CN1553787A - Laser skin perforator - Google Patents
Laser skin perforator Download PDFInfo
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- CN1553787A CN1553787A CNA018189024A CN01818902A CN1553787A CN 1553787 A CN1553787 A CN 1553787A CN A018189024 A CNA018189024 A CN A018189024A CN 01818902 A CN01818902 A CN 01818902A CN 1553787 A CN1553787 A CN 1553787A
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- Prior art keywords
- laser beam
- skin
- cup
- shaped spare
- perforation device
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- A61B5/150061—Means for enhancing collection
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Abstract
A laser perforator for perforating skin of a patient and obtaining of blood samples consists of laser light source for producing an output laser beam, a focusing arrangement for focusing the output laser beam at a skin area selected for perforation, a guiding arrangement, a power supply unit and a retaining arrangement for retaining the skin area. The retaining arrangement is formed to intensify blood circulation in the skin area selected for perforation.
Description
The U.S. Provisional Application S.N.60/249 that this non-provisional application requires Valentin A.Gruzdev and Pavel V.Efremkin to propose on November 16th, 2000 according to 35 USC 119 (e), 175 priority.
Technical field
The present invention generally relates to medical laser instrument, and the skin that is specifically related to be used for to patient is contactlessly bored a hole with the Medical Instruments of blood sample collection.
Background technology
The capillary tube blood sampling is a kind of process that obtains blood sample from patient's subcutaneous capillary bed.Be used for using from the traditional method that patient gathers small amounts of blood the skin perforator of machinery, this perforator has the sharp-pointed device such as metal lancet or syringe needle.There are many shortcomings in operation like this, and wherein two are that the health care worker or the public may be subjected to being used for infection to the device of punch skin, and handle and dispose biologically dangerous refuse expense costliness.
Laser is used as a kind of precision instrument efficiently in many surgical procedures.In all lasing sources, what be concerned about in the medical treatment is such as being doped with the crystalline rare earth element of the ionic YAG of erbium (Er) (yttrium-aluminium-garnet).
People can use various lasant materials to produce different wavelength of laser as a kind of work medium.These materials include, but are not limited to, and are doped with oxide and the fluoride laser crystal and the glass of rare earth element.With such crystal and glass and impurity fusion, to determine resulting optical maser wavelength.
In using the situation of laser, its system generally includes one and is used for lasing light source and be used for laser beam is guided into the optical component of a target.Lasing light emitter can produce continuously or the output of the laser energy of pulse.A part of also then evaporating sample to target sample transmission laser energy can produce side-product usually, as the flue gas from sample, carbonized particles or/or splatter granule.These side-products can constitute a threat to the coherent operation of laser system, this is because they may be deposited on the object lens of system, thereby damage or change optical component, reduce output, make the energy distribution pattern distortion in light or the laser beam, the performance of system is reduced.
Known in the state of the art have be suitable for the method and apparatus of patient's skin histology being bored a hole by focussed laser beam.When skin perforator conforms to the light emission strong absorption zone of biological tissue at the wavelength of laser irradiation, the most effective to the perforation of skin.Prevent that in the process of biological tissue being handled with laser beam condensing of blood from also being very important.When the laser emission wavelength of the employed yttrium aluminum of perforator erbium garnet (yttriumaluminum erbium garnet) laser instrument is 2.94 microns and laser pulse duration between 50 to 500 microseconds time, just can realize this point.In the prior art, focus on the skin histology and fritter skin when evaporation of laser focusing location just bored a hole when laser beam.
Some is used for contactlessly patient's skin being bored a hole and the operation of the medical treatment device of blood sample collection simultaneously can produce tangible pain usually, and causes the patient with pain experience frightened and worried.Although the design of modern laser beam perforation device is attempted eliminating such pain and worry, the discomfort that reduces patient further can increase the practicality of this new capillary tube blood collecting technology significantly.At United States Patent (USP) 5,908, in the method and apparatus that is disclosed in 416, attempt by providing laser beam to reduce pain in the perforation procedure with special shape.But such method makes, and optical system is more complicated, the loss that causes laser beam energy, make instrument expensive more and be difficult to make.In such device, the increase of laser energy compensation can cause the diversity of laser beam bigger, finally causes the skin burn in punched areas.
Therefore, need a kind ofly can reduce pain and the worried laser beam perforation device that patient is stood in the blood sampling operation.Also need a kind of laser beam perforation device of being infected with owing to the product of skin histology evaporation of preventing.
Summary of the invention
One aspect of the present invention provides and a kind ofly is used for to patient's punch skin and obtains the laser beam perforation device of blood sample.This perforator comprises that a lasing light emitter, that is used for producing an outgoing laser beam is used for outgoing laser beam is focused on focusing structure, a guide frame and a power subsystem of selected skin area of boring a hole.One retention system is set, to strengthen the blood circulation in selected skin area of boring a hole.This skin retention system comprises the centre portion of the cardinal principle hollow that is formed with a flexible leg.Centre portion places one to be arranged on the joint cup-shaped spare in the place ahead and between the diapire at rear.In the centre portion of cardinal principle hollow, engaging between cup-shaped spare and the diapire, a base element is set.Flexible leg deformable reducing the volume of centre portion significantly, and causes its pressure inside to rise.The skin retention system comprises that also one is used for regulating the pressure-regulating device of pressure in centre portion.After having carried out the pressure adjusting, in centre portion, form an area of low pressure, to produce suction force, make at least a portion of skin area deeply engage cup-shaped spare.Pressure adjustment structure can be the form of a valve, and a bias piece is set so that the centre portion that is out of shape is returned to its initial not deformation position.
About another aspect of the present invention, the rear wall that engages cup-shaped spare is formed with an opening that passes through for laser beam.One blooming piece can be provided, and the fluid that is used to prevent to engage between the interior zone of cup-shaped spare and perforator that comprises lasing light emitter and focusing structure is communicated with, and this blooming piece is provided with opening.This catch is used the laser irradiation material transparent is made.
About another aspect of the present invention, but, can regulate the laser energy that is sent to patient skin by means of an optical element that has variable thickness along its length.This optical element is made with the material with predetermined laser irradiation light transmission features.Optical element is arranged between the skin area and lasing light emitter that will bore a hole.Optical element can have the shape of wedge shape and have a roughly cylindrical outer wall, and optical element can be rotatably set between lasing light emitter and the focusing structure.In another embodiment of the present invention, optical element moves transverse to the direction of laser beam.
One side more of the present invention provides a kind of perforator unwillingly that prevents to activate.This device comprises a plurality of segments that independently engage, and all joint segments are arranged slidably along the longitudinal axis of cup-shaped spare.The end portion of all segments forms the part of the switch that can operate between disconnection and make position.On the position that disconnects, the end portion that engages segment separates with a conductive plate that is arranged on a rear wall place that engages cup-shaped spare, to disconnect the supply line of LASER Light Source.On make position, the end portion that engages segment engages with conductive plate, to activate the supply line of lasing light emitter.This device comprises a sliding part, and this sliding part is removable in a plane transverse to beam direction, so that at a normal place place of device, sliding part stops up a central passage of perforator and prevents that laser beam from unexpectedly sending.
Engage the internal cavity that cup-shaped spare can be formed with a cardinal principle hollow, and form by the one sidewall at least.Can form one and engage perforate in sidewall, the laser beam of hollow interior region tangentially points to by engaging the outstanding skin area of perforate so that enter substantially, produces an elongated otch with the punched areas at skin.Perhaps, be suitable for admitting the joint perforate of skin area can be formed on the front portion that engages cup-shaped spare, be arranged to and enter interior zone laser beam direction at angle.
