CN1377645A - Tea polyphenol buccal tablet for preventing and curing tooth decay and its preparing method - Google Patents
Tea polyphenol buccal tablet for preventing and curing tooth decay and its preparing method Download PDFInfo
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- CN1377645A CN1377645A CN02110270A CN02110270A CN1377645A CN 1377645 A CN1377645 A CN 1377645A CN 02110270 A CN02110270 A CN 02110270A CN 02110270 A CN02110270 A CN 02110270A CN 1377645 A CN1377645 A CN 1377645A
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- preventing
- tea polyphenol
- dental caries
- xylitol
- mannitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
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- Biotechnology (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The tea polyphenol baccal tablet for preventing and treating decayed tooth is prepared with the raw material including tea polyphenol, xylitol, mannitol, beta-cyclodextrin, natural food additive and lubricant. Its preparation process includes grinding beta-cyclodextrin in water, adding tea polyphenol before further grinding into paste, low temperature dyring, grinding xylitol, mannitol and natural food additive to 400-600 mesh, mixing the said material, mixing the mixture with alcohol, granulating, drying at temperature below 60 deg.c, mixing with lubricant and tableting. The present invention can inhibit bacteria in oral cavity efficiency.
Description
Technical field
The present invention relates to prevent and treat the medicine buccal tablet of dental caries disease and prepare this medicine buccal tablet technical field.
Background technology
Tea polyphenols is a green tea extract.For oral disease, tea polyphenols is the medicine that can effectively suppress cariogenic bacteria, Streptococcus mutans, outlying streptococcus growth clinically.At present; international and domestic for preventing and treating the dental caries disease and taking care of one's teeth; mostly adopt the toothpaste of fluorine by making; Liniment and gargarism are finished; the relatively short shortcoming of cycle that it all exists in time of staying in the oral cavity and acts on tooth, it is unfavorable for the effective inhibition to above-mentioned various oral cavities bacterium.If often use toothpaste, Liniment and gargarism to have not very convenient, not really refined shortcoming again whenever and wherever possible.Chinese patent 94113979.4 discloses a kind of decayed tooth preventing toffee and manufacture method thereof, the composition that also contains tea polyphenols in its prescription, but it with toffee as the carrier of control dental caries disease drug very science not, be exactly one of factor that causes easily the dental caries disease because of toffee or saccharide itself, and diabetics then can't use; Moreover tea polyphenols content therein is lower in this patent, compares relatively poor so it plays the effect that suppresses relevant various oral cavities bacterium.
Summary of the invention
The invention provides a kind of tea polyphenol buccal tablet of preventing and treating dental caries and preparation method thereof, it has solved the time of staying in the oral cavity that existing toothpaste, Liniment and gargarism all exist and has acted on the tooth cycle short and be unfavorable for effective inhibition to various oral cavities bacterium, and toffee has the problem of certain side effect to tooth as the carrier of control dental caries disease drug itself.
The objective of the invention is to be achieved through the following technical solutions: a kind of tea polyphenol buccal tablet of preventing and treating dental caries, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 1-7 xylitol 25-45
Mannitol 20-40 beta-schardinger dextrin-15-25
Natural additive for foodstuff 7-12 lubricant 0.5-2
A kind of preparation method of preventing and treating the tea polyphenol buccal tablet of dental caries is got predetermined amount of beta-cyclodextrin and is added the purified water that 2-5 doubly measures and grind well, and adds to grind in the rearmounted grinder of a certain amount of tea polyphenols to be pasty state, and cold drying is a clathrate; Get a certain amount of xylitol, mannitol, natural additive for foodstuff insert be treated in the micropowder datatron behind the 400-600 order stand-by; At this moment, above-mentioned mixed material after handling respectively together inserted in the mixer mix, and insert a certain amount of 95% ethanol and make soft material, make granule with nylon mesh, again this granule is inserted in the drying baker dry below 60 ℃, dried granule and a certain amount of lubricant are together inserted in the batch mixing bucket, and are compressed to the lamellar that contains of national standard.
