CN1857378A - Compound wild kiwi tablet and its preparing method - Google Patents
Compound wild kiwi tablet and its preparing method Download PDFInfo
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- CN1857378A CN1857378A CN 200610050086 CN200610050086A CN1857378A CN 1857378 A CN1857378 A CN 1857378A CN 200610050086 CN200610050086 CN 200610050086 CN 200610050086 A CN200610050086 A CN 200610050086A CN 1857378 A CN1857378 A CN 1857378A
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Abstract
The present invention discloses a kind of compound wild kiwi tablet and its preparation process. The compound wild kiwi tablet is prepared with wild kiwi, angelica, astragalus root, tuckahoe, and American ginseng in certain weight proportion, and through decocting, filtering, concentrating filtrate to form extractum, spray drying the extractum, vacuum or vacuum freeze drying, crushing, sieving, mixing with supplementary material, pelletizing, drying, tabletting, and coating. The present invention is one health food with high curative effect and possessing functions of benefiting Qi, nourishing blood and raising immunity. It is suitable for being taken by health people and patients with immunological hypofunction.
Description
Technical field
The present invention relates to a kind ofly have antitumor, encourage healthy trends, enhance immunity ability effect, be that the compound recipe of primary raw material is swallowed sheet with a kind of wild Fructus actinidiae chinensis (being commonly called as the Radix actinidiae valvatae)---Chinese mugwort can tablet and the Preparation method and use of this tablet.
Background technology
Do not have clear and definite disease though sub-health state is meant people's body, the vigor that presents reduces, adaptive faculty goes down, the state that a kind of physiological function between health and disease reduces.Global the survey showed that according to one of The World Health Organization (WHO), and the people of whole world true health only accounts for 5%, diagnoses ill people to account for 20%, and the sub-health state that has 75% people to be in.Subhealth state has become the No.1 stealthy killer of current harm humans health, also is one of difficult problem of facing of modern medicine.Along with the continuous enhancing of the development of Chinese national economy and broad masses of the people's health care consciousness, people call the natural health care of healthy gain, determined curative effect, and inquiring after can be away from subhealth state, stay the active drug in youth forever.Yet at present because people absorb animal food and polish food is too much, add that work rhythm anxiety, pressure are big, caused " modern civilization disease ", not good as energy, emotion is low, insomnia and dreamful sleep etc.Moreover, the development of modernization industry, people's living environment goes from bad to worse, air, water source, grain, fruit, vegetable etc. and human life material in close relations is in the encirclement of harmful substance invariably, this has brought many severe impairment to people, such as gene mutation, cell senescence (free radical increases), immunne response weakens etc., concentrated expression go out as tumor patient increase, sub-health state generalizes.Therefore, effective health food of antitumor, enhancing immunity gains great popularity.But nourishing product on the market mostly is the scorching medicine of shape sun at present, and the non-chronically ill man and the person of having a delicate constitution are suitable for; Press for a kind of raising immunologic function of research and development, health invigorating resistance against diseases, the gentle pure natural preparation of effect of promotion physical rehabilitation.
The Radix actinidiae valvatae is a kind of wild Fructus actinidiae chinensis resource, is medical herbs commonly used among the people.Put down in writing according to the Chinese medicine dictionary: have the effect of removing toxic substances and promoting subsidence of swelling, expelling wind and removing dampness, the clinical deep abscess that is used for the treatment of, osteomyelitis, rheumatic arthralgia, sore swollen toxin, liver cirrhosis jaundice ascites etc.; In addition, its curative effect to all kinds of digestive tract tumor has also obtained approval widely.This wild Fructus actinidiae chinensis of discovered in recent years is suppressing tumor growth, and improving the sign of life aspect has unique effect, has become another the anticarcinogen source from Actinidia after Fructus actinidiae chinensis (A.chinensis Planch.) root.However, up to the present, yet there are no the report of the relevant health food of this plant.We use the modern pharmaceutical technology, overcome the weak point of all multi-pharmaceuticss, make and swallow sheet, not only convenient for production, have reduced the loss of thermal sensitivity composition and volatile ingredient in the prescription again, when guaranteeing curative effect, conveniently take and carry.This is to inheriting and develop motherland's medicine legacy, and is significant.