The accompanying drawing summary
Fig. 1 is the sketch map of a laser beam perforation device of the present invention, and it comprises a skin fixing device;
Figure 1A shows the perforator front region that has a suction structure;
Fig. 2 shows one of punching machine and engages cup-shaped spare;
Fig. 2 A shows another embodiment that engages cup-shaped spare;
Fig. 3 shows an embodiment again who engages cup-shaped spare;
Fig. 4 shows an embodiment again who engages cup-shaped spare;
Fig. 5 is the sketch map that the application of an optical element that is used for punching machine is shown;
Fig. 6 is the sketch map that the Another Application of optical element is shown;
Fig. 6 A shows the manufacturing process of optical element;
Fig. 7 shows the front portion of the punching machine that has optical element;
Fig. 8 shows an amended front portion of punching machine;
Fig. 9 is the forward sketch map of punching machine, shows a security feature of the present invention;
Fig. 9 A is the profile along the hatching 9A-9A gained of Fig. 9;
Fig. 9 B is the profile along the hatching 9B-9B gained of Fig. 9;
Figure 10 illustrates the profile of another security feature of the present invention under extended position;
Figure 11 is the security feature shown in Figure 10 that is illustrated under the operating position;
Figure 12 shows another security feature of the present invention;
Figure 13 is the sketch map that all places of focusing structure is shown;
Figure 13 A illustrates when lens are in the A of position shown in Figure 13 the figure of formed wound in the skin patient;
Figure 13 B illustrates when lens are in the B of position shown in Figure 13 the figure of formed wound in the skin patient;
Figure 13 C illustrates when lens are in the C of position shown in Figure 13 the figure of formed wound in the skin patient;
Figure 14 shows a focusing structure of the present invention;
Figure 15 shows another focusing structure of the present invention;
Figure 16 shows a focusing structure more of the present invention;
Figure 17 shows an operating position of laser beam perforation device assembly;
Figure 18 shows the situation of assembly shown in Figure 17 before housing is inserted in the admittance cavity of base fully;
Figure 19 shows another embodiment of laser beam perforation device assembly of the present invention;
Figure 20 shows the employed winding construction of transformator of Figure 19; And
Figure 21 illustrates another winding construction of transformator shown in Figure 20.
The specific embodiment
The pain that reduces patient in punch skin operation is a complex work, and it need consider following factor: the safety of instrument and wieldy design, select the zone of perforation, skin area anticipated and regulate intensity of laser beam before perforation procedure.Also need the correct focusing determining an optimum energy intensity and in punched areas, realize laser beam for each patient.
To in the process of punch skin, make the pain minimum, importantly reduce laser energy intensity and the wound size minimum that makes in the patient skin tissue, and keep the output of blood to be in a constant basis simultaneously at the punch position place.In one embodiment of the invention, this task is that the blood flow in the skin part of selecting to bore a hole by excitation is finished, like this, even very little perforation also can obtain the blood of requirement.The excitation of blood flow in punched areas can realize by this regional skin is in the coupling opening of skin fixing device.
See also Fig. 1 now, the figure shows a laser skin punching machine or a laser skin perforator 10 that is formed with a skin fixing device of the blood flow that is suitable for encouraging in the punched areas.Critical piece at the laser skin perforator shown in Fig. 1 comprises: one produces the impulse type lasing light emitter 12 of laser beam output; One is used on specific skin surface part focussed laser beam to produce the focusing structure 14 of high energy effect; One power module 16 and one is used for selected site of perforation is remained on device 18 within the focal zone of laser beam.
Impulse type lasing light emitter 12 and skin fixing device 18 are usually located in the housing 20 of perforator.Skin fixing device 18 is arranged on the place, front portion of housing, and impulse type lasing light emitter 12 is positioned at thereafter.Skin positioner 18 comprises the centre portion 22 of hollow substantially, and this centre portion 22 has a flexible outer wall 24 between its proximal part 26 and end portion 28.In centre portion, have at least a spring or bias piece 32 between near-end and end, to extend.In embodiment illustrated in fig. 2, the proximal part 26 of fixing device is the form of a joint cup-shaped spare, and this joint cup-shaped spare is suitable for engaging with the skin part that will bore a hole in the process of blood collection operation.
As among Fig. 2 and the 2A best shown in, a typical cup-shaped spare 30 that engages is frusto-conical, and is formed with a hollow interior space 34 substantially.In order to engage with the skin that will bore a hole (for example patient's finger) better, the front end 36 that engages cup-shaped spare is provided with one and engages perforate 37, and this joints perforate 37 has in two planes that are arranged on the longitudinal axis that is spaced from each other and is approximately perpendicular to joint cup-shaped spare, rounded inner region 38 and exterior domain 40 roughly.Select the diameter (D of exterior domain 40
Outward) with the diameter (D of inner region 38
In) between ratio, make it greater than 7: 3 (D
Outward: D
In＞7: 3).Distance between the inside and outside zone is between 1.0 to 5.0 millimeters.
In the end 28 of skin fixing device, be provided with an air relief valve 42.As shown in Figure 2, air relief valve 42 comprises conical surely regulating part 44, this regulating part 44 be suitable for the wall that is arranged on end portion 28 in one admit opening 46 to engage slidably.From regulating part 44 one handle 48 that stretches out.Between the outer wall of handle 48 and end portion, be provided with a switch 49.Although a special design of air relief valve 42 has been discussed hereinbefore, should be understood that, the conventional valve structure of also having considered in instrument of the present invention, to use other.
In operation, when the operator pushes the front end 36 that engages cup-shaped spare 30 on the skin histology zone that is suitable for boring a hole, just applied initial pressure.This causes, and blood flows into to punched areas when initial.Consider the flexibility of the outer wall 24 of centre portion, when the operator applies bigger power and presses to skin further will engage cup-shaped spare 30, proximal part 26 just more near end portion 28, obviously shortens the centre portion 22 of hollow, and its inner relevant pressure rises.This opens air relief valve 42, like this, just inside, skin fixed position is compressed gas release in ambient atmosphere.When exerting pressure on the skin that does not continue patient, 24 biased of flexible walls of centre portion or spring 32 drive, and are returned to (see figure 1) on its original extended position.In such motor process, in the centre portion 22 of hollow, formed lower pressure region, cause valve 42 to be closed.This and formation are aspirated, and the zone of perforation skin is deep in the joint perforate 37 of proximal part more.This further is out of shape skin, and more blood flow in the punched areas.When valve 22 cuts out, handle 48 just brought to end portion 28 near, and actuation switch 49.This has started power module 16, and to lasing light emitter 12 power supplies, makes the laser beam of punch skin with generation.
Now see also Figure 1A, the figure shows another embodiment of the present invention.In this embodiment, engaging zone, inner space between cup-shaped spare 30 and the focusing structure 14 manages by one and exports 11 and be connected with a suction structure 13.For the interior zone that prevents instrument is polluted, remove the skin evaporant and other the undesired product that in the process of blood sampling operation, are produced, and make and accumulate in a filter 23 places.
In the embodiment shown in fig. 1, in order to prevent the accidental activation of lasing light emitter 12, an optical pickocff or capacitance sensor 39 can be set in the hollow centre portion 22 of skin fixing device.As long as have light to pass to engage perforate 37 to enter into hollow centre portion 22 and go on record at pick off 39 places, power module 16 just can not activated.Like this, as long as conjugate foramen 37 and patient's skin is spaced, but just holding device does not activated.Pick off 39 only engage perforate by skin part stop up, on every side light just allows power module to send high-voltage pulses to lasing light emitter 12 in the time of can't being penetrated in the hollow centre portion.
Pick off 39 also can be the form of a photoconductive resistance or photodiode, and its illumination in centre portion inside just activates when reaching a predetermined extent.In alternate embodiment, the function of pick off can be by a kind of to being realized at the device that the capacitance interference that the location caused that engages perforate 37 places writes down by selected skin part.In the embodiment shown in fig. 1, optical sensor 39 forms the part of the centre portion interior zone of skin fixing device.But be noted that pick off is placed in the other parts of laser beam perforation device and fall within protection scope of the present invention.
