CN1364182A - Self adhesive pre-formed sheet device for local use - Google Patents

Abstract

A pre-formed, sheet device comprising (a) less than 10 % of a polysaccharide mixture consisting of (i) a red seaweed polysaccharide; (ii) a mannose containing polysaccharide selected from a galactomannan, glucomannan, and derivatives or mixtures thereof and; (iii) a fermentation polysaccharide, or derivatives thereof; and (b) form about 30 % to about 99.5 % of water; wherein the device comprises less than 10 % total polysaccharide. The pre-formed, sheet devices of the invention are suitable for topical application and display desirable amounts of syneresis and/or improved mechanical properties such as strength or flexibility, as well as excellent moisturisation, hydration and cooling benefits. Further, the devices of the present invention are easy to handle, unobtrusive and conform to the contours of a target surface when applied.

Description

Be suitable for the preformed autohension sheet device of topical application

Described field

The present invention relates to new preformed sheet device (device) and composition thereof.The present invention is specifically related to comprise the autohension device of moisture polysaccharide mixture, it is suitable for topical application, and show the required synersis amount and/or the mechanical property of improvement, as intensity and snappiness, and show fabulous moisten, the beneficial effect of hydration and nice and cool effect.In addition, device of the present invention is easy handling when using, and is unobtrusive, and can fit with the profile of application surface.These desired characteristic are by the chemical constitution of polysaccharide mixture and the selection of rheological properties are reached.

Background technology

There had been multiple method already, as adopting methods such as cream frost, gel or emulsion to skin, hair or nail conveying effective constituent.But these formulations always do not make things convenient for suitable, and can not make effective constituent in certain the area of application controlled release, perhaps can make its inefficacy because of external environmental factor when effective constituent is transported to the area of application.In addition, some effective constituent is not suitable for the said products formulation, causes the difficulty of composition preparation, makes composition still have the problem of chemistry and physical stability aspect.

For overcoming the relevant inconveniences of formulation such as above-mentioned and cream frost and emulsion, the benefit of employing skin care with paster or other similar devices recognized in this area.Existing multiple Beauty sticking piece or device are through commercially available or disclosedly can be used for carrying the skin care active composition, as VITAMIN, anti-acne active ingredient, moisturizing agent etc.What disclose in the document also can be used as the percutaneous dosing device with commercially available paster and the device of medical field.But the shortcoming of many these class pasters or device is that its physical product form can cause the application characteristic of user or the perceptible discomfort of wearer.For example, EP-A-392 has described a kind of preparation method of gel paster in 845 the specific embodiments, wherein paster need be on skin on-the-spot formation, cause and use trouble.EP-B-309 has described a kind of dry doubling sheet in 309, and it needs wet skin or drenches that paster makes its hydration and attached on the skin.On the contrary, other pasters or device are too moistening or sticky, and the contained jelling agent of paster or device can't form the solid gel structure, thereby cause paster or device to be difficult to operate or be used for skin.

Some paster or device are too dry or lack snappiness, thus with the profile of application surface can not good fit.And other pasters or device have strong viscosity and stopping property, make discomfort when wearing with removal, and many pasters can not make effective constituent effectively discharge and infiltration.

Known polysaccharide composition can be used in autohension paster or the device.For example EP-A-682 938, WO96/25923, and EP-A-750905, WO98/17263, EP-A-850649, EP-A-674913 and WO84/02466 have disclosed the various polysaccharide that are applicable to adhesive patches or device.In addition, the many adhesive patches addressed in the above-mentioned document or device randomly contain beauty treatment or therapeutic activity composition.

GB 1,341, and 999 disclose the one-tenth glue medium that is applicable to that nursing is burnt, and wherein contains liquid phase, burns and nurse composition and a certain amount of gel former.It is flexible wherein addressing into glue medium, and has the continuous non-sticky surface and the plasticity-of substantially dry, thus can with body fit.Wherein address the mixture that preferred jelling agent is xanthan gum and tracasol.Also disclose the antibiotic deposited pad of nursing of burning in the embodiment, wherein contained agarose, water and Silver Nitrate.The mild dehydration contraction that becomes glue medium has been discussed in the document has been helped the wetting surface that has applied the nursing composition of burning, be easy to from mould, break away from medium.

JP-B2-276 1936 discloses moisture pack agent in sheet form, wherein contains xanthan gum and the tracasol mixed with water-soluble solvent.Pack agent in sheet form in this invention at high temperature has fabulous shape retention property, has moisture feeling, and has the effect of height skin moisturizing.Also contain 0.1% beautifying skin component in the embodiment in the disclosed Wet-dressing agent.

EP-A-161 681 discloses a kind of gel film, wherein contains polysaccharide and polyatomic alcohol water solution.The preferred polysaccharide that is applicable to gel film is the mixture or the carrageenin itself of carrageenin and polygalactomannan.Randomly contain drug component in the said composition, as skin irritant, antiphlogistic, analgesic agent and microbiotic.It is transparent or unobtrusive wherein disclosing this gel film, has pure and fresh sense and good adhesivity, and has sufficient elasticity, ductility and soundness.

WO97/17944 discloses the cosmetic preparation that is made of gelatinous material, this gelatinous material is by containing solubility alginate (0.1-5%), agar (0.01-0.5%), pectin (0.01-0.5%), the polysaccharide equilibrium mixture of xanthan gum (0.05-1%) and excess water constitutes.Gelatinous material randomly is rich in water-soluble or the water-dispersible activeconstituents.This gelatinous material can be processed into the structurizing gel, it it is said that easy handling also can adapt with skin surface.

WO90/14110 discloses the self-sustaining sheet with requirement size, shape and thickness, the pharmaceutical preparation that applies pad or wafer form, wherein contains the xanthan gum of water-insoluble alginate and suspension agent such as independent application or the mixture of xanthan gum and tracasol.It is said that gum gellan also is the suspension agent that is suitable for.Suspension agent in the preparation also can be used as jelling agent.Can randomly contain anti-inflammatory agent or antiseptic-germicide, iodine in the said preparation.The preparation of sheet or wafer form can be flexible, and is used on the plasticity backing forming whole surgical dressing, and gel can be naked or be hidden through the tulle face.Can contain the calcium source in this gel preparation, it can be used to absorb the transudate of skin injury or wound jointly with alginate.Said preparation also can be stayed the skin original place, changes weekly 1 time or 2 times.

JP-A-54 92618 discloses a kind of wetting compress, wherein contains the crosslinked alginate aqueous gel matrix of calcium ion, has the composition and the water of anti-inflammatory and analgesic activity.Embodiment 5 discloses the moistening of mixture compress of locust bean gum, Rhizoma amorphophalli powder, 3% solution of sodium alginate, single hypophosphite monohydrate calcium source and styrene-butadiene copolymer latex.The document proposes to add the hape retaining power that water-soluble polymers can promote compress, and by adding tracasol and konjak mannan or adopting carrageenin can obtain elastomeric gel separately.But in wetting compress, add water-soluble polymers and it is said that as selecting Rhizoma amorphophalli powder and tracasol for use meeting hinders the release of water.In addition, the matrix gel that contains of this invention wet dressing it is said and be difficult for to discharge water outlet.

The paster of beauty treatment and medical field and device can obtain the improvement of required physics and application characteristic by adopting polysaccharide gel, but do not propose to contain the device of specific moisture polysaccharide mixture of the present invention, device wherein of the present invention has improved mechanical property and/or has required synersis amount, thereby can provide autohension paster or device, and it can effectively discharge ingredient from polysaccharide matrix, as effective composition and water, carry in application, to have hydration, moisten or the effective constituent of nursing role.

Be surprised to find that at present by the moisture polysaccharide mixture that is lower than 10%: by red seaweed polysaccharide; The polysaccharide or its mixture that contain seminose; And fermentation polysaccharide or derivatives thereof composition, a kind of preformed sheet device can be provided, it has fabulous application characteristic, and has improved synerisis, and/or mechanical property.The device that contains above-mentioned moisture polysaccharide mixture can form the self-sustaining sheet device, and it has the high degree of flexibility that can fit with skin, hair or nail profile phase, and can form high-strength structure, its easy handling and be used for application surface.Moisture polysaccharide mixture is selected, so that it also can be made into the premolding sheet device with required synersis amount.

Summary of the invention

The present invention relates to preformed sheet device, wherein contain;

(a) be lower than 10% polysaccharide mixture, it is composed of the following components;

(i) red seaweed polysaccharide;

(ii) contain the polysaccharide of seminose, be selected from polygalactomannan, glucomannan, and their derivative or mixture and;

The polysaccharide that (iii) ferments, or derivatives thereof; And

(b) about 30% to about 99.5% water;

Wherein the total amount of contained polysaccharide is lower than 10% in this device.

Preformed sheet device of the present invention has required synersis amount, and fabulous application characteristic can be provided, as the not conspicuous property when the topical application, and ease for operation, stickiness, is moistened and cooling effect at hydration.In addition.Preformed sheet device of the present invention has fabulous mechanical property, and can form high-strength structure by the moisture polysaccharide mixture of thin layer, and has elasticity to a certain degree, and is flexible.

Second aspect of the present invention provides a kind of beautifying nursing method, comprising use preformed sheet device on skin, hair or nail.

A third aspect of the present invention provides the purposes of a kind of polysaccharide mixture in intensity, synerisis or the snappiness of improving moisture preformed sheet device, and this polysaccharide mixture is composed of the following components:

(i) red seaweed polysaccharide;

(ii) contain the polysaccharide of seminose, be selected from polygalactomannan, glucomannan, and derivative or mixture and;

The polysaccharide that (iii) ferments, or derivatives thereof.

Detailed Description Of The Invention

Premolding sheet device of the present invention contains the specific polysaccharide mixture mixed with water, and following various optional components.Unless otherwise indicated, all content and ratio are all to account for the gross weight of composition in the device.When with egative film during, do not comprise the weight of egative film in the calculating device during gross weight of composition as the annex of device.

Here the term of Cai Yonging " preformed " is meant that described device is made with pre-determined thickness, shape and size product form, wherein this device can take out from packing, place or be covered on the application surface with finger, need not to smear, embrocate or apply product forms in application surface.

Here the term of Cai Yonging " sheet device " is meant that described device is beauty treatment or medical plaster or facial mask form, it has plane or on-plane surface layout, wherein paster is a successive, individual layer-, double-deck-, or multilayer patch, and have according to the concrete position of skin, hair or the nail of need nursing and predetermined shape, facial mask then be discrete individual layer of being used to cover facial zone-, double-deck-, or the multilayer patch, have perforate at eye, nose and mouth on it.

Here the term of Cai Yonging " synersis " is meant that gel oozes out the process that shrinks because of liquid in put procedure.There is no particular restriction in theory, it is believed that gelatinous composition can form three dimensional matrix, its can in conjunction with or embedding composition in other compositions.Synerisis it is believed that and comprises that spontaneous being separated of initial homogeneous system forms gel phase and the liquid phase that links to each other.Transudate is a solution, and its composition is decided according to contained component in the initial gel.When device of the present invention was used for the application region, device volume reduced, thereby made bonded composition such as water or effective constituent release and infiltration application region in the gel matrix.

Here the term of Cai Yonging " polysaccharide " is meant the straight or branched polymkeric substance of natural existence or the synthetic monosaccharide unit that makes of warp, and it is scattered in the water under low dried concentration is to expand, and makes the water gelling.

Here the term of Cai Yonging " non-barrier property " is meant that described preformed sheet device can not block air and moisture substantially and penetrate skin, hair or nail surface.

Preformed sheet device of the present invention is suitable for the part and is used for skin, hair or nail.Polysaccharide mixture

Contain specific polysaccharide mixture in the preformed sheet device of the present invention as basal component.

Polysaccharide mixture of the present invention can form the sheet device of self-sustaining autohension.For improving the globality of device, can on device, randomly adopt barrier property or non-barrier property substrate material as annex, often be called " egative film ".For increasing the intensity of preformed sheet device, the composition that can be used as the gel toughener can be added, in polysaccharide mixture as monovalence or a polyvalent salt.The positively charged ion that is applicable to monovalence or a polyvalent salt can be selected from potassium, sodium, ammonium, zinc, aluminium, calcium and magnesium ion, or their mixture.The negatively charged ion that be suitable for relevant with above-mentioned positively charged ion can be selected from: chlorion, citrate, sulfate radical, carbonate, borate and phosphate radical, or their mixture.

The specific mixture of finding polysaccharide and water at present can form the gel with required aesthetic characteristic and application characteristic.In addition, the polysaccharide in the mixture of the present invention can percentage or ratio combine to improve the physical property of premolding sheet device.Polysaccharide mixture of the present invention can provide improved synerisis to this aqueous premolding sheet device, or mechanical property, as snappiness or intensity.In preferred embodiments, polysaccharide mixture of the present invention has improved the snappiness of premolding sheet device, intensity, and synerisis.

The total content of polysaccharide is lower than 10% in the premolding sheet device of the present invention.Premolding sheet device of the present invention general preferred containing is lower than 10%, more preferably less than 5%, particularly be lower than 3% and preferably be higher than 0.5%, more preferably is higher than 0.7% polysaccharide mixture (calculating with dry weight).

Polysaccharide mixture in the device of the present invention is grouped into by following one-tenth: (i) red seaweed polysaccharide, (ii) contain the polysaccharide of seminose, be selected from polygalactomannan, glucomannan, and derivative or mixture and; The polysaccharide that (iii) ferments, or derivatives thereof.

