CN209392585U - A kind of electric field bringing device of selective depression specific cells growth - Google Patents
A kind of electric field bringing device of selective depression specific cells growth Download PDFInfo
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- CN209392585U CN209392585U CN201820261308.5U CN201820261308U CN209392585U CN 209392585 U CN209392585 U CN 209392585U CN 201820261308 U CN201820261308 U CN 201820261308U CN 209392585 U CN209392585 U CN 209392585U
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Abstract
The utility model relates to a kind of electric field bringing devices of selective depression specific cells growth, designed power supply device can export effective voltage and the adjustable ac voltage signal of frequency, the matched electrod-array connecting with power supply device can block alternating current to apply electric fields to cell or organism by dielectric capacitance piece, by selecting suitable frequency and electric field, the effect for inhibiting target cell growth can be effectively realized.
Description
Technical field
The utility model relates to a kind of electric field bringing devices of selective depression specific cells growth.More particularly to being directed to
Under the specific frequency of different target cell, power supply device and auxiliary electrode array that field strength inhibits target cell growth are improved.
Background technique
Based on electric field to the biological effect of cell and living tissue, living cells is for the reaction of the alternating electric field applied
With frequency dependence.In low frequency (below 1 kHz), alternating electric field can be stimulated by making membrane depolarization nerve and
Muscle.In addition, low frequency or impulse electric field can be with accelerating union of bone fracture.Under high frequency condition (frequency higher than 10 megahertzs),
Alternating electric field can cause tissue to generate heat, this can be used for tumour ablation.
It recently include that electro photoluminescence exists since current existing cancer therapy includes the lasting limitation of chemotherapy or radiotherapy
Interior new form of therapy has caused the extensive research and probe of people or clinical application interest.Medium frequency electric field for a long time by
Think there is no significant impact to bioprocess, it is low strong because their alternating cannot cause very much effective neuromuscular stimulation fastly
Degree can only also cause limited heating effect.However research and clinical discovery in recent years, when electric field frequency is in 100-500 thousand
When in the range of hertz, applied alternating field has apparent inhibition to the speed of growth of different cancer cells in vitro and in vivo
Effect.It is this kind of to study the development for having subsequently resulted in the new electric field therapy of therapeutic field of tumor.Particular technique is national at some
For medical research and the clinical treatment for brain tumor and other cancers.
There is specific result of study to show, applies low-intensity, the alternating electric field of intermediate frequency can press down by destroying mitosis
The merisis of active tumour cell processed.In addition, finite element simulation calculation is also it has been proved that apply electric field, can to influence tumour thin
The division and growth of born of the same parents.
Under the conditions of AC field, different electric dipoles can be rotated since the alternating in alternating electric field direction changes.It is general
Logical cell compares with tumour cell, since their internal different topochemistry compositions correspond to different electric dipoles, they
With different dielectric responses.For example ordinary cells are different from the chemical bond details of the DNA chain of tumour cell, it means that two kinds
The DNA chain of cell can correspond to different dielectric responses.There is experimental evidence to show that the alternating electric field under specific frequency can be with
Lead to the DNA key rupture failure of inside tumor cells, and then the electric field for leading to death of neoplastic cells, but being applied is for common thin
The DNA chain of born of the same parents does not influence significantly, nor affects on the growth of normal cell.
Although there are many orders that can inhibit in vitro and in vivo growth of cancer cells under the electric field action of specific frequency
The inspirer experimental result of people, and had been approved by food and drug administration (FDA) and can use NovoCure
The oncotherapy electric field equipment clinical treatment brain tumor of company, but still for the accurate therapy mechanism to electric field treatment at present
It is not clear enough.In order to more efficiently detect and treat tumour, and scientist and doctor's deep structure research is helped to understand that electric field is controlled
The precise mechanism for inhibiting tumour growth is treated, while avoiding or minimizing and applying electric field unfavorable shadow possible for internal normal cell
Ring, many countries, including Singapore, Australia, the U.S., France, Czech, Israel, Switzerland, Denmark, Hong Kong,
Germany is inside all in the accurate therapy mechanism for promptly studying electric field treatment tumour.
