CN1488376A - Medicinal cap sule for treating enteric disease and nusosinusitis and preparing method thereof - Google Patents
Medicinal cap sule for treating enteric disease and nusosinusitis and preparing method thereof Download PDFInfo
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- CN1488376A CN1488376A CNA031168736A CN03116873A CN1488376A CN 1488376 A CN1488376 A CN 1488376A CN A031168736 A CNA031168736 A CN A031168736A CN 03116873 A CN03116873 A CN 03116873A CN 1488376 A CN1488376 A CN 1488376A
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- herba
- herba andrographis
- senecionis scandentis
- andrographis
- percolation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a drug capsule to cure intestines disease and sinusitis, and the preparing method, using Common Andrographis Herb and Climbing Groundsel Herb as main raw material, associated with micronized silica gel. It is applied to symptoms such as enteritis, colonitis, bacteroidal dysentery and sinusitis, has better curative effect on the patient suffering sinusitis whose course of diseases is short and whose middle nose channel have no rhinopolypus, has good curative effect on the patient suffering from acute diarrhea, acute dysentery and acute enteritis, especially the patient taking other medicine to cause maladjustment of bacteric crowd to produce side-effect. It has functions of cleaning heat and detoxifying, diminishing inflammation and acesodyne, and anti-diarrhoea. It better preserves effective substance in medicinal materials, shelf life up to above two years and having advantages of good stability, accurate curative effect, saving time, low cost, etc.
Description
Technical field
What the present invention relates to is Chinese patent medicine in the field of medicaments, especially relates to a kind of have heat-clearing and toxic substances removing, anti-inflammatory analgetic, the treatment intestinal tract disease of antidiarrheal dysentery relieving effect and medicament capsule of sinusitis and preparation method thereof.
Background technology
Thousand happiness sheet kinds are recorded in " Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government " the 17, this standard the preparation method of thousand happiness sheet kind coated tablets, thousand happiness sheets are mainly used in symptoms such as enteritis, colitis, bacillary dysentery and sinusitis, but the preparation method complexity of thousand happiness sheet kind coated tablets, production technology is reasonable inadequately, time-consuming, the cost height, and it is less to contain the active substance of medical material in the product, poor stability, sugar-coat easily dissolves again, and keeping life is shorter.
Summary of the invention
The object of the present invention is to provide a kind ofly have that the active substance that contains medical material in heat-clearing and toxic substances removing, anti-inflammatory analgetic, the effect of antidiarrheal dysentery relieving, the product is more, the medicament capsule of good stability, determined curative effect, production technology proper treatment intestinal tract disease and sinusitis and preparation method thereof.
The object of the present invention is achieved like this: the raw material of medicament capsule of the present invention comprises adjuvant, it is characterized in that: also comprise Herba Andrographis and Herba Senecionis Scandentis.
Per 1000 contained Herba Andrographis and Herba Senecionis Scandentis are by weight:
Herba Andrographis 1000-3000 gram
Herba Senecionis Scandentis 1000-3000 gram
Per 1000 contained Herba Andrographis and Herba Senecionis Scandentis the best by weight are:
Herba Andrographis 2000 grams
Herba Senecionis Scandentis 2000 grams
Preparation method of the present invention is:
(1), Herba Andrographis is ground into coarse powder,, flood after 24 hours,, obtain the Herba Andrographis percolate with the speed of per kilogram per minute 3-5ml percolation slowly according to percolation alcohol solvent under fluid extract and the extractum item;
(2), collect 12000ml Herba Andrographis percolate, under agitation add and wait water gaging, centrifugal, precipitation separation obtains the Herba Andrographis precipitate, solution recovery ethanol is condensed into the thick extractum of Herba Andrographis;
(3), Herba Senecionis Scandentis is ground into coarse powder, mix with above-mentioned Herba Andrographis coarse powder and Herba Andrographis precipitate behind percolation, stir, do solvent impregnated 12 hours according to percolation under fluid extract and the extractum item with 3 times of amount 0.8%NaOH solution, add the water percolation, with the speed of per kilogram per minute 3-5ml percolation slowly, obtain Herba Senecionis Scandentis and Herba Andrographis mixing percolate;
(4), collect 10000ml Herba Senecionis Scandentis and Herba Andrographis mixing percolate, reuse hydrochloric acid adjusting pH value 2-3 stirs, and is centrifugal, abandoning supernatant, collecting precipitation obtains Herba Senecionis Scandentis and Herba Andrographis mixed sediment;
(5), in Herba Senecionis Scandentis and Herba Andrographis mixed sediment, add the thick extractum of Herba Andrographis, mix, stir, 70 ℃ of drying under reduced pressure are pulverized, and cross 60 mesh sieves, add 1% micropowder silica gel mixing, make capsule, get product.
