CN209236115U - Spectral coverage OCT and the confocal synchronous scanning system of line - Google Patents
Spectral coverage OCT and the confocal synchronous scanning system of line Download PDFInfo
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- CN209236115U CN209236115U CN201821082196.3U CN201821082196U CN209236115U CN 209236115 U CN209236115 U CN 209236115U CN 201821082196 U CN201821082196 U CN 201821082196U CN 209236115 U CN209236115 U CN 209236115U
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Abstract
The utility model discloses a kind of spectral coverage OCTs and the confocal synchronous scanning system of line, comprising: spectral domain optical coherent tomographic module, slow scanning module, short scan module, lighting module, slotted mirror, imaging len, dichroscope and detector.The utility model combines line scanning confocal ophthalmoscope and spectral coverage OCT, shares most device, and see the bottom cost, while eliminating the ghost of line scanning confocal, realize dual system work independently and interval work.The utility model slotted mirror, replace spectroscope, reduce influence of the cornea ghost to image, the scanning galvanometer of the spectral coverage OCT of the utility model separates, and short scan mirror module is shared with line confocal system, 4f system is formed by the confocal imaging len of bridging line, realizes the conjugation scanning of spectral coverage OCT.The utility model all uses in two faces of dichroscope, and the reflection of sample light is done in side, and the reflection after grating beam splitting is done in side.
Description
Technical field
The utility model relates to optical imagery and biomedical diagnostic apparatus field, in particular to a kind of spectral coverage OCT and line
Confocal synchronous scanning system.
Background technique
Clinically there is various fundus retina image-forming technology, including eye ground camera, optical coherence tomography at present
Technology, cofocus scanning technology etc. all play an important role to biological study and medical diagnosis on disease.
Laser cofocus scanning ophthalmoscope filters out the high-resolution imaging mode of veiling glare by numerous studies by being conjugated aperture,
And it is successfully applied to biological study and medical diagnosis, including on ophthalmology is imaged, and laser rays cofocus scanning technology is total in laser
Conjugation aperture is changed to conjugation slit on the basis of coke scanning, image taking speed is substantially increased, may be implemented to eye ground
High speed real time imagery.In addition to this, gold standard of the optical coherence tomography as ophthalmology Fundus examination, Neng Goushi
Existing high-resolution tomoscan and three-dimensional reconstruction, by the confocal eye ground imaging technique of line and Optical Coherence Tomography Imaging Technology
It combines, can provide eye ground multi-faceted information simultaneously.
Line scanning confocal ophthalmoscope and spectral coverage OCT (optical coherent chromatographic imaging) are all mature ophthalmology imaging technique, energy
To human eye retina carry out imaging in vivo, the former be transversal scanning imaging, the latter is the Depth Imaging of tomography, have it is different at
As feature.Although principle is different, the detector of the two is all the line-scan digital camera used, and scanning optical path is almost the same, therefore
The two can be combined, share major part device, reduced while to realize the imaging of multi-functional eye ground hard
Part cost.The acquisition for clinically needing to be carried out image with two sets of equipment respectively, increases time overhead and hardware cost.After set
System can reduce hardware cost, conducive to the Miniaturization Design of system.
Utility model content
The technical problem to be solved by the utility model is in view of the deficiency of the prior art, provide a kind of spectral domain
OCT and the confocal synchronous scanning system of line.
In order to solve the above technical problems, the technical solution adopted in the utility model is: a kind of spectral coverage OCT is confocal synchronous with line
Scanning system, comprising: spectral domain optical coherent tomographic module, slow scanning module, short scan module, lighting module, slotted mirror,
Imaging len, dichroscope and detector；
The sample light issued in spectral domain optical coherent tomographic module successively pass through slow scanning module, dichroscope reflection, at
It is combined after lens transmission, slotted mirror transmission, then with the light after slotted mirror reflects that lighting module issues,
Illumination imaging is carried out to sample after the reflection of short scan module jointly；In conjunction with imaging by sample reflect and successively through too fast
Scan module reflection, slotted mirror transmission, imaging len transmission reach dichroscope, and chromatography light beam therein passes through dichroic
After mirror reflection and slow scanning module, interfered into spectral domain optical coherent tomographic module, light beam spy therethrough after interference
It is reflected into detector and is imaged by the another side of dichroscope after survey optical path；Confocal imaging light beam therein is saturating by dichroscope
Enter in shared detector after penetrating and is imaged.
