CN205698065U - The porous tooth implant of drug-carrying slow-released system - Google Patents
The porous tooth implant of drug-carrying slow-released system Download PDFInfo
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- CN205698065U CN205698065U CN201620135452.5U CN201620135452U CN205698065U CN 205698065 U CN205698065 U CN 205698065U CN 201620135452 U CN201620135452 U CN 201620135452U CN 205698065 U CN205698065 U CN 205698065U
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- drug
- tooth implant
- loose structure
- released system
- implantation body
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- 239000007943 implant Substances 0.000 title claims abstract description 41
- 238000002513 implantation Methods 0.000 claims abstract description 36
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 22
- 238000009826 distribution Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 2
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 210000002449 bone cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000004053 dental implant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000004409 osteocyte Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
- 241000282817 Bovidae Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 229940112869 bone morphogenetic protein Drugs 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000002153 concerted effect Effects 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000002642 osteogeneic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
A kind of porous tooth implant of drug-carrying slow-released system, it is provided with the external screw thread being connected with alveolar bone including the outer surface of implantation body's body described in implantation body's body, in loose structure between described externally threaded adjacent thread, described loose structure is provided with the hole for placing slow releasing pharmaceutical.This utility model provides and a kind of is effectively improved bond strength, promotes the porous tooth implant of drug-carrying slow-released system combining speed.
Description
Technical field
This utility model relates to porous tooth implant field, especially a kind of porous tooth implant.
Background technology
In recent years, the application of Dental Implant technology causes the highest attention of people, and the tooth of plantation can not only solve the puzzlement that tradition artificial tooth is repaired, also the inconvenience that detachable dental prostheses brings has been broken away from, Dental Implant is attractive in appearance, effect is natural, is comfortable on, and gmatjpdumamics access expansion tooth.The good performance of the success of implant operation and repair function depends on many factors, and the combination effect of implantation body and alveolar bone is wherein one of key factor.In order to promote the combination of implantation body and alveolar bone, the tooth implant with rough surface is widely applied, and zoopery studies surface with clinical practice, compared with smooth surface, rough surface can increase synosteosis surface area, and beneficially implantation body and the combination of alveolar bone.But, the bond strength of the implantation body and alveolar bone with rough surface reaches far away preferable clinical effectiveness, increases the bond strength of implantation body and alveolar bone the most further, improves the effectiveness at a specified future date of implantation body, promote the success rate of implant operation, be letter problem to be solved.
Titanium is as one of medical material implanted, and can its surface texture be the key factor of impact plantation quality, determine implantation body to a great extent and make function by integrating parallel long-term with bone.The existence of titanium implant surface microcellular structure can increase the surface area of implantation body, improves mechanical lock and makes a concerted effort, beneficially implant and the combination of osseous tissue.The design of stephanoporate implant needs to meet claimed below:
(1) stephanoporate implant designed not only can meet the external shape of personalization, can also build controlled internal void simultaneously；
(2) loose structure designed needs to meet the biological and requirement of mechanical property, need enough rigidity and intensity ensures will not deform after in its implanted alveolar bone destruction, also to ensure that its elastic modelling quantity is the most suitable with the elastic modelling quantity of natural bone, it is to avoid produce stress shielding simultaneously；
(3) loose structure designed need to meet the technological requirement increasing material manufacturing technology；
(4) the structural behaviour parameter of loose structure should be controlled.
Existing implantation body is all to be completed by traditional machining, obtains final shape and structure by surface post processing the most again.For the loose structure of implant surface, iff using tradition manufacturing process, it is difficulty with.
Existing tooth implant is the best with alveolar bone bond strength, and implantation body needs 3-6 month very long osteogenesis healing stage after implanting between prosthesis.
Summary of the invention
For the deficiency that the bond strength overcoming existing tooth implant is poor, rapidity is poor, this utility model provides and a kind of is effectively improved bond strength, promotes the porous tooth implant of the drug-carrying slow-released system combining speed.
This utility model solves its technical problem and be the technical scheme is that
A kind of porous tooth implant of drug-carrying slow-released system, it is provided with the external screw thread being connected with alveolar bone including the outer surface of implantation body's body described in implantation body's body, in loose structure between described externally threaded adjacent thread, described loose structure is provided with the hole for placing slow releasing pharmaceutical.
Further, in described loose structure, each hole is the most in spiral distribution.
Further, each hole is in being equidistantly spaced from.
Further, at the outer surface of described implantation body body, porosity is 30-70%.
The diameter of described hole is between 300-800 micron
Technology of the present utility model is contemplated that: along with metal increases the development of material manufacturing technology, the loose structure of bigger design freedom and porous implant can directly manufacture, including the geometric properties that some of them are the most small, so loose structure is designed when, it is not limited to the restriction of traditional design and manufacture method and theory, can consider that bionical structure and mechanical property requirements design structure more freely more.Selective laser melting (SLM) technology has specific accurate geometry or the medical metal part of complex internal hole because it can be produced by the successively accumulation of metal dust, and receives much concern.