Also can finish by the following technical programs for further realizing purpose of the present invention: the described tea polyphenol buccal tablet of preventing and treating dental caries, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 2-6 xylitol 28-40
Mannitol 23-36 beta-schardinger dextrin-17-22
Natural additive for foodstuff 8-11 lubricant 0.8-1.6
The described tea polyphenol buccal tablet of preventing and treating dental caries, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 3-5 xylitol 32-38
Mannitol 25-32 beta-schardinger dextrin-18-21
Natural additive for foodstuff 9-10 lubricant 0.9-1.2
The described tea polyphenol buccal tablet of preventing and treating dental caries, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 4-5 xylitol 35-38
Mannitol 27-30 beta-schardinger dextrin-18-20
Natural additive for foodstuff 9.5-10 lubricant 0.9-1.1
The described tea polyphenol buccal tablet of preventing and treating dental caries, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 4.5 xylitol 36.7
Mannitol 28.78 beta-schardinger dextrin-s 19.4
Natural additive for foodstuff 9.62 lubricants 1
Prevent and treat the tea polyphenol buccal tablet of dental caries, said tea polyphenols is pure tea polyphenols.
Said medicament is tablet or piece type.
Described preparation method of preventing and treating the tea polyphenol buccal tablet of dental caries, the micropowder fineness of xylitol, mannitol, natural additive for foodstuff mixed material is the 450-500 order.
Described preparation method of preventing and treating the tea polyphenol buccal tablet of dental caries, the micropowder fineness of xylitol, mannitol, natural additive for foodstuff mixed material is 500 orders.
The beneficial effect that the present invention can produce: because of it takes the form of buccal tablet, so it is not only convenient but also refined when often using whenever and wherever possible; The amount that includes tea polyphenols because of it is bigger, so it can effectively suppress cariogenic bacteria, Streptococcus mutans and outlying streptococcic growth; Because of its material fineness is treated to more than 500 orders, it is longer that its hardness reaches melting time more greatly, so time that is stopped in the oral cavity and to act on cycle of tooth longer relatively, it helps the effective inhibition to various oral cavities bacterium, and its therapeutic effect is more satisfactory; Because of it does not contain glucide, so diabetics also can use; Moreover, delicate mouthfeel during its containing, lubricate, do not have any granular sensation.
The specific embodiment
Tea polyphenol buccal tablet of preventing and treating dental caries of the present invention and preparation method thereof, it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 4.5 xylitol 36.7
Mannitol 28.78 beta-schardinger dextrin-s 19.4
Natural additive for foodstuff 9.62 lubricants 1
A kind of preparation method of preventing and treating the tea polyphenol buccal tablet of dental caries is got predetermined amount of beta-cyclodextrin and is added the purified water that 2-5 doubly measures and grind well, and adds to grind in the rearmounted grinder of a certain amount of tea polyphenols to be pasty state, and cold drying is a clathrate; Get a certain amount of xylitol, mannitol, natural additive for foodstuff insert be treated in the micropowder datatron behind 500 orders stand-by; At this moment, above-mentioned mixed material after handling respectively together inserted in the mixer mix, and insert a certain amount of 95% ethanol and make soft material, make granule with nylon mesh, again this granule is inserted in the drying baker dry below 60 ℃, dried granule and a certain amount of lubricant are together inserted in the batch mixing bucket, and are compressed to the lamellar that contains of national standard.
The technology that the present invention does not describe in detail partly is known technology.
