CN205215191U - Relevant chromatographic device of optics of formation of image in blood vessel - Google Patents
Relevant chromatographic device of optics of formation of image in blood vessel Download PDFInfo
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- CN205215191U CN205215191U CN201521071829.7U CN201521071829U CN205215191U CN 205215191 U CN205215191 U CN 205215191U CN 201521071829 U CN201521071829 U CN 201521071829U CN 205215191 U CN205215191 U CN 205215191U
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Abstract
The utility model provides a relevant chromatographic device of optics of formation of image in blood vessel, the device mainly include tunable laser lamp -house, interferometer, pipe probe, probe controlling means, collection system and computer. The tunable laser lamp -house who utilizes the near infrared band forms the relevant chromatography signal of hematal optics, and probe controlling means drives 360 degrees high -speed circumference scannings of pipe probe and stretches into simultaneously and withdrawing, obtains the interior high resolution structure chart of one section blood vessel like.
Description
Technical field
This utility model belongs to photoelectronic imaging, bio-imaging technical field, is specifically related to a kind of optical coherence tomograph of Ink vessel transfusing imaging
Background technology
Chromatography imaging technique refers to and carries out axial imaging to testee, it is actually an inverse Problem: utilize object received forward direction transmission data or backscattering data under multi-angle or multi-frequency wave field are irradiated, by inversion algorithm, ask for the relative position of scattering object in object, geometry or inherent parameter.Optical coherence imaging is chromatography imaging technique application optically.
The optical technology of advanced person and hypersensitive detection are integrated by optical coherent chromatographic imaging, add modern computer graphical process, develop into an emerging tomography diagnostic techniques.It is compared with other medical imaging technologies, such as X-ray tomography, ultrasound tomography etc., has following superiority:
1) radiationless damage, Noninvasive
The transmitting power of optical coherent chromatographic imaging light source, in 1 ~ 20mW, can not cause damage to biological tissue.In time detecting tissue surface, can by light source direct irradiation, scanning probe mechanism does not need tightly to contact with tissue surface.In time diagnosing in-vivo tissue, can in conjunction with endoscopic technique detection body internal cavity superficial tissue, pathological tissues done to pathological section is this has certain destructive method so avoid.
2) high sensitivity
Optical coherent chromatographic imaging can reach very high detectivity, because interferometer measurement is the intensity of field instead of light.Reference signal effectively can strengthen faint back scattering optical signal.With optimization system design, approximate quantum limit detection can be obtained.Typical optical coherence imaging systems can reach the detectivity of 90dB ~ 100dB, and the optical signalling that detect from most of scattering biological tissue 2 ~ 3mm degree of depth is enough.
3) high-resolution
Optical coherent chromatographic imaging can provide the axial resolution being similar to micron dimension (1 ~ 15 μm) independent of lateral resolution, and this depends primarily on the bandwidth of wideband light source or the tuning range of tunable optical source.
OCT is by being combined with overdelicate catheter-like detecting head, develop into the Ink vessel transfusing OCT imaging system based on conduit system, after angiography, intravascular ultrasound, more accurately can obtain a kind of means of Ink vessel transfusing microstructure chromatography image, in order to differentiate atherosclerotic plaque and to identify vulnerable plaque, and decision-making foundation can be provided for interventional therapy, there is huge development prospect.
Utility model content
For solving above-mentioned the deficiencies in the prior art, this utility model provides a kind of optical coherence tomograph controlling accurate, remarkably productive a kind of Ink vessel transfusing imaging,
The technical solution of the utility model comprises:
Tunable laser source: for providing light source for the optical coherence tomograph of Ink vessel transfusing imaging, the tunable laser source of light source to be centre wavelength be 1310nm, for Michelson's interferometer provides the light source of near infrared band, the triggering signal of light source is as the external timing signal of harvester, probe control device;
Interferometer: interferometer is all-fiber Michelson structure, for generation of sample light and reference light interference signal, comprise 80:20 fiber coupler, the first circulator, the second circulator, faraday rotation mirror, fibre delay line, 50:50 fiber coupler and photoelectricity balanced detector;
Catheter probe: infrared light converges on target vessel wall by catheter probe, then the reflected light of target vessel wall different layers is collected and transmits back Michelson's interferometer sample arm;
Harvester: by the triggering signal of tunable laser source as external timing signal, synchronous acquisition interference image, harvester comprises Data Acquisition Card and image pick-up card, the signal of telecommunication that in Data Acquisition Card synchronous acquisition interferometer, photoelectricity balanced detector exports, image pick-up card is converted to digital picture and is input to frame memory after over-sampling, quantification, realize high speed acquisition, then enter computer;
Computer: date processing is carried out to the data image signal that harvester exports, comprises the Fourier transformation of interference signal, polar coordinate transform, image enhancement processing etc.
