CN204121602U - A kind of deep brain stimulation system based on Neural stem cell - Google Patents
A kind of deep brain stimulation system based on Neural stem cell Download PDFInfo
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- CN204121602U CN204121602U CN201420556841.6U CN201420556841U CN204121602U CN 204121602 U CN204121602 U CN 204121602U CN 201420556841 U CN201420556841 U CN 201420556841U CN 204121602 U CN204121602 U CN 204121602U
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Abstract
This utility model discloses a kind of deep brain stimulation system based on Neural stem cell, comprise: the stimulating electrode in embedding brain, the electrode receiving coil be connected with stimulating electrode afterbody, be positioned at the stimulation transmitting coil above electrode receiving coil, be positioned at the pulse generator outside brain, and connect the connecting line stimulating transmitting coil and pulse generator.This utility model can reduce equipment cost, extension device service life, and operating difficulty is low, little to the side effect of patient.
Description
Technical field
This utility model relates to brain orientation magnetic stimulating technology field, deep, particularly relates to a kind of deep brain stimulation system based on Neural stem cell that pulse generator need not be embedded in chest.
Background technology
At present, the modulation of cerebral nerve function comprises Non-Invasive transcranial magnetic stimulation (transcranial magnetic stimulation, TMS) and has the deep brain stimulation (Deep brain stimulation, DBS) of wound property.TMS utilizes electromagnetic induction principle, discharged to stimulating coil by electrical switch by the high-voltage capacitance of energy storage, stimulating coil produces the magnetic field permeates skull of transition, the cortex shallow at brain table brings out faradic current, stimulate intracranial neural, cause the change of nervous cell membrane potential, excitatoty change and regulate function of nervous system.Neural stem cell intensity, along with the increase exponentially form decline of distance, it is generally acknowledged that the effective stimulus degree of depth of TMS only has 2 ~ 2.5 centimetres.TMS can make cerebral deep to be stimulated of special H type coil, but field stimulation is large, and precision is not high.DBS requires that the cerebral deep of high accuracy (grade) stimulates, and DBS is the treatment technology of a kind of new delayed ischemic neurological deficits implemented of functional neurosurgery surgery in recent years, belongs to the Therapeutic Method having wound property, highly difficult, high cost.
DBS equipment is usually referred to as brain pacemaker, comprises 3 vivo implantation type parts: stimulate the electrode of deep brain, connecting line and electric pulse generator.This technical requirement neurosurgeon is when anesthesia of patient, the skull hole that diameter is 14 millimeters is cut at head, adopt the airmanship of three-dimensional locating frame, cerebral deep electrode is inserted cerebral deep target stimulation position, connect from scalp by the subcutaneous implantation connecting line of cervical region to chest, then receive chest subcutaneous implantation titanium shell by battery-driven electric pulse generator.Send electric pulse to selection brain district by it, regulate different stimulus frequency and intensity, disease such as treatment central motion and emotive function obstacle etc.
At present, the indication of DBS is the dyskinesia, as parkinson, tremor syndromes, myodystonia; Pain syndrome: as central pain syndrome, nociceptive pain, neuropathic pain; Also may treat mental disorder as obsession, depression, addictive disorders etc.
Although DBS technology thinks a kind of method for the treatment of delayed ischemic neurological deficits safely and effectively, there is following defect:
1, equipment cost is high;
2, the pulse generator of DBS needs by battery powered, limited battery life, and changing battery will carry out second operation, and external charging cost is higher.
3, require that the surgical technic of doctor is high, difficulty is large, operating time is long.
4, large to patient's wound surface, from the beginning arrive neck and all want embedding foreign body to breast, can surgical injury be produced; Side effect is many, and stimulator and connecting line are as having rejection, pain and other discomforts in the embedding body of foreign body.
Utility model content
In order to overcome the deficiencies in the prior art, the utility model proposes one and can reduce equipment cost, extension device service life, operating difficulty is low, the deep brain stimulation system based on Neural stem cell little to the side effect of patient.
In order to achieve the above object, the utility model proposes a kind of deep brain stimulation system based on Neural stem cell, comprise: the stimulating electrode in embedding brain, the electrode receiving coil be connected with described stimulating electrode afterbody, be positioned at the stimulation transmitting coil above described electrode receiving coil, be positioned at the pulse generator outside brain, and connect the connecting line of described stimulation transmitting coil and pulse generator.
Preferably, described electrode receiving coil is enclosed with silica gel.
Preferably, described electrode receiving coil is wrapped in the brain Intradermal of brain, and described stimulation transmitting coil is placed in outside brain skin.
Preferably, also should comprise based on the deep brain stimulation system of Neural stem cell: be positioned at the coil fixed plastics sheet outside brain, described stimulation transmitting coil is fixed on described coil fixed plastics sheet.
Preferably, described coil fixed plastics sheet is fastened on brain by elastic band.
Preferably, described pulse generator is provided with optimum configurations and start-stop button.
Preferably, the stimulus intensity of described pulse generator is: 0 ~ 25mA, and frequency is: 2 ~ 250Hz, and pulse width is: 50 ~ 500us.