Claims (10)
1, a kind of tea polyphenol buccal tablet of preventing and treating dental caries is characterized in that it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 1-7 xylitol 25-45
Mannitol 20-40 beta-schardinger dextrin-15-25
Natural additive for foodstuff 7-12 lubricant 0.5-2
2, the tea polyphenol buccal tablet of preventing and treating dental caries according to claim 1 is characterized in that it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 2-6 xylitol 28-40
Mannitol 23-36 beta-schardinger dextrin-17-22
Natural additive for foodstuff 8-11 lubricant 0.8-1.6
3, the tea polyphenol buccal tablet of preventing and treating dental caries according to claim 1 is characterized in that it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 3-5 xylitol 32-38
Mannitol 25-32 beta-schardinger dextrin-18-21
Natural additive for foodstuff 9-10 lubricant 0.9-1.2
4, the tea polyphenol buccal tablet of preventing and treating dental caries according to claim 1 is characterized in that it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 4-5 xylitol 35-38
Mannitol 27-30 beta-schardinger dextrin-18-20
Natural additive for foodstuff 9.5-10 lubricant 0.9-1.1
5, the tea polyphenol buccal tablet of preventing and treating dental caries according to claim 1 is characterized in that it is the medicament (in weight portion) that comprises that the following weight proportion raw material is made:
Tea polyphenols 4.5 xylitol 36.7
Mannitol 28.78 beta-schardinger dextrin-s 19.4
Natural additive for foodstuff 9.62 lubricants 1
6, according to claim 1 or 2 or 3 or the 4 or 5 described tea polyphenol buccal tablets of preventing and treating dental caries, it is characterized in that said tea polyphenols is pure tea polyphenols.
7, according to claim 1 or 2 or 3 or the 4 or 5 described tea polyphenol buccal tablets of preventing and treating dental caries, the dosage form that it is characterized in that this buccal tablet is a tablet.
8, a kind of preparation method of preventing and treating the tea polyphenol buccal tablet of dental caries is characterized in that: get predetermined amount of beta-cyclodextrin and add the purified water that 2-5 doubly measures and grind well, add to grind in the rearmounted grinder of a certain amount of tea polyphenols and be pasty state, cold drying is a clathrate; Get a certain amount of xylitol, mannitol, natural additive for foodstuff insert be treated in the micropowder datatron behind the 400-600 order stand-by; At this moment, above-mentioned mixed material after handling respectively together inserted in the mixer mix, and insert a certain amount of 95% ethanol and make soft material, make granule with nylon mesh, again this granule is inserted in the drying baker dry below 60 ℃, dried granule and a certain amount of lubricant are together inserted in the batch mixing bucket, and are compressed to the lamellar that contains of national standard.
9, tea polyphenol buccal tablet of preventing and treating dental caries according to claim 8 and preparation method thereof is characterized in that: the micropowder fineness of xylitol, mannitol, natural additive for foodstuff mixed material is the 450-500 order.
10, tea polyphenol buccal tablet of preventing and treating dental caries according to claim 8 and preparation method thereof is characterized in that: the micropowder fineness of xylitol, mannitol, natural additive for foodstuff mixed material is 500 orders.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02110270A CN1377645A (en) | 2002-04-17 | 2002-04-17 | Tea polyphenol buccal tablet for preventing and curing tooth decay and its preparing method |
| AU2003236124A AU2003236124A1 (en) | 2002-04-17 | 2003-04-14 | Tea polyphenol buccal tablet for preventing and treating tooth decay and its preparing method |
