CN209392452U - A kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing - Google Patents
A kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing Download PDFInfo
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- CN209392452U CN209392452U CN201820869795.3U CN201820869795U CN209392452U CN 209392452 U CN209392452 U CN 209392452U CN 201820869795 U CN201820869795 U CN 201820869795U CN 209392452 U CN209392452 U CN 209392452U
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Abstract
The utility model discloses a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, the dressing includes Dressing substrate layer and magnesium hydride micro-nano rice flour antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface or the magnesium hydride micro-nano rice flour antibiotic layer is at least partly implanted in the Dressing substrate layer.Magnesium hydride micro-nano rice flour on the magnesium hydride micro-nano rice flour antibiotic layer, which encounters wound fluid moisture absorption immediately and reacts, is converted to micro-nano magnesium hydroxide particle, local alkalescence is caused simultaneously, there is the broad-spectrum sterilization and preferable biocompatibility for being not required to light induction；The hydrogen of simultaneous reactions release has nontoxic, inflammatory properties, and prevents wound adhesion effect with certain.It stores and easy to use, safe, environmentally friendly, the anti-infection of antibacterial anti-inflammatory is conducive to wound surface reparation.
Description
Technical field
The utility model relates to medical wound and wound dressings, and particularly relating to one kind has the function of antibacterial anti-inflammatory and pacify
Entirely, environmentally friendly micro-nano magnesium hydride dressing.
Background technique
After human skin is injured, wound locally has different degrees of tissue necrosis and rupture of blood vessel bleeding, in a few hours
Just there is inflammatory reaction, show as congested, slurries exudation and leukocytoplania.Body has a series of biochemical programs and attempts to carry out
Repair and reconstruction, basic process include post-hemorrhagic period, inflammatory phase, hyperplasia phase and maturation and remodeling phase.During repairing herein,
Covering of the medical dressing as wound, usually plays an important role: can temporarily replace the partial action of skin barrier, be
Wound healing provides advantageous microenvironment；Also inhibit wound infection with control wound exudate, hemostasis simultaneously, reduces or remove
Scar formation, quickening wound healing and other effects.
Wound repair is influenced in order to avoid bacterial wound infection and inflammation, can often add antimicrobial component in medical dressing.
It common are silver ion, chitin/chitosan and germ killing drugs etc. on the market at present.However silver-series antibacterial agent raw material is expensive, cost
Higher, antimycotic and mould effect is poor, and silver be not human essential elements, vivo biodistribution safety and biocompatibility compared with
Difference also has destruction using environmentally safe.Chitin/chitosan class natural antibacterial agent bacteriostasis relies on ambient enviroment pH strong
Property, and it is weaker to Gram-negative bacteria rejection ability.And common germ killing drugs are also easy to produce drug resistance, and often there is also pairs
Effect.
Utility model content
To solve the above problem in the presence of the prior art, the utility model provides a kind of safe and environment-friendly, biofacies
The good micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing with antibacterial anti-inflammatory function of capacitive.Its main feature is that with micro-nano magnesium hydride
MgH2Additive and antibacterial anti-inflammatory effective component as common Dressing substrate.When micro-nano magnesium hydride encounters wound fluid
Moisture absorption immediately and the MgH that reacts2+2H2O→Mg(OH)2+2H2↑
Reacting the micro-nano magnesium hydroxide particle being converted into has significant antibacterial functions, the larger easy absorption of specific surface area
Microorganism, and the active oxygen radical ROS generated around particle simultaneously can destroy bacterial cell wall construction to kill rapidly carefully
Bacterium.In addition, according to endocytosis-dissociation mechanism, Mg (OH)2Micro-nano granules can be entered inside bacterial cell by encytosis, in water
OH is discharged in property environment-, normal pH microenvironment is destroyed, causes nucleic acid and protein chemistry to be denaturalized, to cause bacterial death.Micro-nano
Rice magnesium hydroxide particle antimicrobial efficiency is high, has broad-spectrum sterilization, can also carry out in the dark independent of light source.And it is dropped
Solution product magnesium ion is a great number of elements needed by human, and biological safety is high.
Above-mentioned reaction simultaneously also releases nontoxic hydrogen, and oxygen has on the one hand been completely cut off near wound, has caused hypoxemia ring
Border further suppresses the growth of oxygen consumption bacterium, while the physical action of gas release can also mitigate to a certain degree, prevent wound viscous
Even；Another aspect hydrogen has specific anti-inflammatory effect, without hormone and aspirin class side effects of pharmaceutical drugs, therefore has
Conducive to the anti-inflammatory at the surface of a wound, promote the recovery of wound, while studies have reported that hydrogen also has elimination and prevents scar
Effect.