Now see also Fig. 3 and 4, they show the alternate embodiment that engages cup-shaped spare, and these engage cup-shaped spare may further alleviate the pain that patient stands in the process of punch skin.Can regulate the size of punch skin by the angle that changes laser beam sensing skin surface.Vertically perforation and otch can produce needed blood volume under the more shallow penetration depth in skin histology usually.Owing to reduce in neural closeness, so the pain that such technology causes in blood collection procedure is less near the skin surface place.
In the embodiments of figure 3, engage cup-shaped spare 50 and be the form of an elongated Tapered Cup, the leading section and that this Tapered Cup has a sealing is the inside of hollow substantially.In the inwall that engages cup-shaped spare 50, be extended with an elongated joint perforate 57, and this elongated joint perforate 57 is spaced apart with the longitudinal axis that engages cup-shaped spare 50.When being placed on a finger or other skin surface of being suitable for boring a hole in the elongated joint perforate 57, only limited skin area extends through the inside that perforate enters into hollow.Like this, just between skin and perforate, formed an elongated engaging zones.As shown in Figure 3, laser beam tangentially points to the skin area that penetrates cup-shaped spare hollow inside.So just produce one and had the otch that is penetrated into the longitudinal extension of a finite depth in the skin histology.
In the embodiment shown in Fig. 4, engage the direction of the interior and exterior domain of perforate 57 transverse to laser beam, and be arranged to the longitudinal axis that engages cup-shaped spare at angle and non-perpendicular.Specifically, interior and plane exterior domain be arranged to the direction of laser beam at angle.Such layout forms an oval-shaped engaging zones at skin with engaging between the perforate 57 usually.Like this, in the embodiment shown in fig. 4, laser beam is exposed to the skin area of perforation with an angle; To be formed near one of the extension of skin surface place elongated otch.
As among Fig. 4 best shown in, can a test strip 21 of easily disposing be set at the place, perimeter of the joint perforate 57 that engages cup-shaped spare, to be used for visual and/or quantized quick hemanalysis.
In the present invention, engaging cup-shaped spare can be an integrally formed part of laser skin perforator and/or especially skin fixing device usually.Perhaps, engaging that cup-shaped spare can form can be from the disposable unit that punching machine takes off.Under these circumstances, engage cup-shaped spare and can be used as the disposable container that is suitable for collecting the blood sample that is produced.An example of so disposable joint cup-shaped spare 15 has been shown in Fig. 2 A.In fact blood sample is collected in the interior hollow region 34 that engages cup-shaped spare, and this hollow region 34 is positioned at the anterior rear that engages perforate 37.For the blood of visually estimating to be gathered, a sidewall 17 that engages cup-shaped spare can be made with material transparent.The inner surface 19 of container side wall can have a coating at least in part, and this coating is suitable for showing the existence of sugar part, concentration of cholesterol or the like in the process of quick hemanalysis.Operate this device for the ease of the operator, the outside of sidewall can be covered with a kind of anti-slip material at least in part.
For in and offensive odour and the member that further prevents punching machine be subjected to the pollution of the product of skin evaporation, the inner surface 19 that engages cup-shaped spare can be covered with layer of absorbent.An example of such material is an activated carbon.
We know, the thickness of skin and ability that blood is provided have different significantly between a patient and another one.People also know, compare patient's softness, delicate skin, to harder skin bore a hole need be bigger laser energy.When in the process of blood sampling, when indistinguishably all patients being applied equicohesive laser energy, the soft delicate individual patients of skin can be born bigger unnecessary pain usually.The intensity adjustments of laser energy is arrived the minimum needed level of perforation, constituted the lightest important prerequisite of pain that patient is stood.The laser skin perforator of prior art provides various and can regulate the supply of electrical energy that lasing light emitter is powered and control the electronic installation of laser beam to patient's the energy intensity that skin sent.Such electronic installation is normally complicated, and not exclusively reliable.
Now see also Fig. 5,6 and 6A, these there is shown another embodiment of the present invention, and this embodiment has comprised the optical element 27 of a variable thickness.This optical element is arranged between skin and the lasing light emitter 12 usually.Optical element 27 can also be arranged between skin and the focusing structure 14, perhaps between focusing structure 14 and lasing light emitter 12.Optical element 27 is formed with the shape of a wedge shape, and is to be used in the material that has predetermined light transmission features under the desired laser irradiation wavelength situation to make.As shown in Figure 6A, when along be placed to a cylindrical longitudinal axis at angle a plane or during this cylinder of all plane cutting, just can form this optical element.Typical optical element body comprises a roughly cylindrical outer surface 29 and first and second bottoms 31 and 33 that are provided with at angle mutually.Perhaps, roughly the longitudinal axis with optical element is vertical in a bottom.The alternative design of other of optical element all falls within protection scope of the present invention.As shown in Figure 5, when on the direction of optical element 27 transverse to laser beam when mobile, just can be regulated the laser energy that is sent to skin.(see figure 6) in another embodiment when the longitudinal axis 35 of optical element separates with the direction of laser beam and parallel and optical element 27 during around this longitudinal axis rotation, just can be regulated the energy of laser.
Now see also Fig. 7, the figure shows the part of laser skin perforator, the joint cup-shaped spare 26 of this skin perforator forms and housing 20 integrally formed parts.In such structure, the focal position of laser beam be fixed on the coupling opening 37 of cup-shaped spare and the skin area that is suitable for boring a hole between the engaging zones place.Engage cup-shaped spare and be formed with an adjusting part 39 that is positioned at focusing structure 41 fronts.Adjusting part comprises that one admits a recess 43 and an optical element 27.As indicated above, shape and outer surface that optical element 27 can have a wedge shape are roughly cylinder shape.Optical element can rotate around its longitudinal axis, and stretches in the inner chamber body that engages cup-shaped spare by the admittance recess 43 that is formed in the sidewall that engages cup-shaped spare.In the embodiment shown in fig. 7, the rotation axis of optical element 27 is roughly parallel to the longitudinal axis of housing 20.In order to regulate the energy intensity of laser beam, rotary optical spare 27 is exposed to laser beam with the part of the optical element that will have different-thickness.Aspect this, when a thicker punch skin was needed bigger energy intensity, the part that the thickness of optical element 27 reduces was exposed to laser beam, and vice versa.Optical element 27 prevents from also to comprise that the inside of the perforation structure of focusing structure is subjected to being infected with of skin evaporate.
As Fig. 8 best shown in, engage cup-shaped spare comprise a blooming piece 43 ', this blooming piece 43 ' be used in the material that has predetermined light transmission features under the desired irradiation intensity to make.This diaphragm 43 ' have thickness of a predetermined fixed, and the laser energy that can will pass it reduces to a predetermined level.Such structure allow by the diaphragm 43 of selecting to have optimum thickness ' a replaceable joint cup-shaped spare select to be sent to the best laser energy intensity of skin area.
The after-opening that engages cup-shaped spare can form has transformable internal diameter, and this internal diameter can not surpass the size of laser beam periphery usually.Size by selecting such inner opening 43 just can be adjusted in the laser energy intensity at site of perforation place to satisfy the specific disease human needs.
Although be to describe the above embodiments, should be understood that, the body skin position that in the punch skin operation, also can use except finger in conjunction with a finger that is used for perforation procedure.