In order to which the country can study the accurate therapy mechanism of electric field treatment tumour, curative effect is improved, possible side effect is reduced,
It is necessary to design suitable power supply device and auxiliary electrode device to apply AC field, for use in there is urgent need at present
Biomedical research.
The utility model can be used in view of tumour cell is for the intensity of electric field and the dependence of frequency provided with one kind
Biomedical research, alternating current is blocked, frequency and the adjustable ac power supply apparatus of voltage and auxiliary electrode array are applied.
It can be used for the growth of selective inhibition target cell, promotes to carry out biomedical research using AC field and clinic is controlled
It treats.Experiment close proof, inhibits the best electric field treatment frequency of tumour growth and the size of different tumour cells inversely.
In addition alternating electric field acts on the optimal inhibition of different cancer cells and is also closely related with electric field strength.It is directed in experiment once finding
The suitable frequency of target tumor realizes the growth for inhibiting target cell using dielectric response caused by electric field, so that it may
Achieve the purpose that treat tumour.
Summary of the invention
A kind of electric field bringing device of selective depression specific cells growth comprising power supply device and matched electrode,
Wherein power supply device can be made of with output voltage and the adjustable AC signal of frequency, electrode insulation capacitance material, can be hindered
Alternating current passes through still conducting electric field.
Further, the output voltage of power supply device is continuously adjustable, and range is 0 to 65 volts, the output wave of power supply device
Shape is sine wave, triangular wave, square wave.
Further, the output signal of power supply device is sequentially output by 4 ports, provides the voltage in 4 directions, Mei Geduan
The output time of mouth can be adjusted within the scope of 0.1 second to 10 seconds.
Further, there are two interfaces, each port to be made up of two interfaces for each output port of power supply device
One current loop.
Further, the output signal of power supply device can be sequentially output by two ports, provide the voltage of both direction.
Further, the output signal of power supply device can continuously be exported by a port, provide the voltage in a direction.
Further, the internal electric source of power supply device is by rechargeable battery powered.
Further, the reference frequency output of power supply device is 0 hertz to 1 megahertz.
Further, the single electrode connecting with power supply device is made of flexible dielectric.
Further, the single electrode connecting with power supply device is made of the single ceramic piece with high dielectric constant.
Further, the single electrode being connect with power supply device by the potsherd with high dielectric constant in varying numbers simultaneously
Connection composition.
Further, it is furnished with thermistor behind each dielectric piece for the single electrode connecting with power supply device, once circle
It is more than particular value that piece temperature, which increases, and power supply device blocks output immediately, while with warning note.
Further, the single electrode connecting with power supply device is by two panels, and three pieces, nine, 12 or 16 diameters are identical,
Potsherd with high dielectric constant forms, and there are gap between potsherd, gap is slightly larger than the diameter of potsherd.
If being used for cell experiment, the electrode that a pair is parallel to each other can continuously apply alternating voltage from a direction.
If being used for cell experiment, two pairs of orthogonal electrodes can successively apply alternating voltage from both direction.
If being used for zoopery, the electrode that a pair is parallel to each other can continuously apply alternating voltage from a direction.
If being used for zoopery, two pairs of orthogonal electrodes can successively apply alternating voltage from both direction.
If being used for human clinical trial, the electrode that a pair is parallel to each other can continuously apply alternating current from a direction
Pressure.
If being used for human clinical trial, two pairs of orthogonal electrodes can successively apply alternating current from both direction
Pressure.
If being used for human clinical trial, the electrode that four pairs of mutual angles are 45 degree can successively apply friendship from four direction
Galvanic electricity pressure.
If being used for cell experiment, the electric field applied using electrod-array can be ground by adjusting electric field strength and frequency
Study carefully the influence that different electric field strengths and frequency grow specific cells.
If being used for zoopery, the electric field applied using electrod-array can be ground by adjusting electric field strength and frequency
Study carefully the influence that different electric field strengths and frequency grow specific cells.
If being used for human clinical trial, the electric field applied using electrod-array can be by adjusting electric field strength and frequency
Rate studies the influence that different electric field strengths and frequency grow specific cells in human body.