Cited literature 2:
1.. Zhao Ruiqin, Song Zhenfeng, 2002: the progress of subhealth state problem, foreign medical science social medicine fascicle, 19 (1): 10-13;
2.. He Jing, 2004: walk out subhealth state, away from " Lycoperdon polymorphum Vitt " life, scientific and technological digest, 7:82-87;
3.. Zhou Xingzhao, 2000; Tang Fuan opinion pulmonary carcinoma card is controlled Zhejiang College Of Traditional Chinese Medicine journal, 24 (2): 45;
4.. Jin Ruizhi, Wang Guoqiang, 1998; Radix actinidiae valvatae's soup treatment expansion example is released Zhejiang Journal of Traditional Chinese Medicine, 33 (1): 35;
5.. next ordinary, Zhang Hongyan, 2002; Zhejiang area is commonly used Chinese medicine Radix actinidiae valvatae progress, Zhejiang College Of Traditional Chinese Medicine journal, 26 (1): 77-78.
Summary of the invention
Purpose of the present invention provides a kind of taking dose little in order to overcome the deficiency of above technology, produces, takes, compound wild kiwi tablet easy to carry and preparation method thereof.
The present invention realizes by following measure:
1. compound wild kiwi tablet (Chinese mugwort energy tablet) and preparation method comprise the steps:
1.1 the prescription of compound wild kiwi tablet (Chinese mugwort energy tablet) is formed
The prescription of compound wild kiwi tablet is counted with weight portion:
Wild Fructus actinidiae chinensis 30-120 part
Radix Angelicae Sinensis 5-20 part
Radix Astragali 10-40 part
Poria 10-30 part
Radix Panacis Quinquefolii 1-5 part.
Its optimization formula is counted with weight portion:
60 parts of wild Fructus actinidiae chinensiss
10 parts of Radix Angelicae Sinensis
20 parts of the Radixs Astragali
15 parts in Poria
Radix Panacis Quinquefolii 1-5 part.
1.2 the preparation technology of compound wild kiwi tablet (Chinese mugwort energy tablet)
Get the prescription Chinese crude drug, extract to be prepared into suitable technology and swallow sheet, its preparation technology can adopt following technology, also can adopt other suitable technology.
Technology one by the partition uniform mixing, decocts with water the five tastes medical material 2-3 time, and each 1-3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, and thick paste spray drying/vacuum drying/vacuum lyophilization becomes dried cream, and crushing screening is made uniform powder.Add appropriate amount of auxiliary materials, mixing is granulated, drying, and tabletting, coating, promptly.
Technology two uses the edible ethanol of 60-95% to extract 2-3 time wild Fructus actinidiae chinensis, and each 1.5-2 hour, merge extractive liquid, filtered, and reclaims ethanol, and it is standby to get extractum; Poria adds flooding, and leachate filters, filtrate for later use; Radix Angelicae Sinensis, the Radix Astragali, Radix Panacis Quinquefolii decoct with water 2-3 time with above-mentioned wild Fructus actinidiae chinensis medicinal residues, and each 1-3 hour, collecting decoction, filter, filtrate is mixed wild Fructus actinidiae chinensis extractum and Poria filtrate, is condensed into thick paste, thick paste spray drying, vacuum drying or vacuum lyophilization become dried cream, and crushing screening is made uniform powder, the adding adjuvant, mixing, granulate drying, tabletting, coating, promptly.
1.3 the adjuvant and the concrete technology of preparation compound wild kiwi tablet (Chinese mugwort energy tablet)
The technology Chinese crude drug is ground into coarse powder/be cut into decoction pieces, is generally 5-50 purpose coarse powder/be cut into decoction pieces, and the best was a 20-40 order coarse powder.
Thick paste final pulverizing before adding adjuvant is 80-160 purpose fine powder in the technology, and the best is broken into 200-300 purpose fine powder for superfine powder.