Now referring to Fig. 9,9A and 9B, these illustrate and are suitable for the device of the present invention that prevents that the laser beam perforation device is accidentally actuated.In this embodiment, engage cup-shaped spare 130 as power supply being connected to lasing light emitter and with the switch of power supply with the lasing light emitter disconnection.Cup-shaped spare 130 comprises a pedestal 122 and a plurality of joint segment 124.This pedestal is formed with an inner cavity 126, and this inner cavity 126 extends forward and is suitable for admitting slidably a plurality of joint segments from a rear wall 128.Although considered the segment of any fair amount, in the embodiment of Fig. 9, engage cup-shaped spare 130 and be formed with four symmetric segments placing along its longitudinal axis.Each engages segment and comprises that at least one is suitable for being suitable for the rear portion 134 of moving slidably with the front portion 132 of patient's skin engagement and one in inner chamber body 126.The rear portion 134 of each segment has one from its outwardly directed bonding part or contact 136, and this bonding part or contact 136 are suitable for engaging the respective openings 138 in the conductive plate that links to each other with base rear wall 128.When pressurized, each segment 124 slides along the longitudinal axis of cup-shaped spare and the segment ground that is independent of other in inner chamber body 126.One bias piece or a spring 140 are arranged between the rear wall of the rear end of each segment and cup-shaped spare.As shown in Figure 9, when skin initially engaged with anterior 132 and do not have substantial inside power to be applied on the joint segment, the resistance of bias piece or spring 140 was enough to keep the rear portion 134 (comprising contact or bonding part 136) of all segments spaced apart with the opening 138 in the conductive plate.Under such state, the power supply circuits from the power subsystem to the lasing light emitter disconnect.Only engage segment and pressed by skin at each so that move in inner chamber body at the rear portion of each segment (comprising contact 136) and each protuberance or contact 136 when opening 138 engages accordingly, lasing light emitter just activated.As an alternative example, engage cup-shaped spare and can form a solid single component, rather than be divided into a plurality of one joint segments.
Now see also Figure 10 and 11, show another embodiment of joint cup-shaped spare of the present invention on two figure, it comprises the elongated outer extension member 154 in the inner hollow space that the frame piece 150 that is formed with a hollow interior space 152 and telescopically place frame piece.One elongated open 156 that is positioned at the center engages the whole length of recess 158 to a flange 160 extend through outer extension members 154 that are provided with at the one terminal part from one.Engage recess 158 and be configured as the skin area of joint such as patients fingers, so that it is suitable for boring a hole.One spring or bias piece 162 place between the rear wall 164 of the flange 160 of inner hollow space and frame piece.The focus of laser beam is fixedly located in the anterior inner place of frame piece.Position (see figure 10) in elongation comprises that the outer extension member 154 that engages recess 158 is protruding from the interior hollow space 152 of frame piece.In order to begin perforation procedure, the skin area that is suitable for boring a hole initially is positioned over and engages in the recess 158.Then, on outer extension member 154, apply an inside power, cause that to push down outer extension member 154 moves to the resistance of the bias piece 162 on the hollow space 152.When outer extension member 154 arrives its slotting in frame piece and do not have the position (being shown in Figure 11), selected skin area just is exposed to the focus of laser beam, so that perforation of moment takes place for it.For safer, the material 153 that the inner surface of the central opening 156 of outer extension member can be had high-absorbility by the wavelength place in a laser irradiation carries out coating.In the embodiment shown in Figure 10 and 11, until outer extension member pressurized and move to insert and do not have the position firmly, so that the skin area that is suitable for boring a hole when being positioned at the laser beam foucing place that fixedly installs, just can be bored a hole.
Figure 12 illustrates another kind and be suitable for the device that prevents that laser skin perforator is accidentally actuated.The structure of this device is to top similar with reference to the described device of Fig. 9.But, in the embodiment shown in fig. 12, engage cup-shaped spare 180 and be provided with a groove 188 that in a plane of the rear wall 182 that is roughly parallel to base part, extends.Slidable member 185 with an opening 181 is arranged to and groove fit.Between the inside of groove 188 and slidable member 185, a bias piece 187 is set.At the extended position (shown in the solid line among Figure 12) of standard, sliding part is protruding from groove.Under this state, opening 185 is shifted to the side, causes a solid section of slidable member 185 to stop up the main channel that firmly engages cup-shaped spare.In this case, the extension of slidable member 185 has stoped moving downward of joint cup-shaped spare 180.Thereby just prevented that unexpected laser beam irradiation from emitting.In order to carry out punch skin, the operator inwardly pushes the extension of sliding part, so that opening 185 is consistent with the main channel, and can moves down whole joint cup-shaped spare and comes to activate the contact with top with reference to the described mode of Fig. 9.
For the ease of such operation, the part 57 of cup-shaped spare 26 and other parts can the coating anti-slip materials.For safer, the part of cup-shaped spare 26 inner surfacies can coating has the material (seeing the part 153 of Figure 10) of the absorption of high level to laser irradiation.When cup-shaped spare is not to be pressed in the skin part that will bore a hole veritably, but pressurized unexpectedly, when for example being pressed onto by child, such structure can not allow laser activated.
Another embodiment of the present invention provides a kind of punch skin device with focusing system, a desired depth place of the skin histology that this focusing system can allow user focus the laser beam into will to bore a hole.As hereinafter discussing in further detail, it is an important condition that eases the pain in perforation procedure that the laser beam that target is arranged like this in skin histology focuses on.
In the structure shown in Figure 13, the skin area that is suitable for boring a hole is fixedly located in and leaves lasing light emitter and focusing system one preset distance place, and this focusing system comprises a condenser lens 170 that can move along the axis of laser beam.In this, Figure 13 shows focusing structure or lens 170 sketch map in the focal position of its three position A, B in the moving of the longitudinal axis of laser beam and C and three corresponding laser beam a, b and c.Position shown in these with hereinafter form corresponding with reference to Figure 13 A, 13B and the described wound of 13C.At position A, a (seeing Figure 13), the focus of laser beam is positioned at a desired depth place of skin histology.At position B, b, laser beam focuses on the surface of skin, and at position C, c, focus is left skin surface and separated a gap with skin surface.
As noted above, Figure 13 A, 13B and 13C have schematically represented the wound in the skin of patient under corresponding condenser lens position.Figure 13 A shows that focus when laser beam is positioned at tissue and the wound when separating with skin surface.Figure 13 B shows the wound when laser beam focuses on skin surface, and the wound shown in Figure 13 C then is formed when the focus of laser beam is positioned at the skin surface outside.
For pain that patient is stood in perforation procedure is the lightest, be preferably in an in-house desired depth place focussed laser beam (seeing Figure 13 A), rather than on the surface or leave surface (shown in Figure 13 B and 13C).This be because, in the process of perforation, the laser beam evaporation biological tissue, and form attempt from site of perforation overflow one at a high speed, air under pressure stream.When laser beam foucing be positioned at a desired depth place in the skin histology time (seeing Figure 13 A), the wound that is produced is configured as the shape with a taper, its tip is positioned at skin histology and wide opening is positioned at skin surface.Such shape of wound is convenient to the escape of gas and skin histology evaporate, and can not cause unnecessary pressure and irradiation to neuromechanism on every side.The optimum depth of focus point depends on the condition and the needed blood volume of patient skin.In the application of department of pediatrics or when test needs a small amount of blood, for example the diabetes patient is carried out the glucose test, the focal depth of recommendation is 0.12 millimeter (end of epidermis) and between 1.5 millimeters.When test needed more substantial blood, focus should be left 1.5 to 4.0 millimeters of skin surfaces.In order to evaporate the territory, jack to jack adapter shadow zone shown in Figure 13 A, and this moment laser beam focus be positioned at the degree of depth place of 0.12 to 4.0 millimeter of skin histology, the diameter of laser beam should be between 1.0 to 3.0 millimeters.
In the embodiment shown in Figure 13 B, in the process of perforation procedure, laser beam focuses on the surface of skin.Under such state, laser beam is boiled one little opening at the skin surface place.The wound that is produced forms has a conical in shape, and wide bottom is positioned at gos deep into the inner place of skin histology, and a little opening is at skin surface.Finite time escapes by this little opening only to allow interior tissue vaporized gas and product to have very.This makes and produces highly compressed product in the wound, causes hemorrhage (congestive edema) of tangible pain and surrounding tissue.
