CN1369290A - 'Yizhi' capsule for brain health - Google Patents
'Yizhi' capsule for brain health Download PDFInfo
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- CN1369290A CN1369290A CN 01136349 CN01136349A CN1369290A CN 1369290 A CN1369290 A CN 1369290A CN 01136349 CN01136349 CN 01136349 CN 01136349 A CN01136349 A CN 01136349A CN 1369290 A CN1369290 A CN 1369290A
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- seed
- brain
- herba apii
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Abstract
A "Yizhi" capsule for invigorating function of brain and improving memory power is prepared from perilla seed and celery seed through extracting oil and proportioning. Its advantages are no EPA, and containing DHA.
Description
Technical field
A kind of health product-Cognex that is used for brain-strengthening, raising memory relates to technical field of organic chemistry.
Background technology
Have the health food that improves memory function on the current market, most of product primary raw materials are fish oil.Contain omega-3 unsaturated fatty acid in the fish oil, DHA (being the english abbreviation of docosahexaenoic acid) especially has vessel softening, nourishing the brain and improving intelligence, improves the effect of vision, is commonly called as " NAOHUANGJIN ".EPA (being the english abbreviation of 22 carbon, five diluted acids) has the function of the rubbish (cholesterol and triglyceride) in the cleaning blood vessel, is commonly called as " blood vessel street cleaner ", and it is that human body Suo Bi Xu De Camp supports material.DHA, EPA in the human body convert by metabolism usually, but infant and old people's conversion efficiency is low, therefore, must be when human body lacks from external absorption, but price factor has restricted fish oil popularizing in China, the shortcoming of EPA is to generate prostaglandin in addition, and children taking is excessive may to cause sexual precosity.DHA, EPA in the fish oil exist simultaneously, are difficult to separately during mass production.
Summary of the invention
In order to overcome the side effect of the EPA that prior art exists, we have designed the prescription of Cognex.
Cognex, the oil that it is characterized in that selecting for use natural plants Fructus Perillae, seed of Herba Apii graveolentis to extract are joined for primary raw material and are made, and its proportioning is 1: 1.
Cognex is to heat in Fructus Perillae and the seed of Herba Apii graveolentis pulverizing back input supercritical extraction reactor, when equipment reaches uniform temperature, to use CO
2Pressurization, when reaching certain pressure, the beginning cycling extraction can obtain perilla oil or seed oil of Herba Apii graveolentis after 4 hours or 5 hours, adds the VE sealing respectively and preserve in two kinds of oil, mix homogeneously is made soft intelligence growth promoting capsule or Fructus Alpiniae Oxyphyllae hard capsule according to the preparation method of soft capsule or hard capsule according to the above ratio.
Alpha-linolenic acid content is up to 60%-70% in the perilla oil, and alpha-linolenic acid is the necessary fatty acid of human body, and it is the precursor of the serial unsaturated fatty acid of ω-3 in the body.Alpha-linolenic acid generates a series of metabolites through the effect that desaturase and carbochain prolong enzyme, wherein DHA most importantly.DHA is the main component of nervous system membrane phospholipids such as brain, retina, and the title of " NAOHUANGJIN " is arranged.DHA content in nervous system such as brain and retina is quite abundant, plays a significant role to keeping aspects such as normal retinal function and the activity of promotion learning behavior.Perilla oil energy hypermnesis function, major reason is its content that can increase the DHA in the nervous system, perilla oil can promote that novel protein generates in the brain, regulates the level of monoamine neurotransmitter in the brain.
Seed oil of Herba Apii graveolentis is to be extracted and got by seed of Herba Apii graveolentis, and it contains benzofuranones such as Butylphthalide and Senkyunolide A.Butylphthalide has the function of unique protection brain cell, has the effect that strengthens learning and memory, and its this effect is by anti-cerebral ischemia, improve the moral function disappearance, increase regional cerebral blood flow and improve approach such as brain energy metabolism and bring into play.
Perilla oil and seed oil of Herba Apii graveolentis all have the effect that improves learning and memory, and their mechanism of action is different.We once promoted the effect of mice and learning and memory in rats to test to the mixture of perilla oil and seed oil of Herba Apii graveolentis, confirm that the two has synergism aspect the learning and memory improving, so the mixture of selecting perilla oil and seed oil of Herba Apii graveolentis is as Fructus Alpiniae Oxyphyllae class health product, make them improve the effect of learning and memory by way of performance from difference, we entrust Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene health food functional check center that Cognex has been carried out animal experiment and human trial respectively to see Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene health food functional check center " improve memory (animal experiment) report " report number: battalion defends merit searching 2001-0035 number, and " improving memory (human trial) report " report number: battalion defends the merit searching and confirms that Cognex has animal of improvement (mice) and human body learning and memory ability for 2001-0035 number.