Preferably, the short scan module includes the first scanning galvanometer and the first scanning lens.
Preferably, the slow scanning module includes the second scanning galvanometer and the second scanning lens.
Preferably, first scanning lens and the imaging len form 4f system, first scanning galvanometer and
Second scanning galvanometer is located at the focal position of the 4f system.
Preferably, the scan axis of first scanning galvanometer and the second scanning galvanometer is mutually perpendicular to.
Preferably, the scan axis of second scanning galvanometer is parallel with slit direction.
Preferably, ophthalmoscope is additionally provided with along optical path between the short scan module and sample.
Preferably, the lighting module include the lighting source set gradually along optical path, the first collimation lens, cylindrical mirror or
Person's Bao Weier prism.
Preferably, the spectral domain optical coherent tomographic module include optical coherence tomography light source, coupler, reference arm with
And detection optical path, after the coupler, a part enters in the reference arm light that the optical coherence tomography light source issues
The road Qie Beiyuan reflexes to the coupler, and another part enters the slow scanning module, is passed through by the reflected light beam of sample
The beam interference in coupler with reference arm reflection is reentered after the slow scanning module, interfering beam passes through the detection light
It is reflected into detector and is imaged by the another side of dichroscope behind road.
Preferably, the detector is line-scan digital camera.
The beneficial effects of the utility model are: the utility model combines line scanning confocal ophthalmoscope and spectral coverage OCT, share
Most device, see the bottom cost, while eliminating the ghost of line scanning confocal, realizes working independently and gap work for dual system
Make.The utility model slotted mirror replaces spectroscope, reduces influence of the cornea ghost to image, the spectrum of the utility model
The scanning galvanometer of domain OCT separates, and shares short scan mirror module with line confocal system, passes through the confocal imaging lens group of bridging line
At 4f system, the conjugation scanning of spectral coverage OCT is realized.The utility model all uses in two faces of dichroscope, side
The reflection of sample light is done, the reflection after grating beam splitting is done in side.
Detailed description of the invention
Fig. 1 is the spectral coverage OCT of the utility model and the structural schematic diagram of the confocal synchronous scanning system of line；
Fig. 2 is the side view of the detection optical path of the utility model；
Fig. 3 is the structural schematic diagram of the slotted mirror in an embodiment of the present invention；
Fig. 4 is the structural schematic diagram of the slotted mirror in another embodiment of the utility model.
Description of symbols:
10-optical coherence tomography light sources；11-couplers；12-first collimators；13-the first condenser lens；14—
Reflecting mirror；15-the second collimation lens；16-gratings；17-the second condenser lens；18-the second collimator；20-the first scanning
Galvanometer；21-the first scanning lens；22-ophthalmoscopes；30-the second scanning galvanometer；31-the second scanning lens；40-illumination lights
Source；41-the first collimation lens；42-cylindrical mirrors or Bao Weier prism；50-slotted mirrors；60-imaging lens；70-two
To Look mirror；80-detectors；90-eye grounds.
Specific embodiment
The utility model is described in further detail below with reference to embodiment, to enable those skilled in the art's reference say
Bright book text can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded one or more
The presence or addition of a other elements or combinations thereof.
As shown in Figure 1, a kind of spectral coverage OCT of the present embodiment and the confocal synchronous scanning system of line, comprising: spectral domain optical is relevant
Chromatograph module, slow scanning module, short scan module, lighting module, slotted mirror 50, imaging len 60, dichroscope 70 and
Detector 80.