Under the state shown in Figure 13 C, the focus of laser beam is left skin surface and is positioned at outside the skin surface.Such state causes the wound that has wider bottom in the skin histology and obviously narrow down at the skin surface place.The gas that skin produced and the product in evaporation territory, jack to jack adapter shadow zone can not be effectively by at the skin surface place relative less opening overflow effectively.This produces sizable pressure inevitably, and this pressure is applied to the inner skin tissue and causes sizable pain.Shown in Figure 13 C, laser beam does not arrive the surface of skin with focusing on, and broadens significantly then.Because the skin area that is evaporated increases dimensionally,, therefore cause more pain so should increase this laser beam energy intensity.Gather more blood if desired, pain increases along with the increase of the laser energy intensity that is applied with being directly proportional.
Also can realize that with reference to Fig. 1,2,3 and 4 described removable joint cup-shaped spares the optimization of laser beam focuses on by adopting as mentioned.In laser beam perforation device with default laser beam foucing position, the correct location that the suitable fastener that can nationality helps to select to have required length realizes boring a hole skin part.Like this, by selecting short or long joint cup-shaped spare, just engaging zones and the relative skin part that engages cup-shaped spare may be placed to the desired depth place (seeing Figure 15) that focussing plane is positioned at skin histology.Therefore, can realize needed focusing for patient to each, and in fact skin part can be chosen in any part place of human body.
Figure 14,15 and 17 shows laser beam is focused on the alternate manner of optimizing degree of depth place, and this mode is that nationality is positioned skin to realize apart from focusing structure one preset distance place with helping control.In the structure in Figure 14, sending a low intensive visible spectrum light beam from light source 180 and with after the skin part that will bore a hole tangentially engages, it just is accepted device 182 and detects.This has triggered the signal of telecommunication that points to power module 184, causes lasing light emitter 186 to activate, and sends the laser beam that points to the engaging zones place between this light beam and the skin.Punch skin like this, just takes place immediately.
In the embodiment shown in fig. 15, send a low intensive visible spectrum light beam to skin surface at angle from light source 180.When from skin reflex, it just is accepted device 182 and detects, and produces the signal of telecommunication of a sensing power subsystem.Like this, just lasing light emitter 186 is powered, the skin area that begins to accept the visible spectrum light beam with aligning gives off laser beam.
According to Figure 16, the desired distance between skin part and the punching machine is controlled by a capacitance sensor.Like this, when focusing system be arranged on apart from skin surface one when requiring distance, this capacitance sensor just disturbs, and produces a signal of telecommunication with to the laser energy supply.
Now see also Figure 17 and 18, two and illustrate a small-sized laser beam perforation 200, this perforator 200 has one can be from energy supply base 204 isolating light-duty hand-held housings 202.It is in order to charge to being arranged on the intravital rechargeable unit 210 of shell that base is set, and also is in order to be used for depositing of housing when the laser beam perforation device is not used.Cavity 228 extends downwards from a top of base, and its shape and size are configured to admit at least the part of hand-held housing 202.
As in Figure 17 and 18 clearly shown in, the chargeable power subsystem of a lasing light emitter 210 and reservior capacitor 212 forms is arranged on the inside of hand-held housing 202.One electric transducer 231 and a transformator 232 are placed in the power supply base.Reservior capacitor has a cover contact 235, and they are corresponding with the contact 233 in being arranged on the handheld housing phosphor bodies.Admit cavity 228 to be formed with the contact 234 that matches.For reservior capacitor is charged, the hand-held housing 202 that comprises lasing light emitter is placed on to be admitted in the cavity 208, so that the contact 233 of housing is connected with the contact 234 of cavity.For the reason of secure context, as shown in Figure 18, be zero potential, and be not connected with the circuit of perforator in these contacts at its rotine positioning place.When housing is placed in the admittance cavity 208 (seeing Figure 17), contact 233 and 234 is connected on contact 235 and 236.Like this, reservior capacitor just is connected with power supply circuits with lasing light emitter.In above-mentioned structure, there is not opening near contact 235 and 236.Therefore, as shown in figure 18, when when admitting cavity 208 to take out housings 202, contact 235 moves inward, so that be not connected between the outside of these contacts and housing.In a similar fashion, in power supply base, inwardly move in this locational contact 236 so that these contacts with admit between the cavity directly being connected.In case with the insertion of housing 202 to admittance cavity 208, reservior capacitor 212 just is charged to desired degree fully.Then, can from power supply base, take out housing, and can activate lasing light emitter by pressing button 237.
Now see also Figure 19-21, these illustrate another embodiment of laser skin perforator assembly of the present invention.Similar with the embodiment of Figure 17 and 18, this assembly comprises two main independent sectors: a hand-held housing 252 and a power supply base 254.In the present embodiment, a transformator 261 is divided into two independent unit.First module comprises main winding 258, and control unit 231 is positioned at the interior zone of power supply base 254.The transformator Unit second that comprises time winding 259 is positioned at hand-held housing 252.Being positioned at intravital other critical piece of handheld housing is: the rechargable power supplies unit of a reservior capacitor 212 forms, an electric transducer 267 and a lasing light emitter 210.
One admits cavity to stretch out from the top of base downwards.The shape and size of cavity are configured to admit at least a bottom of hand-held housing.Base forms a compartment that is suitable for holding a main coil assembly 258 around the interior zone of admitting cavity.Main coil can be wrapped in an electric insulation but on the reel of magnetic conduction.
Such design does not need the open like that electrical contact in contact 33,34 of similar Figure 17 and 18, and has further strengthened the electrical security of perforator.In order further to improve the transformer ratio of transformator 261, a locking device 241 can be set, be positioned at regularly in the intravital precalculated position of receiving compartment of power supply base will hand housing.For reservior capacitor is charged, will hand housing and put into the unitary admittance cavity of power supply base (seeing Figure 18), provide needed voltage main winding is connected on the dc source and in placing the inferior winding of housing.When the voltage in the winding reached by the predetermined level of control unit (it is corresponding with the charging fully of reservior capacitor), charging process is termination just.Perforator just has been to use all set now, and can take out it from admitting cavity.Inferior winding can be arranged to main winding in line, perhaps parallel as shown in figure 21 with main winding, as shown in figure 22.In addition, inferior winding can be the form of a no core construction, perhaps also can have an iron core.The design that has Transformer Winding separately like this need not the electrical contact of the direct disconnection between housing and the power supply base.Such structure has guaranteed the charging of safe operation and " wireless " generating laser.
Claims (30)
1. one kind is used for patient's skin is bored a hole and obtained the laser beam perforation device of blood sample, and this kind perforator comprises:
Be used for producing an outgoing laser beam a LASER Light Source, be used for outgoing laser beam is focused on a focusing structure, a guide frame, a power subsystem at selected skin area place of boring a hole and a retention system that is used for keeping skin area, described retention system is configured to strengthen the blood circulation of the selected skin area that is used for boring a hole.
2. laser beam perforation device as claimed in claim 1, it is characterized in that, described skin retention system comprises a cardinal principle hollow, has the zone line of a flexible leg, described zone line is provided with between one and engages the preceding between the diapire of cup-shaped spare and at the rear, and a bias piece is arranged on that the zone line of hollow substantially is interior, between described structure cup-shaped spare and the described diapire.
3. laser beam perforation device as claimed in claim 2, it is characterized in that described flexible leg deformable is to reduce the volume of described zone line significantly, and its pressure inside is increased, described skin retention system also comprises a pressure controlled pressure-regulating device that is used in the zone line.
4. laser beam perforation device as claimed in claim 3, it is characterized in that, after pressure is regulated, in the zone line of described cardinal principle hollow, form an area of low pressure, make at least a portion of skin area be deep into the suction that engages in the cup-shaped spare with generation, thereby strengthen its inner blood circulation.
5. laser beam perforation device as claimed in claim 34, it is characterized in that, described pressure regulating mechanism is a valve, and the zone line that described bias piece helps to be out of shape is returned to its initial not deformation position, and described skin retention system also comprises a device that is used for activating power subsystem.
6. laser beam perforation device as claimed in claim 2, it is characterized in that described joint cup-shaped spare is arranged on the front end place of perforator, this joint cup-shaped spare is formed with one and engages perforate, this joint perforate has an external diameter and an internal diameter, and the ratio of external diameter and internal diameter is about 7: 3.
