CN206594182U - A kind of reagent consumable container enters level detecting apparatus - Google Patents

Abstract

The utility model is related to medical analysis instrument field, enter level detecting apparatus there is provided a kind of reagent consumable container, including multiple stations, motor and the first detection means, each station is suitable for place into one or more containers for holding reagent or consumptive material, the motor can drive and be relatively moved between the station and first detection means so that first detection means read the container on the multiple station one by one enter an information.The utility model also provides a kind of method for entering a situation using the device detection reagent consumptive material, and this enters level detecting apparatus and method can be applied in CTC circulating tumor cell detecting systems, improves the detection efficiency and order of accuarcy of CTC system.

Description

A kind of reagent consumable container enters level detecting apparatus

Technical field

The utility model is related to full-automatic medical analysis instrument field, specifically provides one kind and enters level detecting apparatus.

Background technology

Circulating tumor cell (Circulating Tumor Cell, CTC) refers to cyclic system is come off and entered from tumour The cancer cell of system, it can be spontaneous or come off by operation of diagnosis and treatment from entity tumor focus (primary tumor or transfer stove), is followed into body Loop system (such as peripheral blood).Most of CTC can occur apoptosis or swallowed after entering peripheral blood, and minority can escape and anchor disease On tissue or organ beyond stove, and then develop into transfer stove, increase malignant tumor patient mortality risk.These cells can be with Found by simple blood testing, can as cancer biological markers, whether there is tumour, and it in indication body Hereditary conditions and drug susceptibility.Different from surgical intervention, CTC is compatible with longitudinal research, being capable of effective guiding treatment. CTC detections can be effectively applied to external early diagnosis, prognostic evaluation, (including rapid clinical chemotherapeutics is sieved individualized treatment Choosing and the detection of drug resistance), tumor recurrence monitoring and the exploitation of new tumour medicine etc..But CTC detecting steps are more, it is numerous to operate It is trivial, it also counteracts that the popularization of this technology clinically.

Conventional CTC detections at present are divided into two steps, i.e. CTC enrichments (or capture) step and CTC detection and analysis steps. Conventional CTC capture techniques have gradient density centrifugal technology, filter film technology, Flow Cytometry, microfluidic chip technology and exempted from Epidemic disease magnetic bead technology.Wherein, immunomagnetic bead technique is related to the steps such as the mixing of sample, cell magnetic suck, is adapted in large volume loading Under the conditions of a small amount of special cells are separated, for CTC detection application it is especially advantageous, its operating procedure is relatively easy, easily Automated in realizing.

However, the reagent and consumptive material species that are related in CTC detections are various, held in traditional CTC system in artificial placement After the container of reagent or consumptive material, continuing with manual confirmation, it is put in place, and records corresponding sample message on relevant position. Because the step relies on manual operation, easily there is operational error, cause sample correspondence it is incorrect, the problems such as put not in place. Current existing automation equipment is generally import equipment and automaticity is low, efficiency (time-consuming) and flux are relatively low.

Therefore, what those skilled in the art was directed to developing a kind of intelligent, reagent of precision and consumptive material enters position system System, helps reviewer's Confirmation reagent and consumable container to put correctly, further coordinates the CTC tumour cells detection system of automation System, completes the detection to the automation of tumour cell, high efficiency and high-accuracy.

Utility model content

In view of the drawbacks described above of prior art, technical problem to be solved in the utility model be to provide a kind of reagent or Consumptive material enters level detecting apparatus, including multiple stations, motor and the first detection means, each station be suitable for place into one or Multiple containers for holding reagent or consumptive material, the motor, which can be driven between the station and first detection means, to be occurred relatively It is mobile so that first detection means read the multiple station upper container one by one enter an information.Wherein, a packet is entered Include and hold the container of reagent or consumptive material and whether enter whether corresponding station and/or installation site meet service requirement.

Further, the motor is stepper motor.

Further, first detection means includes code reader.

Further, first detection means includes infrared detection component, the positional information for detecting the container.

Further, in addition to volume calculation module, for calculating remaining liquid volume in the container.

Further, in addition to second detection device, the sample message to input the container.

Technique effect

(1) relative movement between detection means and container is driven using motor, can automatically completed to all stations The typing and check and correction of upper container information, prevent from slipping up caused by artificial operation；

(2) use infrared detection component, can automatic identification container place position, it is to avoid because place it is not in place caused by follow The damage problem of centrifuge component in ring tumour cell system；

(3) volume calculation module is utilized, record takes the volume and sample liquids cumulative volume of liquid every time, calculates amount of samples feelings Condition, after consumptive material runs out of in single container, automatically replaceable container, and when all container in-fighting timber-useds are most, can be to instrument User sends prompting.

The technique effect of design of the present utility model, concrete structure and generation is made furtherly below with reference to accompanying drawing It is bright, to be fully understood from the purpose of this utility model, feature and effect.

Brief description of the drawings

Fig. 1 is that the structure of machine self-checking system is looked squarely on centrifugation portion test tube in a preferred embodiment of the present utility model Figure；

Fig. 2 is the top view of self-checking system in Fig. 1 embodiments；

Fig. 3 is the plan view of the feed bin self-checking system in another preferred embodiment of the present utility model；

Fig. 4 is the top view of self-checking system in Fig. 3 embodiments.