The pure extracting method that adopts in the technology, the alcohol extraction condition is: the edible ethanol with 60-95% is a solvent, can adopt heating reflux method or ooze foot of a hill or mountain method or method that other is suitable is extracted, the best is with 70% edible ethanol heating and refluxing extraction 2 times, each 2 hours.
The water extracting method that adopts in the technology, water are put forward condition and be: warm macerating (50 ℃-90 ℃) decocted 2-3 time after 5-12 hour, and amount of water is doubly measured for the 6-15 of dose for the first time, and second and third time doubly measured for the 4-12 of dose, each 0.5-4 hour; The best is after 8 times of water gagings boil, and 80 ℃ of warm macerating 5 hours decoct 3 times, and amount of water is respectively 10,8,8 times of dose, and the time was respectively 2,2,1 hours.Medicinal residues add when frying in shallow oil together, can add when decocting for the second time.
The drying of extract can adopt vacuum drying or spray drying or other proper method in the technology.The vacuum drying temperature is controlled at 50 ℃-80 ℃; The best is 60 ℃.Spray drying is for to be condensed into the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100 ℃-200 ℃, and leaving air temp is 50 ℃-150 ℃; Best relative density is 1.08-1.10 (60 ℃), and inlet temperature is 150 ℃-170 ℃, and leaving air temp is 80 ℃-100 ℃.
Concentrate in the technology and adopt concentrating under reduced pressure/thin film concentration/vacuum film to concentrate or other proper method.
Filter in the technology and can adopt conventional the filtration, centrifugal, ultrafiltration or other suitable method.
The tablet of gained can be with suitable coating material coating, as stomach dissolution type film-coat pre-mixing agent (Opadry), hydroxypropyl cellulose or other suitable material in the technology.
Used adjuvant can be lecithin, xylitol, sucrose, beta-schardinger dextrin-, HP-in the technology, and one or more in sorbitol, magnesium stearate or other the suitable adjuvant mix use, account for 15%～45% of total formula ratio.
2. the quality standard control of compound wild kiwi tablet (Chinese mugwort energy tablet) comprises functional component detection, stability test, hygiene inspection, toxicological experiment and pharmacological evaluation.
On functional component detects, require crude polysaccharides content 〉=3%, total saponin content 〉=2%; In stability test, require sample under 37 ℃ of-40 ℃ of temperature and 75% relative humidity condition, to be incubated 3 months, each index meets the relevant regulations of national health food; In hygiene inspection, require each index of sample to meet the relevant regulations of national health food; Toxicological experiment shows that Salmonella reversion test, mouse microkernel test, the sperm malformation test of Chinese mugwort energy tablet are all negative; Large and small Mus acute toxicity, long term toxicity test there is no toxic reaction; In pharmacological evaluation, no matter compound wild kiwi tablet (Chinese mugwort can tablet) still is that the defective body constitution of hypoimmunity can both provide body's immunity significantly to normal body constitution.
3. the effect of compound wild kiwi tablet (Chinese mugwort can tablet)
Compound wild kiwi tablet of the present invention (Chinese mugwort energy tablet) number medicine share, and plays the effect of antitumor, enhancing immunity.
Wild Fructus actinidiae chinensis (Radix actinidiae valvatae) is as China's southeast endemicity medical herbs, among the people long medicinal history arranged.For this reason, recorded this medicine in " local medical material standard " (Zhejiang Department of Public Health, 1994), for the developmental research and the comprehensive utilization of this medicine are laid a good foundation.Experimentation shows: with the Radix actinidiae valvatae is the various digestive tract tumor of master's decoction for the treatment based on hepatocarcinoma, and clinical efficacy is obvious, and the Radix actinidiae valvatae has the effect that improves patient's life quality and prolong life cycle.