7. laser beam perforation device as claimed in claim 1 is characterized in that, the focal point settings of laser beam is in the inside of skin histology, and its degree of depth is apart between 0.12 to 1.5 millimeter of the skin surface.
8. laser beam perforation device as claimed in claim 7, it is characterized in that, described skin retention system is formed with a removable joint cup-shaped spare, and realizes the described focal position degree of depth by means of the described removable joint cup-shaped spare of selecting to have a predetermined length.
9. laser beam perforation device as claimed in claim 6 is characterized in that, described removable joint cup-shaped spare comprises the interior space of hollow substantially that is suitable for collecting blood sample.
10. laser beam perforation device as claimed in claim 9 is characterized in that, a spatial outer wall is made with transparent material in the described at least hollow, and a spatial inner surface is formed with a test structure that is used to test blood sample in the described hollow.
11. laser beam perforation device as claimed in claim 8, it is characterized in that, one rear wall of described joint cup-shaped spare is formed with and is suitable for the opening that the confession laser beam passes through, described opening is by a catch capping, this catch prevents to engage cup-shaped spare and is communicated with fluid between the perforator interior zone that comprises lasing light emitter and focusing structure, and described catch is used the laser irradiation material transparent is made.
12. laser skin perforator as claimed in claim 7 is characterized in that, focuses on and guide frame activates when the focus of laser beam is positioned at the desired depth of skin histology.
13. laser beam perforation device as claimed in claim 13 is characterized in that, visually controls described desired depth, is perhaps controlled by means of folded light beam or a frame for movement or an electric capacity control structure.
14. laser beam perforation device as claimed in claim 8, it is characterized in that, described focusing structure comprises a condenser lens, and this condenser lens can move along the axis of laser beam, so that laser beam focused on the desired depth place that is positioned at from the skin histology at lasing light emitter one fixed range place.
15. laser beam perforation device as claimed in claim 1, it is characterized in that, the laser energy that is sent to skin area is regulated by means of an optical element that has different-thickness along its length, described optical element is made with the material with predetermined laser irradiation light transmission, and described optical element is arranged between skin area and the lasing light emitter.
16. laser beam perforation device as claimed in claim 15 is characterized in that, described optical element has the shape of wedge shape and has a roughly cylindrical outer wall, and described optical element can be rotatably set between lasing light emitter and the focusing structure.
17. laser beam perforation device as claimed in claim 15 is characterized in that, described optical element has the shape of wedge shape and has one and is roughly columniform outer wall, and described optical element can move transverse to the direction of laser beam.
18. laser beam perforation device as claimed in claim 16 is characterized in that, described optical element can be around its longitudinal axis rotation, and consequently in the process of rotation, optical element is transverse to the direction setting of laser beam.
19. laser beam perforation device as claimed in claim 1 is characterized in that, also comprises being used for preventing during not with patient's skin engagement at perforator a device of lasing light emitter accidental activation.
20. laser beam perforation device as claimed in claim 19, it is characterized in that, described device forms the part of the joint cup-shaped spare that is arranged on the place ahead, described device comprises a plurality of segments that independently engage of arranging along the longitudinal axis of cup-shaped spare slidably, one end portion of each described segment forms the part of the switch that can operate between its disconnection and make position, wherein, on open position, the end portion that engages segment is with to be arranged on a conductive plate that engages cup-shaped spare one rear wall place spaced apart, to disconnect the supply line of described lasing light emitter, and on described make position, the end of all joint segments engages with conductive plate, to activate the supply line of lasing light emitter.
21. laser beam perforation device as claimed in claim 20, it is characterized in that, described device also is included in a movable sliding part in the plane transverse to laser beam, wherein, on a normal place of device, described sliding part stops up a central passage of perforator, thereby prevents that laser beam from unexpectedly emitting.
22. laser skin perforator as claimed in claim 19 is characterized in that, selects described device from comprise optical pickocff and capacitance sensor one group.
23. laser beam perforation device as claimed in claim 1, it is characterized in that, an elongated joint cup-shaped spare that also comprises a front end place that is arranged on perforator, described joint cup-shaped spare has the internal cavity of hollow substantially and is formed by its a sidewall at least, in described sidewall, form one and engage perforate, the laser beam that enters described cardinal principle hollow interior region tangentially points to outstanding skin area by described joint perforate, to produce an elongated otch in the punched areas of skin.
24. laser skin perforator as claimed in claim 23, it is characterized in that, a joint cup-shaped spare that also comprises a front end place that is arranged on perforator, described joint cup-shaped spare has the internal cavity of a cardinal principle hollow, be suitable for accepting one of skin area and engage perforate and be formed on the place, front portion that engages cup-shaped spare, described joint perforate be arranged to and enter described interior zone laser beam direction at angle.
25. laser beam perforation device that is used to obtain blood sample, it comprises: be used for producing an outgoing laser beam a LASER Light Source, be used for outgoing laser beam is focused on a focusing structure, a guide frame and a chargeable power subsystem at selected skin area place of boring a hole, described lasing light emitter and described chargeable power subsystem are arranged in the one first hand-held housing, and described power subsystem is positioned at and first housing, one second housing independently, and permanent being electrically connected is not provided between first and second housings.
26. laser skin perforator as claimed in claim 25 is characterized in that, described lasing light emitter and described power subsystem temporarily are electrically connected, and by means of interior and outer contact chargeable power subsystem is charged, described outer contact disconnects with circuit.
27. laser skin pick off as claimed in claim 25 is characterized in that, lasing light emitter and power circuit temporary transient is connected by means of neutral contact electrically and by means of machinery, electromagnetism, magnetic and/or optical converting device realizes.
28. laser beam perforation device as claimed in claim 25 is characterized in that described power subsystem comprises a transformator, and the main winding setting of transformator comprises in the housing of power subsystem, the inferior winding of transformator is arranged in the housing that comprises lasing light emitter.
29. as laser beam perforation device as described in the claim 28, it is characterized in that, inferior winding with main around arranging in line or parallel.