Description of drawings
Figure of description, Fig. 1 are the process charts of soft intelligence growth promoting capsule, and Fig. 2 is the process chart of Fructus Alpiniae Oxyphyllae hard capsule.
The specific embodiment
Shown in Figure of description, the production technology of Cognex is as follows:
1, the preparation of raw oil:
Fructus Perillae is pulverized the back drop in the supercritical extraction reactor, extraction kettle, extraction-container I, extraction-container II, basin are heated respectively, when the temperature of the said equipment reaches 40 ℃-45 ℃, 65 ℃-75 ℃, 55 ℃-63 ℃, 35 ℃-40 ℃ respectively, open CO
2Gas bottle, by compressor pump preceding four kinds of equipment are pressurizeed, when pressure reaches 27Mpa-32Mpa, 6Mpa-9Mpa, 7Mpa-9Mpa, 6Mpa-8Mpa respectively, the beginning cycling extraction, extract after 4 hours,, get transparent oil sample material from extraction-container I discharge hole for discharge, add a spot of VE, sealing is preserved.
Seed of Herba Apii graveolentis is pulverized the same method supercritical extraction in back, and extracting pressure is that 18Mpa-23Mpa, temperature are 32 ℃-37 ℃, extracts 5 hours, gets light yellow translucent oil sample material, adds a small amount of VE, and sealing is preserved.
With above-mentioned two kinds of grease mix homogeneously proportionings: perilla oil: seed oil of Herba Apii graveolentis=1: 1.Begin all to require in 100,000 grades of cleaning shops, to operate from mixing the oil sample operation to each operation of finished product packing.
2, preparation of soft capsule:
(1) change glue: in changing the glue jar, add deionized water, glycerol, be heated to 70 ℃-80 ℃, add a certain proportion of gelatin, nipalgin again, constantly stir, about 1 hour of colloidal sol, evacuation eliminates bubble.
(2) pelleting:, carry out pelleting by the soft capsule pellet processing machine with Fructus Perillae, seed of Herba Apii graveolentis oily thing mix homogeneously.
(3) typing: with cylinder typing 4 hours-6 hours.
(4) drying: in soft capsule drying machine inner drying 8 hours-12 hours.
(5) select ball: pick out underproof typing ball, empty flat ball.
(6) sterilization: put and spill in the machine of washing, 95% ethanol cleans.
(7) packed products: promptly obtain soft intelligence growth promoting capsule.
The preparation of 3 hard capsules:
(1) dress hard capsule:, be filled in the special hard capsule by capsule filling machine with perilla oil, seed oil of Herba Apii graveolentis mix homogeneously.
(2) seal: at capsule shell seam sealing machine front cover tunic.
(3) select ball: pick out underproof special-shaped ball, leakage of oil ball, empty flat ball.
(4) packed products: promptly obtain the Fructus Alpiniae Oxyphyllae hard capsule.
This new prescription and technology have been avoided the existence of EPA, have reached the purpose of obtaining DHA.In health food, added simultaneously the seed oil of Herba Apii graveolentis that contains Butylphthalide (have and improve memory effect) first.