Specifically as shown in Figure 1, power supply device includes rechargeable battery, signal generator, voltage amplifier and voltage output are certainly
Dynamic switching device.The output switching port of power supply device has 4.As shown in Fig. 2, voltage output is successively from 1,2,3,4 mouthfuls of switching port
It is connected to electrod-array.There are two jacks to draw two conducting wires for each delivery outlet, constitutes a circuit.
If only needing two delivery outlets to be sequentially output voltage, as shown in Figure 3, it is only necessary to connect 1-4 mouthfuls with a pair of electrodes
It connects；Then 2-3 mouthfuls are connect with another pair of electrode.If only needing to need from a delivery outlet output voltage by 1-2-3-4
Mouth is connect with a pair of electrodes.
Biomedical with clinical application, if directly applying electric field to human body using metal electrode, electric current is being conducted
Under the action of, the electrification mineral ion in human body cell will appear migration, lead to the variation of intracellular ion concentration, this is for people
Body is harmful.Can be directly related with the life security of human body additionally, due to high conduction electric current, apply electric field using metal electrode
It carries out medical research and treatment, voltage can not be excessively high, it is limited to apply voltage.Due to it is purely capacitive for conduction electric current be insulation,
It is conducting for AC field, so in the clinical experiment for applying alternating voltage, if utilizing the high dielectric constant of insulation
Capacitance material apply alternating voltage as electrode, so that it may avoid side effect of the conduction electric current to cell.Pass through capacitance electrode
The electric field for being applied to human body is regional area, and only regional area is not conducted current through and adds by electric field action
The human region of electric field.
In addition, not all cell growth is along single direction in cell experiment.However electric field is arrow
There is amount directionality to need to improve the functioning efficiency of electric field in all directions in two (as shown in Figure 3) or multiple sides
To the electric field (as shown in Figure 2) for applying same frequency.
Due to organism be ellipse or it is irregular, need when necessary using flexible dielectric make electrode, it is ensured that
With well contacting for human body different parts.
Since organism is oval or irregular, as shown in figure 4, a unitary electrode needs to utilize multi-disc when necessary
The potsherd of high dielectric constant makes electrode according to different arrays, it is ensured that contacts with organism or the good of human body different parts.
Based on use above background, it is suitable to need to make using the dielectric ceramic or flexible dielectric of high dielectric constant
Capacitance electrode array, to meet blocking electric current, in the effect of different directions conducting electric field.
Understanding for the utility model is based on above-mentioned design, specific tumors cell can be prevented to grow.
Detailed description of the invention
Be described in detail referring to made by the following drawings to made by non-limiting example by reading, the utility model its
Its feature, objects and advantages will become more apparent upon:
Fig. 1 show power supply device.Power supply device includes four components interconnected: charge power supply, waveform signal hair
Raw device, voltage amplifier, voltage output switching port.The delivery outlet of power supply device has 4, is sequentially output by 1,2,3,4 delivery outlet
The voltage of same frequency.There are two jacks and external circuit to constitute a circuit for each delivery outlet.In figure, 100 be power supply device,
101 be waveform generator, and 102 be voltage amplifier, and 103 be output switching port, and 104 be rechargeable battery.
Apply the electric field in 4 directions to the line graph of an organism surface using power supply device shown in Fig. 2.Electric field along
The successively intermittent application of 4 directions.The delivery outlet of power supply device has 4, is sequentially output voltage by 1,2,3,4 delivery outlet.Biology
The letter (a, b, c, d) of body therapentic part 200 is electrode position.4 of electrod-array and power supply device that 4 pairs of electrodes form are defeated
Outlet is sequentially connected.There are two jacks for each port, and each pair of electrode is allowed to form a circuit.
Fig. 3 show the line graph for applying the voltage in 2 directions using power supply device.Power supply device passes through 2 delivery outlets
It is connect with the electrode slice on 300 side of cell liquid.Two pairs of electrodes are added to cell liquid along X and Y-direction.The delivery outlet of power supply device has
4, there are two jacks for each port, and each pair of electrode is allowed to form a circuit.Voltage is sequentially output by 1,2,3,4 delivery outlet,
Due to 1-4,2-3 mouthfuls of connections, output voltage is successively exchanged along X and Y-direction and is applied on cell liquid.