The present invention is to be primary raw material with Herba Andrographis and Herba Senecionis Scandentis, is aided with micropowder silica gel again and makes adjuvant, forms by certain prepared.Medicament capsule of the present invention is used for enteritis, colitis, symptom such as bacillary dysentery and sinusitis, short to the course of disease, sinusitis patient's curative effect that the middle nasal meatus does not have in the breath is better, to acute diarrhea, acute dysentery, the patient treatment of acute enteritis is effective, particularly those are because of taking the patient that other medicine causes dysbacteriosis to have side effects, it has heat-clearing and toxic substances removing, anti-inflammatory analgetic, the effect of antidiarrheal dysentery relieving, the present invention has compared with prior art: production technology more becomes to improving rationally, kept the active substance in the medical material more, quality standard and product stability improve greatly, the effect duration of medicine reached more than 2 years, and had good stability, determined curative effect, save time, cost is low, the finished product of producing is more elegant in appearance, advantage easy to use.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but should understands the non-scope that only limits to these embodiment of scope of the present invention.
Embodiment 1:
(1), take by weighing 2000g Herba Andrographis, then Herba Andrographis is ground into coarse powder, according to percolation alcohol solvent under fluid extract and the extractum item, flood after 24 hours, with the speed of per kilogram per minute 3-5ml percolation slowly, obtain the Herba Andrographis percolate;
(2), collect 12000ml Herba Andrographis percolate, under agitation add and wait water gaging, centrifugal, precipitation separation obtains the Herba Andrographis precipitate, solution recovery ethanol is condensed into the thick extractum of Herba Andrographis;
(3), take by weighing the 2000g Herba Senecionis Scandentis, then Herba Senecionis Scandentis is ground into coarse powder, mix with above-mentioned Herba Andrographis coarse powder and Herba Andrographis precipitate behind percolation, stir, do solvent impregnated 12 hours according to percolation under fluid extract and the extractum item with 3 times of amount 0.8%NaOH solution, add the water percolation,, obtain Herba Senecionis Scandentis and Herba Andrographis mixing percolate with the speed of per kilogram per minute 3-5ml percolation slowly;
(4), collect 10000ml Herba Senecionis Scandentis and Herba Andrographis mixing percolate, reuse hydrochloric acid adjusting pH value 2-3 stirs, and is centrifugal, abandoning supernatant, collecting precipitation obtains Herba Senecionis Scandentis and Herba Andrographis mixed sediment;
(5), in Herba Senecionis Scandentis and Herba Andrographis mixed sediment, add the thick extractum of Herba Andrographis, mix, stir, 70 ℃ of drying under reduced pressure are pulverized, and cross 60 mesh sieves, add 1% micropowder silica gel mixing, make capsule, get product.
Embodiment 2:
(1), take by weighing 1000g Herba Andrographis, then Herba Andrographis is ground into coarse powder, according to percolation alcohol solvent under fluid extract and the extractum item, flood after 24 hours, with the speed of per kilogram per minute 3-5ml percolation slowly, obtain the Herba Andrographis percolate;
(2), collect 12000ml Herba Andrographis percolate, under agitation add and wait water gaging, centrifugal, precipitation separation obtains the Herba Andrographis precipitate, solution recovery ethanol is condensed into the thick extractum of Herba Andrographis;
(3), take by weighing the 1000g Herba Senecionis Scandentis, then Herba Senecionis Scandentis is ground into coarse powder, mix with above-mentioned Herba Andrographis coarse powder and Herba Andrographis precipitate behind percolation, stir, do solvent impregnated 12 hours according to percolation under fluid extract and the extractum item with 3 times of amount 0.8%NaOH solution, add the water percolation,, obtain Herba Senecionis Scandentis and Herba Andrographis mixing percolate with the speed of per kilogram per minute 3-5ml percolation slowly;
Step (4), (5) are identical with embodiment 1.
Embodiment 3:
(1), take by weighing 2000g Herba Andrographis, then Herba Andrographis is ground into coarse powder, according to percolation alcohol solvent under fluid extract and the extractum item, flood after 24 hours, with the speed of per kilogram per minute 3-5ml percolation slowly, obtain the Herba Andrographis percolate;
(2), collect 12000ml Herba Andrographis percolate, under agitation add and wait water gaging, centrifugal, precipitation separation obtains the Herba Andrographis precipitate, solution recovery ethanol is condensed into the thick extractum of Herba Andrographis;
(3), take by weighing the 2000g Herba Senecionis Scandentis, then Herba Senecionis Scandentis is ground into coarse powder, mix with above-mentioned Herba Andrographis coarse powder and Herba Andrographis precipitate behind percolation, stir, do solvent impregnated 12 hours according to percolation under fluid extract and the extractum item with 3 times of amount 0.8%NaOH solution, add the water percolation,, obtain Herba Senecionis Scandentis and Herba Andrographis mixing percolate with the speed of per kilogram per minute 3-5ml percolation slowly;
Step (4), (5) are identical with embodiment 1.
