CN201626820U - Full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device - Google Patents
Full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device Download PDFInfo
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- CN201626820U CN201626820U CN2010201769865U CN201020176986U CN201626820U CN 201626820 U CN201626820 U CN 201626820U CN 2010201769865 U CN2010201769865 U CN 2010201769865U CN 201020176986 U CN201020176986 U CN 201020176986U CN 201626820 U CN201626820 U CN 201626820U
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- liquid medicine
- tank body
- magnetic stirring
- split charging
- supporting station
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Abstract
The utility model provides a full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device which comprises a workbench (1) and a split charging tank (2). The utility model adopts the technical proposal of combining the workbench with the split charging tank, wherein the workbench has the functions of automatic constant temperature control, utilizing a semiconductor refrigerating component for refrigerating and magnetic separation stirring, the problems and defects in prior art that the system seal performance is unreliable, the temperature control accuracy is low and irregular, and the hygienic condition of the filing zone can be destroyed by a mechanical stirrer and ice bath; the full-automatic constant temperature magnetic stirring sterile liquid medicine split charging device controls the temperature of the liquid medicine in the split charging tank by the workbench automatic constant temperature refrigerating function, ensures the efficacy of the liquid medicine in the split charging tank by the non-contact magnetic stirring function and also prevents the liquid medicine in the split charging tank from polluting the environment or protects the liquid medicine against the environmental contamination, therefore the split charging of liquid medicine meets the requirements of the new edition of pharmacopeia and GMP, and the purposes of ensuring the sealing safety, reliability and stability of the system and realizing constant temperature and uniformity of liquid medicine are realized.
Description
Technical field
The utility model relates to a kind of soup and divides tinning, specifically is meant in medicine and biopreparate production, is used for a kind of fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device of sterile liquid medicine preparation and packing.
Background technology
In the preparation and packing of active medicine and biologically active agents (as vaccine),, must meet the following conditions according to standard: the necessary withstanding corrosion of material of medicine liquid tank contact soup, no cast, any surface finish does not have the dead angle, is easy to clean, sterilize; (2) sterile liquid medicine can guarantee the germ-free condition of system into and out of jar (sterile liquid medicine, auxiliary material advance jar during preparation, and sterile liquid medicine goes out jar when sampling and can) time; Can continue to stir, guarantee the soup homogeneity; Keep 2～8 ℃ of constant temperature, reduce the loss of activity of soup; The stirring system of tank body and insulation must not destroy (containing low-temperature receiver) gnotobasis in can district.
Prior art does not still have the special-purpose soup that meets above-mentioned requirements fully and divides tinning, and general pharmaceutical factory how will medium and small stainless cylinder of steel installs additional and is used for soup behind respirator, mechanical agitator, the ice bath and prepares and can.Version GMP in 2010 and Chinese Pharmacopoeia (on July 1st, 2010 went into effect) " ice bath " with liquid drug clearly change " 2～8 ℃ " into, and the preparation and the can of soup proposed requirements at the higher level.Prior art exists that system sealing is unreliable, temperature control precision is not high or lack of standardization, the problems and shortcomings of mechanical agitator and ice bath destructible can district clean environment.
Summary of the invention
Problems and shortcomings at above-mentioned prior art existence, the utility model adopts and is controlled by automatic constant-temperature, semiconductor refrigerating is refrigerated, the bench board of the isolated agitating function of magnetic force and the technical scheme of dividing the tinning combination, a kind of fully-automatic thermostatic magnetic stirring sterile liquid medicine packaging device is provided, be intended to divide tinning inner liquid medicine temperature by the control of bench board automatic constant-temperature refrigeration, non-contact magnetic force stirs and divides tinning inner liquid medicine function, guarantee that branch tinning inner liquid medicine is free from environmental pollution or by environmental pollution, make the soup packing meet new edition pharmacopeia and GMP requirement, reach and guarantee system sealing safety, reliably, stable, the purpose of the homogeneity of the constant and soup of fluid temperature.