Implantation body's sides of body is configured with beneficially medicament storage release and the loose structure of Bone Ingrowth, medicine can promote that under fluid environment bone cell differentiation grows, osteocyte also is able to grow into inside loose structure, so that implantation body and alveolar bone strong bonded, to shorten operation healing stage, to promote synosteosis, increase osseointegration intensity, improve the effectiveness at a specified future date of tooth implant, promote the success rate of implant operation.
The beneficial effects of the utility model are mainly manifested in: be effectively improved bond strength, lifting combines speed, is easily achieved loose structure.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the porous tooth implant of drug-carrying slow-released system.
Detailed description of the invention
Below in conjunction with the accompanying drawings this utility model is further described.
With reference to Fig. 1, the porous tooth implant of a kind of drug-carrying slow-released system, including implantation body's body 1 and loose structure 2；Body outer surface is provided with the external screw thread 3 being connected with alveolar bone, and loose structure is embedded between screw thread, and in described loose structure 2, each hole is the most in spiral distribution, and porous is conducive to medicament storage release and Bone Ingrowth；The hole of described loose structure 2 is individually present, and does not has connectivity structure, and pore-size is between 300-800 micron between hole, and porosity is that 30-70% is controlled.
A kind of manufacture method of the porous tooth implant of drug-carrying slow-released system, its step is as described below:
1), in the three-dimensional softwares such as Unigraphix, Pro/E, Solidworks, thread implant based on certain parameter is designed.
2), in the three-dimensional softwares such as Unigraphix, Pro/E, Solidworks, on the basis of step 1 implantation body, setting up porous mould, parameter has: the regularity of distribution in the cross sectional shape in hole, aperture, hole depth, porosity and hole, designs the file exporting STL form afterwards.
3), use SLM technical matters, be the implantation body that raw material 3D prints the inner design of step 2 with titanium alloy powder, then remove implantation body's pore interior residual powder with the EtOH Sonicate concussion that mass fraction is 70%.
4), by the implantation body after sonic oscillation carry out sandblasted and acid-etching, remove surface residual and do not melt inorganic matter.
Above-mentioned steps 3) in selective laser melting (Selective Laser Melting, SLM) technology be the mid-90 in 20th century occur a kind of novel rapid shaping (Rapid Prototyping, RP) technology.It has, and moulding process is simple, stock utilization is high, the suitability is wide and shaping efficiency advantages of higher, thus of great interest.It can go out the metal parts close to complete consistency by straight forming.Hierarchy slicing information according to profiled member three-dimensional CAD model, scanning system (galvanometer) controls laser beam and acts on the powder in region to be formed.After one layer scanned, the piston in piston cylinder can decline the distance of a thickness；Then powder feed system carries a certain amount of powder, and the roller of paving powder system is sprawled the powder of thick layer and is deposited on molded layer.Then, above-mentioned 2 forming processes are repeated, until the slicing layer of all three-dimensional CAD models is the most scanned.So, three-dimensional CAD model is by successively accumulation mode straight forming metal parts.After porous tooth implant has sintered, implantation body is placed in powder body heap in a vacuum chamber and be slowly cooled to room temperature, remove and stick the extra powder on tooth implant.
The basic technological parameters of described SLM technology is as follows: processing thickness 30 μm, scanning speed 7m/s, laser power 200W, dot spacing 75 μm, vacuum below oxygen content 1000ppm.
Described powder body material is titanium alloy or cochrome.
The porous tooth implant of described drug-carrying slow-released system, has the feature that
Body thread implant is the implantation body of Parametric designing, and the specification of implantation body and thread parameter are all controlled；
Loose structure based on implantation body's body, the cross sectional shape in its hole is not unique, can be the geometries such as circle, square, rhombus；
The molding of loose structure is in order to meet SLM processing technique requirement, and pore diameter size requires more than 300 microns, and parametrization is controlled；
The porosity of loose structure accounts for, by porose sectional area summation, the ratio that implant surface is long-pending, is all unified size owing to institute is porose, as long as therefore number or the regularity of distribution in change hole just can change porosity, is finally reached controlled porosity；
Bone morphogenetic protein(BMP) (BMPs) belongs to the member in transforming growth factor superfamily, wherein BMP-2 have the most by force, the most quick self-bone grafting ability.But clinically, if BMP-2 being directly applied to local, will quickly be disperseed and absorb, it induces osteogenetic effect very limited.In order to obtain the maximum self-bone grafting ability of BMP-2, need to find a kind of preferably carrier.Preferably carrier material not only has good biocompatibility, it is possible to is loaded in Cranial defect by medicine with various ways such as adsorbing, combine, inlay, also to have certain mechanical strength and degradation speed.Conventional carrier has collagen, hyaluronate sodium (SA), antelope base apatite (HA), demineralized bone matrix (DBM), calcium phosphate (TCP), polylactic acid P (LA) etc..
After completing the manufacture post processing of implantation body, using loose structure as the carrier platform of BMP2 granule, thus build drug sustained release system.Further, by controlling the cross sectional shape of loose structure, aperture, hole depth, porosity and this series of parameters of the regularity of distribution in hole, the rate of release of BMP2, burst size and deenergized period can be controlled.