30. laser beam perforation device as claimed in claim 30 is characterized in that, comprises that also the hand-held housing that is used for comprising lasing light emitter is fixedly attached to the intravital bindiny mechanism of power supply base shell.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24917500P | 2000-11-16 | 2000-11-16 | |
| US60/249,175 | 2000-11-16 | ||
| US10/001,004 | 2001-11-15 | ||
| US10/001,004 US6733493B2 (en) | 2000-11-16 | 2001-11-15 | Laser skin perforator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1553787A true CN1553787A (en) | 2004-12-08 |
| CN100525705C CN100525705C (en) | 2009-08-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018189024A Expired - Fee Related CN100525705C (en) | 2000-11-16 | 2001-11-16 | Laser skin perforator |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6733493B2 (en) |
| EP (1) | EP1343428B1 (en) |
| JP (1) | JP3962335B2 (en) |
| KR (1) | KR100902695B1 (en) |
| CN (1) | CN100525705C (en) |
| AT (1) | ATE421295T1 (en) |
| AU (1) | AU2001297665B2 (en) |
| CA (1) | CA2429271C (en) |
| DE (1) | DE60137539D1 (en) |
| RU (1) | RU2309699C2 (en) |
| WO (1) | WO2002069782A2 (en) |
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| CN103561650A (en) * | 2011-03-31 | 2014-02-05 | (株)艾莎特 | Portable lancing device using laser and equipped with double safety device and disposable cap used therewith |
| CN103732141A (en) * | 2011-03-11 | 2014-04-16 | Gtc株式会社 | Method and apparatus for generating laser |
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| CN108201443A (en) * | 2016-12-19 | 2018-06-26 | 比亚迪股份有限公司 | A kind of laser blood-taking device |
| CN116763427A (en) * | 2023-08-26 | 2023-09-19 | 深圳市北扶生物医疗科技有限公司 | Skin laser operation device |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| KR200225362Y1 (en) * | 2000-07-07 | 2001-06-01 | 박종윤 | Portable combined medical laser instrument using high power semiconductor Laser Diode which equipped sensor in front of instrument. |
| US6733493B2 (en) * | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| ATE497731T1 (en) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| ATE450210T1 (en) | 2001-06-12 | 2009-12-15 | Pelikan Technologies Inc | SELF-OPTIMIZING LANCET DEVICE WITH ADAPTATION AGENT FOR TIME Fluctuations in SKIN PROPERTIES |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| ES2352998T3 (en) | 2001-06-12 | 2011-02-24 | Pelikan Technologies Inc. | LANCETA ELECTRIC ACTUATOR. |
| WO2002100252A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| EP2604215B1 (en) | 2003-02-25 | 2017-10-11 | Tria Beauty, Inc. | Eye-safe dermatologic treatment apparatus and method |
| EP1628567B1 (en) | 2003-05-30 | 2010-08-04 | Pelikan Technologies Inc. | Method and apparatus for fluid injection |
| WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
| EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
| US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
| EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| WO2006000873A2 (en) * | 2004-06-21 | 2006-01-05 | Kilolambda Technologies Ltd. | Dermatological laser system |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| CN101115449B (en) * | 2005-03-02 | 2011-12-07 | 美体安有限公司 | Adipose resolve apparatus for low-power laser |
| WO2006111201A1 (en) * | 2005-04-18 | 2006-10-26 | Pantec Biosolutions Ag | Laser microporator |
| FI121698B (en) * | 2005-07-19 | 2011-03-15 | Ihq Innovation Headquarters Oy | Health monitoring device and sensor cartridge for the health monitoring device |
| US7886748B2 (en) * | 2006-02-15 | 2011-02-15 | Advanced Vision Education, Llc | Method for using intense pulsed light to non-invasively treat conjunctival blood vessels, pigmented lesions, and other problems |
| JP4909987B2 (en) | 2006-03-22 | 2012-04-04 | パナソニック株式会社 | Blood test equipment |
| EP1997431A1 (en) * | 2006-03-22 | 2008-12-03 | Panasonic Corporation | Biosensor and apparatus for measuring concentration of components |
| JP5017256B2 (en) * | 2006-03-22 | 2012-09-05 | パナソニック株式会社 | Blood test equipment |
| CN101404936B (en) | 2006-03-22 | 2011-08-24 | 松下电器产业株式会社 | Blood test device |
| CA2646716A1 (en) * | 2006-03-22 | 2007-09-27 | Matsushita Electric Industrial Co. Ltd. | Laser perforation device and laser perforation method |
| WO2007108515A1 (en) | 2006-03-22 | 2007-09-27 | Matsushita Electric Industrial Co., Ltd. | Blood test device |
| GB2450658B (en) * | 2006-04-27 | 2011-05-18 | Meditech Internat Inc | Probe |
| US20080179301A1 (en) * | 2006-08-25 | 2008-07-31 | Guy Garty | Systems and methods for etching materials |
| JP2008067743A (en) * | 2006-09-12 | 2008-03-27 | Matsushita Electric Ind Co Ltd | Blood examination device |
| JP5011936B2 (en) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | Blood test equipment |
| JP5011935B2 (en) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | Blood test equipment |
| JP2010507425A (en) * | 2006-10-25 | 2010-03-11 | パンテック バイオソリューションズ アクチェンゲゼルシャフト | Chip member for laser light emitting element |
| US20080119830A1 (en) * | 2006-10-31 | 2008-05-22 | Ramstad Paul O | Disposable tip for laser handpiece |
| US20100042016A1 (en) * | 2006-12-21 | 2010-02-18 | Panasonic Corporation | Blood sensor and blood inspection device using it |
| US8437828B2 (en) * | 2007-01-17 | 2013-05-07 | Panasonic Corporation | Blood inspection device |
| US20100324451A1 (en) * | 2007-02-09 | 2010-12-23 | Panasonic Corporation | Blood testing apparatus |
| TW200911317A (en) * | 2007-04-27 | 2009-03-16 | Arkray Inc | Laser drilling device, and protective member and cartridge for laser drilling device |
| WO2009008267A1 (en) * | 2007-07-11 | 2009-01-15 | Konica Minolta Opto, Inc. | Bodily fluid collection device and bodily fluid collection method |
| WO2009011213A1 (en) * | 2007-07-17 | 2009-01-22 | Konica Minolta Opto, Inc. | Body liquid collecting auxiliary sheet, and body liquid collecting device using the auxiliary sheet |
| JPWO2009011138A1 (en) * | 2007-07-18 | 2010-09-16 | パナソニック株式会社 | Puncture device, blood test device, and puncture method |
| US8795200B2 (en) * | 2007-07-31 | 2014-08-05 | Panasonic Healthcare Co., Ltd. | Piercing device and blood inspection device |
| JP5254233B2 (en) * | 2007-08-07 | 2013-08-07 | パナソニック株式会社 | Puncture device and blood test device |
| WO2009021225A1 (en) * | 2007-08-08 | 2009-02-12 | Spectragenics, Inc. | Capacitive sensing method and device for detecting skin |
| WO2009031313A1 (en) * | 2007-09-04 | 2009-03-12 | Panasonic Corporation | Blood analysis device and blood analysis system using the same |
| WO2009060701A1 (en) * | 2007-11-06 | 2009-05-14 | Konica Minolta Opto, Inc. | Microopening forming apparatus and body liquid collecting system using the microopening forming apparatus |
| WO2009098902A1 (en) * | 2008-02-07 | 2009-08-13 | Panasonic Corporation | Blood sensor, blood testing device and blood analysis method |
| US20090254155A1 (en) * | 2008-04-04 | 2009-10-08 | Medical Quant Usa, Inc. Dba Multi Radiance Medical | Therapeutic emitter retaining device |
| US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
| WO2009132355A1 (en) | 2008-04-25 | 2009-10-29 | Tria Beauty, Inc. | Optical sensor and method for identifying the presence of skin and the pigmentation of skin |
| JP5401918B2 (en) * | 2008-10-29 | 2014-01-29 | パナソニック株式会社 | Puncture device |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| US8764682B2 (en) * | 2009-02-04 | 2014-07-01 | Panasonic Healthcare Co., Ltd. | Measurement device and puncture device |
| DE102010000642B4 (en) * | 2009-03-12 | 2015-05-07 | Erbe Elektromedizin Gmbh | Switching control device and handling part of a medical instrument |