Wild Fructus actinidiae chinensis is of long duration as growing the traditional herbal medicine that body complement and anti-disease cure the disease in China.It has is good for the stomach, treats dyspepsia, has the effect of removing toxic substances and promoting subsidence of swelling, expelling wind and removing dampness; The clinical deep abscess that is used for the treatment of, osteomyelitis, rheumatic arthralgia, sore swollen toxin, liver cirrhosis jaundice ascites etc. among the peoplely are usually used in treating all kinds of digestive tract tumor.It is suppressing tumor growth discovered in recent years, and improving the sign of life aspect also has unique effect.But disease is planted by Zhiduo County, and detumescence row become silted up, and can dissolve dead cell, and human body Central Asia chlorine nitrate class carcinogen is decomposed, regulating QI of the middle-JIAO, therefore can play analgesic relieving restlessness, promote the production of body fluid moisturize, health long-life, treatment dyspepsia, the effect of diseases such as inappetence.Numerous in recent years scholars study the pharmacologically active at each position of wild Fructus actinidiae chinensis plant, find to have blood fat reducing, anti peroxidation of lipid, removing reactive oxygen free radical, suppress tumor cell as some compositions such as Fructus actinidiae chinensis polysaccharide, improving the pharmacologically active of aspects such as immunologic function, is a kind of effective immunomodulator.
In addition, the Radix Astragali in the prescription has the effect of QI invigorating, strong body constitution; But Poria strengthening the spleen and stomach, mind tranquilizing and the heart calming; Radix Angelicae Sinensis energy benefiting blood and regulating blood circulation is moisturized laxation; Radix Panacis Quinquefolii lung benefiting the moon, clear asthenic fire.According to traditional Chinese medical science composition principle, carry out reasonable science compatibility, make whole prescription play heat-clearing and toxic substances removing, sore-throat relieving eliminating stagnation; QI invigorating, enrich blood; Profit nourishing bone marrow, the effect of regulating body's immunity.
Therefore, compound wild kiwi tablet of the present invention (Chinese mugwort energy tablet) has following advantage: certain antitumor, the effect of enhancing immunity are arranged, safe without toxic side effect, be applicable to physical weakness, be back on one's feet after a long illness, cancer rehabilitation and immunologic hypofunction crowd, simultaneously, normal body constitution crowd is also played the functions of prevention and health care that improves immunity; And preparation method is simple, is applicable to suitability for industrialized production and ingredient is not lost, and has overcome loaded down with trivial details, the frequent shortcoming of instructions of taking, and oral dose is less relatively, can play a role rapidly.
The specific embodiment
Following example can be for reference in order to further specify the present invention, but do not limit the scope of the invention thus.
Embodiment 1: five tastes medical material is cleaned respectively, remove impurity, it is standby to be up to the standards; Take by weighing 12.0 kilograms of wild Fructus actinidiae chinensiss (Radix actinidiae valvatae), 2.0 kilograms of Radix Angelicae Sinensis, 4.0 kilograms of the Radixs Astragali, 3.0 kilograms in Poria, 0.5 kilogram of Radix Panacis Quinquefolii, pulverize separately becomes coarse powder, and uniform mixing is standby; Medicinal material coarse powder adds water temperature and soaks (60 ℃) after 12 hours, and decocting three times, amount of water are respectively 10,8,8 times of dose, and the time was respectively 2,2,1 hours; Collecting decoction filters, and filtrate is concentrated into the concentrated solution that relative density is 1.05-1.15 (60 ℃), and spray drying is collected and obtained 2.9 kilograms of dried cream powders, and superfine powder is broken into the even fine powder of 200 purposes; Add 20% xylitol powder, with pure water spraying, boiling granulating (75 ℃ of inlet temperature; Injection flow rate 5R/MIN; 50 ℃ at dry terminal point); Granule adds 0.5% magnesium stearate, mixing, granulate, tabletting, coating (70～75 ℃ of inlet temperature, 45～55 ℃ of temperature of outgoing airs); Promptly get the present invention and get tablet, sheet is heavily controlled 0.5g ± 5%/sheet.
Usage and consumption: oral, 3 times on the 1st, each 1-2 sheet.
