CN209104118U - Electric spray ion source - Google Patents
Electric spray ion source Download PDFInfo
- Publication number
- CN209104118U CN209104118U CN201721913774.9U CN201721913774U CN209104118U CN 209104118 U CN209104118 U CN 209104118U CN 201721913774 U CN201721913774 U CN 201721913774U CN 209104118 U CN209104118 U CN 209104118U
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- CN
- China
- Prior art keywords
- ion source
- coating
- spray head
- electric spray
- spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007921 spray Substances 0.000 title claims abstract description 47
- 239000011248 coating agent Substances 0.000 claims abstract description 19
- 238000000576 coating method Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 13
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 230000008602 contraction Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 8
- 150000002500 ions Chemical class 0.000 description 19
- 239000000523 sample Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 12
- 230000006698 induction Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229960001948 caffeine Drugs 0.000 description 6
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 6
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical class C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000012488 sample solution Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011953 bioanalysis Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The utility model provides a kind of electric spray ion source, and the electric spray ion source includes spray head, electrode；Further comprise: coating, the coating use hydrophobicity or hydrophilic material, and the inner wall of the spray head is arranged in the coating.The utility model has many advantages, such as that Ionization Efficiency height, high sensitivity, signal-to-noise ratio are high.
Description
Technical field
The utility model relates to ion sources, in particular to electric spray ion source.
Background technique
Cell is the basic unit of vital movement, is carried out on unicellular and subcellsular level to vital movement real-time, former
The problem of position, dynamic detection are the challenges that life science proposes analytical chemistry.Open type mass ions source technology because
High sensitivity, can analyze the features such as ultra-small volume sample, selectivity good, fast response time obtained in single cell analysis it is wide
General application.
Single cell metabolite and trace samplings may be implemented under open type environment in induction Nanoliter electrospray technology of ion source
Sampling and efficient analysis, amount of samples can be reduced to pL rank, and sensitivity with higher and accuracy, be able to solve slender
It is difficult to the problem of detecting below born of the same parents or other biological sample nL ranks, is provided for environment measuring, bioanalysis etc. scientific, efficient
Technical support.The deficiency of above-mentioned induction Nanoliter electrospray technology of ion source is:
It is unstable that sample is sprayed flow velocity, can not adjust the spray time of different samples, cause different sample ionization efficiency,
The problems such as sensitivity for analysis is low with signal-to-noise ratio.
Utility model content
To solve the deficiency in above-mentioned prior art, the utility model provide a kind of high sensitivity, signal-to-noise ratio it is high,
Reusable electric spray ion source realizes the efficient analysis of unicellular metabolin and content polarity sample.
The purpose of this utility model is achieved through the following technical solutions:
A kind of electric spray ion source, the electric spray ion source include spray head, electrode；The electric spray ion source is further
Include:
Coating, the coating use hydrophobicity or hydrophilic material, and the inner wall of the spray head is arranged in the coating.
Compared with prior art, the utility model has the beneficial effect that
1. can be improved the Ionization Efficiency of sample, higher sensitivity and signal-to-noise ratio are obtained；
2. the coating of different chemical property can be bonded for different samples, make to incude Nanoliter electrospray ion source application model
It encloses more extensively；
3. the spraying flow velocity of sample can be changed, keep spray time adjustable, realizes corpusculum enthusiasm sample and unicellular generation
Thank to the efficient analysis of object；
4. can ensure that sample forms lasting, stable, lasting electron spray；
5. method is simple, easy to operate, spray head is reusable.
Detailed description of the invention
Referring to attached drawing, the disclosure of the utility model will be easier to understand.Skilled addressee readily understands that
Be: these attached drawings are used only for illustrating the technical solution of the utility model, and are not intended to the protection to the utility model
Range is construed as limiting.In figure:
Fig. 1 is the structure diagram according to the induction Nanoliter electrospray ion source of the utility model embodiment；
Fig. 2 is the diphenylamines mass spectrogram measured according to the prior art；
Fig. 3 is the diphenylamines mass spectrogram measured according to the utility model embodiment 2；
Fig. 4 is the caffeine mass spectrogram measured according to the prior art；
Fig. 5 is the caffeine mass spectrogram measured according to the utility model embodiment 2.
Specific embodiment
Fig. 1-5 and following description describe the optional embodiments of the utility model how to instruct those skilled in the art
Implement and reproduce the utility model.In order to instruct technical solutions of the utility model, it has simplified or omitted some conventional aspects.This
Field technical staff should be understood that the variation or replacement from these embodiments will be in the scope of the utility model.This field
Technical staff should be understood that following characteristics can be combined in various ways to form multiple modifications of the utility model.As a result, originally
Utility model is not limited to following optional embodiments, and is only limited by the claims and their equivalents.