The purpose of this utility model is achieved in that a kind of fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device, comprise bench board, divide tinning, wherein: described bench board is made of electronic scales, supporting station, magnetic stirring apparatus, refrigerator, controller from going up down; Wherein, supporting station is the rectangular channel shape lid that four limits are provided with frame, and supporting station caping center is provided with manhole; Supporting station be fixed on electronic scales above, magnetic stirring apparatus is positioned at the groove shape lid chamber of supporting station, is fixed on the center above the electronic scales, the top work surface of magnetic stirring apparatus is in the supporting station caping centre hole, and a little less than the upper surface of supporting station; Be fixed with the refrigerator of a cylinder tubbiness above the supporting station; The bucket wall of refrigerator is a corrosion-resistant steel interlayer wall, is provided with semiconductor chilling plate in the interlayer wall, the tank body external diameter bearing fit of the internal diameter of interlayer wall and tinning in described minute, and interlayer wall bottom is provided with the temperature sensor socket of manhole; One side of bench board is fixed with a root post, the top of column is provided with automatic weight detection, temperature detection, refrigeration control, stirs control, the controller that can preset working parameter, controller links to each other with electronic scales, magnetic stirring apparatus, refrigerator, temperature sensor, power supply respectively by connecting wire;
The thin-wall stainless steel cylinder bulk containers of tinning in described minute for constituting by bottom tank body, top cover; Wherein, the outer wall of tank body is provided with carrying handle and pivot shaft, and the bottom of inner tank wall is provided with in the cooresponding position of temperature sensor socket with described bench board and stretches in the tank body chamber inner osed top inserting tube; Tank body upper edge place is laid with some knob locking closure devices; Be fixed with the flange frame glass window on the cover, be fixed with feed tube, drain pipe; Feed tube is shorter, and when cover covered on the tank body bead, the lower port of feed tube was positioned at the top of tank inner chamber; Drain pipe is longer, and when cover covered on the tank body bead, the lower port of drain pipe was positioned at the bottom of tank inner chamber; The cover top center is provided with the interface of air filter; The lower edge of cover is provided with the seal ring caulking groove.
Principle of work
During application, stationary table places can packing station place, and cleaning and sterilizing is identical with other facilities, and process prescription is omitted.
The cleaning and the sterilization that divide tinning: by the pivot shaft support tank body is flipped upside down,, will clean up inside and outside the tank body with the water for injection flushing; To clean up inside and outside the cover with water for injection; Just putting tank body, the magnetic agitation ball of some cleanings is packed in the tank body, cover is added the seal ring that cleaned to be covered on the tank body mouth, buckle knob locking closure device and tighten, cover is fixed, top center interface at cover is loaded onto air filter, afterwards minute tinning integral body is carried out high pressure steam sterilization, pressurize test and air filter integrity test, to divide after the test in the round barrel shape refrigerator 13 of bench board that tinning 2 integral body are placed to the preparation station, the temperature sensor socket of temperature sensor by bench board inserted in the inserting tube of tank body, the preparation flexible pipe is connected the entrance of the feed tube of cover, and power turn-on can begin the soup preparation.
Soup is in feed tube pours into the branch tinning, and start-up control device bench board is started working; Electronic scales shows the net weight that enters branch tinning soup, and data in real time is fed back to the controller processing; Magnetic stirring apparatus stirs by the magnetic agitation ball rotation that rotating field drives in the tank body; The semiconductor chilling plate of refrigerator freezes, and by tank wall the jar inner liquid medicine is cooled off; Temperature sensor will divide tinning inner liquid medicine temperature to feed back to the controller processing in real time; Controller produces foam by pre-set programs control stirring rate in case enter the soup of branch tinning; Controller is pressed parameter preset control refrigerator refrigeration, will divide tinning inner liquid medicine temperature constant within 2～8 ℃ of scopes; The operator can monitor a jar interior situation by the observation window on the cover.
Preparation finishes, the sealing feed tube, by manually dividing tinning from the bench board of preparation station, to propose, integral body moves in the refrigerator of the bench board that is placed to the packing station, the temperature sensor socket of temperature sensor by bench board inserted in the inserting tube of tank body, the packing flexible pipe is connected the exit of the drain pipe of cover, power turn-on, can the constant temperature refrigeration with stir under begin packing.