| PCT/CN2003/000264 WO2003086359A1 (en) | 2002-04-17 | 2003-04-14 | Tea polyphenol buccal tablet for preventing and treating tooth decay and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02110270A CN1377645A (en) | 2002-04-17 | 2002-04-17 | Tea polyphenol buccal tablet for preventing and curing tooth decay and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1377645A true CN1377645A (en) | 2002-11-06 |
Family
ID=4741008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02110270A Pending CN1377645A (en) | 2002-04-17 | 2002-04-17 | Tea polyphenol buccal tablet for preventing and curing tooth decay and its preparing method |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1377645A (en) |
| AU (1) | AU2003236124A1 (en) |
| WO (1) | WO2003086359A1 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1957732B (en) * | 2006-11-03 | 2010-05-12 | 安徽福康药业有限责任公司 | Xylitol hard candy, and preparation method |
| CN101829209A (en) * | 2010-04-28 | 2010-09-15 | 广西大学 | Preparation method of fruit-flavored sweet tea polyphenols |
| CN101926430A (en) * | 2010-08-06 | 2010-12-29 | 陈森全 | Polyphenol buccal tablets and preparation method thereof |
| CN105456047A (en) * | 2011-09-28 | 2016-04-06 | 狮王株式会社 | Oral composition |
| CN110339175A (en) * | 2019-08-19 | 2019-10-18 | 云南农业大学 | A kind of tea polyphenol buccal tablet preventing and treating canker sore |
| CN113633574A (en) * | 2021-08-23 | 2021-11-12 | 合肥赛为智慧医疗有限公司 | Anti-caries mouthwash and preparation method thereof |
| WO2022088724A1 (en) * | 2020-10-28 | 2022-05-05 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method therefor |
| WO2024016109A1 (en) * | 2022-07-18 | 2024-01-25 | 南京中科游子生物技术研究院有限公司 | Oral care composition of tea active substance and method for preparing same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066960C (en) * | 1994-07-19 | 2001-06-13 | 李文兴 | Carious-tooth resistant compound and its preparation method |
| CN1073424C (en) * | 1996-05-28 | 2001-10-24 | 山东泉城药厂 | Preparation of tablet for preventing and curing dental diseases |
| CN1090911C (en) * | 1996-12-11 | 2002-09-18 | 樊华轩 | Tea flakes and their production |
| JPH11180840A (en) * | 1997-12-22 | 1999-07-06 | Lion Corp | Xylitol-containing tablet |
| CN1367663A (en) * | 1999-09-08 | 2002-09-04 | Amt技术公司 | Ocular biometer |
-
2002
- 2002-04-17 CN CN02110270A patent/CN1377645A/en active Pending
-
2003
- 2003-04-14 WO PCT/CN2003/000264 patent/WO2003086359A1/en not_active Application Discontinuation
- 2003-04-14 AU AU2003236124A patent/AU2003236124A1/en not_active Abandoned
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1957732B (en) * | 2006-11-03 | 2010-05-12 | 安徽福康药业有限责任公司 | Xylitol hard candy, and preparation method |
| CN101829209A (en) * | 2010-04-28 | 2010-09-15 | 广西大学 | Preparation method of fruit-flavored sweet tea polyphenols |
| CN101829209B (en) * | 2010-04-28 | 2012-12-05 | 广西大学 | Preparation method of fruit-flavored sweet tea polyphenols |
| CN101926430A (en) * | 2010-08-06 | 2010-12-29 | 陈森全 | Polyphenol buccal tablets and preparation method thereof |
| CN105456047A (en) * | 2011-09-28 | 2016-04-06 | 狮王株式会社 | Oral composition |
| CN105456047B (en) * | 2011-09-28 | 2018-08-07 | 狮王株式会社 | Composition for oral cavity |
| CN110339175A (en) * | 2019-08-19 | 2019-10-18 | 云南农业大学 | A kind of tea polyphenol buccal tablet preventing and treating canker sore |
| WO2022088724A1 (en) * | 2020-10-28 | 2022-05-05 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method therefor |
| CN114469794A (en) * | 2020-10-28 | 2022-05-13 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method thereof |
| CN113633574A (en) * | 2021-08-23 | 2021-11-12 | 合肥赛为智慧医疗有限公司 | Anti-caries mouthwash and preparation method thereof |
| WO2024016109A1 (en) * | 2022-07-18 | 2024-01-25 | 南京中科游子生物技术研究院有限公司 | Oral care composition of tea active substance and method for preparing same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003086359A1 (en) | 2003-10-23 |
| AU2003236124A1 (en) | 2003-10-27 |
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