The emergent light of tunable laser source is entered by 80:20 fiber coupler first port, and with the ratio of 80:20 respectively from second, third port assignment to reference arm and sample arm.The emergent light of 80:20 fiber coupler second port enters sample arm, the light beam entering sample arm incides the first port of the first circulator, light goes out to enter probe control device from the second end-fire of the first circulator and then incides catheter probe, light incides sample from catheter probe, the back-scattering light of sample returns the first circulator, and enters the first port of 50:50 fiber coupler from the first circulator the 3rd port.The emergent light of 80:20 fiber coupler the 3rd port enters reference arm, the light beam entering reference arm incides the first port of the second circulator, light goes out to enter fibre delay line from the second end-fire of the second circulator, the effect of fibre delay line regulates reference arm light path, reference arm is mated with sample arm light path, the emergent light of fibre delay line incides faraday rotation mirror, acting as of faraday rotation mirror eliminates polarization state change at random to the impact of interference signal, the light that faraday rotation mirror reflects gets back to the second circulator, the second port of 50:50 fiber coupler is entered again from the 3rd end of the second circulator.Reference light and sample light interfere in 50:50 fiber coupler, and interference light enters photoelectricity balanced detector from the output port 3 of 50:50 fiber coupler and port 4.Interference signal is converted to the signal of telecommunication by photoelectricity balanced detector, and the signal of telecommunication enters harvester again.
Advantage of the present utility model and good effect:
The optical coherence tomograph of this Ink vessel transfusing imaging is the Ink vessel transfusing imaging technique that resolution is the highest, resolution can reach 10 μm ~ 20 μm, can observe blood vessel wall interior, in, adventitia, accurate display Ink vessel transfusing ultrastructure, that one has high-resolution real-time arteriography technology, the Ink vessel transfusing fault image of microscopic level can be obtained, coronary atherosclerosis speckle and the thrombosis of assist physician identification instability, in percutaneous coronary intervention, play directive function.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the optical coherence tomograph of a kind of Ink vessel transfusing imaging of the present utility model
Detailed description of the invention
The optical coherence tomograph of embodiment 1, a kind of Ink vessel transfusing imaging
The optical coherence tomograph of 1 one kinds of Ink vessel transfusing imagings, this device comprises:
Tunable laser source 1: for providing light source for the optical coherence tomograph of Ink vessel transfusing imaging, the tunable laser source of light source to be centre wavelength be 1310nm, for interferometer 17 provides the light source of near infrared band, the triggering signal of light source is as the external timing signal of harvester 18, probe control device 7.