Wherein, spectral domain optical coherent tomographic module includes optical coherence tomography light source 10, coupler 11, reference arm and spy
Optical path is surveyed, for carrying out Depth Imaging to sample, wherein sample can be 90 retina of eye ground；
Short scan module includes the first scanning galvanometer 20 and the first scanning lens 21；Along light between short scan module and sample
Road is additionally provided with ophthalmoscope 22；
Slow scanning module includes the second scanning galvanometer 30 and the second scanning lens 31；
Lighting module includes the lighting source 40 set gradually along optical path, the first collimation lens 41, cylindrical mirror or Bao Weier
Prism 42；
The confocal illumination light of line of the two lateral reflections incidence of 50 reflecting mirror of slotted mirror, 14 reflecting surface, has filtered out optical axis position
Light, reduce cornea ghost images.Middle slit position also penetrates and returns from sample through the optical coherence tomography illumination light of scanning
The optical coherence tomography light and the confocal light of line returned.As shown in Figures 3 and 4, two kinds of typical hollow slots reflecting mirrors 50 are given
Schematic diagram comprising be coated with the sheet glass (Fig. 3) of slit reflectance coating or be cut into the reflecting mirror 14 (Fig. 4) of slit；
The sample light issued in the face reflectance spectrum domain optical coherence chromatography module of dichroscope 70, and will be anti-by sample
It is emitted back towards the chromatography light beam come to be reflected back in spectral domain optical coherent tomographic module, another face will be through spectral domain optical coherent tomographic module
In detection optical path project light reflect into detector 80, dichroscope 70 goes back the reflected confocal imaging light beam of transmission sample
Into detector 80；
Detector 80 is line-scan digital camera, and line-scan digital camera is the detector 80 for being used as line cofocus scanning, also can be used as spectral domain light
Learn the detector 80 of coherent tomographic scanning.
Wherein, the first scanning lens 21 and imaging len 60 form 4f system, the first scanning galvanometer 20 and the second scanning vibration
Mirror 30 is located at the focal position of the 4f system.The scan axis of first scanning galvanometer 20 and the second scanning galvanometer 30 mutually hangs down
Directly.The scan axis of second scanning galvanometer 30 is parallel with slit direction.The hot spot that second collimator 18 comes out is by the second scanning vibration
It after the scanning of mirror 30, moves back and forth, is scanned along slit direction.
In one embodiment, the first collimation lens 41f=40mm, cylindrical mirror or Bao Weier (Powell) prism f=
100mm, the first scanning lens 21f=50mm, imaging len 60f=50mm, the second scanning lens 31f=40mm, first focuses
Lens 13f=40mm, the second condenser lens 17f=150mm, the second collimation lens 1515f=50mm, slit width 3mm.
Wherein, the illumination light that lighting source 40 issues becomes directional light after the first collimation lens 41, by cylindrical mirror or
Becoming Line beam after person Bao Weier (Powell) prism, is incident on slotted mirror 50, optical axis and neighbouring light are filtered out,
Remaining light is reflected to the first scanning galvanometer 20, is incident on sample after short scan lens, scanning lens and ophthalmoscope 22, than
Such as eye ground 90.Then pass through the reflection of eye ground 90, backtracking to slotted mirror 50, light beam passes through slit
Reflecting mirror 50 transmits dichroscope 70, focuses on line-scan digital camera.40 wavelength of lighting source is 655nm, and dichroscope 70 is short
Wave is logical, and cutoff wavelength 750nm, short-pass, long wave are anti-.
Wherein, after coupler 11, a part enters in reference arm and former the light that optical coherence tomography light source 10 issues
Road reflexes to coupler 11, and another part enters slow scanning module, by the reflected light beam of sample after slow scanning module
The beam interference in coupler 11 with reference arm reflection is reentered, interfering beam is after detecting optical path by dichroscope 70
Another side is reflected into detector 80 and is imaged.