The purpose of this utility model is achieved through the following technical solutions:
The utility model relates to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, the dressing includes Dressing substrate layer
With magnesium hydride micro-nano rice flour antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface, or
The magnesium hydride micro-nano rice flour antibiotic layer is at least partly implanted in the Dressing substrate layer.
Preferably, in the magnesium hydride micro-nano rice flour antibiotic layer magnesium hydride micro-nano rice flour having a size of 10nm-10 μm.
Preferably, when the magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface, magnesium hydride micro-nano
The coated weight of rice flour is g-1mg/ square centimeters of Dressing substrate layers of 1 μ.
Preferably, when the magnesium hydride micro-nano rice flour antibiotic layer is at least partly implanted in the Dressing substrate layer, hydrogenation
It is g-1mg/ square centimeters of Dressing substrate layers of 1 μ that magnesium micro-nano rice flour, which loads on Dressing substrate surface and the amount of inside,.
Preferably, generated amounts of hydrogen is 0.0018-1.8mL/ square centimeters of dressing when the dressing uses.
Preferably, the Dressing substrate layer is natural gauze layer, non-woven fabrics of synthetic fiber layer, foaming polymer film layer, water
Gel layer, alginic acid salt deposit, agarose layer, collagen/gelatine layer or chitin/chitosan film layer.
Preferably, antibacterial agent is filled on the magnesium hydride micro-nano rice flour antibiotic layer.
Preferably, the antibacterial agent is silver, copper, nano zine oxide, nano-titanium dioxide, quaternary ammonium salts antibacterial agent, shell gather
One or more of sugar.
Compared with prior art, the utility model has the following beneficial effects:
1, the magnesium hydride micro-nano rice flour on the magnesium hydride micro-nano rice flour antibiotic layer in the wound dressing of the utility model encounters
Wound fluid moisture absorption immediately simultaneously reacts and is converted to micro-nano magnesium hydroxide particle, while causing local alkalescence, has and be not required to
The broad-spectrum sterilization of light induction and preferable biocompatibility；The hydrogen of simultaneous reactions release has nontoxic, inflammatory properties, and
Wound adhesion effect is prevented with certain.
2, the utility model wound dressing storage and it is easy to use, safe, environmentally friendly, antibacterial anti-inflammatory it is anti-infection, be conducive to
Wound surface reparation.
Detailed description of the invention
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other spies of the utility model
Sign, objects and advantages will become more apparent upon:
Fig. 1 is a kind of topology example figure of the micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing of the utility model；Wherein, 1
It is magnesium hydride micro-nano rice flour antibiotic layer for Dressing substrate layer, 2.
Specific embodiment
The utility model is described in detail combined with specific embodiments below.Following embodiment will be helpful to this field
Technical staff further understands the utility model, but does not limit the utility model in any form.It should be pointed out that ability
For the those of ordinary skill in domain, without departing from the concept of the premise utility, various modifications and improvements can be made.
These are all within the protection scope of the present invention.
Embodiment 1
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, including Dressing substrate layer and magnesium hydride it is micro-
Nano powder antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is all implanted in Dressing substrate layer.
The nanometer magnesium hydride of partial size 10-100nm is dispersed in the polyethylene of melting by 2%w/v, by above-mentioned solution
The polyvinyl adhesive-bonded fabric dressing of composite Nano magnesium hydride is processed into through process flows such as spinneret, paving guiding principle, hot pressing volumes.At this point, hydrogen
Change that magnesium micro-nano rice flour antibiotic layer is substantially all is implanted in Dressing substrate (polyvinyl non-woven fabrics) layer；Corresponding magnesium hydride micro-nano
The amount that rice flour loads on Dressing substrate is g/ square centimeters of dressing of 5 μ；Generated amounts of hydrogen is when the dressing use
0.0086mL/ square centimeters of dressing.
Above-mentioned dressing is subjected to Antimicrobial test, to representative Gram-positive S staphylococcus and gram
24 hours bacteriostasis rates of negative bacterium are up to 95% or more.Vitro in fibroblast toxicity test shows that toxicity is 0-1 grades,
Fibroblast survives proliferation rate 90% or more.
Embodiment 2
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, and structural schematic diagram is as shown in Figure 1, packet
Include Dressing substrate layer 1 and magnesium hydride micro-nano rice flour antibiotic layer 2；2 part of magnesium hydride micro-nano rice flour antibiotic layer is implanted in dressing base
In body layer 1.