Embodiment 2: five tastes medical material is cleaned respectively, remove impurity, it is standby to be up to the standards; Take by weighing 3.0 kilograms of wild Fructus actinidiae chinensiss (Radix actinidiae valvatae), 0.5 kilogram of Radix Angelicae Sinensis, 1.0 kilograms of the Radixs Astragali, 1.0 kilograms in Poria, 0.1 kilogram of Radix Panacis Quinquefolii, pulverize separately becomes coarse powder, and uniform mixing is standby; Medicinal material coarse powder adds water temperature and soaks (60 ℃) after 12 hours, and decocting three times, amount of water are respectively 10,8,8 times of dose, and the time was respectively 2,2,1 hours; Collecting decoction filters, and filtrate is concentrated into the concentrated solution that relative density is 1.05-1.15 (60 ℃), and spray drying is collected and obtained 2.9 kilograms of dried cream powders, and superfine powder is broken into the even fine powder of 200 purposes; Add 35% mannitol powder, fully mixing is used 2%PVP
K30(50% alcoholic solution) system soft material is with pure water spraying, boiling granulating (75 ℃ of inlet temperature; Injection flow rate 5R/MIN; 50 ℃ at dry terminal point); Granule adds 2.5% magnesium stearate, mixing, granulate, tabletting, coating (70～75 ℃ of inlet temperature, 45～55 ℃ of temperature of outgoing airs); Promptly get the present invention and get tablet, sheet is heavily controlled 0.5g ± 5%/sheet.
Usage and consumption: oral, 3 times on the 1st, each 1-2 sheet.
Embodiment 3: five tastes medical material is cleaned respectively, remove impurity, it is standby to be up to the standards; Take by weighing 10.0 kilograms of wild Fructus actinidiae chinensiss (Radix actinidiae valvatae), 1.8 kilograms of Radix Angelicae Sinensis, 3.5 kilograms of the Radixs Astragali, 3.0 kilograms in Poria, 0.5 kilogram of Radix Panacis Quinquefolii, pulverize separately becomes coarse powder standby; Get Radix actinidiae valvatae's coarse powder, the edible ethanol heating and refluxing extraction with 70% 2 times, each 2 hours, merge extractive liquid, filtered, and reclaims ethanol, and it is standby to get extractum; The Poria coarse powder adds water temperature and soaks, and leachate filters, filtrate for later use; Radix Angelicae Sinensis, the Radix Astragali, Radix Panacis Quinquefolii coarse powder decoct with water 3 times with above-mentioned Radix actinidiae valvatae's medicinal residues, time was respectively 2,2,1 hours, collecting decoction, filter, filtrate and above-mentioned Radix actinidiae valvatae's extractum and Poria filtrate merge, being concentrated into relative density is the concentrated solution of 1.05-1.15 (60 ℃), and vacuum lyophilization gets dry extract 1.5 kilograms, micronizing to 200 order; Add 35% mannitol powder, fully mixing is used 2%PVP
K30(50% alcoholic solution) system soft material is with pure water spraying, boiling granulating (75 ℃ of inlet temperature; Injection flow rate 5R/MIN; 50 ℃ at dry terminal point); Granule adds 2.5% magnesium stearate, mixing, granulate, tabletting, coating (70～75 ℃ of inlet temperature, 45～55 ℃ of temperature of outgoing airs); Promptly get the present invention and get tablet, sheet is heavily controlled 0.5g ± 5%/sheet.
Usage and consumption: oral, 3 times on the 1st, each 1-2 sheet.