Claims (1)
1 one kinds of Cognexs that are used for brain-strengthening, raising memory relate to organic chemistry filed, it is characterized in that the oil of selecting for use natural plants Fructus Perillae, seed of Herba Apii graveolentis to extract is that primary raw material is made, and its proportioning is 1: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011363495A CN1166386C (en) | 2001-10-11 | 2001-10-11 | 'Yizhi' capsule for brain health |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011363495A CN1166386C (en) | 2001-10-11 | 2001-10-11 | 'Yizhi' capsule for brain health |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1369290A true CN1369290A (en) | 2002-09-18 |
| CN1166386C CN1166386C (en) | 2004-09-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011363495A Expired - Lifetime CN1166386C (en) | 2001-10-11 | 2001-10-11 | 'Yizhi' capsule for brain health |
Country Status (1)
| Country | Link |
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| CN (1) | CN1166386C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005002568A1 (en) | 2003-06-20 | 2005-01-13 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthlide in preventing and treating dementia |
| EP1757286A4 (en) * | 2004-06-18 | 2010-02-10 | Shijiazhuang Pharma Group | The application of l-n-butylphthlide in preventing and treating dementia |
| CN101940292A (en) * | 2010-07-26 | 2011-01-12 | 无锡市天赐康生物科技有限公司 | Health-care food for assisting in improving memory function and preparation method thereof |
| CN103813722A (en) * | 2011-09-13 | 2014-05-21 | 以瓦伦萨国际营业的美国营养品有限公司 | Plant derived seed extract rich in essential fatty acids derived from perilla seed: composition of matter, manufacturing process and use |
| US9414620B2 (en) | 2008-04-10 | 2016-08-16 | U.S. Nutraceuticals, LLC | Perilla seed composition |
| US9532965B2 (en) | 2008-04-10 | 2017-01-03 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use |
| US9610313B2 (en) | 2008-04-10 | 2017-04-04 | U.S. Nutraceuticals | Eye health composition and method using plant derived seed extract rich in essential fatty acids derived from perilla seed and carotenoids |
| CN109106738A (en) * | 2018-09-12 | 2019-01-01 | 沈阳高名医药科技有限公司 | A kind of nervonic acid composition and its application in neuroprotection |
| CN110025651A (en) * | 2019-04-02 | 2019-07-19 | 江苏圣典医药科技有限公司 | A kind of compound celery oil self-emulsifying soft capsule and preparation method thereof with anti-aging effects |
-
2001
- 2001-10-11 CN CNB011363495A patent/CN1166386C/en not_active Expired - Lifetime
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005002568A1 (en) | 2003-06-20 | 2005-01-13 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthlide in preventing and treating dementia |
| US8552058B2 (en) | 2004-06-18 | 2013-10-08 | CSPC Zhongqi Pharmaceutical Technology (Shijazhuang) Co., Ltd. | Application of L-n-butylphthalide in preventing and treating dementia |
| EP1757286A4 (en) * | 2004-06-18 | 2010-02-10 | Shijiazhuang Pharma Group | The application of l-n-butylphthlide in preventing and treating dementia |
| US9511106B2 (en) | 2008-04-10 | 2016-12-06 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essential fatty acids derived from perilla seed: composition of matter, manufacturing process and use |
| US9114142B2 (en) | 2008-04-10 | 2015-08-25 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essential fatty acids derived from perilla seed: composition of matter, manufacturing process and use |
| US9138452B2 (en) | 2008-04-10 | 2015-09-22 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essential fatty acids derived from Perilla seed: composition of matter, manufacturing process and use |
| US9414620B2 (en) | 2008-04-10 | 2016-08-16 | U.S. Nutraceuticals, LLC | Perilla seed composition |
| US9532965B2 (en) | 2008-04-10 | 2017-01-03 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use |
| US9610313B2 (en) | 2008-04-10 | 2017-04-04 | U.S. Nutraceuticals | Eye health composition and method using plant derived seed extract rich in essential fatty acids derived from perilla seed and carotenoids |
| US9770047B2 (en) | 2008-04-10 | 2017-09-26 | U.S. Nutraceuticals, LLC | Perilla seed composition |
| CN101940292B (en) * | 2010-07-26 | 2012-09-05 | 无锡市天赐康生物科技有限公司 | Health-care food for assisting in improving memory function and preparation method thereof |
| CN101940292A (en) * | 2010-07-26 | 2011-01-12 | 无锡市天赐康生物科技有限公司 | Health-care food for assisting in improving memory function and preparation method thereof |
| CN103813722A (en) * | 2011-09-13 | 2014-05-21 | 以瓦伦萨国际营业的美国营养品有限公司 | Plant derived seed extract rich in essential fatty acids derived from perilla seed: composition of matter, manufacturing process and use |
| CN109106738A (en) * | 2018-09-12 | 2019-01-01 | 沈阳高名医药科技有限公司 | A kind of nervonic acid composition and its application in neuroprotection |
| CN110025651A (en) * | 2019-04-02 | 2019-07-19 | 江苏圣典医药科技有限公司 | A kind of compound celery oil self-emulsifying soft capsule and preparation method thereof with anti-aging effects |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1166386C (en) | 2004-09-15 |
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Granted publication date: 20040915 |