Red seaweed polysaccharide: the polysaccharide that is categorized as red seaweed polysaccharide be subordinated in the marine plant species of Rhodophyceae class isolated.Red seaweed polysaccharide can make aqueous gel have physical strength.Be applicable to that red seaweed polysaccharide of the present invention comprises: agar, the trademark naming of (CTFA) is an agar block on industry, it is derived from various Gelidium plants or close red algae platymiscium, can title " agar 100 " or " agar 150 " be purchased (Belcamp from TIC Gums, MD, USA), or with " agar K-100 " available from Gumix International Inc. (Fort Lee, NJ, USA); Agarose, can title " Sea Plaque  " be purchased from FMC (Philadelphia, PA, USA) and with " agarose Type 1-b " be purchased from Sigma-Aldrich Co.Ltd. (Poole, UK); Carrageenin, comprise λ-, ι-and κ-part, it is the water extract that is obtained by multiple China fir algae section or red tail feather dish section plant, the trademark naming of (CTFA) is a carrageen on industry, can title " Gelcarin  LA ", " Seakem  3/LCM " or " Viscarin  XLV " available from FMC (Philadelphia, PA, USA); And danish agar, available from GumTechnology Corporation (Tucson, Arizona, USA) and ContinentalColloids Inc. (Chicago, IL, USA), or the mixture of above component.The red seaweed polysaccharide that is applicable to this is preferably selected from agar, agarose, kappa carrageenan and danish agar, or their mixture.The red seaweed polysaccharide that is applicable to this more preferably is selected from agar and agarose, or their mixture.

Pointed out already that carrageenin was not the product of homogeneous chemically, but contained the set of sulfated galactan product, and comprised a certain proportion of galactopyranose residue, with 3,6-Anhydrogalactose residue form exists.Some part of carrageenin can be separated from the red algae extract and obtained, and carries out the chemistry definition and epsilon is adopted in name with structure.Only λ-, ι-and kappa carrageenan have commercial significance.Its different qualities mainly can be illustrated with the different of sulfate group mass contg by Anhydrogalactose.In addition, the existence of sulfate group can cause as the carrageenin of anionic polysaccharide can be by in the Aquo System cation-modified.Therefore, potassium ion can remarkably influenced the gelling of kappa carrageenan, the gelling that calcium ion then can remarkably influenced ι-carrageenin.

On the other hand, the electric neutrality Polygalactan of agar-comprise high-content Anhydrogalactose can not add positively charged ion gelling independently.Anhydrogalactose content is the highest in the carrageenin class, sulfuric ester content is minimum for kappa carrageenan, therefore has the most effective gelling characteristic.

Polygalactomannan: polygalactomannan is the polysaccharide of plant origin, and it is present in the albuminous cell of multiple leguminous seeds.Collective term " polygalactomannan " comprises the polysaccharide that all are made of semi-lactosi and mannose residue.Polygalactomannan is the polysaccharide that contains seminose, the β that wherein contains (1 → 4)-link to each other-unitary linear backbone of D-mannopyranose base.For the ring side group of being with, it is by the isolated galactopyranose residue of ∝-(1,6)-glycosidic link.Polygalactomannan also can contain a spot of other saccharide residue.The polygalactomannan that is applicable to this has trigonella natural gum; Clover; Trifolium; Tracasol (the commodity called after tragon of (CTFA) on industry), can title " Seagul L " available from FMC (Philadelphia, PA, USA); Tara gum, can available from Starlight Products (Rouen, France) or Bunge Foods (Atlanta, GA, USA); Guar gum derived from the grinding endosperm of Cyamopsis tetragonolobus, can title " Burtonite V7E " available from TIC Gums (Belcamp, MD, USA), with " Jaguar C " available from Rhone-Poulenc (Marietta, GA, USA), or with " Supercol " available from Aqualon (Wilmington, DE, USA); And available from Starlight Products (Rouen, cassia gum France), or their mixture.The polygalactomannan preferred average 1 that is applicable to this to about 5 mannose group unit by one (1 → 6)-link to each other-∝-D-galactopyranose base unit replaces, and is selected from guar gum, tracasol and cassia gum, or their mixture.

Glucomannan: glucomannan is the polysaccharide that contains seminose, wherein contains the main chain of β (1 → the 4)-glucose that links to each other and the straight chain basically of mannose residue.The C-6 position of seminose or glucosyl residue can be replaced by ethanoyl on the polysaccharide main chain.Have 1 ethanoyl substituting group on general every 6-20 the glycosyl.Be applicable to that the ratio of seminose and glucose is about 0.2 to about 3 in this glucomannan or derivatives thereof.The preferred glucomannan that is applicable to this comprises Rheolex RX-L, and it is the common name of the powder class that obtains through Yan Mo Amorphophalus rivieri (Chinese yam) stem tuber, can trade(brand)name " Nutricol ^Rhizoma amorphophalli powder " available from FMC (Philadelphia, PA, USA); With the deacetylate Rheolex RX-L; Or their mixture.

The fermentation polysaccharide, or derivatives thereof: the fermentation polysaccharide is a polysaccharide commercially available, that obtain through microbial fermentation in the substratum of carbon containing and nitrogenous source, buffer reagent and trace element.Be applicable to that fermentation polysaccharide or derivatives thereof of the present invention comprises gum gellan, the commodity called after gum gellan of (CTFA) on industry, be the polymer mixed polysaccharide glue that sugar is made through the pure growth fermentation with many natural ponds Rhodopseudomonas, can title " Kelcogel " available from Kelco (San Diego, CA, USA); Xanthan gum is a kind of polymer mixed polysaccharide glue that sugar is made through the pure growth fermentation with xanthomonas campestris, the commodity called after xanthan gum of (CTFA) on the industry, for example can title " Keltrol CG1000/BT/F/GM/RD/SF/T/TF " available from Calgon (Pittsburgh, PA, USA), or with " Kelzan " available from Kelco (San Diego, CA, USA); Natto gum; Pullulan; Rhamsan gum (rhamsan gum); Curdlan; Succinoglycan; Welan glue; Dextran, can title " Sephadex G-25 " available from Pharmacia FineChemicals (Piscataway, NJ, USA), and their derivative; And sclerotium gum, can title " Amigel " available from Alban Muller International (Montreil, France), or their mixture.Be applicable to that preferably the fermentation polysaccharide or derivatives thereof in the polysaccharide mixture of the present invention is selected from: xanthan gum and gum gellan, or their mixture.The polysaccharide or derivatives thereof that more preferably ferments is an xanthan gum.

When the fermentation polysaccharide was gum gellan, the inventor found to change by the consumption that changes gum gellan in the polysaccharide mixture synersis amount of sheet device of the present invention.In containing the sheet device of red seaweed polysaccharide, add the amount that gum gellan can reduce liquid exudate in the continuous gel phase usually.

When containing xanthan gum as the fermentation polysaccharide in the polysaccharide mixture, xanthan gum can form synergy with the polysaccharide that contains seminose.And this synergy can be improved the elasticity of aqueous gel, and this effect can not cause disadvantageous effect to the physical strength of red seaweed polysaccharide gel.For the viewpoint of synerisis that improves the premolding sheet device and mechanical property, preferred xanthan gum is preferably about 2: 1 to about 1: 4 with the ratio that contains the polysaccharide of seminose.

In preferred embodiments, comprise the polysaccharide that contains seminose in the polysaccharide mixture, it is the mixture of polygalactomannan and glucomannan or derivatives thereof.

It is generally acknowledged and contain glucomannan and/or polygalactomannan in the polysaccharide mixture that the polysaccharide that contains seminose is used for replenishing red seaweed polysaccharide.This synergy it is believed that it is because reacting to each other between polysaccharide causes.Red seaweed polysaccharide can form double-spiral structure, and glucomannan has relative non-replacement zone on the main polymer chain of being positioned at polygalactomannan.On the main polymer chain these are non-relatively to replace the spirane structure generation interaction of zone and red seaweed polysaccharide, and what make preformed sheet device of the present invention has intensity and a snappiness.

As mentioned above, synerisis to a certain degree all can take place in all gels.Synerisis provides the mechanism of effective constituent to the application site transmission.The liquid level that is exuded to continuous gel phase surface can spread rapidly, is convenient to make device to wear the time weak point.Preformed sheet device of the present invention is suitable for having the synersis amount of appropriateness, and preferred device sense of touch of the present invention is wetting.The present inventor finds that the synersis amount of appropriateness is the unusual Ideal Characteristics of device that contains polysaccharide mixture, the transudate of gel device surface is easy to and application surface adhesion because be exuded to, and covers having additional binder or being coated with the egative film of tackiness agent of gelinite thereby need not to adopt.For relatively, if the synersis amount of gel device is extremely low, even wetted applications position then, device still can not be well attached on application site, and too high synersis amount can cause product invalid and lack adsorptive power.

For making the premolding sheet device have the viewpoint of improved synerisis and mechanical property, preferably the ratio of red seaweed polysaccharide and the polysaccharide that contains seminose is about 20: 1 to about 1: 5 in polysaccharide mixture, more preferably about 7: 1 to about 1: 2.Water

Another main component of premolding sheet device of the present invention is a water.In the premolding sheet device of the present invention the content of total water account for device weight 30% to about 99.5%, be preferably about 40% to about 95%, more preferably about 50% to about 85%.Egative film

In a preferred embodiment of the invention, preformed sheet device of the present invention comprises egative film.Egative film is barrier property or non-barrier property lamella, is used to make device to have additional globality and this device of support.

Preferred egative film is non-barrier property.This aqueous moisture polysaccharide mixture can cover or water and cast from the backsheet surface.

Egative film can adopt various materials.It is suitable for having following characteristic: (i) enough application wet strength, (ii) enough snappinesies, (iii) enough rebound resiliences and porousness, (iv) enough thickness, (v) enough wetting abilities, spreadable and infiltrate in the egative film as the polysaccharide gel mixture, (vi) with the abundant consistency of polysaccharide mixture, preventing that genetic horizon from splitting, (vii) enough transparencies or translucency, and (viii) Shi Yi size.

The non-limiting example that meets the egative film that is suitable for of above-mentioned condition comprises: fabric and non-woven material; Polymer sheet such as porous, shaped thermoplastic film, shaping membrane, the thermoplastic film of porous plastic film and shaped by fluid pressure; Natural sponge; Synthetic sponge; Polymkeric substance mesh sponge; Ply of paper; The polyalcohol stephanoporate foams; The collagen lamella; Polymkeric substance gauze etc.The egative film that preferably is applicable to this is ply of paper, non-woven material and shaping membrane, and particularly porous, shaped film is economical and be applicable to various materials because of it.

Non-woven material is meant by fiber orientation or randomly-oriented by friction and/or adhesive aggregation and/or the bonding lamella of making, wire side, lining, pad or cotton wool layer.These materials generally do not comprise weaving, braiding, flocking, the stitchbonded product with binder or silk blend, or by the wet milling process warp or without the felting product of sewing.Non-woven material can be made of random fiber and carded fiber layer combination.Fiber can be natural or synthetic source.

In addition, they can be short fiber material or continuous fibre long filament or through in-place mo(u)lding.

Non-woven material can be made of multiple natural and synthon.

The natural fiber that is meant is derived from plant, animal, insect, or the byproduct of plant, animal, insect.Synthetic be meant that fiber mainly is to be made by various artificial materials, or by making through the further natural materials of process variations.Substrate raw material commonly used generally is the fiber that contains any common synthetic or natural weaving length, or the fiber net surface of their mixture.

Be applicable to that natural fiber of the present invention is a silky fibre, keratin fiber, as xylon, camel-hair fiber, etc., and cellulosic fibre, comprise wood pulp cellulose, cotton fibre, hemp fibre, jute fibre, flax fiber, and their mixture.

Be applicable to that synthon of the present invention comprise: acetic ester fiber, acrylic fiber, cellulose ester fiber, modified acrylic fibre, tynex, polyester fiber, polyolein fiber, polyvinyl alcohol fiber, rayon fiber, urethane foam, and their mixture.Some these class synthon and other useful fiber and see WO98/18444 by the specific examples of its non-woven material of making in conjunction with in the present invention as a reference, and comprise the esters of acrylic acid material, as Acrilan, Creslan and based on the fiber of vinyl cyanide, Orlon; Cellulose ester fiber, as rhodia, A Nier, and A Xier; And polymeric amide, as nylon-type (for example, nylon 6, nylon 66, NYLON610, and analogous components).

The method for preparing non-woven material is known in the art, has generally to describe in WO98/18444, and its combination in the present invention as a reference.In the present invention, nonwoven layers can be made through several different methods, comprises hydro entanglement, air entanglement, heat bonding, and the combination of these methods.In addition, egative film of the present invention can be made up of one or more layers.In addition, the multilayer egative film can comprise film or other non-filamentary materials.

Being used for the non-woven material of being made by synthon of the present invention also can be purchased through number of ways.The example that is applicable to this nonwoven sheet layer material is found in WO98/18444, and comprises HEF40-047, and it is the porous hydroentangled material that contains 50% artificial silk, 50% polyester approximately, and unit weight is about every square metre 51 (gsm), available from Veratec, and Inc., Walpole, MA; Novonet ^149-616, it is to contain 100% polyacrylic heat bonding grid material approximately, and unit weight is about 60gsm, available from Veratec, Inc., Walpole, MA; And HEFNubtex ^149-801 contains many knots porous hydroentangled material of 100% polyester approximately, and unit weight is about 84gsm, available from Veratec, and Inc.Walpole, MA.