The nanometer magnesium hydride of partial size 200-1000nm is dispersed in by 10%w/v containing the anhydrous of 1% silane coupling agent
It in ethanol solution, lifts and takes out after the natural gauze after activation is immersed above-mentioned solution 15 minutes, continue vacuum after 50 DEG C of drying
Air drying 24 hours.At this point, magnesium hydride micro-nano rice flour antibiotic layer is at least partly implanted in Dressing substrate (natural gauze) layer；
The amount that corresponding magnesium hydride micro-nano rice flour loads on Dressing substrate is g/ square centimeters of dressing of 50 μ；The dressing is produced when using
Amounts of hydrogen be 0.086mL/ square centimeters of dressing.
Above-mentioned dressing is subjected to animal (rabbit) body antibacterial experiment, in 72h to staphylococcus aureus, staphylococcus epidermis and
The bacteriostasis rate of Escherichia coli is up to 95% or more.Wound healing rate is fast about compared with control group polyvinyl adhesive-bonded fabric dressing
25%.
Embodiment 3
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, including Dressing substrate layer and magnesium hydride it is micro-
Nano powder antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface.
500nm-10 μm of partial size of micro-nano magnesium hydride is dispersed in wiring solution-forming in dehydrated alcohol by 15%w/v,
Above-mentioned solution even application is continued vacuum air drying 24 hours behind chitosan film Dressing substrate surface, 50 DEG C of drying.This
When, magnesium hydride micro-nano rice flour antibiotic layer is coated in chitosan film Dressing substrate layer surface；Corresponding magnesium hydride micro-nano rice flour load
In Dressing substrate amount be g/ square centimeters of dressing of 350 μ；Generated amounts of hydrogen is 0.6mL/ square centimeters when dressing use
Dressing.
Antimicrobial test the result shows that, do not spray the chitosan film Dressing substrate of nanometer magnesium hydride to Gram-positive gold
24 hours bacteriostasis rates of staphylococcus aureus and Gram-E. coli are respectively 78% and 63%, spray nanometer magnesium hydride
Bacteriostasis rate rises to 99% afterwards.Vitro in fibroblast toxicity test shows that toxicity is 0-1 grades, and fibroblast survives proliferation
Rate is 90% or more.
Embodiment 4
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, including Dressing substrate layer and magnesium hydride it is micro-
Nano powder antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface.
100-500nm nanometers of magnesium hydrides of partial size are equal by 0.5%w/v by the nano silver of 5%w/v and partial size 20-50nm
It is even to be scattered in the dehydrated alcohol containing 1% silane coupling agent, by the uniform drop coating of above-mentioned solution in foaming polymer film dressing matrix
On, continue vacuum air drying 24 hours after 50 DEG C of drying.At this point, magnesium hydride micro-nano rice flour antibiotic layer (is filled with nano silver
Grain) it is coated in foaming polymer film dressing matrix layer surface；The amount that corresponding magnesium hydride micro-nano rice flour loads on Dressing substrate is
0.8mg/ square centimeters of dressing；Generated amounts of hydrogen is 1.4mL/ square centimeters of dressing when dressing use.
Above-mentioned dressing is subjected to animal (rabbit) body antibacterial experiment, in 72h to staphylococcus aureus, staphylococcus epidermis and
The bacteriostasis rate of property Escherichia coli is up to 99.9% or more.
Embodiment 5
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, including Dressing substrate layer and magnesium hydride it is micro-
Nano powder antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface.
The nanometer magnesium hydride of partial size 50-100nm is dispersed in wiring solution-forming in dehydrated alcohol by 8%w/v, it will be above-mentioned
Solution even application continues vacuum air drying 24 hours after collagen dressing matrix surface, 50 degrees Celsius of drying.At this point, hydrogenation
Magnesium micro-nano rice flour antibiotic layer is coated in collagen dressing matrix layer surface；Corresponding magnesium hydride micro-nano rice flour loads on Dressing substrate
Amount is g/ square centimeters of dressing of 100 μ；Generated amounts of hydrogen is 0.17mL/ square centimeters of dressing when dressing use.
Antimicrobial test the result shows that, do not spray the collagen dressing matrix of nanometer magnesium hydride to Gram-positive S
24 hours bacteriostasis rates of staphylococcus and Gram-E. coli are almost 0, spray nanometer magnesium hydride after bacteriostasis rate on
It is raised to 99% or more.Vitro in fibroblast toxicity test show toxicity be 0 grade, fibroblast survive proliferation rate 95% with
On.