A kind of deep brain stimulation system based on Neural stem cell that the utility model proposes, compared to existing technology, has following beneficial effect:
1, need not the embedding connecting line of original DBS and the pulse generator of titanium alloy casing, reduce body embedded set parts, make large-arealy have invasive procedures to become Minimally Invasive Surgery, decrease operating difficulty, operating time, operation risk and side effect; Be beneficial to the popularization of DBS technology;
2, pulse generator and the coil of stimulating electrode are without directly contacting, and local be that wireless electric pulse conducts, and pulse generator replaceable battery (or with rechargeable battery) at any time, the cost of material is low, convenient maintenance and replacement, can use indefinite duration;
3, equipment cost is low.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of this utility model based on the deep brain stimulation system of Neural stem cell;
Fig. 2 is this utility model based on the deep brain stimulation system moderate stimulation receiving coil of Neural stem cell and the connection diagram of stimulating electrode in skull.
In order to make the technical solution of the utility model clearly, understand, be described in further detail below in conjunction with accompanying drawing.
Detailed description of the invention
Should be appreciated that specific embodiment described herein only in order to explain this utility model, and be not used in restriction this utility model.
As shown in Figure 1, a kind of deep brain stimulation system based on Neural stem cell that this utility model preferred embodiment proposes, comprise: the stimulating electrode 1 in embedding brain, the electrode receiving coil 2 be connected with described stimulating electrode 1 afterbody, be positioned at the stimulation transmitting coil 3 above described electrode receiving coil 2, be positioned at the pulse generator 4 outside brain, and connect the connecting line 5 of described stimulation transmitting coil 3 and pulse generator 4.
Wherein, electrode receiving coil 2 is enclosed with silica gel, is embedded in skull tapping, is wrapped in the brain Intradermal of brain, sews up scalp and completes Minimally Invasive Surgery.
Described stimulation transmitting coil 3 is placed in outside brain skin, and is fixed on human brain by the coil fixed plastics sheet 6 outside brain; Coil fixed plastics sheet 6 is fastened on brain by elastic band 7.
Particularly, according to electromagnetic induction and the electromagnetic conversion principle of transcranial magnetic stimulation, be connected to pulse generator 4 with 1 ~ n miniature stimulation transmitting coil 3 (how many decisions according to stimulating electrode 1) as adapter.
Cerebral deep stimulating electrode 1 adopts the cerebral deep implanted electrode of DBS, the afterbody of stimulating electrode 1 connects a diameter and is 14 millimeters (this size can set according to practical situation, do not limit at this) silica gel parcel coil, as the receiving coil of stimulating electrode 1, be embedded in skull tapping, sew up scalp and complete Minimally Invasive Surgery.
The electric pulse that pulse generator 4 sends produces transient magnetic field through stimulation oversaturation transmitting coil 3, when this magnetic field is near close electrode receiving coil 2, induced voltage is produced at electrode receiving coil 2 internal cutting coil, stimulated the target tissue of cerebral deep by stimulating electrode 1, reach the object stimulating cerebral deep.
The present embodiment only need cut at head local skin, opens the aperture of 14mm diameter with hole making drill in skull, prepares to insert stimulating electrode 1, as shown in Figure 2.
Below elaborate the ultimate principle of this utility model embodiment:
Such as, stimulate the corpus hypothalamicum in brain district, deep, only need first utilize the image data of MRI to carry out three-dimensional localization on computers in advance with nuclear magnetic resonance (MRI), under the prerequisite avoiding critical function district, determine that stimulating electrode 1 inserts position, direction, the degree of depth.Function surgeon utilizes type solid frame positioning equipment, and stimulating electrode 1 is inserted target stimulation position, and error can be grade.
The present embodiment retains the cerebral deep stimulating electrode 1 in original DBS system, encloses (1 ~ n circle), as embedding parts at the tail end connecting line 5 of stimulating electrode 1.
At the afterbody of stimulating electrode 1, the tapping of skull connects the receiving coil of stimulating electrode 1, and receiving coil is with silica gel peplos, and receiving coil size, close to diameter 14mm, can be filled among skull holes, then sew up scalp, makes DBS become Wicresoft's minor operation.
Portable hand-holding type pulse generator 4 can regulate various stimulus parameter easily, export connecting line 5 and receive stimulation transmitting coil 3, stimulate transmitting coil 3 according to the position of head imbedded electrode receiving coil 2, correspondence is fixed on coil fixed plastics sheet 6, there is elastic band 7 at coil fixed plastics sheet 6 two ends, when being convenient to stimulate, transmitting coil 3 is stimulated relatively to be fixed on above electrode receiving coil 2.
Stimulate transmitting coil 3 and stimulate receiving coil standoff distance very little, composition one secondary iron-core-free transformator.Stimulate elementary as transformator of transmitting coil 3, stimulate secondary as transformator of receiving coil, change the current parameters in primary coil, just equal proportion can change induced voltage and the stimulating current of stimulation receiving coil.