Embodiment 4: five tastes medical material is cleaned respectively, remove impurity, it is standby to be up to the standards; Take by weighing 4.0 kilograms of wild Fructus actinidiae chinensiss (Radix actinidiae valvatae), 0.6 kilogram of Radix Angelicae Sinensis, 1.5 kilograms of the Radixs Astragali, 1.0 kilograms in Poria, 0.3 kilogram of Radix Panacis Quinquefolii, pulverize separately becomes coarse powder standby; Get Radix actinidiae valvatae's coarse powder, the edible ethanol heating and refluxing extraction with 70% 2 times, each 2 hours, merge extractive liquid, filtered, and reclaims ethanol, and it is standby to get extractum; The Poria coarse powder adds water temperature and soaks, and leachate filters, filtrate for later use; Radix Angelicae Sinensis, the Radix Astragali, Radix Panacis Quinquefolii coarse powder decoct with water 3 times with above-mentioned Radix actinidiae valvatae's medicinal residues, time was respectively 2,2,1 hours, collecting decoction, filter, filtrate and above-mentioned Radix actinidiae valvatae's extractum and Poria filtrate merge, being concentrated into relative density is the concentrated solution of 1.05-1.15 (60 ℃), and vacuum lyophilization gets dry extract 1.5 kilograms, micronizing to 200 order; Add 20% xylitol powder, with pure water spraying, boiling granulating (75 ℃ of inlet temperature; Injection flow rate 5R/MIN; 50 ℃ at dry terminal point).Granule adds 0.5% magnesium stearate, mixing, granulate, tabletting, coating (70～75 ℃ of inlet temperature, 45～55 ℃ of temperature of outgoing airs).Promptly get the present invention and get tablet, sheet is heavily controlled 0.5g ± 5%/sheet.
Usage and consumption: oral, 3 times on the 1st, each 1-2 sheet.
The compound wild kiwi tablet (Chinese mugwort energy tablet) that makes with said method carries out quality standard control, and the result is as follows:
1. compound wild kiwi tablet (Chinese mugwort energy tablet) functional component detection, stability and hygiene inspection
According to " dependence test is carried out in the requirement of Chinese pharmacopoeia (2000 editions) and Ministry of Public Health " health food check and assessment technique standard " (2003 editions), the result shows: crude polysaccharides content 〉=3% in the compound wild kiwi tablet (Chinese mugwort energy tablet), total saponin content 〉=2%; In stability test, sample is incubated 3 months under 37 ℃ of-40 ℃ of temperature and 75% relative humidity condition, and each index (functional component, moisture, ash, protein, heavy metal and microorganism etc.) all meets the relevant regulations of national health food; In hygiene inspection, each index of sample (functional component, moisture, ash, protein, heavy metal and microorganism etc.) meets the relevant regulations of national health food.
2. compound wild kiwi tablet (Chinese mugwort can tablet) toxicological experiment
First and second stage toxicity test
According to the requirement of Ministry of Public Health " health food check and assessment technique standard " (2003 editions), compound wild kiwi tablet (Chinese mugwort energy tablet) is carried out first and second stage toxicity test.Result of the test shows: phase I large and small Mus acute oral toxicity median lethal dose(LD 50) (LD
50), bisexuality is pressed acute toxicity grading criteria and is judged the true border of this sample non-toxic type all greater than the 1000mg/kg body weight; The result is negative for the second stage Salmonella reversion test; Mouse marrow cell micro nuclear test and mouse sperm deformity result of the test are all negative.This explanation, compound wild kiwi tablet (Chinese mugwort energy tablet) does not show mutagenicity.
30 days feeding trials of rat
According to the requirement of Ministry of Public Health " health food check and assessment technique standard " (2003 editions), compound wild kiwi tablet (Chinese mugwort energy tablet) is carried out 30 days feeding trials of rat.Result of the test shows: establish basic, normal, high three the dosage groups of compound wild kiwi tablet (Chinese mugwort energy tablet), be equivalent to 25 times, 50 times and 100 times of people's recommended intake respectively, 30 days every indexs of feeding trial three dosage groups of rat there is no the overt toxicity reaction.