Beneficial effect
Automatic guidance is interrupted refrigeration and just can be controlled in the claimed range fluid temperature is constant; Semiconductor refrigerating is compression mechanism cold-peace ice bath relatively, has the little advantage of volume, and the clean environment air-flow is not had disturbance, no destructive effect; The non-contact magnetic force of magnetic stirring apparatus stirs, and has avoided the mechanical contact formula to stir and has had the pollution and jar inner liquid medicine hidden danger to outside environmental pollution of external environment condition to the jar inner liquid medicine.
Expand design
For the ease of the packing into or take out of minute tinning, the refrigerator of described bench board can be designed to close the symbol structure by the wall of the straight tube of the many slit bamboo or chopped woods of hinge bonded assembly arc; When packing the branch tinning into, launch wall and hold the branch tinning tightly; Take out when dividing tinning, launch wall and take out the branch tinning.
Above-mentioned, the utility model adopts automatic constant-temperature control, semiconductor refrigerating is refrigerated, the bench board of the isolated agitating function of magnetic force and the technical scheme of dividing the tinning combination, having overcome prior art exists system sealing unreliable, temperature control precision is not high, lack of standardization, the problems and shortcomings of mechanical agitator and ice bath destructible can district clean environment, a kind of fully-automatic thermostatic magnetic stirring sterile liquid medicine packaging device that is provided, divide tinning inner liquid medicine temperature by the control of bench board automatic constant-temperature refrigeration, non-contact magnetic force stirs and divides tinning inner liquid medicine function, guarantee that branch tinning inner liquid medicine is free from environmental pollution or by environmental pollution, make the packing of soup meet the requirement of new edition pharmacopeia and GMP, reached and guaranteed system sealing safety, reliably, stable, the purpose of the homogeneity of the constant and soup of fluid temperature.
Description of drawings
Fig. 1 is the structural representation of fully-automatic thermostatic magnetic stirring sterile liquid medicine packaging device of the present utility model.
Below in conjunction with the embodiment in the accompanying drawing the utility model is described in further detail, but should not be construed as any restriction of the present utility model.
Among the figure: bench board 1, electronic scales 11, magnetic stirring apparatus 12, refrigerator 13, semiconductor chilling plate 131, controller 14, temperature sensor 15, supporting station 16, point tinning 2, tank body 21, carrying handle 211, pivot shaft 212, inserting tube 213, cover 22, observation window 221, feed tube 222, air filter 223, breathing pipe 224, drain pipe 225, knob locking closure device 226, magnetic agitation ball 01, power lead 02.
The specific embodiment
Consult Fig. 1, a kind of fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device of the present utility model, comprise bench board 1, divide tinning 2, wherein: described bench board 1 is made of electronic scales 11, supporting station 16, magnetic stirring apparatus 12, refrigerator 13, controller 14 from going up down; Wherein, supporting station 16 is the rectangular channel shape lid that four limits are provided with frame, and supporting station 16 caping centers are provided with manhole; Supporting station 16 be fixed on electronic scales 11 above, magnetic stirring apparatus 12 is positioned at the groove shape lid chamber of supporting station 16, be fixed on the center above the electronic scales 11, the top work surface of magnetic stirring apparatus 12 is in the supporting station 16 caping centre holes, and a little less than the upper surface of supporting station 16; Be fixed with the refrigerator 13 of a cylinder tubbiness above the supporting station 16; The bucket wall of refrigerator 13 is a corrosion-resistant steel interlayer wall, is provided with semiconductor chilling plate 131 in the interlayer wall, the tank body 21 external diameter bearing fits of the internal diameter of interlayer wall and tinning 2 in described minute, and interlayer wall bottom is provided with temperature sensor 15 sockets of manhole; One side of bench board is fixed with a root post, the top of column is provided with automatic weight detection, temperature detection, refrigeration control, stirs control, the controller 14 that can preset working parameter, controller 14 links to each other with electronic scales 11, magnetic stirring apparatus 12, refrigerator 13, temperature sensor 15, power supply respectively by connecting wire;
The thin-wall stainless steel cylinder bulk containers of tinning in described minute 2 for constituting by bottom tank body 21, top cover 22; Wherein, the outer wall of tank body 21 is provided with carrying handle 211 and pivot shaft 212, and the bottom of tank body 21 inwalls is provided with in the cooresponding position of temperature sensor 15 sockets with described bench board 1 and stretches in the tank body chamber inner osed top inserting tube 213; Tank body 21 upper edge places are laid with some knob locking closure devices 226; Be fixed with flange frame glass window 221 on the cover 22, be fixed with feed tube 222, drain pipe 225; Feed tube 222 is shorter, and when cover 22 covered on tank body 21 beads, the lower port of feed tube 222 was positioned at the top of tank body 21 inner chambers; Drain pipe 225 is longer, and when cover 22 covered on tank body 21 beads, the lower port of drain pipe 225 was positioned at the bottom of tank body 21 inner chambers; Cover 22 top center are provided with the interface of air filter 223; The lower edge of cover 22 is provided with the seal ring caulking groove.