The ply of paper egative film of being made by natural materials can be made of wire side or lamella, and wire side or lamella are to be formed on the filament screen cloth by fibrous suspension through the most conventional method.Can be referring to people such as C.A.Hampel work " chemistry encyclopedia ", the 3rd edition, 1973,793-795 page or leaf (1973); " big U.S. encyclopedia " (The Encyclopedia Americana), 21 volumes, 376-383 page or leaf (1984); With G.A.Smook work " paper pulp and paper technical manual ", paper and paper pulp industrial technology association (1986); All the full text combination in the present invention as a reference.Being used for the ply of paper egative film of being made by natural materials of the present invention can be purchased by a plurality of approach.The ply of paper egative film that is purchased that is applicable to this comprises " Kimwipes EX-L ", available from Kimberley-Clark Corp., Roswell, GA, USA; Airtex ^, it puts cellulose layer for the embossing gas shop that unit weight is about 85 gsm, available from James River, and Green Bay, WI; And Walkisoft ^, it puts Mierocrystalline cellulose for the embossing gas shop that unit weight is about 90gsm, available from Walkisoft U.S.A., and Mount Holly, NC.

Egative film also can be made by polymer sheet.Its non-limiting example comprises porous, shaped thermoplastic film, shaping membrane, porous, shaped film, porous plastic film and shaped by fluid pressure film.The polymer sheet layer material can be prepared by known method in the patent documentation, for example according to US-A-4,324,246 (Mullane and Smith, authorize April 13 nineteen eighty-two) in method, it is above and be lower than the fusing point of material that thermoplastic materials sample such as the thick polyethylene film of 0.0038cm are heated to its softening temperature temperature of mold (plastic for thermoplastic materials or).To contact with the forming silk screen of heating through the thermoplastic materials sheet material of heating.Forming silk screen preferably has the porous metal bolting silk net of required aperture, pattern and configuration.Adopt vacuum that thermoformable film is adsorbed on the forming silk screen.Thereby on screen cloth, form the film in required pattern and aperture.Still film is applied vacuum, the warm air injection stream is passed through film.The warm air injection stream penetrates film by the pattern and the size in the hole in the moulding screen cloth.Fluid permeable matrix layer according to the described method preparation of people's patents such as Mullane is commonly called " shaping membrane ".These sheet layer materials also can adopt jet water course to prepare through same procedure by film.These materials are commonly referred to as " hydroforming film ".Another embodiment of this material sees US-A-4, and 609,518 (people such as Curro, on September 2nd, 1986 authorized) are in full in conjunction with in the present invention as a reference.

The another kind of shaping membrane egative film that is applicable to this is that porous, shaped film-it is the three-dimensional wire side of a kind of elasticity, have fibrous outward appearance and sense of touch, comprise on-liquid perviousness plastic material, wherein said wire side has porousness, and perforate is partly limited by a plurality of decussating fibers shapes, can be referring to US-A-4,342,314, (Radel and Thompson, authorize August 3 nineteen eighty-two), in conjunction with in the present invention as a reference.US-A-4, the sheet layer material described in 342,314 can adopt hydrophobic plastic to make, hydrophobic plastic such as polyethylene, polypropylene, PVC, and analogous components, and know can be used for absorptivity (as menstruation etc. with) in the product.The embodiment of this class material is being called shaping membrane on the sanitary towel of " DRI-WEAVE " described in the above-mentioned patent and in the name of commercially available P﹠G.In addition, can carry out surface treatment to reduce its hydrophobicity to these materials.

In addition, egative film can be a polymkeric substance mesh sponge, sees EP-A-702550 and WO98/18444, and combination in the present invention as a reference in full.

This egative film can also be the polyalcohol stephanoporate foams, sees US-A-5,260,345 (people such as DesMarais, on November 9th, 1993 authorized), and US-A-4, and 394,930 (Koroman, authorize July 26 nineteen eighty-three) are in conjunction with in the present invention as a reference.The feature of polymer foam generally is: will relatively not contain monomeric gas or liquid disperses in containing the liquid of polymerisable monomer with the bubble form, polymerisable monomer polymerization in containing monomeric liquid then is bubble, thereby forms foam structure around it.The polymer dispersion of gained can be the porosu solid structure, and it is the abscess aggregate, and the border or the wall of abscess comprise solid polymeric material.Abscess itself contains and does not contain monomeric gas or liquid relatively, and it forms in liquid dispersion before polymerization " bubble ".Specifically, but surperficial possess hydrophilic property and liquid hold the softness deformation of depositing characteristic micropore (perforate or closed abscess) foam-body material be specially adapted to the present invention.The example of polymeric foams material is those materials that make through the water-in-oil emulsion polymerization.This class emulsion is not contain monomeric water and form by the oil phase that contains polymerisable monomer more on a small quantity is relative with more amount.Not conforming to monomeric dispersion " interior " water relatively and can form dispersive " bubble ", is the oil-continuous phase that contains polymerisable monomer around it.In oil-continuous phase carry out monomer polymerization reactions, form the fine-celled foam body structure thereafter.Can be repressed and/or dry these foams remove and still be present in liquid, aqueous in the foamy structure that polymerization forms.This area generally is called this class polymerized emulsion High Internal Phase Emulsion or " HIPE " foams.

The polymerization porous foam body that comprises the foams of being made by water-in-oil emulsion described here can have closed relatively abscess or open-celled structure relatively, and whether this will be filled with or to contain polymer materials and/or its content be what decides according to cell wall or border (being the abscess form).Be applicable to that polyalcohol stephanoporate foams of the present invention are materials of those relative open-celled structures, wherein independently the foam bubble hole majority is not separated from one another by the polymeric material of hole bubble fully.Therefore, have perforate or " form " between the abscess for the foams of perforate substantially, it flow to other abscesses to an abscess that is enough to make liquid be easy to from foam structure greatly.

Be applicable to of the present invention basic for the foams of open-celled structure generally have reticulated structure, wherein independently abscess by a plurality of continuous three-dimensional branched network qualifications.Polymeric material stockline material can constitute the branched network of open celled foam body structure, and it also can be called as " pillar ".Except that open-celled structure, be applicable to that preferably this polymerization porous foam body is hydrophilic.

Polyalcohol stephanoporate foams of the present invention should have enough wetting abilities, but make on the polysaccharide gel mixture egative film diffusion and infiltration, and can be fully compatible with polysaccharide mixture and slabbing do not take place.Although above-mentioned polymerization porous foam body is intended to various liquid treatment articles for use, as paper diaper, menstruation is used and the incontinence product, and this class material also is suitable for and makes egative film of the present invention.

In another example, but the porous collagen thin slice of the deformation that the perforated bottom sheet material that is suitable for can be made by lyophilization constitute.This method can form the collagenic material sheet with open-celled foams internal structure.This class material has intensity, but deformation, can with polysaccharide glue highly compatible, and have and be suitable for enough transparencies or the translucency make egative film of the present invention.The commercially available collagen sheet of Shi Yonging comprises " Collagen Fiber Mask " herein, available from Beaute Attica, Inc., Redmond, WA, USA; " professional collagen mask ", available from Luminescence, Maple Plain, MN, USA; " Pure Soluble Collagen Lifting Masque (Lifting Masque) ", available from Five StarFormulators, Inc., Palo Alto, CA, USA; And " pure collagen mask ", available from Maybrook, Inc., Lawrence, MA, USA.

Egative film can also be polymkeric substance gauze (extruded netting), sees US-A5, and 715,561 (on February 10th, 1998 is open for Tuthill, Yeazell, and Girardot) are in conjunction with in the present invention as a reference.The polymkeric substance gauze can also be a tubular-shaped structures, and the performance of this base polymer gauze can be described (node width, the weight in average of line material length and repeating unit) by the physical size of resulting structures.The mesh of tubular gauze material can be a rhombus, square, and hexagon or other shapes, but and can have intensity and polymkeric substance deformation (as new LDPE (film grade)) formation by various.For example the diamond-mesh gauze is the plastics wire side of being made through extrusion molding by counterrotating die head, and there are a plurality of extrusion cavities in each die head edge.Fiber is extruded in the reverse rotation meeting order of die head or wire harness is arranged along both direction, and is angled with the operating direction of extruding pipeline.Wire harness sex-intergrade at interval forms node.Two wire harness directions generally are acute angle each other, thus wire harness can with node at each dihedral diamondwise.US-A-3 has carried out describing in more detail to this method among 957,565 people such as () Livingston.Although these polymkeric substance gauzes (extruded netting) can be used to implement for personal cleaning, this class gauze also is suitable for and makes egative film of the present invention.

Egative film can be made into multiple shape and form, comprises fiat gasket, thick liner, and thin slice, and size surface area is about 0.25cm ²To about 1,000cm ²Definite size and dimension can be decided according to required purposes and product performance.Convenient especially use be can with the comfortable shape of fitting easily of other parts of user's face, neck, hand, foot and health.This class shape can be a square, circle, and trilateral, rectangle, ellipse, or other are by the compound shape that constitutes of these shapes, as can be described as " pickle ", " butterfly ", " month shape ", " semicircle ", " Donna cast ", or other shapes.

Egative film of the present invention can comprise and has the two-layer of differing texture or multilayer lamella.Can make differing texture by the mixture of employing differing materials or through different preparation methods or its combination.In addition, the different lamellas of egative film can be made into different colours, thereby help the user further to distinguish different surfaces.Effective constituent

In another preferred embodiment of the present invention, contain one or more effective constituents of safe and effective amount in the preformed sheet device.

Here the term of Cai Yonging " safe and effective amount " the consumption height that is meant effective constituent improves the symptom of being nursed or makes skin, hair or nail reach required beneficial effect to being enough to, be enough to avoid severe side effect but its consumption should be low to moderate, the ratio of its suitable effect and risk is in rational medical judgment scope.The size of the safe and effective amount of effective constituent will be judged according to concrete effective constituent, infiltration performance skin or that be positioned at the effective constituent on hair and/or the nail, user's age, user's healthy state, user's factors such as skin, hair or nail situation.

Effective constituent comprises pharmaceutically useful salt, and term " pharmaceutically useful salt " is meant and is applicable to the customary salt that contacts with tissue that it does not have disadvantageous toxicity, pungency, uncompatibility, unstable, transformation reactions etc.

Preformed sheet device of the present invention generally contains about 0.01% to about 40% at least a effective constituent that accounts for device weight or their mixture, is preferably about 0.05% to about 30%, most preferably is about 0.1% to about 20%.

Can classify to the effective constituent that is applicable to this according to the mode of action of its curative effect or expection.But be understood that the effective constituent that is applicable to this has more than one curative effect sometimes, or by more than one mode of action generation effects.Classification of the present invention thus and is not that effective constituent is defined in concrete application or listed purposes only for simplicity.Following effective constituent is applicable to premolding sheet device of the present invention.

Anti-acne active ingredient: acne vulgaris can effectively be treated and prevent to anti-acne active ingredient, and it is the pilosebaceous follicle chronic disease.Symptom comprises pilosebaceous follicle organ inflammation, thereby causes damage, comprises papule, warts, and tumour, acne and serious scar produce.Corynebacterium acnes belongs to and staphylococcus epidermidis belongs to the common meeting of bacterium to exist in the warts content.The anti-acne active ingredient that is suitable for comprises the Keratin sulfate agent described in the WO98/18444.Other activeconstituentss that are suitable for comprise retinoids mixture such as vitamin A acid (for example, cis and/or trans retinoic acid) and derivative (for example, retinoic acid ester class) thereof; Vogan-Neu and ester thereof (for example, propionic acid retinol ester, retinol acetate); Sylvic acid, adapalene, tazarotene, wallantoin, Aloe extract, arbietic acid and salt thereof, ASEBIOL (available from LaboratoriesSerobiologiques, is positioned at Somerville, NJ), azaleic acid, thorn bark of a cork tree (barberry) extract, Arctostaphylos ura-ursi extract, blackberry lily, benzoquinoline ketone, benzoyl peroxide, Berberine, BIODERMINE (available from Sederma, is positioned at Brooklyn, NY), Vitamin P complex as a class material, Hydagen B, S-Carbocisteine, Radix Dauci Sativae extract, yaupon oil (cassin oil), the Syzygium aromaticum extract, citral, geranial, climazole, COMPLETECH MBAC-OS (available from Lipo, is positioned at Paterson, NJ), CREMOGEN M82 is (available from Dragoco, be positioned at Totowa, NJ), Fructus Cucumidis sativi extract, dehydro-acetic acid and salt thereof, trans-dehydroandrosterone and sulfate-derivatives thereof, dichlorophenyl imidazoles diazacyclo pentane, d, 1-Xie Ansuan and ester thereof, the DMDM glycolylurea, erythromycin, aescinate grass alcohol (escinol), ethylhexyl list glyceryl ether, 2-hydroxyl undeeanoic acid ethyl ester, farnesol, farnesyl acetate, Geraniol, trans-Geranylgeraniol, glabridin, glyconic acid, glucono-lactone, single caprin, oxyacetic acid, grapefruit seed extract, gugu lipid, HEDERAGENIN (available from Maruzen, is positioned at Morristown, NJ), Hesperitin, chamenol, lupulus extract, staybelite, the 10-hydroxydecanoic acid, isarol, il-1-alpha-2 antagonists, KAPILARINE is (available from Greentech, be positioned at Saint Beauzire, France), KETOKONAZOL, lactic acid, pamorusa oil, LOCHOCHALCONE LR15 (available from Maruzen, is positioned at Morristown, NJ), linolic acid, LIPACIDE C8CO (available from Seppic, is positioned at Paris, France), lovastatin, 4-methoxyl group Whitfield's ointment, metronidazole, Minocycline HCl, mukurossi, the chinaberry seed oil, niacinamide, nicotinic acid and ester thereof, nisin, panthenol, 1-pentadecylic alcohol, rose (peonia) extract, Folium Menthae extract, Chinese celery (phelladendron) extract, 2-phenyl-benzothiophene derivative, Phloretin, PHLOROGINE is (available from Secma, be positioned at Pontrieux, France), phosphatidylcholine, proteolytic enzyme, Quercitroside, red sandalwood extract, rosemary extract, rutin, sage extract, saligenin, Whitfield's ointment, Serine, Radix Scutellariae extract, siberhegner extract, siberian saxifrage extract, silicol, the lauryl sodium phosphate, the sulfo group ethanamide, the SOPHORA extract is (available from Maruzen, be positioned at Morristown, NJ), Sorbic Acid, sulphur, sunder vati extract, tea tree oil, tetrahydrochysene sylvic acid, Threonine, Thymi Serpylli Herba extract, tioxolone, tocopherol and ester thereof, trehalose 6-undecylenate, 3-tridecylene-2-alcohol, triclosan, tropolone, UNITRIENOL T27 is (available from Unichem, be positioned at Chicago, IL), Vitamin D3 500,000 I.U/GM and analogue thereof, white thyme oil (white thyme oil), extract of willow bark, wogonin, ylang ylang oil, R-Glyceric acid zinc (zinc glycerolate), zinc linoleate, zinc oxide, 2-Mercaptopyridine-N-oxide zinc, zinc sulfate, zwitterionics (for example, hexadecyl dimethyl betaine) and composition thereof.