Reference：1st, blood sample centrifuge tube, 2, infra-red ray detection device,

201st, code reader, 202, linear electric motors, 203, reagent consumption material box,

2031st, bar magnet magazine, 2032, stirring bar stock box, 2033, kit, 2034, pipette tips box

Embodiment

Embodiment of the present utility model is described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning Same or similar element or element with same or like function are represented to same or similar label eventually.Below by ginseng The embodiment for examining accompanying drawing description is exemplary, it is intended to for explaining the utility model, and it is not intended that to the utility model Limitation.

Embodiment 1

In the centrifugation portion for present embodiments providing CTC circulating tumor cell detecting systems, bit trial device pair is entered using this Centrifuge tube enters the apparatus and method that a situation is tested.When Fig. 1, Fig. 2 are that centrifuge tube has been put into station, enter the knot of a device Structure schematic diagram.Centrifuge tube 1 is put into when centrifugal device is static, the side of centrifuge tube 1 is provided with infra-red ray detection device 2.It can see Go out, when centrifuge tube 1 is properly placed its correspondence station, its underpart can shelter from light of the part from infra-red ray detection device 2, So as to which the circumference that from other end infrared receiving device, can be put into centrifuge tube 1 carries out computing, entering for centrifuge tube 1 is obtained Position situation.

Centrifugal device in the present embodiment using stepper motor as driving, therefore, complete to one group on the station from Entering after the detection of position for heart pipe 1, can rotate clockwise a station, and continuation carries out detecting into position to the centrifuge tube on next station. Motor only drives the motion of centrifuge tube 1, and the remains stationary of infrared detecting device 2, both relative motions, using stepper motor one by one Drive reading centrifuge tube 1 enters an information.

Also include hand-held code reader and fuselage code reader in CTC circulating tumor cell detecting systems in the present embodiment, can To read the matched bar code of centrifugation pipe surface or two bit codes, wherein, fuselage code reader is also stationarily mounted to detect work Position side, can directly read the sample message for the centrifuge tube for being put into detection station.

The application method for entering level detecting apparatus in the present embodiment is as follows：

1. first passing through hand-held code reader inputs the sample message of centrifuge tube, and uploads；

2. place corresponding centrifuge tube on detection station；

3. read the sample message and positional information of centrifuge tube respectively using fuselage code reader and infra-red ray detection device, and Upload；

4. being uploaded to terminal, and the data obtained is compared and computing, such as occur centrifuge tube place vertical direction less than Position, or misplace station, then program malfunctions and pointed out；

5. centrifuge rotates a station；

6. repeat the above steps, until completing into a detection process.

Embodiment 2

In the feed bin self-checking system for present embodiments providing CTC circulating tumor cell detecting systems, filled using position detection is entered Put the apparatus and method for realizing the consumption monitoring to reagent consumptive material.

As shown in figure 3, code reader 201 is driven by linear electric motors 202, can linear scanning on the platform.Reagent consumption material box 203 are made up of four parts：Respectively bar magnet magazine 2031, stirring bar stock box 2032, kit 2033 and pipette tips box 2034, four Bar code is posted on the relevant position for dividing point storage box, on the same line, code reader 201 can be successively read along linear electric motors for distribution The bar code of each point of storage box, computer is uploaded to by the sample message of corresponding point storage box.

Sampling equipment is controlled using digitlization mechanical arm in CTC circulating tumor cell detecting systems in the present embodiment, When being completed per sub-sampling, taken sample message and corresponding sample position is can record, for taking for fluid sample, is taken Sample system is using the controllable liquid shifting equipment of step-length, and the volume per sub-sampling is controllable, therefore, can be according to sample initial volume and record The sample volume taken every time calculate the surplus for obtaining sample in point storage box, when sample size is not enough automatic replacing sample or Prompting operating personnel are supplemented.

Also include hand-held barcode scanning gun in CTC circulating tumor cell detecting systems in the present embodiment, a point storage box can be read The matched bar code in surface or two bit codes.

The application method of feed bin self-checking system in the present embodiment comprises the following steps：

1. feeding of starting shooting；

2. the bar code of four kinds of points of storage boxes is input to computer using hand-held barcode scanning gun；

3. starting check problem, linear electric motors driving code reader scans the bar code information of point storage box one by one, and is uploaded to electricity Brain；

4. comparison information, both are not inconsistent intelligence and reported an error, and machine is out of service.

Preferred embodiment of the present utility model described in detail above.It should be appreciated that the ordinary skill people of this area Member just can make many modifications and variations without creative work according to design of the present utility model.Therefore, all this technology necks Technical staff passes through logic analysis, reasoning or limited reality on the basis of existing technology according to design of the present utility model in domain Available technical scheme is tested, all should be in the protection domain being defined in the patent claims.

Claims (6)

1. a kind of reagent consumable container enters level detecting apparatus, it is characterised in that including multiple stations, motor and the first detection dress Put, each station is suitable for place into one or more containers for holding reagent or consumptive material, and the motor can drive the station Relatively moved between first detection means, so that first detection means is read on the multiple station one by one The container enter an information.

2. enter level detecting apparatus as claimed in claim 1, it is characterised in that the motor is stepper motor.

3. enter level detecting apparatus as claimed in claim 1, it is characterised in that first detection means includes code reader.

4. enter level detecting apparatus as claimed in claim 1, it is characterised in that first detection means includes infrared detection group Part, the positional information for detecting the container.

5. enter level detecting apparatus as claimed in claim 1, it is characterised in that also including volume calculation module, for calculating State remaining liquid volume in container.

6. enter level detecting apparatus as claimed in claim 1, it is characterised in that also including second detection device, to input State the sample message of container.