Principle of work
During application, bench board 1 fixedly places can packing station place, and cleaning and sterilizing is identical with other facilities, and process prescription is omitted.
The cleaning and the sterilization that divide tinning 2: by pivot shaft 212 supports tank body 21 is flipped upside down,, will clean up inside and outside the tank body 21 with the water for injection flushing; To clean up inside and outside the cover 22 with water for injection; Just putting tank body 21, the magnetic agitation ball 01 of some cleanings is packed in the tank body 21, cover 22 is added the seal ring that cleaned to be covered on 21 mouthfuls of tank bodies, buckle knob locking closure device 226 and tighten, cover 22 is fixing, top center interface at cover 22 is loaded onto air filter 223, afterwards minute tinning 2 integral body are carried out high pressure steam sterilization, pressurize test and air filter integrity test, to divide after the test in the round barrel shape refrigerator 13 of bench board 1 that tinning 2 integral body are placed to the preparation station, the temperature sensor socket of temperature sensor 15 by bench board 1 inserted in the inserting tube 213 of tank body 21, the preparation flexible pipe is connected the entrance of the feed tube 222 of cover 22, power turn-on can begin the soup preparation.
Soup is in feed tube 222 pours into branch tinning 2, and start-up control device 14 bench board 1 are started working; Electronic scales 11 shows the net weight that enters branch tinning 2 soups, and data in real time is fed back to controller 14 processing; Magnetic stirring apparatus 12 stirs by magnetic agitation ball 01 rotation that rotating field drives in the tank body 21; The semiconductor chilling plate 131 of refrigerator 13 freezes, and by tank body 21 outer walls the jar inner liquid medicine is cooled off; Temperature sensor 15 will divide tinning 2 inner liquid medicine temperature to feed back to controller 14 processing in real time; Controller 14 produces foam by pre-set programs control stirring rate in case enter the soup of branch tinning 2; Controller 14 is pressed parameter preset control refrigerator 13 refrigeration, will divide tinning 2 inner liquid medicine temperature constant within 2～8 ℃ of scopes; The operator can monitor a jar interior situation by the observation window on the cover 22 221.
Preparation finishes, sealing feed tube 222, by manually dividing tinning 2 from the bench board 1 of preparation station, to propose, integral body moves in the refrigerator 13 of the bench board 1 that is placed to the packing station, the temperature sensor socket of temperature sensor 15 by bench board 1 inserted in the inserting tube 213 of tank body 21, the packing flexible pipe is connected the exit of the drain pipe 225 of cover 22, power turn-on, can the constant temperature refrigeration with stir under begin packing.