On-steroidal anti-inflammatory activity composition (NSAIDS): be applicable to that this NSAIDS and ester thereof see WO98/18444, in conjunction with in the present invention as a reference.The example of other nonsteroidal anti-inflammatories (NSAIDS) comprising: Flufenamic Acid; Panthenol and ether thereof and ester derivative, panthenol ether for example, nitrilotriacetic panthenol ester; Pantothenic acid and salt thereof and ester derivative, particularly calcium pantothenate; Aloe, Hydagen B, wallantoin and Radix Glycyrrhizae section plant compound (the glycyrrhiza glabra genus/kind), comprise glycyrrhetinic acid, Potenlini, and derivative, for example stearic alcohol ester of salt such as Monoammonium glycyrrhizinate and ester such as glycyrrhetinic acid.

Local anesthetic: the example that is applicable to this local anesthetic has anaesthesine and bupivacaine.Other examples that are suitable for see WO98/18444, in conjunction with in the present invention as a reference.

Artificial tanning agent and promotor: the artificial tanning agent by increase in the skin melanochrome or by forming melanochrome increases in the skin outward appearance to help to simulate natural Exposure to Sunlight effect.The non-limiting example of artificial tanning agent and promotor: comprise tyrosine glucose ester and Acetyl tyrosine, brasilin, caffeine, coffee bean extract, dna fragmentation, isobutyl methylxanthine, methyl xanthine, PHOTOTAN (available from Laboratoires Serobiologiques, is positioned at Somerville, NJ), prostaglandin(PG), tea extract, theophylline, UNIPERTAN P2002 is (available from Unichem, be positioned at Chicago, IL) and UNIPERTAN P27 (, be positioned at Chicago, IL) available from Unichem; And their mixture.Other artificial tanning agents that are applicable to this are found in WO98/18444.

Antiseptic-germicide: the example that is applicable to this antiseptic-germicide comprises alcohol, benzoate, Sorbic Acid, and their mixture.

Antimicrobial and anti-mycotic activity composition: antimicrobial and anti-mycotic activity composition can effectively pre-bacteriological protection and propagation and the growth of fungi.Antimicrobial and the non-limiting example anti-mycotic activity composition comprises: KETOKONAZOL, ciclopirox cholamine, benzoyl peroxide, tsiklomitsin, nonane diacid and derivative thereof, ethyl acetate, helenine, isoalantolactone, Radix Arnebiae (Radix Lithospermi) extract (alaninin), anise, arnica montana extract (helenalin acetic ester and 11,13 dihydro helenalins), bracken extract (containing phlorizin, the extract of lucinol), thorn bark of a cork tree extract (berberine hydrochloride), bay sweet extract, Cortex Myricae Rubrae extract (arbutin), benzalkonium chloride, benzethonium chloride, phenylformic acid and salt thereof, st-yrax, benzylalcohol, blessing Ji grass, the bletilla stem tuber, red root, rose-wood oil, burdock, butyl p-hydroxybenzoate, oleum alchitri, CAE is (available from Ajinomoto, be positioned at Teaneck, NJ), cajaput (cajeput) oil, rhizoma atractylodis, caraway oil, card lamb's-quarters bark (selling) with trade(brand)name ESSENTIAL OIL, White cedar oil, Phytoconcentrol Chamomile, chaparral, chlorphenesin, roxenol, Oleum Cinnamomi, pamorusa oil, clove(bud)oil, dehydro-acetic acid and salt thereof, dill seed oil, DOWICIL 200 is (available from Dow Chemical, be positioned at Midland, MI), Echinacea, Fructus oleae europaeae acid, Epimedium, ethyl p-hydroxybenzoate, FO-TI, galbanum, garden burnet, GERMALL 115 and GERMALL II (available from ISP-Sutton Labs, are positioned at Wayne, NJ), German chamomile oil, giant knotweed (giant knotweed), GLYDANT is (available from Lonza, be positioned at Fairlawn NJ), GLYDANT PLUS (available from Lonza, is positioned at Fairlawn, NJ), grapefruit seed oil, two isethionic acid hexamidines, chamenol, honey, rhododendron, lupulus, amaranth, IODOPROPYNL BUTYL CARBAMIDE is (available from Lonza, be positioned at Fairlawn, NJ), p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester, JM ACTICARE is (available from Microbial Systems International, be positioned at Nottingham, UK), juniper berries, KATHON CG is (available from Rohm and Haas, be positioned at Philadelphia, PA, USA), labdanum, lavender, melissa oil, lemongrass, methyl p-hydroxybenzoate, peppermint, mume, mustard, myrrh, the chinaberry seed oil, orthoxenol, OLIVE LEAF extract is (available from BioBotanica, be positioned at Hauppauge, NY), parsley, patchouli oil, tree peony root, PHENONIP (available from Nipa Labs, is positioned at Wilmington, DE), phytosphingosine, Pinus pumilio oil, PLANSERVATIVE (available from Campo Research, is positioned at Raffles Quay, Singapore), propylparaben, purslane, Quillaia saponaria, rheum officinale, Pelargonium roseum oil, Rosmarinus officinalis, Salvia japonica Thunb., Whitfield's ointment, yellow camphor tree, savory, river Radix Angelicae Sinensis, sodium metabisulfite, S-WAT, SOPHOLIANCE (available from Soliance, is positioned at Compiegne, France), Sorbic Acid and salt thereof, sphingosine, sweet Stevia (stevia), Styrox, tannic acid, tea, tea tree oil (cajuput oil), Thymus vulgaris, triclosan, triclocarban, tropolone, rosin, Umbelliferone (mycocide), and yucca, or their mixture.Other examples that are applicable to the antimicrobial of this and anti-mycotic activity composition are found in WO98/18444.

The skin soothing agent: the skin soothing agent can effectively prevent or treat skin inflammation.The skin soothing agent can promote skin appearance effect of the present invention, and for example, these compositions help skin gloss and color more all even pleasant.The non-limiting example of skin soothing agent comprises: absinth, gum arabic, escin, the alder buckthorn extract, wallantoin, aloe, APT (available from Centerchem, is positioned at Stamford, CT), mountain tobacco, Astragalus, astragalus root extract, azulene, BAICALIN SR 15 (available from Barnet Products Dist., is positioned at Englewood, NJ), the root of large-flowered skullcap, the bighead atractylodes rhizome, Canada turpentine, bee pollen, BIOPHYTEX is (available from LaboratoriesSerobiologiques, be positioned at Somerville, NJ), Hydagen B, Root of Roughleaf Ironweed, Black Cohosh P.E, the Wei spirit is celestial, the celestial extract of Wei spirit, agueweed, Borrago officinalis, borage oil, Borrago officinalis seed oil, bromelin, mary bush, the mary bush extract, CANADIAN WILLOWBARK extract (available from Fytokem), gama wax, rhizoma atractylodis, the canola plant sterol, capsicum, carboxypeptidase, celery seed, the stem of celery extract, CENTAURIUM (available from Sederma, is positioned at Brooklyn, NY), the Minor centaury extract, lindazulene, Phytoconcentrol Chamomile, chamomile extract, chaparral, Vitex negundo var cannabifolia, Vitex negundo var cannabifolia extract, chickweed, chicory root, the chicory root extract, East Indian balmony, the radix paeoniae rubrathe, Aveeno Bath, comfrey, the comfrey extract, CROMIST CM GLUCAN is (available from Croda, be positioned at Parsippany, NJ), darutoside, dehurian angelica Radix Angelicae Sinensis, DEVIL ' S CLAW is (available from MMP, be positioned at Plainfield, NJ), divalent metal is (as magnesium, strontium, manganese), Agropyron repens, Lai wood, EASHAVE is (available from Pentapharm, be positioned at Basel, Switzerland), eleutherol, ELHIBIN is (available from Pentapharm, be positioned at Basel, Switzerland), ENTELINE 2 is (available from Secma, be positioned at Pontrieux, France), Chinese ephedra, Herba Epimedii, esculiw, root of Redsepal Eveningprimrose, Herba Euphrasiae Regelii, EXTRACT LE100 is (available from sino Lion, be positioned at World Trade Centre, NY), windproof, Radix Agrimoniae, ficin, Fructus Forsythiae, glossy ganoderma, Jehol Ligusticum Rhizome, GATULINE A is (available from Gattefosse, be positioned at Saint Priest, France), rough gentian, the germanium extract, ginkgo, Ginkgo, Radix Ginseng extract, groundraspberry, the Ge Erge extract, gotu kola, grapefruit extract, guaiac(um), the guggal extract, helenalin ester, Lawsonia inermis, rhododendron, the Herba lagopsis supinae extract, horse-chestnut, meadow pine, giant knotweed, Hypericum, isarol, amaranth, ipecac, Semen Coicis, jujube, kola nut extract, LANACHRYS 28 is (available from Lana Tech, be positioned at Paris, France), lemon oil, the capsule of weeping forsythia, licorice, ligusticum acutilobum, glossy privet, the Root of Garden Lovage root, Luffa, Myristica flower, Flower of Lily Magnolia, Fructus Viticis extract, margasipidin, prochamazulene, MICROAT IRC is (available from Nurture, be positioned at Missoula, MT), peppermint, mistletoe, MODULENE is (available from Seporga, be positioned at Sophia Antipolis, France), Semen phaseoli radiati extract, Moschus, oat extract, oranges and tangerines, panthenol, papoid, Tree Peony Bark, tree peony root, PHYTOPLENOLIN is (available from Bio Botanica, be positioned at Hauppauge, NY), PREREGEN (available from Pentapharm, is positioned at Basel, Switzerland), purslane, QUENCH T (available from Centerchem, is positioned at Stamford, CT), quillaja, red Salvia japonica Thunb., glutinous rehmannia, rheum officinale, Rosmarinus officinalis, rosmarinic acid, royal jelly, rue, rutin, sandalwood, pseudo-ginseng, Asparagus curillus, sabal, SENSILINE (available from Silab, is positioned at Brive, France), SIEGESBECKIA (available from Sederma, is positioned at Brooklyn, NY), the stearic alcohol ester of glycyrrhetinic acid, STIMUTEX (available from Pentapharm, is positioned at Basel, Switzerland), Styrox, birch oil, sweet woodruff, Tagetes, tea extract, Thymi Serpylli Herba extract, tienchi genseng, tocopherol, tocopherol acetate, triclosan, turmeric, urimei, ursonic acid, the kahikatea skin, witch hazel, the flower bud of lily magnolia, milfoil, yeast extract, yucca, and their mixture.

Sun-screening agent: the example that is applicable to this sun-screening agent sees WO98/18444, in conjunction with in the present invention as a reference.The example that is applicable to this other sun-screening agents comprises: diethanolamine p-methoxycinnamic acid ester, dioxybenzone, ethyl dihydroxypropyl PABA, para-amino benzoic acid glyceryl ester, lawsone (lawsome) and Protosol, the anthranilic acid menthol ester, methyl o-aminobenzoate, octyldimethyl PABA, red petroleum, Uvinul MS 40, triethanolamine salicylate, and their mixture.