Reference arm mainly includes first collimator 12, the first condenser lens 13 and reflecting mirror 14, and three is located at same light
On axis, and the reference light direction separated along coupler 11, first collimator 12, the first condenser lens 13 and reflecting mirror 14 are successively
First collimator 12, the first condenser lens 13 and reflecting mirror 14 are successively passed through in setting, i.e. reference light, and anti-by reflecting mirror 14
After penetrating, reference light successively passes through the first condenser lens 13 again and first collimator 12 enters in interferometer coupler 11 and sample light
Interference；
The light beam allocation proportion of coupler 11 is 20:80, wherein 80% light beam enters in reference arm, and in reference arm
It is reflexed in interferometer by former road, and other 20% light beam enters slow scanning module by the second collimator 18 as sample light
In；
Detecting optical path includes the second collimation lens 1515, the grating 16 and second set gradually along the optical path direction of interference light
Condenser lens 17, interfering beam forms collimated light beam by the second collimation lens 1515, will when collimated light beam passes through grating 16
The light beam of each frequency spectrum separates, and another face by being incident on dichroscope 70 after 17 focussing force of the second condenser lens,
And it is reflected in detector 80 and receives；
Specifically, optical coherence tomography light source 10 issue light after coupler 11, wherein 80% light beam enters reference
In arm, and reflexed in coupler 11 on the road reference arm Nei Beiyuan, and other 20% light beam is quasi- by second as sample light
Straight device 18 enters in slow scanning module；The reflected chromatography light beam of sample enters back into coupler 11 after slow scanning module, with
With reference to the interference of light, interference light is again successively after the second collimation lens 1515, grating 16 and the second condenser lens 17, by dichroic
Another face of mirror 70, which is reflected into detector 80, to be received.Wherein, the wavelength of optical coherence tomography light source 10 is 850 ± 75nm.
Referring to Fig.1, the illumination light that lighting source 40 issues successively passes through the first collimation lens 41, cylindrical mirror or Bao Weier
(Powell) it is incident on after prism on slotted mirror 50, the sample light issued in spectral domain optical coherent tomographic module successively passes through
Slow scanning module, the reflection of dichroscope 70, imaging len 60 are transmitted, after the transmission of slotted mirror 50, then are issued with lighting module
By slotted mirror 50 reflection after light combine, jointly by the first scanning galvanometer 20, the first scanning lens 21 and inspection
Eye ground 90 is incident on after glasses 22, in conjunction with imaging reflected by sample and successively by ophthalmoscope 22, short scan mould
Block reflection, the transmission of slotted mirror 50, the transmission of imaging len 60 reach dichroscope 70, and chromatography light beam therein passes through dichroic
After the reflection of mirror 70, the second scanning lens 31, the second scanning galvanometer 30, interfered into spectral domain optical coherent tomographic module, is done
After relating to rear light beam detection optical path therethrough (successively by the second collimation lens 1515, grating 16 and the second condenser lens 17)
It is reflected into detector 80 and is imaged by the another side of dichroscope 70；Confocal imaging light beam therein is transmitted by dichroscope 70
Enter in shared detector 80 afterwards and is imaged.Because having shared identical detector 80, cannot be imaged simultaneously, other component
It can work independently.Therefore it only needs to switch optical filter in work, without stopping a certain system.
It is not only in the description and the implementation although the embodiments of the present invention have been disclosed as above
Listed utilization, it can be applied to various fields suitable for the present invention completely, for those skilled in the art,
Other modifications may be easily implemented, therefore without departing from the general concept defined in the claims and the equivalent scope, this reality
It is not limited to specific details with novel.
Claims (10)
1. a kind of spectral coverage OCT and the confocal synchronous scanning system of line characterized by comprising spectral domain optical coherent tomographic module, slow
Scan module, short scan module, lighting module, slotted mirror, imaging len, dichroscope and detector；
The sample light issued in spectral domain optical coherent tomographic module successively passes through slow scanning module, dichroscope reflection, imaging thoroughly
Mirror is transmitted, after slotted mirror transmission, then is combined with the light after slotted mirror reflects that lighting module issues, jointly
Illumination imaging is carried out to sample after the reflection of short scan module；In conjunction with imaging reflected by sample and successively by short scan
Module reflection, slotted mirror transmission, imaging len transmission reach dichroscope, and chromatography light beam therein is anti-by dichroscope
It penetrates with after slow scanning module, is interfered into spectral domain optical coherent tomographic module, light beam detection light therethrough after interference
It is reflected into detector and is imaged by the another side of dichroscope behind road；Confocal imaging light beam therein is after dichroscope transmits
Into being imaged in shared detector.