Claims (4)
1, a kind of medicament capsule for the treatment of intestinal tract disease and sinusitis, raw material comprises adjuvant, it is characterized in that: also comprise Herba Andrographis and Herba Senecionis Scandentis.
2, the medicament capsule of treatment intestinal tract disease as claimed in claim 1 and sinusitis is characterized in that: per 1000 contained Herba Andrographis and Herba Senecionis Scandentis are by weight:
Herba Andrographis 1000-3000 gram
Herba Senecionis Scandentis 1000-3000 gram.
3, the medicament capsule of treatment intestinal tract disease as claimed in claim 2 and sinusitis is characterized in that: per 1000 contained Herba Andrographis and Herba Senecionis Scandentis the best by weight are:
Herba Andrographis 2000 grams
Herba Senecionis Scandentis 2000 grams.
4, preparation is characterized in that as the method for the medicament capsule of claim 2 or 3 described treatment intestinal tract diseases and sinusitis:
(1), Herba Andrographis is ground into coarse powder,, flood after 24 hours,, obtain the Herba Andrographis percolate with the speed of per kilogram per minute 3-5ml percolation slowly according to percolation alcohol solvent under fluid extract and the extractum item;
(2), collect 12000ml Herba Andrographis percolate, under agitation add and wait water gaging, centrifugal, precipitation separation obtains the Herba Andrographis precipitate, solution recovery ethanol is condensed into the thick extractum of Herba Andrographis;
(3), Herba Senecionis Scandentis is ground into coarse powder, mix with above-mentioned Herba Andrographis coarse powder and Herba Andrographis precipitate behind percolation, stir, do solvent impregnated 12 hours according to percolation under fluid extract and the extractum item with 3 times of amount 0.8%NaOH solution, add the water percolation, with the speed of per kilogram per minute 3-5ml percolation slowly, obtain Herba Senecionis Scandentis and Herba Andrographis mixing percolate;
(4), collect 10000ml Herba Senecionis Scandentis and Herba Andrographis mixing percolate, reuse hydrochloric acid adjusting pH value 2-3 stirs, and is centrifugal, abandoning supernatant, collecting precipitation obtains Herba Senecionis Scandentis and Herba Andrographis mixed sediment;
(5), in Herba Senecionis Scandentis and Herba Andrographis mixed sediment, add the thick extractum of Herba Andrographis, mix, stir, 70 ℃ of drying under reduced pressure are pulverized, and cross 60 mesh sieves, add 1% micropowder silica gel mixing, make capsule, get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031168736A CN1488376A (en) | 2003-05-09 | 2003-05-09 | Medicinal cap sule for treating enteric disease and nusosinusitis and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031168736A CN1488376A (en) | 2003-05-09 | 2003-05-09 | Medicinal cap sule for treating enteric disease and nusosinusitis and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1488376A true CN1488376A (en) | 2004-04-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031168736A Pending CN1488376A (en) | 2003-05-09 | 2003-05-09 | Medicinal cap sule for treating enteric disease and nusosinusitis and preparing method thereof |
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| CN (1) | CN1488376A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104722A2 (en) | 2004-04-28 | 2005-11-10 | Hutchison Medipharma Enterprises Limited | Crude extracts from andrographis paniculata |
| US8557308B2 (en) | 2007-11-02 | 2013-10-15 | Nutrition Science Partners Limited | Andrographis paniculata extract |
-
2003
- 2003-05-09 CN CNA031168736A patent/CN1488376A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104722A2 (en) | 2004-04-28 | 2005-11-10 | Hutchison Medipharma Enterprises Limited | Crude extracts from andrographis paniculata |
| USRE42718E1 (en) | 2004-04-28 | 2011-09-20 | Hutchison Medipharma Enterprises Limited | Crude extracts from andrographis paniculata |
| USRE43423E1 (en) | 2004-04-28 | 2012-05-29 | Hutchison Medipharma Enterprises Limited | Crude extracts from Andrographis paniculata |
| US8557308B2 (en) | 2007-11-02 | 2013-10-15 | Nutrition Science Partners Limited | Andrographis paniculata extract |
| US8557302B2 (en) | 2007-11-02 | 2013-10-15 | Nutrition Science Partners Limited | Andrographis paniculata extract |
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