Porous tooth implant described in the utility model, including implantation body's body 1 and loose structure 2, implantation body's body outer surface is provided with external screw thread 3, and this external screw thread 3 is connected with alveolar bone.Described loose structure 2 is embedded between screw thread, and porous is the most in spiral distribution, and pore-size is between 300-800 micron, and porosity is that 30-70% is controlled；Described external screw thread 3 is a kind of common mechanical connection with the connection of alveolar bone, for implanting the fixing of incipient species implant and alveolar bone, after implantation, the medicine within described loose structure 4 starts slowly release under fluid environment, promote osteocyte fast-growth, bone cell growth space can also be provided, thus form the embedded structure of cell structure 4 and alveolar bone, the biological fixation of tooth implant and alveolar bone can be obtained, it is achieved the most clinical Integrated implant effect.
Example: be illustrated in figure 1 the two-dimensional structure schematic diagram of the porous tooth implant of drug-carrying slow-released system, this implantation body's main body is rotary structure, and with screw thread between cervical region to root, major diameter of thread is identical with implant neck diameter.At implantation body's mid portion, screw thread sets up loose structure at interval.This implantation body's model is 3.75*10mm, and recess diameter is 3.75mm, a length of 10mm.In loose structure, single hole sectional area is rhombus, and its catercorner length is 0.5mm, and the degree of depth is also 0.5mm.Hole is axially equally being uniformly distributed, and is Spiral distribution at circumferencial direction, and sets up a hole every 60 °.
Claims (5)
1. a porous tooth implant for drug-carrying slow-released system, including implantation body's body, it is special
Levy and be: the outer surface of described implantation body body is provided with the external screw thread being connected with alveolar bone, described
In loose structure between externally threaded adjacent thread, described loose structure is provided with for placing slow
The hole of release thing.
2. the porous tooth implant of drug-carrying slow-released system as claimed in claim 1, its feature
Being: in described loose structure, each hole is the most in spiral distribution.
3. the porous tooth implant of drug-carrying slow-released system as claimed in claim 2, its feature
It is: each hole is in being equidistantly spaced from.
4. the porous tooth implant of the drug-carrying slow-released system as described in one of claims 1 to 3,
It is characterized in that: at the outer surface of described implantation body body, porosity is 30-70%.
5. the porous tooth implant of drug-carrying slow-released system as claimed in claim 2, its feature
It is: the diameter of described hole is between 300-800 micron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620135452.5U CN205698065U (en) | 2016-02-23 | 2016-02-23 | The porous tooth implant of drug-carrying slow-released system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620135452.5U CN205698065U (en) | 2016-02-23 | 2016-02-23 | The porous tooth implant of drug-carrying slow-released system |
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| Publication Number | Publication Date |
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| CN205698065U true CN205698065U (en) | 2016-11-23 |
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| CN201620135452.5U Expired - Fee Related CN205698065U (en) | 2016-02-23 | 2016-02-23 | The porous tooth implant of drug-carrying slow-released system |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106859792A (en) * | 2017-03-10 | 2017-06-20 | 浙江工业大学 | The through-hole porous tooth implant of multisection type |
| CN107374760A (en) * | 2017-07-24 | 2017-11-24 | 芜湖微云机器人有限公司 | A kind of gradient porous planting body with medicine carrying function |
| WO2019104852A1 (en) * | 2017-12-01 | 2019-06-06 | 广州市健齿生物科技有限公司 | Porous dental implant having surface inlaid with degradable layer and preparation method therefor |
| US10575886B2 (en) | 2018-05-09 | 2020-03-03 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US10993753B2 (en) | 2018-05-09 | 2021-05-04 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11191582B2 (en) | 2018-05-09 | 2021-12-07 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11224470B2 (en) | 2018-05-09 | 2022-01-18 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
-
2016
- 2016-02-23 CN CN201620135452.5U patent/CN205698065U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106859792A (en) * | 2017-03-10 | 2017-06-20 | 浙江工业大学 | The through-hole porous tooth implant of multisection type |
| CN106859792B (en) * | 2017-03-10 | 2022-06-17 | 浙江工业大学 | Multi-section type through hole porous dental implant |
| CN107374760A (en) * | 2017-07-24 | 2017-11-24 | 芜湖微云机器人有限公司 | A kind of gradient porous planting body with medicine carrying function |
| WO2019104852A1 (en) * | 2017-12-01 | 2019-06-06 | 广州市健齿生物科技有限公司 | Porous dental implant having surface inlaid with degradable layer and preparation method therefor |
| US10575886B2 (en) | 2018-05-09 | 2020-03-03 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US10993753B2 (en) | 2018-05-09 | 2021-05-04 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11191582B2 (en) | 2018-05-09 | 2021-12-07 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11224470B2 (en) | 2018-05-09 | 2022-01-18 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11589907B2 (en) | 2018-05-09 | 2023-02-28 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
| US11857233B2 (en) | 2018-05-09 | 2024-01-02 | Warsaw Orthopedic, Inc. | Bone screw and method of manufacture |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161123 Termination date: 20200223 |