Embodiment 1:
Fig. 1 schematically illustrates the structure diagram of the induction Nanoliter electrospray ion source of the utility model embodiment 1, such as
Shown in Fig. 1, the induction Nanoliter electrospray ion source includes:
Spray head 2, the spray head both ends open lead directly to section and internal diametric reduction from the first opening to the second opening direction
It is sequentially distributed；It is maximum in the internal diameter of the first opening, it is minimum in the internal diameter of the second opening；
Coating 4, the coating use hydrophobicity or hydrophilic material, determine with specific reference to sample to be tested, e.g., described hydrophobic
Property material use polyvinyl alcohol, the hydrophilic material use hydroxyl or amino ionic coating；The coating is arranged in the spray
The inner wall of head, such as internal diametric reduction；The spray head is arranged in by PB-DS-PB method in the hydrophobicity or hydrophilic material
Inner wall；
Electrode 3, the electrode enter from the first opening and are deep into the internal diametric reduction；The central axis of the electrode
Line is conllinear with the central axis of internal diametric reduction；
Power supply 1, the power supply are that the electrode applies high-voltage dc voltage.
The working method according to above-mentioned induction Nanoliter electrospray ion source of the utility model embodiment, the work side
Method the following steps are included:
(A1) the second open end of above-mentioned spray head is immersed in sample solution, if Immersion time is 10-15s, the sample
Product solution enters in spray head；
The distance of the electrode 3 and solution 5 is 0.3-1cm；
(A2) apply voltage on the electrode, the sample in spray head is ionized, and is projected inside the spray head, and enter matter
Spectrometer injection port；The distance of the spray head 1 to the mass spectrograph injection port 5 is 0.3-1.5cm.
Embodiment 2:
According to the induction Nanoliter electrospray ion source of the utility model embodiment 1 and its working method in diphenylamines detection
Application examples.
In the application examples, in order to be adapted to the detection of diphenylamines, coating is using the hydrophobic material to match, such as poly- second
Enol polymer；The inner wall of the internal diametric reduction of the spray head is arranged in by PB-DS-PB method for hydrophobic material.
In the working method of ion source, namely during detection diphenylamines:
Above-mentioned spray head is soaked in 10~15s in sample solution, sample solution can be introduced to the point of spray head, sample
Spacing between solution and electrode is 0.3~1cm.Spray head is between electrode and mass spectrum injection port, the point of spray head and institute
Stating the distance between mass spectrometric injection port can be 0.3~1.5cm.High-voltage dc voltage is set as 1.0kV, and sheath gas is set as
0L/min, Mass Spectrometer Method m/z range are set as 50~1000, and test sample is that diphenylamines standard sample (is dissolved in methanol, concentration
50ppb), as shown in figure 3, Mass Spectrometer Method sensitivity improves 9 times, as shown in Figure 2,3.
Embodiment 3:
According to the induction Nanoliter electrospray ion source of the utility model embodiment 1 and its working method in caffeine detection
Application examples.
In the application examples, in order to be adapted to the detection of caffeine, coating is using the hydrophilic material to match, such as band hydroxyl
The ionic coating of base or amino；Hydrophilic material is arranged in the internal diametric reduction of the spray head by PB-DS-PB method
Wall.
In the working method of ion source, namely during detection caffeine:
Above-mentioned spray head is soaked in 10~15s in sample solution, sample solution can be introduced to the point of spray head, sample
Spacing between solution and electrode is 0.3~1cm.The distance between the point of spray head and the mass spectrometric injection port can be
0.3~1.5cm.High-voltage dc voltage is set as 2.0kV, and sheath gas is set as 0 L/min, and Mass Spectrometer Method m/z range is set as 50~
1000, test sample is caffeine standards sample (being dissolved in methanol, concentration 50ppb), as shown in figure 5, Mass Spectrometer Method sensitivity mentions
It is 12 times high, as shown in Figure 4,5.
Claims (5)
1. a kind of electric spray ion source, the electric spray ion source includes spray head, electrode；It is characterized by: the electron spray from
Component further comprises:
Coating, the coating use hydrophobicity or hydrophilic material, and the inner wall of the spray head is arranged in the coating；
The both ends open of the spray head, inside have internal diametric reduction, are open along from first onto the second opening direction, described
The internal diameter of spray head gradually tapers up, minimum in the internal diameter of the second opening；
The electrode enters from the first opening and is deep into the internal diametric reduction.
2. electric spray ion source according to claim 1, it is characterised in that: the internal diameter of the spray head is arranged in the coating
Contraction section.
3. electric spray ion source according to claim 1, it is characterised in that: the central axis and internal diameter of the electrode are shunk
The central axis of section is conllinear.
4. electric spray ion source according to claim 1, it is characterised in that: the hydrophobic material uses polyvinyl alcohol.
5. electric spray ion source according to claim 1, it is characterised in that: the hydrophilic material uses hydroxyl or amino
Ionic coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721913774.9U CN209104118U (en) | 2017-12-31 | 2017-12-31 | Electric spray ion source |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721913774.9U CN209104118U (en) | 2017-12-31 | 2017-12-31 | Electric spray ion source |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209104118U true CN209104118U (en) | 2019-07-12 |
Family
ID=67146089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721913774.9U Active CN209104118U (en) | 2017-12-31 | 2017-12-31 | Electric spray ion source |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209104118U (en) |
-
2017
- 2017-12-31 CN CN201721913774.9U patent/CN209104118U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
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| CP03 | Change of name, title or address |