Interferometer 17: interferometer 17 is all-fiber Michelson structure, for generation of sample light and reference light interference signal; Comprise 80:20 fiber coupler 2, first circulator 3, second circulator 4, fibre delay line 5, faraday rotation mirror 6,50:50 fiber coupler 9 and photoelectricity balanced detector 10;
The emergent light of tunable laser source 1 is entered by 80:20 fiber coupler 2 first port, and with the ratio of 80:20 respectively from second, third port assignment to reference arm and sample arm.The emergent light of 80:20 fiber coupler 1 second port enters sample arm, the light beam entering sample arm incides the first port of the first circulator 3, light goes out to enter probe control device 7 from the second end-fire of the first circulator 3 and then incides catheter probe 8, light incides sample from catheter probe 8, the back-scattering light of sample returns the first circulator 3, and enters the first port of 50:50 fiber coupler 9 from the first circulator 3 the 3rd port.The emergent light of 80:20 fiber coupler 1 the 3rd port enters reference arm, the light beam entering reference arm incides the first port of the second circulator 4, light goes out to enter fibre delay line 5 from the second end-fire of the second circulator 4, the effect of fibre delay line 5 regulates reference arm light path, reference arm is mated with sample arm light path, the emergent light of fibre delay line 5 incides faraday rotation mirror 6, acting as of faraday rotation mirror 6 eliminates polarization state change at random to the impact of interference signal, the light that faraday rotation mirror 6 reflects gets back to the second circulator 4, the second port of 50:50 fiber coupler 9 is entered again from the 3rd end of the second circulator 4, reference light and sample light interfere in 50:50 fiber coupler 9, interference light enters photoelectricity balanced detector 10 from the output port 3 of 50:50 fiber coupler 9 and port 4.Interference signal is converted to the signal of telecommunication by photoelectricity balanced detector 10, and the signal of telecommunication enters harvester 18 again;
Probe control device 7: probe control device 7 realizes the rotation of optical fiber in catheter probe 8 and rectilinear motion, comprises the compositions such as linear electric motors 13, electric rotating machine 11 and fiber rotation connector 12.Fiber rotation connector 12 realizes optical fiber as transmission medium, signal to be transmitted between the platform and another static platform of a rotation, complete the rotary transfer of fiber-optic signal, realize circumferential scanning respectively by control linear electric motors 13 and electric rotating machine 11 and withdraw.
Catheter probe 8: infrared light converges on target vessel wall by catheter probe 8, then the reflected light of target vessel wall different layers is collected and transmits back the sample arm of interferometer 17.
Harvester 18: by the triggering signal of tunable laser source 1 as external timing signal, synchronous acquisition interference image, harvester 18 comprises Data Acquisition Card 14 and image pick-up card 15, the signal of telecommunication that in Data Acquisition Card 14 synchronous acquisition interferometer 17, photoelectricity balanced detector 10 exports, image pick-up card 15 is converted to digital picture and is input to frame memory after over-sampling, quantification, realize high speed acquisition, then enter computer 16.
Computer 16: date processing is carried out to the data image signal that harvester 18 exports, comprises the Fourier transformation of interference signal, polar coordinate transform, image enhancement processing etc.
Claims (1)
1. an optical coherence tomograph for Ink vessel transfusing imaging, is characterized in that this device comprises:
Tunable laser source: for providing light source for the optical coherence tomograph of Ink vessel transfusing imaging, the tunable laser source of light source to be centre wavelength be 1310nm, for Michelson's interferometer provides the light source of near infrared band, the triggering signal of light source is as the external timing signal of harvester, probe control device;
Interferometer: interferometer is all-fiber Michelson structure, for generation of sample light and reference light interference signal, comprise 80:20 fiber coupler, the first circulator, the second circulator, faraday rotation mirror, fibre delay line, 50:50 fiber coupler and photoelectricity balanced detector;
Catheter probe: infrared light converges on target vessel wall by catheter probe, then the reflected light of target vessel wall different layers is collected and transmits back Michelson's interferometer sample arm;
Harvester: by the triggering signal of tunable laser source as external timing signal, synchronous acquisition interference image, harvester comprises Data Acquisition Card and image pick-up card, the signal of telecommunication that in Data Acquisition Card synchronous acquisition interferometer, photoelectricity balanced detector exports, image pick-up card is converted to digital picture and is input to frame memory after over-sampling, quantification, realize high speed acquisition, then enter computer;
Computer: date processing is carried out to the data image signal that harvester exports, comprises the Fourier transformation of interference signal, polar coordinate transform, image enhancement processing etc.;
The emergent light of described tunable laser source is entered by 80:20 fiber coupler first port, and with the ratio of 80:20 respectively from second, 3rd port assignment is to reference arm and sample arm, the emergent light of 80:20 fiber coupler second port enters sample arm, the light beam entering sample arm incides the first port of the first circulator, light goes out to enter probe control device from the second end-fire of the first circulator and then incides catheter probe, light incides sample from catheter probe, the back-scattering light of sample returns the first circulator, and the first port of 50:50 fiber coupler is entered from the first circulator the 3rd port, the emergent light of 80:20 fiber coupler the 3rd port enters reference arm, the light beam entering reference arm incides the first port of the second circulator, light goes out to enter fibre delay line from the second end-fire of the second circulator, the effect of fibre delay line regulates reference arm light path, reference arm is mated with sample arm light path, the emergent light of fibre delay line incides faraday rotation mirror, acting as of faraday rotation mirror eliminates polarization state change at random to the impact of interference signal, the light that faraday rotation mirror reflects gets back to the second circulator, the second port of 50:50 fiber coupler is entered again from the 3rd end of the second circulator, reference light and sample light interfere in 50:50 fiber coupler, interference light enters photoelectricity balanced detector from the output port 3 of 50:50 fiber coupler and port 4, interference signal is converted to the signal of telecommunication by photoelectricity balanced detector, and the signal of telecommunication enters harvester again.