Claims (1)
1. fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device, comprise bench board (1), divide tinning (2), it is characterized in that: described bench board (1) constitutes from going up by electronic scales (11), supporting station (16), magnetic stirring apparatus (12), refrigerator (13), controller (14) down; Wherein, supporting station (16) is the rectangular channel shape lid that four limits are provided with frame, and supporting station (16) caping center is provided with manhole; Supporting station (16) be fixed on electronic scales (11) above, magnetic stirring apparatus (12) is positioned at the groove shape lid chamber of supporting station (16), be fixed on the center above the electronic scales (11), the top work surface of magnetic stirring apparatus (12) is in supporting station (16) the caping centre hole, and a little less than the upper surface of supporting station (16); Be fixed with the refrigerator (13) of a cylinder tubbiness above the supporting station (16); The bucket wall of refrigerator (13) is a corrosion-resistant steel interlayer wall, be provided with semiconductor chilling plate (131) in the interlayer wall, the internal diameter of interlayer wall and described minute tinning (2) tank body (21) external diameter bearing fit, interlayer wall bottom is provided with temperature sensor (15) socket of manhole; One side of bench board is fixed with a root post, the top of column is provided with automatic weight detection, temperature detection, refrigeration control, stirs control, the controller (14) that can preset working parameter, controller (14) links to each other with electronic scales (11), magnetic stirring apparatus (12), refrigerator (13), temperature sensor (15), power supply respectively by connecting wire;
Described minute tinning (2) be the thin-wall stainless steel cylinder bulk containers that constitutes by bottom tank body (21), top cover (22); Wherein, the outer wall of tank body (21) is provided with carrying handle (211) and pivot shaft (212), and the bottom of tank body (21) inwall is provided with in the cooresponding position of temperature sensor (15) socket with described bench board (1) and stretches in the tank body chamber inner osed top inserting tube (213); Tank body (21) upper edge place is laid with some knob locking closure devices (226); Be fixed with flange frame glass window (221) on the cover (22), be fixed with feed tube (222), drain pipe (225); Feed tube (222) is shorter, and when cover (22) covered on tank body (21) bead, the lower port of feed tube (222) was positioned at the top of tank body (21) inner chamber; Drain pipe (225) is longer, and when cover (22) covered on tank body (21) bead, the lower port of drain pipe (225) was positioned at the bottom of tank body (21) inner chamber; Cover (22) top center is provided with the interface of air filter (223); The lower edge of cover (22) is provided with the seal ring caulking groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201769865U CN201626820U (en) | 2010-04-01 | 2010-04-01 | Full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201769865U CN201626820U (en) | 2010-04-01 | 2010-04-01 | Full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201626820U true CN201626820U (en) | 2010-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010201769865U Expired - Lifetime CN201626820U (en) | 2010-04-01 | 2010-04-01 | Full-automatic constant temperature magnetic stirring sterile liquid medicine preparation and split charging device |
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| CN (1) | CN201626820U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101830420A (en) * | 2010-04-01 | 2010-09-15 | 浙江卫信生物药业有限公司 | Fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device |
| CN105668475A (en) * | 2016-02-18 | 2016-06-15 | 张丽凤 | Novel medicine bottle bacteria detection device |
| CN107840297A (en) * | 2016-09-18 | 2018-03-27 | 武汉中原瑞德生物制品有限责任公司 | Liquid filling system and there is its Soup filling machine |
-
2010
- 2010-04-01 CN CN2010201769865U patent/CN201626820U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101830420A (en) * | 2010-04-01 | 2010-09-15 | 浙江卫信生物药业有限公司 | Fully-automatic thermostatic magnetic stirring sterile liquid medicine preparing and packaging device |
| CN101830420B (en) * | 2010-04-01 | 2012-04-11 | 浙江卫信生物药业有限公司 | Full-automatic constant-temperature magnetic stirring sterile liquid medicine preparation and subpackage device |
| CN105668475A (en) * | 2016-02-18 | 2016-06-15 | 张丽凤 | Novel medicine bottle bacteria detection device |
| CN107840297A (en) * | 2016-09-18 | 2018-03-27 | 武汉中原瑞德生物制品有限责任公司 | Liquid filling system and there is its Soup filling machine |
| CN107840297B (en) * | 2016-09-18 | 2020-03-24 | 武汉中原瑞德生物制品有限责任公司 | Liquid filling system and liquid medicine filling machine with same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20101110 Effective date of abandoning: 20120411 |