Fig. 4 show the Ceramic Array formed using multi-disc ceramics.It is noted, that in the Y direction, between potsherd
Away from greater than ceramic diameter.Spacing between X-direction, potsherd is suitable with potsherd radius.
Fig. 5 show the schematic diagram of a 6 orifice plates.Unless stated otherwise, 4 ceramics, composition two are installed in each hole edge
To electrode (as shown in Figure 6), wherein electric field is not added in 01,02,03 hole conducting wire.04,05,06 hole conducting wire connects electric field.Comparison plus with not
Influence of the added electric field to experimental result.Comparative experiments effect.Electrode scheme of installation such as Fig. 6.
Fig. 6 is shown in a 6 orifice plates, and 4 ceramics are installed in hole edge, forms two pairs of electrodes.Contact conductor 400 with
The port of power supply device connects.Apply voltage from both direction.4 high dielectric ceramics are installed and constitute 2 in the side in one of hole
To electrode.
Fig. 7 is shown using power supply device provided by the utility model and electrod-array, for the reality of Tumor cells (F98)
Test result.
Fig. 8 is shown using power supply device provided by the utility model and electrod-array, for lung carcinoma cell (H1299)
Experimental result.
The same or similar appended drawing reference represents the same or similar component in attached drawing.
Specific embodiment
Selection one is used for six orifice plates (Fig. 5) of cell culture.For each hole, side is emptied, and each hole installs 4 absolutely
Edge high-dielectric-constant ceramics are electrode slice (Fig. 6).The potsherd that two panels is parallel to each other can partner capacitance electrode, Mei Dui electricity
At a distance of about 2 centimetres between two potsherds of pole.The connection of the output port of two pairs of orthogonal ceramic electrodes and power supply device.
Liquid medium (lung cancer or the cancer of the brain) containing tumour cell is added to 6 holes of six orifice plates.As a comparison, wherein three
The electrode of the electrode no power of a hole (01,02,03 hole), the other three hole (04,05,06 hole) is powered.Knot is observed after 36 hours
Fruit.Shown in circuit connection and Fig. 3.The direction vertical from two successively applies electric field.Six orifice plates are put according to the fostering requirement of cell
In Medical heat-preserving box.
For the two-direction sine wave voltage that Tumor cells (F98 cell) applies, the electric field side of switching in every 1.1 ± 0.2 seconds
To.The preferred voltage that applies is 25 volts, and optimized frequency is 198 ± 3 kHz.Cellular change is detected after every 36 hours.Knot
Fruit is as shown in Figure 7.
Apply two-direction sine wave voltage, switching one in every 1.1 ± 0.2 seconds for lung carcinoma cell (non-small cell lung cancer, H1299)
Secondary direction of an electric field.The preferred voltage that applies is 30 volts, and preferred frequency is 151 ± 2 kHz.It is detected after every 36 hours thin
Born of the same parents' variation.As a result as shown in Figure 8.
Experimental result characterizes T=(R1-R2)/R1 by calculating treatment enhancing proportionality coefficient T.Wherein R1 and R2 are respectively
The growth rate of specific tumors cell when electric field is not added or applying electric field.Obviously as T=0, without therapeutic effect.Once T >
0, it indicates that the growth rate of specific cells after extra show is slack-off, treats effective.If T > 1 indicates that tumour cell after extra show
Sum is reduced, and negative growth, therapeutic effect highly significant is presented.
Two kinds of cells have corresponding optimal treatment frequency, but all unified suitable high electric field of display can be mentioned obviously
High inhibitory effect.
In biomedical research and clinical trial, according to the figure of animal for research and patient's human body different parts
Form, as shown in Fig. 2, can apply 4 pairs of electrodes, each pair of electrode is sequentially output voltage.Effect can be more obvious.
In biomedical research and clinical trial, according to the figure of animal for research and patient's human body different parts
Form, single electrode can be made of a piece of potsherd with high dielectric constant.Can also be by two panels, three pieces or even nine,
12 or 16 potsherd compositions.Every ceramics have high dielectric constant (relative dielectric constant is greater than 8000).Fig. 4 is shown as band
There is the single electrode of 12 potsherds.There are gaps, at least diameter of the gap on one side slightly larger than maximum potsherd between potsherd.