Skin barrier repair aids: skin barrier repair aids is to help to repair and the skin care auxiliary agent of the natural insulation isolation features of additional epidermis.The example of the skin barrier repair aids that is suitable for comprises: brassicasterol, caffeine, campesterol; by canola deutero-sterol, CERAMAX (available from Quest, is positioned at Ashford; England), CERAMIDE 2 (available from Sederma, is positioned at Brooklyn; NY), CERAMIDE HO3TM (available from Sederma, is positioned at Brooklyn; NY), CERAMIDE II (available from Quest, is positioned at Ashford; England), CERAMIDE 111 (available from Quest, is positioned at Ashford; England), CERAMIDE IIIB (available from Cosmoferm, is positioned at Deift; Netherlands), CERAMIDE IS 3773 (available from Laboratories Serobiologiques, is positioned at Somerville; NJ), CERAMINOL (available from Inocosm, is positioned at ChatenayMalabry; France), CERASOL (available from Pentapharm, is positioned at Basel; Switzerland), CEPHALIP (available from Pentapharm, is positioned at Basel; Switzerland), cholesterol, oxystearic acid cholesterol; the Unimac 5680 cholesterol, the 7-dehydrocholesterol, DERMATEIN BRC is (available from Hormel; be positioned at Austin, MN), DERMATEIN GSL is (available from Hormel; be positioned at Austin, MN), ELDEW CL 30l is (available from Ajinomoto; be positioned at Teaneck; NJ), ELDEW PS 203 (available from Ajinomoto, is positioned at Teaneck; NJ); FUFROBROSIDE (available from Pentapharm, is positioned at Basel, Switzerland); GENEROL 122 is (available from Henkel; be positioned at Hoboken, NJ), the glyceryl serine amides; lactic acid; LACTOMIDE (available from Pentapharm, is positioned at Basel, Switzerland); lanolin; Wool wax alcohol, lanosterol, lauric acid N-lauryl glucamide; Thioctic Acid; N-acetylcystein, Serine, N-acetyl-L-Serine; N-methyl-L-Serine; NET STEROL-ISO (available from Barnet Products, is positioned at Englewood, NJ); niacinamide; nicotinic acid and ester thereof, nicotinic alcohol, palmitinic acid; panthenol; Pantethine (panthetine), phosphodiesterase inhibitor, PHYTO/CER is (available from Intergen; be positioned at Purchaser; NY), PHYTOGLYCOLIPID MILLET EXTRACT (available from BarnetProducts Distributer, is positioned at Englewood; NJ); PHYTOSPHINGOSINE (available from Gist Brocades, is positioned at King of Prussia, PA); PSENDOFILAGGRIN is (available from Brooks Industries; be positioned at South Plainfield, NJ), QUESTAMIDE H is (available from Quest; be positioned at Ashford; England), Serine, Stigmasterol; Sitosterol; stigmastanol, the soy-derived sterol that obtains, sphingosine; s-lactoyl gsh; stearic acid, SUPER STEROL ESTERS (available from Croda, is positioned at Parsippany; NJ); Thioctic Acid, THSC CERAMIDE OIL (available from CampoResearch, is positioned at Raffles Quay; Singapore); trimethylammonium glycerine, nicotinic acid tocopherol, Vitamin D3 500,000 I.U/GM and analogue thereof; or derivatives thereof; and Y2 (available from OceanPharmaceutical), or their mixture.

Crease-resistant and anti-skin atrophy activeconstituents: but crease-resistant and anti-skin atrophy activeconstituents epidermis and/or skin corium effectively replenish or restore.These activeconstituentss are generally by promoting or keeping the natural process of decortication and/or make up dermal matrix each component of layer (for example, collagen and glucosaminoglycan) required skin effect is provided.The non-limiting example of crease-resistant and anti-skin atrophy activeconstituents comprises: nicotinic acid and ester thereof, nicotinic alcohol, oestrogenic hormon and estrogens compounds, or their mixture.Other crease-resistant and anti-skin atrophy activeconstituentss that are applicable to this see WO98/18444.

Skin repair actives: skin repair actives can effectively be repaired epidermis and/or skin corium.The non-limiting example of skin repair actives comprises: glycerol acetate (actein), 27-deoxidation glycerol acetate Cimiside (cimigoside), adapalene; tazarotene, ademetionine, adenosine; the Spike Aletris Herb extract, derived from the aloetic lectin, 3-aminopropyl dihydrogen orthophosphate; AMADORINE (available from Barnet Products, is positioned at Englewood, NJ); the anise extract, AOSINE (available from Secma, is positioned at Pontrieux; France), the arginine benzaminic acid, ASC III is (available from E.Merck; be positioned at Darmstadt, Germany), xitix; Quicifal, Ya Xiya acid, centella asiatica glucoside; ARLAMOL GEO (available from ICI, is positioned at Wilmington, DE); nonane diacid, benzoic acid derivative, brazilnut extract; betulinic acid, BIOCHANIN A, BIOPEPTIDE CL is (available from Sederma; be positioned at Brooklyn, NY) BIOPEPTIDE EL (available from Sederma, is positioned at Brooklyn; NY), vitamin H, blackberry, blueberry bark extract; Rhizoma Belamcandae extract, Black Cohosh P.E, the celestial extract of Wei spirit; the butyryl radicals betulinic acid, catecholamine, phenyl styryl ketone; the Vitex negundo var cannabifolia extract, cis-retinoic acid, citrate; shamrock extract, Coenzyme Q10 99.0 (ubiquinone), Coumestrol; (Barnet Products is positioned at Englewood, NJ) to CPC PEPTIDE; daidzein; Radix Angelicae Sinensis extract, darutoside, debrominate laurinferol (debromolaurinterol); 1-decanoyl-glycerine-phosphonic acids; dehydrocholesterol, dehydrogenation xylenol, dehydrogenation two oxymethoxyallylbenzenes; dehydroepiandrosterone; DERMOLECTINE (available from Sederma, is positioned at Brooklyn, NY); L-dehydroascorbic acid; the trans-dehydroandrosterone sulfuric ester, two methyl allylphenols, 2; the 4-resorcylic acid; diosgenin, ascorbigen Di-Sodium Phosphate, dodecanedioic acid; EDERLINE is (available from Seporga; be positioned at Sophia Antipolis, France), ELESERYL SH is (available from Laboratories Serobiologiques; be positioned at Somerville; NJ), ENDONUCLEINE (available from LaboratoriesSerobiologiques, is positioned at Somerville; NJ); Equol (equol), ergosterol, eriodictyol; oestrogenic hormon and derivative thereof; ethocyn, eythrobic acid, farnesol; farnesyl acetate; Fructus Foeniculi extract, FIBRASTIL (available from Sederma, is positioned at Brooklyn; NY); FIBROSTIMULINES S and P (available from Sederma, are positioned at Brooklyn, NY); FIRMOGEN IS 8445 is (available from LaboratoriesSerobiologiques; be positioned at Somerville, NJ), flavonoid (particularly flavanone such as unsubstituted flavanone and phenyl styryl ketone such as unsubstituted phenyl styryl ketone and monohydroxy and dihydroxyl phenyl styryl ketone); neochanin (formononetin); capsule of weeping forsythia berry extract, gallic acid ester, γ-An Jidingsuan; GATULINE RC is (available from Gattlefosse; be positioned at Saint Priest, France), genistein; genisteine; the dyestuff wood acid, saleripol, Semen Ginkgo extrac; Radix Ginseng extract; ginsenoside, RO, R _6-1, R _6-2, R _6-3, R _c, R _D, R _E, R _F, R _F-2, R _G-1, R _G-2, glucose pyrans glycosyl-1-acid ascorbyl ester, gsh and ester thereof, glycitein (glycitein); eptyloxy 4 Whitfield's ointments, Hesperitin, six hydrogen turmerics, HMG-CoA-reductase inhibitors; the lupulus extract, 11-hydroxyl undeeanoic acid, 10-hydroxydecanoic acid; the 25-hydroxycholesterol oxycholesterol, ISOFAVONE SG 10 (available from Barnet Products, is positioned at Englewood; NJ), kinetin, L-2-oxygen thiazolidine-4-carboxylicesters; the lactate dehydrogenase inhibitor, 1-lauryl ,-lyso-phosphatidylcholine; lectin, LICHOCHALCONE LR15 (available from Maruzen, is positioned at Morristown; NJ), Radix Glycyrrhizae extract, Thioctic Acid; lumisterol, luteolin, ascorbigen trimagnesium phosphate; melatonin, melibiose, inhibitors of metalloproteinase; methoprene, methoprenic acid, 4-methoxyl group Whitfield's ointment; mevalonic acid, MPCCOMPLEX (available from CLR, is positioned at Berlin; Germany), N-acetylcysteine, N-methyl Serine; N methyl taurine, N, N ¹-two (lactoyl) mercaptamine, naringenin, new tigogenin; the 5-MEXORYL SAM, O-removes first Angiotensin, Oleanolic Acid; Pantethine, phenylalanine, light fenchone (photoanethone); phytinic acid and salt thereof, piperidines, intacellin; pratensein, pregnenolone, acetate pregnenolone; the succsinic acid pregnenolone, premarin, quillaic acid; raloxifene, REPAIR FACTOR 1 (available from Sederma, is positioned at Brooklyn; NY), REPAIR FACTOR SPC (available from Sederma, is positioned at Brooklyn; NY), axerophthal, retinoic acid ester (C2-C20 alcohol ester); Vogan-Neu, retinol acetate, glucuronic acid retinol ester; the linolic acid retinol ester, retinol palmitate, propionic acid retinol ester; REVITALIN BT (available from Pentapharm, is positioned at Basel, Switzerland); the S-Carbocisteine, Whitfield's ointment, SEANAMINE FP is (available from Laboratories Serobiologiques; be positioned at Somerville; NJ), STAY-C 50, soybean extraction; spleen extract; tachysterol, taurine, tazarotene; thymulen; thymic extract, Triiodothyronine, tigogenin; the vitamin A acid tocopherol; toxifolin, trans retinoic acid, wound hormone; citric acid three choline; trifoside, uracil derivative, ursonic acid; Vitamin D3 500,000 I.U/GM and analogue thereof; vitamin K, Vitex negundo var cannabifolia extract, Chinese yam extract; yamogenin, and zeatin (zeatin) or their mixture.

Lipid: the embodiment of this suitable class comprises: ricinolic acid spermaceti alcohol ester, oxystearic acid cholesterol ester, Unimac 5680 cholesterol ester, CREMEROL (available from Amerchol, is positioned at Edison, NJ), ELDEW C1301 is (available from Ajinomoto, be positioned at Teaneck, NJ), lanolin, MODULAN is (available from Amerchol, be positioned at Edison, NJ), OHLAN is (available from Amerchol, be positioned at Edison, NJ), vaseline, Phytantriol, with SUPER STEROLESTERS (available from Croda, be positioned at Parsippany, NJ), or their mixture.

Skin whitener: skin whitener is usually used in reducing melanic content in the skin, or reaches this effect by other mechanism.The skin whitener that is applicable to this sees EP-A-758, and 882 and EP-A-748,307, all in conjunction with in the present invention as a reference.Other examples of skin whitener comprise: adapalene, Aloe extract, amino tyrosine; DL-Lactic acid ammonium salt, methyl allylphenol derivative, Fructus Mali pumilae extract; arbutin, xitix, palmitinic acid ascorbigen ester; nonane diacid, bamboo extractive, Arctostaphylos ura-ursi extract; the bletilla stem tuber; Radix Bupleuri extract, Radix Sangusorbae extract, BURNETPOWDER is (available from Barnet Products; be positioned at Englewood; NJ), butylated hydroxy anisole, butylhydroxy toluene; Ligusticum wallichii; Radix Angelicae Sinensis, deoxyarbutin, 1; the 3-diphenyl propane derivative; 2,5 resorcylic acids and derivative thereof, 2-(4-acetoxyl group phenyl)-1; 3-Di Sen; 2-(4-hydroxyphenyl)-1,3-Di Sen, ellagic acid; aescinate grass alcohol (escinol); the estragole derivative, esculiw, Esculetin; FADEOUT is (available from Pentapharm; be positioned at Basel, Switzerland), windproof; Fructus Foeniculi extract; gallic acid and derivative thereof, Ganoderma extract, Jehol Ligusticum Rhizome; GATULINE WHITENING is (available from Gattefosse; be positioned at Saint Priest, France), dyestuff wood acid and derivative thereof; saleripol; glabridin and derivative thereof, glucopyranosyl-1-acid ascorbyl ester, glyconic acid; glycosamine; oxyacetic acid, Potenlini, green tea extract; 4-hydroxy-5-methyl base-3[2h]-furanone; hydroquinine, 4-BHA and derivative thereof, 4-hydroxy benzoic acid derivs; Hydroxyoctanoic acid; the xitix mesoinositol, kojic acid, lactic acid; citron extract; Radix Glycyrrhizae extract, LICORICE P-TH (available from Barnet Products, is positioned at Englewood; NJ); linolic acid, the ascorbigen trimagnesium phosphate, MELFADE is (available from Pentapharm; be positioned at Basel; Switzerland), MELAWHITE (available from Pentapharm, is positioned at Basel; Switzerland); mulberry extract, mulberry tree root extract, niacinamide; nicotinic acid and ester thereof; nicotinic alcohol, 5-MEXORYL SAM, parsley extract; the phellinuslinteus extract; intacellin, pyrogallol derivatives, vitamin A acid; Vogan-Neu; retinol ester (acetic ester, propionic ester, cetylate; linoleate); 2,4-resorcinol derivative, 3; the 5-resorcinol derivatives; rose fruit extract, rucinol, Whitfield's ointment; pine clothing extract; SOPHORA POWDER (available from Barnet Products, is positioned at Englewood, NJ); 4-thioresorcinol (4-thioresorein); 3,4,5-trihydroxy-benzyl derivative; tranexamic acid; TYROSLAT 10,11 (available from Fytokem), Vitamin D3 500,000 I.U/GM and analogue thereof; yeast extract, or their mixture.

Sebum inhibitor: sebum inhibitor can reduce the generation of sebum in the sebiferous gland.The example of the sebum inhibitor that is suitable for comprises: aluminium chlorohydroxide, and ASEBIOL (available from LaboratoriesSerobiologiques, is positioned at Somerville, NJ), BIODERMINE (available from Sederma, is positioned at Brooklyn, NY), climbazole, COMPLETECH MBAC-OS is (available from Lipo, be positioned at Peterson, NJ), reflunomide, Fructus Cucumidis sativi extract, dehydro-acetic acid and salt thereof, dichlorophenyl imidazoles diazacyclo pentane, KETOKONAZOL, LICHOCHALCONE LR 15 (available from Maruzen), niacinamide, nicotinic acid and ester thereof, nicotinic alcohol, Phloretin, PHLOROGINE (available from Secma, is positioned at Pontrieux, France), Benadon and derivative thereof, the S-Carbocisteine, SEPICONTROL AS, Spironolactone, tioxolone, tocopherol, UNITRIENOL T27 (, being positioned at Chicago IL) available from Unichem, and ZINCIDONE is (available from UCIB, be positioned at Clifton, NJ), or their mixture.

