CN1287827C - Blood-supplementing traditional Chinese medicine preparation and its production method - Google Patents
Blood-supplementing traditional Chinese medicine preparation and its production method Download PDFInfo
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- CN1287827C CN1287827C CN 200410013167 CN200410013167A CN1287827C CN 1287827 C CN1287827 C CN 1287827C CN 200410013167 CN200410013167 CN 200410013167 CN 200410013167 A CN200410013167 A CN 200410013167A CN 1287827 C CN1287827 C CN 1287827C
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Abstract
The present invention provides a traditional Chinese medicine preparation for nourishing blood, which is scientifically prepared from the traditional Chinese medicine of fleeceflower root (red, prepared), dried longan pulp (longan) and the like according to the traditional Chinese medicine theory. A production method of the preparation comprises: after processing the fleeceflower root at high temperature and high pressure, preparing the fleeceflower root into prepared fleeceflower root, mixing the prepared fleeceflower root and the dried longan pulp, and preparing the mixture into oral liquids, capsules, granular formulations and tablets by modern pharmacy production technologies comprising water extraction, alcohol deposition, etc. The preparation has the efficiency for invigorating the heart and the spleen, nourishing qi and blood, improving haemoglobin, increasing the number of red blood cells, improving cholesterol (HDL-C) in high-density lipoprotein, reducing cholesterol, resisting aging, etc. The preparation mainly treats palpitation, severe palpitation, amnesia, insomnia, light-headedness, swimming, fatigue, weakness, anemia, hyperlipoidemia and other syndromes caused by dual vacuity of the heart and the spleen and dual vacuity of qi and blood, and curative effect si conspicuous.
Description
Technical field
The present invention relates to a kind of blood tonic preparation, particularly treat the medicine and the production method thereof of blood deficiency, insomnia.
Background technology
The blood deficiency of traditional Chinese medical science indication, be that the erythrocyte number in the unit volume blood and hemoglobin content reduce in the modern medicine, comprise iron deficiency anemia, hemorrhagic anemia, hemolytic anemia, the antianemia factor anemia due to lacking and the anemia of multiple reason such as aplastic anemia.The traditional Chinese medical science is referred to as blood deficiency.Its reason is a lot, but as lose blood, drinking and eating irregularly, wasting QI-blood such as body void after being ill, and cause deficiency of spleen and stomach, can not biochemical QI and blood due to.Clinically show as mainly that shallow complexion, lip are pale, dizziness and tinnitus, sleepyly weakly, nervous breathe hard, insomnia, blood erythrocyte sum and hemoglobin reduction.This disease sickness rate clinically is very high, as puerperal, postoperative, after being ill, no matter in the rural area or the city, a large amount of patients is arranged all, is a kind of commonly encountered diseases.
For the Therapeutic Principle of blood deficiency, when enriching blood, but note QI invigorating simultaneously, because of QI invigorating can hemopoietic.And must distinguish insufficiency of the spleen and primary and secondary that suffer from a deficiency of the kidney, give the method for spleen reinforcing and the kidney invigorating respectively, to strengthen the former of QI and blood biochemistry.Deficiency of both QI and blood, clinical manifestation be pale complexion, dizziness and blurred vision, nervously breathe hard, tired unable, method of treatment is an invigorating qi and benefiting blood, represent side has decoction of ten powerful tonics to add and subtract Radix Angelicae Sinensis, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Fructus Jujubae.Plus-minus, palpitation and insomnia adds ripe Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis.Syndrome of deficiency of both heart and spleen.Clinical manifestation had palpitation, Mental fatigue, lack of appetite, abdominal distention, loose stool, the tongue weak pulse of bursting.Deficiency-weakness of spleen-QI, the hemopoietic deficiency, or have under one's command and have no right, outside the blood oozing from the body openings or subcuta neous tissue arteries and veins, all can cause blood deficiency.Deficiency of heart-blood is difficult gasification, and then temper is also empty, and both often interact, or are syndrome of deficiency of both heart and spleen.Deficiency of heart-blood, the heart is become homeless foster, then cardiopalmus; Deficiency of spleen-QI, the fortuneization mistake is strong, thus lack of appetite, abdominal distention, loose stool.QI and blood deficiency, functional activity is gone down, thus spiritlessness and weakness, pale tongue, thready and weak pulse is all the disease of insufficiency of vital energy and blood.Therapeutic Method, vigorate qi and replenish the blood, invigorating spleen and nourishing heart, the side of representative is a GUIXIN soup, and Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Poria cum Radix Pini, Radix Polygalae, Arillus Longan, Semen Ziziphi Spinosae are arranged, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, Fructus Jujubae.Syndrome of yin deficiency of liver and kidney, clinical manifestation had palpitation, tinnitus, dizzy, dysphoria with smothery sensation, xerostomia, the method for treatment nourishing the liver and kidney, square medicine can be used Fructus Ligustri Lucidi, Herba Ecliptae, Radix Rehmanniae Preparata, baked polygonum capitatum, Fructus Lycii, Carapax Et Plastrum Testudinis (processed), Magnetitum (calcined), Radix Angelicae Sinensis, the Radix Paeoniae Alba.Plus-minus, subcutaneous hemorrhage adds Colla Corii Asini, Herba Agrimoniae.Chinese patent medicine as SHENGXUE WAN, has Cornu Cervi Pantotrichum, Cortex Phellodendri, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae (stir-fry), Ramulus Mori, Semen Lablab Album (stir-fry), Placenta Hominis at present; Bolus of ten powerful tonics, medicine have Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, the Radix Astragali, Cortex Cinnamomi.Radix Polygoni Multiflori pill, medicine has baked polygonum capitatum, Radix Rehmanniae, Radix Achyranthis Bidentatae, Fructus Mori, Fructus Ligustri Lucidi, sudden and violent Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), Folium Mori, Semen Sesami Nigrum, Semen Cuscutae, Fructus Rosae Laevigatae, grass, Fructus Psoraleae, Flos Lonicerae etc. are signed in the Xi.Other still has DANGGUI YANGXUE WAN.More than these medicines, prescription complexity, complicated component, except the cost height, in process of production, wayward effective ingredient, product stability can also be difficult to control, be the main difficult problem of the modernization of Chinese medicine.