3. compound wild kiwi tablet (Chinese mugwort can tablet) pharmacological experiment
Requirement according to Ministry of Public Health " health food check and assessment technique standard " (2003 editions), the pharmacological evaluation of compound wild kiwi tablet (Chinese mugwort energy tablet) in normal mouse carried out the inductive mouse spleen lymphocyte conversion test of following test: ConA, the mice serum hemolysin is measured, antibody-producting cell detects (hemolysis plaque number) and the NK cytoactive is measured.If compound wild kiwi tablet (Chinese mugwort can tablet) continuous 30 days feedings of basic, normal, high three dosage groups are equivalent to 5 times, 10 times and 30 times of people's recommended intake respectively, establish negative control group (distilled water) simultaneously.Result of the test shows, compares with negative control group, and middle and high dosage group all can improve the multiplication capacity of the inductive mouse spleen lymphocyte of ConA, and significant difference (q check, p＜0.05); High dose group can improve the NK cells in mice activity, significant difference (q check, p＜0.05); Middle dosage group can improve mice hemolysis plaque number, and difference has significance (q check, p＜0.05); Middle dosage group can improve the mice serum hemolysin, and difference has significance (q check, p＜0.05).Therefore, think that compound wild kiwi tablet (Chinese mugwort energy tablet) has the function of enhancing immunity to normal body constitution.(seeing Table 1)
Requirement according to Ministry of Public Health " health food check and assessment technique standard " (2003 editions), the pharmacological evaluation of compound wild kiwi tablet (Chinese mugwort energy tablet) in deficient mice carried out the inductive mice spleen T lymphocyte transformation test of following test: ConA, the mice serum hemolysin is measured and macrophage phagocytic function is measured.If compound wild kiwi tablet (Chinese mugwort can tablet) continuous 30 days feedings of basic, normal, high three dosage groups are equivalent to 5 times, 10 times and 30 times of people's recommended intake respectively, establish negative control group (distilled water) simultaneously.Result of the test shows, with the tumor matched group relatively, low, middle dosage group all can significantly improve the lymphocytic multiplication capacity of the inductive mice spleen T of ConA (q check, p＜O.001～0.01); Basic, normal, high three dosage groups all can significantly improve the mice serum hemolysin, and difference has significance (q check, p＜O.001); Low dose group can improve the mouse macrophage activate the phagocytic capacity, significant difference (q check, p＜0.05).Therefore, think that compound wild kiwi tablet (Chinese mugwort energy tablet) has the function of enhancing immunity to hypoimmunity body constitution.(seeing Table 2)
Table 1
Compound wild kiwi tablet (Chinese mugwort energy tablet) is to the pharmacological evaluation of normal mouse
| Group | Number of animals (only) | Lymphopoiesis ability (optical density difference) | Mice serum hemolysin influence (antibody product value) | NK cells in mice activity influence (%) | Hemolysis plaque number (individual/10 6Splenocyte) | |
| Negative control group (H 2O) | 10 | 0.147±0.024 | 140.5±19.1 | 25.8±5.3 | 61±10 | |
| Compound wild kiwi tablet | 0.33g/kg | 10 | 0.169±0.026 | 145.9±26.9 | 59±14 | 26.2±5.8 |
| 0.67g/kg | 10 | 0.229±0.035 * | 166.4±18.7 * | 76±11 * | 27.8±6.4 | |
| 2.00g/kg | 10 | 0.213±0.030 * | 154.7±16.0 | 70±13 | 34.3±4.7 * | |
*Expression q check is compared p＜0.05 with negative control.
Table 2
Compound wild kiwi tablet (Chinese mugwort energy tablet) is to S
180The tumor-bearing mice pharmacological experiment
| Group | Number of animals (only) | Lymphopoiesis ability (cpm) | Mice serum hemolysin influence (antibody product value) | Macrophage phagocytosis of mice (CI%) | |
| Tumor model group (H 2O) | 1O | 1642±704 | 43.2±9.26 | 26.0±4.52 | |
| Compound wild kiwi tablet | 0.33g/kg | 10 | 3749±1105 *** | 123.5±15.59 *** | 30.8±3.99 * |
| 0.67g/kg | 1O | 3013±1390 ** | 111.2±12.11 *** | 27.6±3.41 | |
| 2.00g/kg | 10 | 1483±524 | 121.3±1O.10 *** | 28.1±5.38 | |
*,
*,
* *Expression q check is compared p＜0.05,0.01,0.001 with tumor.
Above result is respectively through Zhejiang Center For Disease Control and Prevention, Inst. of Traditional Chinese Medicine, Zhejiang Prov authority's checking.The result shows: compound wild kiwi tablet (Chinese mugwort energy tablet) has good pharmacologically active, has the effect that improves body immunity, and safe without toxic side effect.