The sebum stimulant: the sebum stimulant can increase sebiferous gland and produce sebum.The non-limiting example of sebum stimulant comprises: bryonolic acid (bryonolic acid), COMPLETECH MBAC-DS (available from Lipo, be positioned at Paterson, NJ), trans-dehydroandrosterone (being also referred to as DHEA), orizanol, and their mixture.

The skin sensitizing agent: the non-limiting example that is applicable to this skin sensitizing agent comprises the composition that cooling feeling can be provided, as: camphor, thymol, 1-menthol and derivative thereof, eucalyptus, methane amide; Menthane ether and menthane ester; And the composition that warmth sensation can be provided, as capsicum tincture, Fructus Capsici extract, red chilly powder, n-nonanoic acid vanillyl acid amides, nicotinic acid derivates (benzyl nicotinate, nicotinic acid methyl ester, nicotinic acid phenylester etc.), capsicine, watercress extract, long and thin hot pepper extract and Rhizoma Zingiberis Recens extract, or their mixture.

Proteinase inhibitor: but proteinase inhibitor is the compound of arrestin hydrolytic process (being that protein resolves into low peptide moiety and amino acid whose process).The example of useful proteases inhibitor comprises: A E COMPLEX is (available from Barnet Products, be positioned at Englewood, NJ), ALE is (available from Laboratoires Seporgia, be positioned at Sophia Antipolis, France), allicin, AOSAINE is (available from Secma Biotechnologies Marine, be positioned at Pontrieux, France), APROTININ is (available from Pentapharm AG, be positioned at Basel, Switzerland), Semen Arecae extract, BLUE ALGAE extract is (available from Collaborative Labs Inc., be positioned at East Setauket, NY), CENTAURIUM is (available from Sederma, be positioned at Brooklyn, NY), CMST (available from Bioetica Inc., is positioned at Portland, ME), DERMOPROTECTINE (available from Sederma, is positioned at Brooklyn, NY), DISACOSIDE HF 60 (is positioned at Englewood available from Barnet Products, NJ), ELHIBIN (available from Pentapharm AG, is positioned at Basel, Switzerland), FLUID OUT COLLOID (available from Vegetech, is positioned at Glendale, CA), HYPOTAURINE is (available from Sogo Pharmaceutical Co.Ltd, be positioned at Chirodaku Tokyo), IN CYTE HEATHER (available from Collaborative LabsInc., is positioned at East Setauket, NY), MICROMEROL (available from CollaborativeLabs Inc., is positioned at East Setauket, NY), PEFABLOC SP is (available from Pentapharm AG, be positioned at Basel, Switzerland), SEPICONTROL AS is (available from Seppic, be positioned at Paris, France), SIEGESBECKIA (available from Sederma, is positioned at Brooklyn, NY), SOPHORINE (available from Barnet Products, is positioned at Englewood, NJ), THIOTAINE is (available from Barnet Products, be positioned at Englewood, NJ), and their mixture.

The skin-tightening agent: the non-limiting example of skin-tightening agent comprises: BIOCARE SA is (available from Amerchol, be positioned at Edison, NJ), Protalbinic acid, FLEXAN 130 (available from National Starch, is positioned at Bridgewater, NJ), GATULINE LIFTING is (available from Gattefosse, be positioned at Saint Priest, France), PENTACARE HP is (available from Pentapharm AG, be positioned at Basel, Switzerland), VEGESERYL (available from Laboratories Serobioloques, is positioned at Somerville, and their mixture NJ).

The antipruritic composition: the non-limiting example of antipruritic composition comprises: STIMU TEX is (available from Pentapharm AG, be positioned at Basel, Switzerland), TAKANAL is (available from Ikeda-Distributor, be positioned at Tokyo, Japan), ICHTHYOL is (available from International Sourcing-Distributor, be positioned at Upper Saddle River, NJ), OXYGENATED GLYCERYL TRIESTERS (available from LaboratoiresSeporgia, is positioned at Sophia Antipolis, and their mixture France).

Hair growth inhibitor: the non-limiting example that is applicable to the composition of hair growth inhibition comprises: 17-β estradiol, adamantyguanidines, adamantylamidines, the adenylosuccinic acid synthase inhibitor, the angiogenesis inhibitor steroide, aspartate transcarbamylase inhibitors, Valisone, Hydagen B, cupric ion, Rhizoma Curcumae Longae extract, cycloxygenase inhibitor, cysterne pathway inhibitor, dehydro-acetic acid, trans-dehydroandrosterone, persimmon leaf (diopyros leak) extract, Urogastron, epigallocatechin, basic lipid acid, Oenothera oil, the gamma glutamyl transpeptidase inhibitor, ginger oil, glucose metabolism inhibitor, glu famine metabolic poison, gsh, green tea extract, heparin, KAPILANNE is (available from International Sourcing Distributor, be positioned at UpperSaddle River, NJ), L, 5 Ornithines, L-asparagine synthase inhibitor, linolic acid, lipoxidase inhibitor, longa extract, Touch-me-notAction Plant amine dihydrochloride, mimosine, inhibitors of nitric oxide synthase, nonsteroidal anti-inflammatory, the ornithine decarboxylase inhibitor, ornithine base transaminase inhibitor, panthenol, phorhetur, phosphodiesterase inhibitor, the Pleion plant milk extract, inhibitors of protein kinase C, 5-alpha reductase inhibitor, the thiohydroxy compound of reaction, tioxolone, transforming growth factor-beta-1, urea, zine ion, and their mixture.

The 5-alpha reductase inhibitor: the non-limiting example of 5-alpha reductase inhibitor comprises: CLOVE55 (available from Barnet Products Distributor, is positioned at Englewood, NJ), the male glycol of ethynyl, genisteine, Genistoside, Licochalcone LR-15, Saw Palmetto P.E, the SOPHORA extract is (available from Maruzen, be positioned at Morristown, NJ), ZINCIDONE (available from UCIB, is positioned at Clifton, and their mixture NJ).

Decortication enzyme promotor: these compositions can promote the activity of endogenous decortication enzyme.The non-limiting example of decortication enzyme promotor comprises: N-methyl Serine, Serine, Trimethyl glycine, and their mixture.

Anti-saccharifying agent: anti-saccharifying agent (anti-glycation agent) can prevent the collagen cross-linking that sugar causes.The suitable examples of anti-saccharifying agent comprises: AMADORINE (available from BarnetProducts Distributor, is positioned at Englewood, NJ).

The effective constituent that preferably is applicable to this comprises and is selected from those compositions of following group: Whitfield's ointment, niacinamide, panthenol, nicotinic acid tocopherol, benzoyl peroxide, 3-hydroxy-benzoic acid, flavonoid (for example, flavanone, phenyl styryl ketone), farnesol, Phytantriol, oxyacetic acid, lactic acid, 4-hydroxy-benzoic acid, acetylsalicylic acid, 2-hydroxybutyric acid, the 2-hydroxypentanoic acid, the 2-hydroxycaproic acid, cis-vitamin A acid, trans-vitamin A acid, Vogan-Neu, retinol ester (for example, the propionic acid retinol ester), phytic acid, N-acetyl-L-cysteine, Thioctic Acid, tocopherol and ester thereof (for example, tocopherol acetate), nonane diacid, arachidonic acid, tsiklomitsin, Ibuprofen BP/EP, Naproxen Base, Ketoprofen, hydrocortisone, acetominophen, Resorcinol, phenoxyethyl alcohol, phenoxypropanol, phenoxy group Virahol, 2,4,4 '-three chloro-2 '-xenol ether, 3,4,4 '-trichloro-symmetrical diphenyl urea, Octopirox, Xylotox, clotrimazole, miconazole, KETOKONAZOL, neomycinsulphate, theophylline, and their mixture.More preferably be selected from following group composition: niacinamide, panthenol, oxyacetic acid, lactic acid, Whitfield's ointment, acetylsalicylic acid, 2-hydroxybutyric acid, 2-hydroxypentanoic acid, 2-hydroxycaproic acid, Vogan-Neu and ester thereof, tocopherol and ester thereof, and their mixture.

When being used for the beautifying nursing method of skin, hair or nail, effective constituent is preferably selected from: crease-resistant and anti-skin atrophy activeconstituents, anti-acne active ingredient, artificial tanning agent and promotor, skin repair actives, skin barrier repair aids, skin whitener, skin sensitizing agent, skin soothing agent, lipid, sebum inhibitor, sebum stimulant, sun-screening agent, proteinase inhibitor, skin-tightening agent, the overworked composition of anti-scabies, and decortication enzyme promotor, or their mixture.Heat preserving agent

Preferred preformed sheet device contains at least a wetting Agent for Printing Inks.

Can add heat preserving agent to reach plastic effect and to increase the moisturizing properties of premolding sheet device when being used for application surface.Some wetting Agent for Printing Inks such as hexylene glycol also can make preformed sheet device of the present invention have anti-microbial property and characteristic.In addition,, it is generally acknowledged, decompose thereby device is difficult under extreme temperature conditions by in preformed sheet device of the present invention, adding the stability that wetting Agent for Printing Inks can increase device although do not wish that any restriction is arranged in theory.

Preformed sheet device of the present invention generally contains 1.0% to about 45% the wetting Agent for Printing Inks of having an appointment, and is preferably about 5% to about 40%, and more preferably from about 10% to about 30%.

Be applicable to that wetting Agent for Printing Inks of the present invention sees WO98/22085, WO98/18444 and WO97/01326 are all in conjunction with in the present invention as a reference.Other wetting Agent for Printing Inkss that are suitable for comprise amino acid and derivative thereof, as proline(Pro) and arginine aspartate, 1; the 3-butyleneglycol, propylene glycol and water, and fine hair Korean pine (codium tomentosum) extract; collagen amino acid or peptide, creatinine, Glycerol dimer; biological carbohydrate gum-1, glucose ammonium salt, glucuronate; glutaminate, glycerol polyethylene glycol ether (for example glycereth 20), glycerine list propoxylated glycerine; glycogen, hexylene glycol, honey; and the extract or derivatives thereof, hydrogenated starch hydrolysates, hydrolysis mucopolysaccharide; inositol; Keratin sulfate amino acid, LAREX A-200 (available from Larex), glucosaminoglycan; methoxyl group PEG 10; methyl gluceth-10 and-20 (all available from Amerchol, is positioned at Edison, NJ); methyl glucoside; the 3-methyl isophthalic acid, 3-butyleneglycol, N-ethanoyl glucose ammonium salt; panthenol; (as PEG 15 butyleneglycols, PEG 4, PEG 5 tetramethylolmethanes for polyoxyethylene glycol and derivative thereof; PEG6; PEG 8, and PEG 9), tetramethylolmethane; 1; the 2-pentanediol, PPG-1 glyceryl ether, PPG-9; 2-Pyrrolidone-5-carboxylate salt and salt thereof; as glyceryl pca, sugared isomer, SEACARE (available from Secma); sericin; silk amino acid, ethanoyl hyaluronate sodium, hyaluronate sodium; poly (sodium aspartate); polyglutamic acid sodium, polyoxyethylene sorbitan ester 20 (sorbeth 20), polyoxyethylene sorbitan ester 6; sugar and sugar alcohol and derivative thereof; as glucose, seminose and Polyglycerine, sorbyl alcohol; trehalose; triglycerin, TriMethylolPropane(TMP), three (methylol) aminomethane salt; and yeast extract, or their mixture.

The heat preserving agent that preferably is applicable to this is selected from: glycerine, butyleneglycol, hexylene glycol, panthenol and polyoxyethylene glycol and derivative thereof, or their mixture.Emulsifier/surfactant

Preformed sheet device of the present invention also can randomly contain-kind or kinds of surface promoting agent and/or emulsifying agent.Emulsifying agent and/or tensio-active agent generally help in external phase to disperse with the suspension non-dispersive mutually.When product is a skin clean when using product, tensio-active agent also is suitable for.For simplicity, emulsifying agent is hereinafter also listed in term " tensio-active agent " item down, and therefore " tensio-active agent " is used for the various tensio-active agents of expression as emulsifying agent or other tensio-active agent purposes (as skin clean).Tensio-active agent known and commonly used can be used for the present composition, if selected composition chemically and physically with the necessary component compatibility of the present composition, and can provide desired characteristic.The tensio-active agent that is suitable for comprises silicone materials, non-silicone material, and their mixture.

Preferably contain have an appointment 0.01% to about 15% tensio-active agent or its mixture in the present composition.Selection to concrete tensio-active agent or surfactant mixture will be decided according to pH and existing other components of composition.

