field, has adopted six subcoils, utilizes its radio-frequency (RF) magnetic field separately in the mutual compensation at space overlap place, has improved the spatial uniformity in single coil magnetic field, has improved the Distribution of Magnetic Field of single coil.
Above-described embodiment only is explanation technical conceive of the present utility model and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present utility model and enforcement according to this, can not limit protection domain of the present utility model with this.All equivalences of doing according to the utility model spirit essence change or modify, and all should be encompassed within the protection domain of the present utility model.
Claims (5)
1. nuclear magnetic resonance device that is used for biological medicine is characterized in that: comprising:
Frequency meter (1) is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator (2) produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil (3), produce alternating electromagnetic field according to the pulse current from described radio-frequency oscillator (2), and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil (3) comprises even number rectangle subcoil (7), first transmission line (9) that back formation one is positioned at the axle center is extended on the long limit of one side of this rectangle subcoil (7) (8), extend to form second transmission line (11) after adjacent minor face (10) bending in long limit (8) therewith, several rectangle subcoils (7) are in parallel and uniformly-spaced arrange and form described radio-frequency coil (3);
Modulator receiver (4) is connected to described radio-frequency oscillator (2), is used for extracting the sample feedback signal from radio-frequency oscillator (2);
The sample hose (5) that is used for the carrying detected sample is positioned on described radio-frequency coil (3) axial line and is positioned under it, and this sample hose is installed on the rotor fixture (6);
First magnet (12) and second magnet (13) lay respectively at described sample hose (5) both sides, and being used for provides static magnetic field to the sample in this sample hose (5).
2. nuclear magnetic resonance device according to claim 1, it is characterized in that: described several second transmission line (11) other end bendings connect by a closed loop coil (14).
3. nuclear magnetic resonance device according to claim 1, it is characterized in that: the magnetic field intensity of described first magnet (12) and second magnet (13) is 1 ~ 1.2 tesla.
4. nuclear magnetic resonance device according to claim 1, it is characterized in that: described rectangle subcoil (7) number is 6, adjacent rectangle subcoil (7) is spaced apart 60 degree.
5. nuclear magnetic resonance device according to claim 1, it is characterized in that: described rotor fixture (6) material is teflon.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320099056 CN203224464U (en) | 2013-03-05 | 2013-03-05 | Nuclear-magnetic-resonance device for biological medicines |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201320099056 CN203224464U (en) | 2013-03-05 | 2013-03-05 | Nuclear-magnetic-resonance device for biological medicines |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103207199A (en) * | 2013-03-05 | 2013-07-17 | 杨晓冬 | Biomedical nuclear magnetic resonance device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103207199A (en) * | 2013-03-05 | 2013-07-17 | 杨晓冬 | Biomedical nuclear magnetic resonance device |
| CN103207199B (en) * | 2013-03-05 | 2016-05-18 | 杨晓冬 | For the nuclear magnetic resonance device of biological medicine |
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Free format text: FORMER OWNER: ZHENG YUAN LI BIAO DOU TIEHUA Effective date: 20140211 Owner name: SUZHOU BEISIMAI MEDICAL INSTRUMENT CO., LTD. Free format text: FORMER OWNER: HUANG YANYAN Effective date: 20140211 |
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Effective date of registration: 20140211 Address after: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 room 333 Patentee after: SUZHOU BEISIMAI MEDICAL INSTRUMENT CO., LTD. Address before: The four road Changshu Economic Development Zone Suzhou city Jiangsu province 215513 No. 11 Science Park 201 Patentee before: Yang Xiaodong Patentee before: Liu Xiaolong Patentee before: Zhang Yun Patentee before: Wei Daxiu |
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Effective date of registration: 20170717 Address after: 1809, room 361000, Chuangxin building, Xiamen Industrial Technology Research Institute, 1300 Jimei Road, Jimei District, Fujian, Xiamen Patentee after: Xiamen Aode Biotechnology Co. Ltd. Address before: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 room 333 Patentee before: SUZHOU BEISIMAI MEDICAL INSTRUMENT CO., LTD. |
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Granted publication date: 20131002 Termination date: 20210305 |
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