Claims (6)
1. compound wild kiwi tablet is characterized in that its prescription is counted with weight portion:
Wild Fructus actinidiae chinensis 30-120 part
Radix Angelicae Sinensis 5-20 part
Radix Astragali 10-40 part
Poria 10-30 part
Radix Panacis Quinquefolii 1-5 part.
2. a kind of compound wild kiwi tablet according to claim 1 is characterized in that its optimization formula is counted with weight portion:
60 parts of wild Fructus actinidiae chinensiss
10 parts of Radix Angelicae Sinensis
20 parts of the Radixs Astragali
15 parts in Poria
Radix Panacis Quinquefolii 1-5 part.
3. the preparation method of compound wild kiwi tablet according to claim 1 is characterized in that, with five tastes material by the partition uniform mixing, decoct with water 2-3 time, each 1-3 hour, collecting decoction, filter, filtrate is condensed into thick paste, and thick paste spray drying, vacuum drying or vacuum lyophilization become dried cream, and crushing screening is made uniform powder, adding adjuvant, mixing, granulate drying, tabletting, coating, promptly.
4. the preparation method of a kind of compound wild kiwi tablet according to claim 3, it is characterized in that described adjuvant can be lecithin, xylitol, sucrose, beta-schardinger dextrin-, HP-, in sorbitol, magnesium stearate or other the suitable adjuvant one or more mix use, account for 15%～45% of total formula ratio.
5. the preparation method of compound wild kiwi tablet according to claim 1 is characterized in that, wild Fructus actinidiae chinensis is extracted 2-3 time with the edible ethanol of 60-95%, and each 1.5-2 hour, merge extractive liquid, filtered, and reclaims ethanol, and it is standby to get extractum; Poria adds flooding, and leachate filters, filtrate for later use; Radix Angelicae Sinensis, the Radix Astragali, Radix Panacis Quinquefolii decoct with water 2-3 time with above-mentioned wild Fructus actinidiae chinensis medicinal residues, and each 1-3 hour, collecting decoction, filter, filtrate is mixed wild Fructus actinidiae chinensis extractum and Poria filtrate, is condensed into thick paste, thick paste spray drying, vacuum drying or vacuum lyophilization become dried cream, and crushing screening is made uniform powder, the adding adjuvant, mixing, granulate drying, tabletting, coating, promptly.
6. the preparation method of a kind of compound wild kiwi tablet according to claim 5, it is characterized in that described adjuvant can be lecithin, xylitol, sucrose, beta-schardinger dextrin-, HP-, in sorbitol, magnesium stearate or other the suitable adjuvant one or more mix use, account for 15%～45% of total formula ratio.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099137A (en) * | 2011-11-11 | 2013-05-15 | 西南科技大学 | Kiwi effervescent tablet and process thereof |
| CN104305056A (en) * | 2014-11-10 | 2015-01-28 | 重庆食品工业研究所 | Microencapsulated kiwi fruit ultramicropowder and preparation method thereof |
| CN115336744A (en) * | 2022-08-19 | 2022-11-15 | 黑龙江省农业科学院食品加工研究所 | Black fungus leisure food and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099137A (en) * | 2011-11-11 | 2013-05-15 | 西南科技大学 | Kiwi effervescent tablet and process thereof |
| CN103099137B (en) * | 2011-11-11 | 2015-04-15 | 西南科技大学 | Kiwi effervescent tablet and process thereof |
| CN104305056A (en) * | 2014-11-10 | 2015-01-28 | 重庆食品工业研究所 | Microencapsulated kiwi fruit ultramicropowder and preparation method thereof |
| CN115336744A (en) * | 2022-08-19 | 2022-11-15 | 黑龙江省农业科学院食品加工研究所 | Black fungus leisure food and preparation method thereof |
| CN115336744B (en) * | 2022-08-19 | 2023-05-05 | 黑龙江省农业科学院食品加工研究所 | Black fungus leisure food and preparation method thereof |
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