Preferred surfactants is a nonionogenic tenside.Wherein be applicable to and of the present inventionly be: the condensation product of oxyalkylene and lipid acid (being the oxyalkylene fatty acid ester).The general formula of this class material is: RCO (X) _nOH, wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly derived from ethylene glycol or oxygen ethene), or-OCH ₂CHCH ₃-(promptly derived from propylene glycol or oxypropylene), and n is about 6 to about 100 integer.Other nonionogenic tensides have the condenses (being oxyalkylene lipid acid diester) of oxyalkylene and 2mol lipid acid.The general formula of these materials is: RCO (X) _nOOCR, wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly derived from ethylene glycol and oxygen ethene), or-OCH ₂CHCH ₃-(promptly derived from propylene glycol or oxypropylene), and n is about 6 to about 200 integer.Other nonionogenic tensides are polycondensation products (being the oxyalkylene fatty alcohol-ether) of oxyalkylene and Fatty Alcohol(C12-C14 and C12-C18).The general formula of this class material is R (X) _nOR ', wherein R is C _10-30Aliphatic group, X are-OCH ₂CH ₂-(promptly derived from ethylene glycol or oxygen ethene), or-OCH ₂CHCH ₃-(promptly derived from propylene glycol or oxypropylene), and n is about 6 to about 100 integer, and R ' is H or C _10-30Aliphatic group, the example comprise PEG 40 hydrogenated castor oils, can trade(brand)name " Cremophor RH 40 " available from BASF (Parsippany, NJ, USA); PEG 60 hydrogenated castor oils, can trade(brand)name " Cremophor RH 60 " available from BASF (Parsippany, NJ, USA); Different cetyl ether-20, can trade(brand)name " Arlasolve 200 " available from ICI (Wilmington, MA, USA); And oleyl ether-20, can trade(brand)name " Volpo N20 " available from Croda Chemicals Ltd. (Goole, North Humberside, England).Other nonionogenic tensides are condensation products [promptly wherein polyoxyalkylene part one end is through fatty acid esterification, and the other end links to each other with Fatty Alcohol(C12-C14 and C12-C18) (promptly linking to each other by ehter bond)] of oxyalkylene and lipid acid and Fatty Alcohol(C12-C14 and C12-C18).The general formula of this class material is: RCO (X) _nOR ', wherein R and R ' are C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly derived from ethylene glycol or oxygen ethene), or-OCH ₂CHCH ₃-(promptly derived from propylene glycol or oxypropylene), and n is about 6 to about 100 integer, and the example comprises: cetyl ether-6, cetyl ether-10, cetyl ether-12, cetearyl ether-6, cetearyl ether-10, cetearyl ether-12, stearyl ether-6, stearyl ether-10, stearyl ether-12, PEG-6 stearate, the PEG-10 stearate, the PEG-100 stearate, PEG-12 stearate, PEG-20 stearin, PEG-80 tallow acid glyceryl ester, the PEG-10 stearin, PEG-30 coconut oil glyceryl ester, PEG-80 coconut oil glyceryl ester, PEG-200 tallow acid glyceryl ester, the PEG-8 dilaurate, PEG-10 SUNSOFT Q-182S, and their mixture.

Other are applicable to that this nonionogenic tenside is alkyl glycoside and alkyl poly glucoside, and it more specifically sees WO98/18444, in conjunction with in the present invention as a reference.

Other ionic surfactant pack that are suitable for are drawn together polyhydroxy fatty acid amide surfactants, and it more specifically is found in WO98/04241.

Other ionic surfactant pack that are applicable to this are drawn together: sugar ester and polyester, alkoxylate sugar ester and polyester, C ₁-C ₃₀The C of lipid acid ₁-C ₃₀Aliphatic alcohol ester, C ₁-C ₃₀The C of lipid acid ₁-C ₃₀The alkoxy derivative of aliphatic alcohol ester, C ₁-C ₃₀The alkoxylated ether of Fatty Alcohol(C12-C14 and C12-C18), C ₁-C ₃₀The polyglycerol ester of lipid acid, polyvalent alcohol C ₁-C ₃₀Ester, polyvalent alcohol C ₁-C ₃₀Ether, alkyl phosphate, polyoxyalkylene aliphatic ether phosphoric acid ester, fatty amide, acyl lactylates, and their mixture.The example of the tensio-active agent that these are not siliceous comprises: polysorbate20, polyoxyethylene glycol 5 soyasterols, stearyl ether-20, cetearyl ether-20, PPG-2 methyl glucose ether SUNSOFT Q-182S, polysorbate80; Polysorbate60, can trade(brand)name " Tween 60 " available from ICI (Wilmington, MA, USA); Stearin, Arlacel-20, polyoxyethylene-4-lauryl ether sodium stearate, Polyglycerine-4-isostearate, lauric acid hexyl ester, PPG-2 methyl glucose ether SUNSOFT Q-182S, and their mixture.

Preferred nonionic is selected from: cetearyl ether-12, coconut oil sucrose ester, stearyl ether-100, polysorbate60, PEG-60 hydrogenated castor oil, different cetyl ether-20, oleyl ether-20, PEG-100 stearate, and their mixture.

Other are applicable to that this emulsifying agent is a polyoxypropylene, fatty alcohol-polyoxyethylene ether.The general formula of these materials is: R (CH ₂CHCH ₃O) _x-(CH ₂CH ₂O) _y-H, wherein R is OC ₁₀-C ₃₀Alkyl or C ₁₀-C ₃₀Alkyl, the mean value of x are 1-20, and the mean value of y is 1-30, and the example comprises PPG-6-decyl myristyl ether-30, can trade(brand)name " Pen 4630 " available from NikkoChemicals Co.Ltd. (Tokyo, Japan); PPG-6-decyl myristyl ether-20, can trade(brand)name " Pen 4620 " available from Nikko Chemicals Co.Ltd. (Tokyo, Japan); And PPG-5 cetyl ether-20, can trade(brand)name " Procetyl AWS " available from Croda Chemicals Ltd. (Goole, North Humberside, England).

Other are applicable to that this emulsifying agent is based on the fatty acid ester of anhydro sorbitol or sorbyl alcohol and the fatty acid ester blends of sucrose fatty ester, specifically are found in WO98/22085, in conjunction with in the present invention as a reference.

The hydrophilic surfactant that is applicable to this alternately or additionally comprises various any positively charged ions known in the art, negatively charged ion, zwitter-ion and amphoterics.For example referring to " washing composition and emulsifying agent " the North America version (1986) of McCutcheon, Allured publishing company publishes; US-A-5011681 (people such as Ciotti, on April 30th, 1991 is open); US-A-4421769 (people such as Dixon, November 20 nineteen eighty-three is open); And US-A-3755560 (people such as Dickert, on August 28th, 1973 is open); These four pieces of documents are all in full in conjunction with in the present invention as a reference.

Various cats products are applicable to this.The cats product that is suitable for sees WO98/18444.

Various anion surfactants also are applicable to this.For example referring to US-A-3929678 (people such as Laughlin, on December 30th, 1975 is open), it is in full in conjunction with in the present invention as a reference.Typical anion surfactant comprises alkyloyl isethionic acid ester (C for example ₁₂-C ₃₀), alkyl and alkyl ether sulphate and salt thereof, alkyl and alkyl ether phosphate and salt thereof, alkyl methyl cow-bezoar acid esters (C for example ₁₂-C ₃₀), and fatty acid soaps (for example an alkali metal salt, for example sodium salt or sylvite).

Both sexes and zwitterionics also are applicable to this.Be applicable to that the both sexes of the present composition and the example of zwitterionics are the compositions that extensively is described as aliphatic secondary amine and tertiary amines derived thing, aliphatic group wherein can be a straight or branched, and reducible 8-22 carbon atom (the preferred C that contains of one of aliphatic substituting group ₈-C ₁₈), and one comprises the anionic water-soluble group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Iminodiacetic acid alkyl ester and imino-diacetic alkanoic acid ester, and aminoalkyl esters, tetrahydroglyoxaline and ammonium derivative.Other both sexes and zwitterionicss that are suitable for can be selected from: trimethyl-glycine, sultaine, hydroxyl sulfo betaine, alkyl sarcosine salt (for example, C ₁₂-C ₃₀), and the alkyloyl sarcosinate.

Premolding sheet device of the present invention can randomly contain the emulsifying agent or the tensio-active agent of polysiloxane.Various silicone emulsifiers are applicable to this.These silicone emulsifiers generally are through organically-modified organopolysiloxane, also are polysiloxane surfactant well known to those skilled in the art.The silicone emulsifiers that is suitable for comprises dimethicone copolyol.These materials be with polydimethylsiloxane--modified for containing polyether lateral chain, as polyoxyethylene chain, polyoxypropylene chains, their combination chain, and contain polyether chain derived from oxygen ethene and oxypropylene.Other examples comprise alkyl-modified dimethicone copolyol,, contain C that is ₂-C ₃₀The compound of side chain.Other dimethicone copolyols that are suitable for comprise the material that contains various positively charged ions, negatively charged ion, both sexes and zwitter-ion side chain.The oil soluble amendment

Also can randomly comprise the oil soluble amendment among the present invention.The example of the oil soluble amendment that is suitable for comprises: mineral oil, vaseline, C ₇-C ₄₀Branched-chain hydrocarbon, C ₁-C ₃₀Carboxylic acid C ₁-C ₃₀Alcohol ester, C2-C30 dicarboxylic acid C ₁-C ₃₀Alcohol ester, C ₁-C ₃₀The carboxylic acid mono-glycerides, C ₁-C ₃₀Carboxylic acid two sweet esters, C ₁-C ₃₀The carboxylic acid triglyceride, C ₁-C ₃₀The carboxylic acid ethylene glycol ester, C ₁-C ₃₀Carboxylic acid ethylene glycol diester, C ₁-C ₃₀The carboxylic acid propylene glycol monoester, C ₁-C ₃₀The carboxylic acid propylene glycol diesters, C ₁-C ₃₀Carboxylic acid monose ester and sugared polyester, polydialkysiloxane, poly-diaromatic siloxane, poly-alkaryl siloxanes, silicone gums is dimethiconol for example, the cyclohexyl methyl polysiloxane that contains 3-9 Siliciumatom, vegetables oil, hydrogenated vegetable oil, propylene glycol C4-C20 alkyl oxide, two C8-C30 alkyl oxides, and their mixture.

These compositions have more detailed description in WO98/18444, its combination in the present invention as a reference.Thickening material

Premolding sheet device of the present invention also can contain thickening polymer, preferably contains about 0.01% to about 5% thickening polymer approximately, and more preferably about 0.05 to about 3%, most preferably is about 0.1% to about 2%.

Thickening polymer can be shared with polysaccharide mixture of the present invention, in order to improve the characteristic of described gel.Thickening polymer can be chemistry or physical crosslinking, or itself adds in the polysaccharide mixture.

The thickening polymer that is applicable to this comprises Polyvinylpyrolidone (PVP), and is poly--the 2-ethyl-2-oxazoline, polyvinyl alcohol, polyoxyethylene, polyvinyl ether, polyvinyl ether and Polyvinylpyrolidone (PVP) and derivative thereof, the multipolymer of methylvinylether and maleic anhydride, copolymer from ethylene and maleie anhydride; Contain polymerizing acrylic acid thing or derivatives thereof, as polyacrylic acid; Polyethylene glycol monomethacrylate, polydimethylacrylamiin, polyacrylate is as ammonium polyacrylate and sodium polyacrylate; And acrylamide and N, N ¹The multipolymer of-methylene-bisacrylamide and polyacrylamide; And polyacrylamide.Additional polysaccharide

Preformed sheet device of the present invention also can contain additional polysaccharide.As mentioned above, the total amount of polysaccharide is lower than 10% (with dry weight basis) in the sheet device of the present invention.If there is additional polysaccharide, then it counts the gross dry weight of the contained polysaccharide of device.

The additional polysaccharide that is suitable for comprises: algal polysaccharide, and as seaweed gel, Lalgine, alginates (as calcium salt, sylvite, aluminium salt or sodium salt), and propylene glycol alginate; The living invertebrates extract in sea is as chitosan and hydroxypropyl chitosan and derivative thereof; The starch or derivatives thereof; Natural fruits extract such as pectin and Sudan Gum-arabic (arabian); The natural phant transudate, as POLY-karaya, tragacanth gum, Sudan Gum-arabic, tamarind gum, and ghatti gum; And Resin adhesive, as shellac, Dammar gum (damar gum), jade-like stone crust glue (copal gum) and gum rosin; Or their mixture.

Other examples that are applicable to this additional polysaccharide have Mierocrystalline cellulose and the derivative of addressing among the WO97/28785 thereof, in conjunction with in the present invention as a reference.Light scattering agent

Also can contain matting agent or light scattering agent in the device of the present invention, particularly organic or organo-siloxane particle, as the PA-12 powder, silicone elastomer powder (for example Dimethicone/Vinyl Dimethicone cross-linked polymer), and poly-alkyl silsesquioxane powder (as Tospearl  145A) available from GE Silicones.Other optional members

Other optional components that can comprise wide region in the present composition.These annexing ingredients should be pharmaceutically useful." described various indefiniteness makeup and the medicinal ingredientss that are usually used in the makeup industry that are applicable in the present composition in the CTFA cosmetic composition handbook (the 2nd edition, 1992), its full text combination in the present invention as a reference.The 537th page of functional classification of having described composition in this book of reference.The functional classification of these and other compositions comprises: abrasive material, absorption agent, microbiotic, anti-hard caking agent, antidandruff agent, antioperspirant, oxidation inhibitor, VITAMIN, biotic additives, SYNTHETIC OPTICAL WHITNER, bleach-activating agent, whitening agent, builder, buffer reagent, sequestrant, chemical additive, tinting material, hairdressing agent, sanitising agent, used for cosmetic astringent matter, the used for cosmetic biocide, denaturing agent, tooth nursing agent, reodorant, the decortication activeconstituents, trichogen, medicinal astringent matter, dyestuff, dye-transfer, enzyme, external-use analgesic, flavour agent, membrane-forming agent, perfume composition, wormer, mould inhibitor, opalizer, oxidation dye, oxygenant, sterilant, the pH regulator agent, pH buffer reagent, active pharmaceutical ingredients, softening agent, sanitas, free-radical scavengers, skin, hair or nail SYNTHETIC OPTICAL WHITNER, skin, hair or nail amendment, skin, hair or nail penetration-assisting agent, stablizer, surface amendment, reductive agent, temperature inhibitor, and heating agent.

Beautify composition and also be applicable to this, as tinting material, volatile oil and skin healing agent.