Embodiment 6
The present embodiment is related to a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, including Dressing substrate layer and magnesium hydride it is micro-
Nano powder antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface.
500nm-5 μm of partial size of micro-nano magnesium hydride is pressed 1% by the nano zine oxide of 3%w/v and partial size 100-200nm
W/v is dispersed in organosilicon glue, above-mentioned composite glue is applied one layer in alginate Dressing substrate surface, room temperature is solid
Change 24 hours or more.At this point, magnesium hydride micro-nano rice flour antibiotic layer is coated in alginate Dressing substrate layer surface；Corresponding hydrogenation
The amount that magnesium micro-nano rice flour loads on Dressing substrate is g/ square centimeters of dressing of 20 μ；Generated amounts of hydrogen is when the dressing use
0.035mL/ square centimeters of dressing.
By above-mentioned dressing carry out animal (rabbit) body antibacterial experiment, for 24 hours in staphylococcus aureus, staphylococcus epidermis and
The bacteriostasis rate of Escherichia coli is up to 99% or more, while wound healing is without obvious hyperplasia or scar.
Specific embodiment of the utility model is described above.It is to be appreciated that the utility model not office
It is limited to above-mentioned particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims,
This has no effect on the substantive content of the utility model.
Claims (8)
1. a kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing, which is characterized in that the dressing includes Dressing substrate layer and hydrogen
Change magnesium micro-nano rice flour antibiotic layer；The magnesium hydride micro-nano rice flour antibiotic layer is coated in the Dressing substrate layer surface or described
Magnesium hydride micro-nano rice flour antibiotic layer is at least partly implanted in the Dressing substrate layer.
2. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the magnesium hydride is micro-
Magnesium hydride micro-nano rice flour is having a size of 10nm-10 μm in nano powder antibiotic layer.
3. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the magnesium hydride is micro-
When nano powder antibiotic layer is coated in the Dressing substrate layer surface, the coated weight of magnesium hydride micro-nano rice flour is 1 μ g-1mg/ square li
Rice Dressing substrate layer.
4. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the magnesium hydride is micro-
When nano powder antibiotic layer is at least partly implanted in the Dressing substrate layer, magnesium hydride micro-nano rice flour loads on Dressing substrate surface
And internal amount is g-1mg/ square centimeters of Dressing substrate layers of 1 μ.
5. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the dressing uses
When generated amounts of hydrogen be 0.0018-1.8mL/ square centimeters of dressing.
6. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the Dressing substrate
Layer be natural gauze layer, non-woven fabrics of synthetic fiber layer, foaming polymer film layer, hydrogel layer, alginic acid salt deposit, agarose layer,
Collagen/gelatine layer or chitin/chitosan film layer.
7. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 1, which is characterized in that the magnesium hydride is micro-
Antibacterial agent is filled on nano powder antibiotic layer.
8. micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing according to claim 7, which is characterized in that the antibacterial agent is
One or more of silver, copper, nano zine oxide, nano-titanium dioxide, quaternary ammonium salts antibacterial agent, chitosan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820869795.3U CN209392452U (en) | 2018-06-06 | 2018-06-06 | A kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820869795.3U CN209392452U (en) | 2018-06-06 | 2018-06-06 | A kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559467A (en) * | 2018-06-06 | 2019-12-13 | 上海交通大学 | Micro-nano magnesium hydride antibacterial and anti-inflammatory wound dressing |
| CN112263777A (en) * | 2020-08-04 | 2021-01-26 | 北京工业大学 | Hydrogen molecule slow-release composite dressing and preparation method thereof |
| CN114470300A (en) * | 2022-03-28 | 2022-05-13 | 浙江蓝禾医疗用品有限公司 | Fluorescent nano dressing and preparation method thereof |
-
2018
- 2018-06-06 CN CN201820869795.3U patent/CN209392452U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559467A (en) * | 2018-06-06 | 2019-12-13 | 上海交通大学 | Micro-nano magnesium hydride antibacterial and anti-inflammatory wound dressing |
| CN112263777A (en) * | 2020-08-04 | 2021-01-26 | 北京工业大学 | Hydrogen molecule slow-release composite dressing and preparation method thereof |
| CN114470300A (en) * | 2022-03-28 | 2022-05-13 | 浙江蓝禾医疗用品有限公司 | Fluorescent nano dressing and preparation method thereof |
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