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| CN201521071829.7U CN205215191U (en) | 2015-12-17 | 2015-12-17 | Relevant chromatographic device of optics of formation of image in blood vessel |
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| CN201521071829.7U CN205215191U (en) | 2015-12-17 | 2015-12-17 | Relevant chromatographic device of optics of formation of image in blood vessel |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411530A (en) * | 2015-12-17 | 2016-03-23 | 天津求实飞博科技有限公司 | Novel optical coherence tomography device |
| CN106166058A (en) * | 2016-08-04 | 2016-11-30 | 温州医科大学 | One is applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN106236205A (en) * | 2016-07-27 | 2016-12-21 | 深圳市中科微光医疗器械技术有限公司 | A kind of type blood vessel navigation system based on near-infrared coherence tomography techniques and method |
| CN107468214A (en) * | 2017-08-22 | 2017-12-15 | 广东视觉支点医疗影像技术有限公司 | A kind of optical coherence tomography system and optical coherence tomographic imaging method |
| CN107713997A (en) * | 2017-11-29 | 2018-02-23 | 复旦大学附属中山医院 | A kind of fluid flow blood imaging device |
| CN109893099A (en) * | 2019-03-26 | 2019-06-18 | 苏州阿格斯医疗技术有限公司 | MLA-OCT imaging catheter, MLA-OCT imaging system and MLA-OCT imaging method |
| CN112957012A (en) * | 2021-02-01 | 2021-06-15 | 浙江省医疗器械检验研究院 | Axial resolution measuring device and method for optical interference tomography system |
-
2015
- 2015-12-17 CN CN201521071829.7U patent/CN205215191U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411530A (en) * | 2015-12-17 | 2016-03-23 | 天津求实飞博科技有限公司 | Novel optical coherence tomography device |
| CN106236205A (en) * | 2016-07-27 | 2016-12-21 | 深圳市中科微光医疗器械技术有限公司 | A kind of type blood vessel navigation system based on near-infrared coherence tomography techniques and method |
| CN106166058A (en) * | 2016-08-04 | 2016-11-30 | 温州医科大学 | One is applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN106166058B (en) * | 2016-08-04 | 2019-05-28 | 温州医科大学 | One kind being applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN107468214A (en) * | 2017-08-22 | 2017-12-15 | 广东视觉支点医疗影像技术有限公司 | A kind of optical coherence tomography system and optical coherence tomographic imaging method |
| CN107468214B (en) * | 2017-08-22 | 2024-04-16 | 广东唯仁医疗科技有限公司 | Optical coherence tomography system and optical coherence tomography method |
| CN107713997A (en) * | 2017-11-29 | 2018-02-23 | 复旦大学附属中山医院 | A kind of fluid flow blood imaging device |
| CN109893099A (en) * | 2019-03-26 | 2019-06-18 | 苏州阿格斯医疗技术有限公司 | MLA-OCT imaging catheter, MLA-OCT imaging system and MLA-OCT imaging method |
| CN109893099B (en) * | 2019-03-26 | 2021-04-23 | 苏州阿格斯医疗技术有限公司 | MLA-OCT imaging catheter, MLA-OCT imaging system and MLA-OCT imaging method |
| CN112957012A (en) * | 2021-02-01 | 2021-06-15 | 浙江省医疗器械检验研究院 | Axial resolution measuring device and method for optical interference tomography system |
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Granted publication date: 20160511 |