Other materials that are applicable to this comprise pigment.The pigment that is applicable to the present composition can be organic and/or inorganic components.Also comprise the material that belongs to the less colored or low gloss in the term pigment category,, and also comprise light scattering agent as the delustring finishing agent.The embodiment of the pigment that is suitable for has ferric oxide, acyl glutamate ferric oxide, titanium dioxide, ultramarine blue, D﹠amp; The C dyestuff, famille rose, and their mixture.Can suitably use pigment composition according to the type of composition.

The pH of sheet device of the present invention is preferably because 3 to about 9, and more preferably from about 4 to about 8.

Premolding sheet device of the present invention be have can with the paster or the facial mask form of the size and dimension of institute site of administration outline good fit.Its definite size and dimension will be decided according to purposes and product performance.Preformed sheet device of the present invention is suitable for the part and is used for nail or epidermis, hair or scalp, human body face or its part, shank, hand, arm, foot, or trunk position.Device of the present invention for example can be square, circle, and rectangle, ellipse, or other shapes of forming by these shapes, as can be described as " semicircle ", " Donna cast ", or other shapes.The surface-area that is suitable for the facial device of using is 0.25cm ²To about 500cm ², be preferably about 1cm to about 400cm ²The thickness of device of the present invention is extremely about 20mm of about 0.5mm, is preferably about 1mm to about 5mm.

Premolding sheet device of the present invention also can be made into or wear as hand, and foot is worn, or the body worn form.Hand is worn form and is generally comprised form of gloves or its part, and foot is worn form and generally comprised socks form or its part.Here the term of Cai Yonging " gloves " comprises " mitten ".Preferred hand is worn form and is comprised the gloves body, and it comprises stage casing part, 1 to 4 finger-stall that links to each other with the stage casing, the thumbstall that links to each other with the stage casing, the palm of the hand one side and the back of the hand one side.Preferred foot is worn form and is comprised the socks body, its by an end seal, the sufficient shape tubular type of an end opening partly constitutes.Device of the present invention also can be made into or is used as the body worn form.Body worn is meant radially around being worn on the body portion that has the longitudinal axis.Its end is connected with each other, and maybe can shorten its length, and it only partly is trapped among on the health.In any shape, the applying that adornment all can be fabulous with body portion.These body portion generally comprise user's back, upper arm, forearm, thigh, shank, neck and trunk.

After device sticked, it can keep about 3 hours at application site, and preferred about 1 hour, more preferably less than 15 minutes.But preformed sheet device full wafer is removed.

According to the contained effective constituent of preformed sheet device of the present invention, it can have following purposes at least: the hydration of skin, hair or nail; Improve microgroove and wrinkle; The aesthetic nursing of acne; Skin compacts; Strengthening effect; Ramollescence; Exfoliating Scrub; Improve and/or the homogenize colour of skin and/or skin texture; Skin, hair or the effect of nail light; Skin or hair conditioning; Help the solarization effect; Reduce appearance of pores; Absorb or control secretory product; The pain of prevention and/or alleviation skin, hair or nail, muscle; Reduce swelling, and/or black eye; Promote wound healing; Make the skin gentleness, pure and fresh or nice and cool; Reduce inflammation; Make face brighten; Alleviate hyperemia; Alleviate expansion; The treatment tetter; Slow closing; Purifying; Perfuming; Reduce bacterium or microorganism growth; The healing effect; Anthelmintic action; Remove disadvantageous hair, dirt or color make-up; Painted or the bleaching in position of this device is used in order.Preferred preformed sheet device of the present invention is used for the hydration of skin, hair or nail; Improve microgroove and wrinkle; Improve and/or the homogenize colour of skin and/or skin matter structure.Method transudate release test

The device that contains polysaccharide glue mixture is measured to determine the synersis amount of premolding sheet device of the present invention by the transudate release test.

Adopt following method to obtain the data of the transudate that from used gel, discharges.Adopt the relevant gel preparation of following method preparation.With 9g (+/-0.1g) heating liquid (＞80 ℃) is poured in the kiver of 91mm diameter, for example in the lid of Falcon-1029 Petri dish.Seal the loss that avoids evaporating of this container.Gel is cooled to room temperature, noiseless curing.Gel is at room temperature preserved and is spent the night, then reading of data.Remove capping, to the container that contains sample weigh (+/-0.005g).Three filter paper (9.0cm Whatman-114 is through wetting reinforcement) are overlayed on the flat gel surface.The flat weight of diameter 9.0cm, heavy 200g placed guarantee on the filter paper that filter paper and gel surface fit tightly.Remove weight after 1 minute, filter paper is uncovered from gel gently.Filter paper should be able to make the gel surface that fits tightly with it have tangible mat surface.Sample is weighed once more, is lost by the difference calculated mass.Gained be to be the gram number of the transudate that discharges the gel film of 9cm from above-mentioned diameter.Gel compression fracture test

Mechanical property by gel compression fracture test determination premolding sheet device of the present invention.Relevant parameter is gel-strength (by measuring the required pressure of cylinder shape mold gel fracture), and the snappiness of gel (by measuring the compression degree of gel at breaking point).Below test method is described in more detail.

(Stable Micro Systems (SMS) structural analysis instrument (TA) TA-XT2i type UK) carries out the compression fracture test for Godalming, Surrey available from Stable Micro Systems Ltd in employing.System controls by SMS ' the s Texture ExpertExceed software (2.03 editions) that moves under Windows-98.Diameter is that the aluminium compressed panel (P-100 probe) of 100mm links to each other with the load unit of 50Kg.These are installed in the TA Probe Carrier, the machine control as calculated of the extending arm of its vertical shifting.

For the preparation sample, adopt following method to prepare gel preparation.In mold, make (diameter 26mm * dark 12mm) accurate solid cylindrical gel film.Sealing contains the mold of sample to avoid evaporating during storage.At room temperature preserving gel film spends the night.Before test, just gel film is taken out the mold separately from it, estimate damaged situation.Abandon the gel film that has damaged (for example containing bubble), because the mechanical property that these damaged meeting influences are measured.Then the N/D gel film is placed under the P100 compressed panel between two parties.

It is under pressure/compact model that Texture Expert Exceed software is installed.Compressed panel is preset in the elemental height of 12.0mm.Fall off rate is set to 0.8mm/s, moves total distance and is set to 10.8mm (be gel film be compressed into 90% o'clock of its elemental height stop to measure).The position that pressure and compressed panel are collected automatically with the ratio of 200pps (point/second) by system.Software is preset as reaching peak pressure tense marker compressed panel position.Peak pressure is a breaking tenacity, i.e. the required pressure of gel film fracture.Compressed panel arrives the deformation range of the miles of relative movement sign gel of gel breaking point from its elemental height.Calculate the mean value (generally carry out 5 replicate(determination)) of sample, in newton at the peak pressure of breaking point.

Adopt the percentage ratio of the initial mold heights of gel to characterize the single shaft deformation (compression) of gel, that is: at breaking point

If gel does not rupture yet in 10.8mm stroke endpoint (i.e. 90% rate of compression), then gel is categorized as under this test conditions ' not fracture '.

Adopt following examples explanation the present invention.

1.Kelgum ^TMBe available from Kelco (San Diego, CA, 1: 1 mixture of xanthan gum USA) and tracasol

2. " Kimwipes EX-L " is available from Kimberley-Clark Corp., Roswell, GA, USA

3. " Collagen Fiber Mask " is available from Beaute Attica, Inc., Redmond, WA, USA

With polysaccharide glue mix with water form the homogeneous dispersion (this step can by with polysaccharide pre-dispersed in non-solvent for example in the polyvalent alcohol and easily reach), add other annexing ingredients.Mixture is heated with stirring to first temperature (about 90 ℃) that is higher than the mixture jellying point, makes the abundant hydration of polysaccharide glue.Liquid gel is distributed in the mold of suitable shape then.The preferred injection molding distributing liquid gel that adopts.Can eliminate like this may by the cutting gel cause damaged, and can improve the soundness of device.Injection molding also can make device be easy to form each different zone of thickness and each zone with other structurizing characteristics.Liquid gel also can form sheet material through injection moulding.Then liquid gel is cooled to second temperature (for example room temperature) that is lower than first temperature, is equal to or less than the mixture jellying point so that gel structure condenses.This device can be deviate from from mold then, or be cut out the paster of suitable shape from gel sheet.Described device can be packed to reduce the mummification of device in storage with low water vapor permeation material then.The packing that is applicable to this device comprises pouch or sealing ware.If device is packaged into pouch, then preferably sealing before use.Can seal by peelable lining such as plastic film, it is easy to peel off down from device.

If adopt egative film (embodiment 1,4 and 6), can before gel distributes, egative film be placed the mold of suitable shape, or in the liquid gel cooling step, egative film be placed on the gel surface.

In some composition, can be in prescription (embodiment 3 and 4) add metal ion (Ca for example ²⁺, K ⁺) to promote the gel-strength of device.In this case, metal ion is added with aqueous solution form, and be stirred in the liquid gel of hydration as the last the ingredients of a mixture that adds.

Can improve aforesaid method according to need according to the characteristic of annexing ingredient.For example, if there is nonaqueous component, this liquid gel that homogenizes before horse back mold or injection moulding is to guarantee the dispersion of nonaqueous component.Similarly, if added the thermo-sensitivity composition, then should be after glue closes step preparation be cooled to optimal temperature (deciding), and in this step, adds the thermo-sensitivity composition according to composition.

Can for example make the liquid gel degassing, to remove dispersive bubble in the liquid through vacuumizing.If there is this degassing step, then should be the final step before liquid gel distributes at once.

As implied above, preformed sheet device has required synersis amount, intensity or snappiness.

Claims (17)

1. preformed sheet device, wherein contain:

(a) be lower than 10% polysaccharide mixture, it is composed of the following components;

(i) red seaweed polysaccharide;

(ii) contain the polysaccharide of seminose, be selected from polygalactomannan, glucomannan, and their derivative or mixture and;

The polysaccharide that (iii) ferments, or derivatives thereof; And

(b) about 30% to about 99.5% water;

Wherein the total amount of contained polysaccharide is lower than 10% in this device.

2. the preformed sheet device of claim 1, wherein red seaweed polysaccharide is selected from: agar, agarose, kappa carrageenan and danish agar, or their mixture.

3. claim 1 or 2 preformed sheet device, wherein red seaweed polysaccharide is selected from: agar and agarose, or their mixture.

4. the preformed sheet device described in arbitrary claim among the claim 1-3, wherein polygalactomannan is selected from: tracasol, guar gum, and cassia gum, or their mixture.

5. the preformed sheet device described in arbitrary claim among the claim 1-4, wherein glucomannan is selected from: Rheolex RX-L and take off acetyl Rheolex RX-L or their mixture.

6. the preformed sheet device described in arbitrary claim among the claim 1-5, fermentation polysaccharide or derivatives thereof wherein is selected from xanthan gum and gum gellan, or their mixture.

7. the preformed sheet device described in arbitrary claim among the claim 1-6 wherein contains few 5% polysaccharide mixture.

8. the preformed sheet device described in arbitrary claim among the claim 1-7, wherein red seaweed polysaccharide is 20: 1 to about 1: 5 with the ratio of the polysaccharide that contains seminose.

9. the preformed sheet device described in arbitrary claim among the claim 1-8, wherein red seaweed polysaccharide is about 7: 1 to about 1: 2 with the ratio of the polysaccharide that contains seminose.

10. the preformed sheet device described in arbitrary claim among the claim 1-9 wherein contains effective constituent, is selected from: crease-resistant and anti-skin atrophy activeconstituents, anti-acne active ingredient, artificial tanning agent and promotor, skin repair actives, skin barrier repair aids, skin whitener, skin sensitizing agent, the skin soothing agent, antimicrobial and anti-mycotic activity composition, lipid, sebum inhibitor, the sebum stimulant, sun-screening agent, antiseptic-germicide, local anesthetic, steroide, non-steroidal anti-inflammatory agents, proteinase inhibitor, skin-tightening agent, the overworked composition of anti-scabies, the hair growth inhibition composition, 5-alpha reductase inhibitor, anti-saccharifying agent, and decortication enzyme promotor, or their mixture.

11. the preformed sheet device described in arbitrary claim among the claim 1-9, wherein contain effective constituent, be selected from: crease-resistant and anti-skin atrophy activeconstituents, anti-acne active ingredient, artificial tanning agent and promotor, skin repair actives, skin barrier repair aids, skin whitener, skin sensitizing agent, the skin soothing agent, lipid, sebum inhibitor, sebum stimulant, sun-screening agent, proteinase inhibitor, skin-tightening agent, the overworked composition of anti-scabies, and decortication enzyme promotor, or their mixture.

12. the preformed sheet device described in arbitrary claim among the claim 1-11 wherein also comprises egative film.

13. the preformed sheet device described in arbitrary claim among the claim 1-12 wherein also contains at least a wetting Agent for Printing Inks.

14. the preformed sheet device described in arbitrary claim among the claim 1-13, its form for have can with nail or epidermis, hair or scalp, human body face or its part, shank, arm, hand, foot, or the facial mask or the paster of the size and dimension of trunk position applying.

15. a beautifying nursing method, comprising at skin, application rights requires 1-9 on hair or the nail, the preformed sheet device described in arbitrary claim in 11,12,13 or 14.

16. the purposes of polysaccharide mixture in intensity, synersis amount or the snappiness of improving aqueous premolding sheet device, wherein this mixture is made of following component:

(i) red seaweed polysaccharide;

(ii) contain the polysaccharide of seminose, be selected from polygalactomannan, glucomannan, and derivative or mixture; And;

The polysaccharide that (iii) ferments, or derivatives thereof.

17. the described preformed sheet device of arbitrary claim among the claim 1-13, its form is selected from: hand is worn; Foot is worn; With the body worn form.