| ES2414433T3 (en) | 2009-10-16 | 2013-07-19 | Shaser, Inc. | Power supply for light-based dermatological treatment devices |
| JP5699091B2 (en) * | 2009-12-10 | 2015-04-08 | 学校法人慶應義塾 | Onychomycosis treatment system |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| WO2012067475A1 (en) * | 2010-11-18 | 2012-05-24 | Instituto Politecnico Nacional | Laser skin perforator with optical position detector |
| US9119636B2 (en) | 2011-06-27 | 2015-09-01 | Boston Scientific Scimed Inc. | Dispersive belt for an ablation system |
| BR112014030878A2 (en) * | 2012-06-14 | 2017-06-27 | Koninklijke Philips Nv | skin care system, docking station for use in one system |
| KR101224220B1 (en) * | 2012-07-23 | 2013-01-21 | (주)라메디텍 | Laser skin perforator adjusting deepth and size of boring |
| BR112015022097A2 (en) * | 2013-03-12 | 2017-07-18 | Depuy Synthes Products Inc | fixture and laser fixture activation system and related system |
| US9247981B2 (en) | 2013-03-12 | 2016-02-02 | DePuy Synthes Products, Inc. | Laser type fixation member securement device and activation system, and related system and methods |
| EP3065661B1 (en) * | 2013-11-07 | 2017-03-29 | Koninklijke Philips N.V. | A skin treatment device providing optical coupling to skin tissue |
| KR102406800B1 (en) | 2014-07-24 | 2022-06-08 | 사이냅스팀 리미티드 | Device and methods for delivery of simulation to a body tissue |
| US11166658B2 (en) | 2016-07-28 | 2021-11-09 | Invitae Corporation | Blood sampling system and method |
| JP7266310B2 (en) * | 2018-01-23 | 2023-04-28 | アピックス メディカル コーポレーション | electrosurgical device |
| KR102144930B1 (en) | 2018-03-09 | 2020-08-14 | (주)라메디텍 | Laser lancing device |
| JP2020069118A (en) * | 2018-10-31 | 2020-05-07 | キヤノン株式会社 | Processing device and processing method |
| CN110269630A (en) * | 2019-07-13 | 2019-09-24 | 深圳市北扶生物医疗科技有限公司 | A kind of laser burn device |
| CN110560930B (en) * | 2019-09-16 | 2021-11-16 | 深圳泰软软件科技有限公司 | Cutting method and device for blood spot of blood sampling card and readable storage medium |
| US11304788B2 (en) * | 2019-11-07 | 2022-04-19 | Orthosnap Corp. | Light concentrating adapter for dental curing |
| US20230285077A1 (en) * | 2021-11-11 | 2023-09-14 | Speclipse Inc | Pulsed laser irradiation device |
| WO2023230615A2 (en) * | 2022-05-27 | 2023-11-30 | The General Hospital Corporation | Negative pressure laser handpiece |
| KR20240114468A (en) * | 2023-01-17 | 2024-07-24 | (주)보성메디텍 | Method for controlling laser blood collection device, laser blood collection device and system thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112328A (en) * | 1988-01-25 | 1992-05-12 | Refractive Laser Research & Development Program, Ltd. | Method and apparatus for laser surgery |
| SU1670858A1 (en) | 1989-10-19 | 1994-04-30 | Горбатова Наталия Евгеньевна | Method of blood drawing |
| RU2005515C1 (en) | 1991-09-16 | 1994-01-15 | Научно-производственная внедренческая фирма "Созет" | Device for contact-free perforation of skin for taking blood samples |
| US5165418B1 (en) | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
| US5643252A (en) * | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
| US5432811A (en) | 1993-03-04 | 1995-07-11 | Tecnal Products, Inc. | Laser rod with polyhedron shaped ends |
| US5464436A (en) * | 1994-04-28 | 1995-11-07 | Lasermedics, Inc. | Method of performing laser therapy |
| US5993439A (en) * | 1994-08-29 | 1999-11-30 | Cell Robotics, Inc. | Lens shield for laser skin perforation |
| US5554153A (en) | 1994-08-29 | 1996-09-10 | Cell Robotics, Inc. | Laser skin perforator |
| US5947957A (en) | 1994-12-23 | 1999-09-07 | Jmar Technology Co. | Portable laser for blood sampling |
| RU2140305C1 (en) | 1995-06-15 | 1999-10-27 | Научно-производственная внедренческая фирма "Созет" | Laser perforator |
| PT1563788E (en) * | 1995-08-29 | 2015-06-02 | Nitto Denko Corp | Microporation of human skin for drug delivery and monitoring applications |
| US6074383A (en) | 1998-09-30 | 2000-06-13 | Becton Dickinson And Company | Laser lancet tip |
| US6733493B2 (en) * | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
-
2001
- 2001-11-15 US US10/001,004 patent/US6733493B2/en not_active Expired - Lifetime
- 2001-11-16 JP JP2002568970A patent/JP3962335B2/en not_active Expired - Fee Related
- 2001-11-16 CN CNB018189024A patent/CN100525705C/en not_active Expired - Fee Related
- 2001-11-16 WO PCT/US2001/044187 patent/WO2002069782A2/en active Search and Examination
- 2001-11-16 AU AU2001297665A patent/AU2001297665B2/en not_active Ceased
- 2001-11-16 EP EP01273927A patent/EP1343428B1/en not_active Expired - Lifetime
- 2001-11-16 CA CA2429271A patent/CA2429271C/en not_active Expired - Lifetime
- 2001-11-16 AT AT01273927T patent/ATE421295T1/en active
- 2001-11-16 DE DE60137539T patent/DE60137539D1/en not_active Expired - Lifetime
- 2001-11-16 KR KR1020037006621A patent/KR100902695B1/en active IP Right Grant
- 2001-11-16 RU RU2003117700/14A patent/RU2309699C2/en active
-
2004
- 2004-05-10 US US10/842,597 patent/US7524317B2/en not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101437452B (en) * | 2006-04-14 | 2010-07-28 | 爱松特技术有限公司 | Painless blood sampling device using Er:YAG laser generating device and blood sugar measuring instrument using the same |
| CN101820816B (en) * | 2007-10-08 | 2013-04-24 | 霍夫曼-拉罗奇有限公司 | Analysis system for automatic skin prick analysis |
| US9325147B2 (en) | 2011-03-11 | 2016-04-26 | Gtc Co., Ltd. | Method and apparatus for generating laser |
| CN103732141A (en) * | 2011-03-11 | 2014-04-16 | Gtc株式会社 | Method and apparatus for generating laser |
| CN103561650B (en) * | 2011-03-31 | 2015-11-25 | (株)艾莎特 | The portable laser blood sampling device possessing double security device and the disposable type cap therewith used |
| CN103561650A (en) * | 2011-03-31 | 2014-02-05 | (株)艾莎特 | Portable lancing device using laser and equipped with double safety device and disposable cap used therewith |
| US9486165B2 (en) | 2011-03-31 | 2016-11-08 | Isotech Co., Ltd. | Portable lancing device using laser and equipped with double safety device and disposable cap used therewith |
| CN104107055A (en) * | 2013-04-18 | 2014-10-22 | 镇江太阳圣华医疗科技有限公司 | Laser glucose meter |
| CN105879184A (en) * | 2016-04-01 | 2016-08-24 | 新乡医学院 | Electronic writing device with examination anxiety resisting function |
| CN108201443A (en) * | 2016-12-19 | 2018-06-26 | 比亚迪股份有限公司 | A kind of laser blood-taking device |
| CN108201443B (en) * | 2016-12-19 | 2021-08-10 | 比亚迪股份有限公司 | Laser blood sampling instrument |
| CN107440726A (en) * | 2017-07-27 | 2017-12-08 | 珠海柯诺医疗科技有限公司 | It is a kind of based on laser blood-taking device can pressure release protection consumptive material |
| CN116763427A (en) * | 2023-08-26 | 2023-09-19 | 深圳市北扶生物医疗科技有限公司 | Skin laser operation device |
| CN116763427B (en) * | 2023-08-26 | 2023-10-20 | 深圳市北扶生物医疗科技有限公司 | Skin laser operation device |
Also Published As
| Publication number | Publication date |
|---|---|
| US20020058953A1 (en) | 2002-05-16 |
| US7524317B2 (en) | 2009-04-28 |
| WO2002069782A2 (en) | 2002-09-12 |
| US6733493B2 (en) | 2004-05-11 |
| RU2309699C2 (en) | 2007-11-10 |
| KR100902695B1 (en) | 2009-06-15 |
| AU2001297665B2 (en) | 2006-09-07 |
| EP1343428A2 (en) | 2003-09-17 |
| EP1343428A4 (en) | 2005-06-15 |
| ATE421295T1 (en) | 2009-02-15 |
| US20040210279A1 (en) | 2004-10-21 |
| RU2003117700A (en) | 2005-02-10 |
| CA2429271A1 (en) | 2002-05-16 |
| DE60137539D1 (en) | 2009-03-12 |
| JP3962335B2 (en) | 2007-08-22 |
| CA2429271C (en) | 2014-01-21 |
| WO2002069782A3 (en) | 2003-05-15 |
| KR20030082546A (en) | 2003-10-22 |
| CN100525705C (en) | 2009-08-12 |
| EP1343428B1 (en) | 2009-01-21 |
| JP2004533866A (en) | 2004-11-11 |
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