There is thermistor behind each potsherd for the single electrode connecting with power supply device, once potsherd temperature liter
Height is more than particular value, and power supply device blocks output, triggering alarm immediately.Temperature raising may be that electrode heat dissipation is bad or in height
Fatigue breakdown generates heat under voltage.
In clinical trial, the electric field applied using capacitance electrode can be studied not by adjusting electric field strength and frequency
The influence that same electric field intensity and frequency grow specific target cells in human body.
Power supply device provided by the utility model and electrod-array are that biomedical research and clinical application are realized and inhibit swollen
Tumor growth has positive effect.And it is provided by the utility model preparation method is simple, suit large area to popularize use, has good
Application prospect.
In addition, the application range of the utility model be not limited to the technique of specific embodiment described in specification, mechanism,
Manufacture, method and step.It is as those skilled in the art it will be understood that right from the disclosure of the utility model
In current technique that is existing or will developing, mechanism, manufacture, material composition, means, method or step later, wherein
They execute with the function that is substantially the same of corresponding embodiment of the utility model description or acquisition be substantially the same as a result, according to
The utility model can apply them.Therefore, the appended claims for the utility model be intended to by these techniques, mechanism,
Manufacture, means, method or step are included in its protection scope.
Claims (13)
1. a kind of electric field bringing device of selective depression specific cells growth, it is characterised in that: it includes power supply device and matches
The electrode of set, wherein power supply device can be made of with output voltage and the adjustable AC signal of frequency, electrode insulation capacitance material,
Alternating current can be hindered to pass through still conducting electric field.
2. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The output voltage of power supply device is continuously adjustable, and range is 0 to 65 volts, the output waveform of power supply device be sine wave, triangular wave,
Square wave.
3. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The output signal of power supply device is sequentially output by 4 ports, provides the voltage in 4 directions, and output time of each port can be
It is adjusted within the scope of 0.1 second to 10 seconds.
4. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
There are two interface, each ports to constitute a current loop by two interfaces for each output port of power supply device.
5. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The output signal of power supply device can be sequentially output by two ports, provide the voltage of both direction.
6. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The output signal of power supply device can continuously be exported by a port, provide the voltage in a direction.
7. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The internal electric source of power supply device is by rechargeable battery powered.
8. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The reference frequency output of power supply device is 0 hertz to 1 megahertz.
9. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, it is characterised in that:
The single electrode connecting with power supply device is made of flexible dielectric.
10. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, feature exist
In: the single electrode connecting with power supply device is made of the single ceramic piece with high dielectric constant.
11. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, feature exist
In: the single electrode connecting with power supply device is composed in parallel by the potsherd with high dielectric constant in varying numbers.
12. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, feature exist
In: it is furnished with thermistor behind each dielectric piece for the single electrode connecting with power supply device, once the raising of disk temperature is more than
Particular value, power supply device block output immediately, while with warning note.
13. a kind of electric field bringing device of selective depression specific cells growth according to claim 1, feature exist
In: the single electrode connecting with power supply device is by two panels, and three pieces, nine, 12 or 16 diameters are identical, has high dielectric constant
Potsherd composition, there are gap between potsherd, gap is slightly larger than the diameter of potsherd.
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| CN201820261308.5U CN209392585U (en) | 2018-02-07 | 2018-02-07 | A kind of electric field bringing device of selective depression specific cells growth |
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| CN201820261308.5U CN209392585U (en) | 2018-02-07 | 2018-02-07 | A kind of electric field bringing device of selective depression specific cells growth |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111420271A (en) * | 2020-04-02 | 2020-07-17 | 河北普尼医疗科技有限公司 | Electrode patch positioning method based on head tumor treatment |
| CN113018682A (en) * | 2021-02-25 | 2021-06-25 | 杭州维那泰克医疗科技有限责任公司 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
-
2018
- 2018-02-07 CN CN201820261308.5U patent/CN209392585U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111420271A (en) * | 2020-04-02 | 2020-07-17 | 河北普尼医疗科技有限公司 | Electrode patch positioning method based on head tumor treatment |
| CN113018682A (en) * | 2021-02-25 | 2021-06-25 | 杭州维那泰克医疗科技有限责任公司 | Cell division suppressing device, method, device, system and storage medium for controlling the same |
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