2. spectral coverage OCT according to claim 1 and the confocal synchronous scanning system of line, which is characterized in that the short scan mould
Block includes the first scanning galvanometer and the first scanning lens.
3. spectral coverage OCT according to claim 2 and the confocal synchronous scanning system of line, which is characterized in that the slow scanning mould
Block includes the second scanning galvanometer and the second scanning lens.
4. spectral coverage OCT according to claim 3 and the confocal synchronous scanning system of line, which is characterized in that first scanning
Lens and the imaging len form 4f system, and first scanning galvanometer and the second scanning galvanometer are located at the 4f system
Focal position.
5. spectral coverage OCT according to claim 4 and the confocal synchronous scanning system of line, which is characterized in that first scanning
The scan axis of galvanometer and the second scanning galvanometer is mutually perpendicular to.
6. spectral coverage OCT according to claim 5 and the confocal synchronous scanning system of line, which is characterized in that second scanning
The scan axis of galvanometer is parallel with slit direction.
7. spectral coverage OCT according to claim 1 and the confocal synchronous scanning system of line, which is characterized in that the short scan mould
Ophthalmoscope is additionally provided with along optical path between block and sample.
8. spectral coverage OCT according to claim 1 and the confocal synchronous scanning system of line, which is characterized in that the lighting module
Including lighting source, the first collimation lens, cylindrical mirror or the Bao Weier prism set gradually along optical path.
9. spectral coverage OCT according to claim 1 and the confocal synchronous scanning system of line, which is characterized in that the spectral domain optical
Coherent tomographic module includes optical coherence tomography light source, coupler, reference arm and detection optical path, the optical coherence tomography light
For the light that source issues after the coupler, a part reflexes to the coupler into the road the reference arm Nei Qiebeiyuan, another
Part enters the slow scanning module, reenters coupler after the slow scanning module by the reflected light beam of sample
The interior beam interference with reference arm reflection, interfering beam are reflected into spy by the another side of dichroscope after the detection optical path
It surveys in device and is imaged.
10. spectral coverage OCT according to claim 9 and the confocal synchronous scanning system of line, which is characterized in that the detector is
Line-scan digital camera.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108742511A (en) * | 2018-07-09 | 2018-11-06 | 中国科学院苏州生物医学工程技术研究所 | Spectral coverage OCT and the confocal synchronous scanning system of line |
| CN113267495A (en) * | 2021-05-06 | 2021-08-17 | 华中科技大学苏州脑空间信息研究院 | Device and method for recombining every two parallel line light spots into collinear line light spots |
| WO2024174733A1 (en) * | 2023-02-22 | 2024-08-29 | 中国科学院苏州生物医学工程技术研究所 | Common-light-path scanning imaging system |
-
2018
- 2018-07-09 CN CN201821082196.3U patent/CN209236115U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108742511A (en) * | 2018-07-09 | 2018-11-06 | 中国科学院苏州生物医学工程技术研究所 | Spectral coverage OCT and the confocal synchronous scanning system of line |
| CN108742511B (en) * | 2018-07-09 | 2023-12-15 | 中国科学院苏州生物医学工程技术研究所 | Spectrum domain OCT (optical coherence tomography) and line confocal synchronous scanning system |
| CN113267495A (en) * | 2021-05-06 | 2021-08-17 | 华中科技大学苏州脑空间信息研究院 | Device and method for recombining every two parallel line light spots into collinear line light spots |
| WO2024174733A1 (en) * | 2023-02-22 | 2024-08-29 | 中国科学院苏州生物医学工程技术研究所 | Common-light-path scanning imaging system |
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