The present embodiment pulse generator 4 can adopt existing pulse generator 4 to adopt portable hand-held pulse generator 4, and pulse generator 4 is provided with optimum configurations and start-stop button 8.This pulse generator 4 is made up of elements such as casing, liquid crystal display screen, button, single-chip microcomputer, battery supply, booster circuit, storage capacitor, pulse wave generator, constant current output circuits, the output parameter that it is adjustable following (being certainly also not limited to following scope):
Stimulus intensity is: 0 ~ 25mA, and frequency is: 2 ~ 250Hz, and pulse width is: 50 ~ 500us, and (string) stimulates time-histories: 0 ~ 20s, and the intermittent time is: 0 ~ 20s, and stimulation duration is: 0 ~ 30m, channel selecting: 1,2,1 and 2.Be 88Hz with stimulus frequency in Fig. 1, stimulation time-histories is 88s, stimulate the intermittent time to be: 88s, stimulate duration to be: 88m, stimulus wave are wide is: 88us, stimulus intensity are: 88mA, channel selecting: 12.
Compared to existing technology, this utility model, based on the deep brain stimulation system of Neural stem cell, has following beneficial effect:
1, need not the connecting line 5 of embedding original DBS and the pulse generator 4 of titanium alloy casing, reduce body embedded set parts, make large-arealy have invasive procedures to become Minimally Invasive Surgery, decrease operating difficulty, operating time, operation risk and side effect; Be beneficial to the popularization of DBS technology;
2, pulse generator 4 and the coil of stimulating electrode 1 are without directly contacting, and local be that wireless electric pulse conducts, and pulse generator 4 replaceable battery (or with rechargeable battery) at any time, the cost of material is low, convenient maintenance and replacement, can use indefinite duration;
3, equipment cost is low.
Above are only preferred embodiment of the present utility model; not thereby the scope of the claims of the present utility model is limited; every utilize this utility model description and accompanying drawing content to do equivalent structure or flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present utility model.
Claims (7)
1. the deep brain stimulation system based on Neural stem cell, it is characterized in that, comprise: the stimulating electrode in embedding brain, the electrode receiving coil be connected with described stimulating electrode afterbody, be positioned at the stimulation transmitting coil above described electrode receiving coil, be positioned at the pulse generator outside brain, and connect the connecting line of described stimulation transmitting coil and pulse generator.
2. the deep brain stimulation system based on Neural stem cell according to claim 1, is characterized in that, described electrode receiving coil is enclosed with silica gel.
3. the deep brain stimulation system based on Neural stem cell according to claim 2, is characterized in that, described electrode receiving coil is wrapped in the brain Intradermal of brain, and described stimulation transmitting coil is placed in outside brain skin.
4. the deep brain stimulation system based on Neural stem cell according to claim 1,2 or 3, is characterized in that, also comprise: be positioned at the coil fixed plastics sheet outside brain, and described stimulation transmitting coil is fixed on described coil fixed plastics sheet.
5. the deep brain stimulation system based on Neural stem cell according to claim 4, is characterized in that, described coil fixed plastics sheet is fastened on brain by elastic band.
6. the deep brain stimulation system based on Neural stem cell according to claim 1, is characterized in that, described pulse generator is provided with optimum configurations and start-stop button.
7. the deep brain stimulation system based on Neural stem cell according to claim 6, is characterized in that, the stimulus intensity of described pulse generator is: 0 ~ 25mA, and frequency is: 2 ~ 250Hz, and pulse width is: 50 ~ 500us.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420556841.6U CN204121602U (en) | 2014-09-19 | 2014-09-19 | A kind of deep brain stimulation system based on Neural stem cell |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420556841.6U CN204121602U (en) | 2014-09-19 | 2014-09-19 | A kind of deep brain stimulation system based on Neural stem cell |
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| CN204121602U true CN204121602U (en) | 2015-01-28 |
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| CN201420556841.6U Expired - Lifetime CN204121602U (en) | 2014-09-19 | 2014-09-19 | A kind of deep brain stimulation system based on Neural stem cell |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107085A (en) * | 2015-09-18 | 2015-12-02 | 深圳英智科技有限公司 | Mobile equipment based cranial electrotherapy stimulation instrument |
| CN105999545A (en) * | 2016-06-08 | 2016-10-12 | 深圳英智科技有限公司 | Cerebral apoplexy rehabilitation device |
| US10201715B2 (en) | 2015-04-15 | 2019-02-12 | Regents Of The University Of Minnesota | Magnetic nanostimulator and nanosensor array for biological material stimulation and sensing |
-
2014
- 2014-09-19 CN CN201420556841.6U patent/CN204121602U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10201715B2 (en) | 2015-04-15 | 2019-02-12 | Regents Of The University Of Minnesota | Magnetic nanostimulator and nanosensor array for biological material stimulation and sensing |
| CN105107085A (en) * | 2015-09-18 | 2015-12-02 | 深圳英智科技有限公司 | Mobile equipment based cranial electrotherapy stimulation instrument |
| CN105999545A (en) * | 2016-06-08 | 2016-10-12 | 深圳英智科技有限公司 | Cerebral apoplexy rehabilitation device |
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