By retrieval, it is as follows that we also find relevant patent documentation:
1,＜application number〉97103837＜Granted publication day〉2000 years 02 month 16 days＜denominations of invention〉a kind of Chinese patent medicine＜applicant who treats cerebrovascular disease〉yellow Zhaoyuan Plumbum preparatium, Heshan town, Pujiang County, Chengdu, Sichuan Province newly developed area＜digest〉the invention discloses a kind of Chinese patent medicine for the treatment of cerebrovascular disease, this medicine is the medicament made from following pharmaceutical composition: the Radix Astragali: 10-20 part Radix Codonopsis: 10-20 part Radix Polygoni Multiflori: 1-20 part Fructus Lycii: 10-20 part Arillus Longan: 10-20 part Rhizoma Dioscoreae: 10-20 part Radix Angelicae Sinensis: 10-20 part Rhizoma Acori Graminei: 5-15 part Radix Polygalae: 5-15 part Fructus Alpiniae Oxyphyllae: 5-15 part Radix Morindae Officinalis: 5-15 part Radix Salviae Miltiorrhizae: 5-15 part Fructus Corni: 5-15 part Semen Cuscutae: 5-15 part Rhizoma Gastrodiae; 5-15 part Radix Rehmanniae Preparata: 15-25 part Concha Margaritifera: 25-35 part Herba Eupatorii: 5-15 part.It has excellent curative to cerebral thrombosis cerebral embolism, cerebral hemorrhage, subarachnoid hemorrhage and brain atrophy.
2,＜application number〉95100046＜denomination of invention〉callisthenics beverage and method for making＜applicant thereof〉Lee deposits, outer again Sanlihe three districts, Beijing 2 No. 13＜digests in the 43rd buildings〉a kind of callisthenics beverage and method for making thereof, select Fructus Crataegi for use, Radix Polygoni Multiflori, Pericarpium Citri Reticulatae, Herba Menthae, Semen Cassiae, Cortex cinnamomi japonici (Ramulus Cinnamomi), longan pulp, dried apricot is a raw material, soaks the water-soluble stock solution that becomes after filtering respectively, cooperates by a certain percentage, wherein: Fructus Crataegi juice 40-50% fleece flower tuber juice 28-30% Sucus Zingberis 2-3% syrup of orange 3.5-4% Herba Menthae juice 5-6% Semen Cassiae juice 2-3% Cortex cinnamomi japonici (Ramulus Cinnamomi) juice 4.5-5% longan gravy 3-6% dried apricot juice 2-3% adds a small amount of white sugar again, vinegar or citric acid, spice is promptly made callisthenics beverage, contain multiple amino system, can bring high blood pressure down and cholesterol, vessel softening suppresses fat function, and old children all should drink.
3,＜and application number〉95100383＜denomination of invention〉" Fatelong " health beverage＜applicant〉Cao Shixuan, No. 47＜the digest in democracy road, Wuchang, Wuhan City, Hubei Province〉the invention discloses a kind of " Fatelong " health beverage, it is prepared by a certain percentage by structure Qi 9-10%, Fructus Mori 9-10%, Poria 9-10%, Semen Sesami Nigrum 4-5%, Semen Juglandis 4-5%, Fructus Jujubae 11-12%, Arillus Longan 14-15%, Semen sojae atricolor 9-10%, Cacumen Platycladi 3-6%, Semen euryales 9-10%, Radix Polygoni Multiflori 13-16%, cane sugar powder, then raw material is decocted, concentrates, mix, granulation, oven dry.This invention simple equipments, easy to implement the method, have YIN nourishing, tonify deficiency, the kidney invigorating, brain-strengthening, controlling nocturnal emission with astringent drugs nourishes blood, promote hair cell metabolism and hair regeneration, prevent that effectively all types of alopecias, withered and yellow morning are white, body nihility power, lassitude, insomnia, neurasthenia are had tangible rehabilitation effect.
4,＜application number〉94113767＜Granted publication day〉2000 years 07 month 05 day＜denominations of invention〉nutritive black-bone chicken wolfberry fruit wine for nourishing blood＜applicant〉Li Farong, 205 Room, Chinese medicine head factory dormitory Building 2, Shi He road, Hefei City, Anhui Province＜digest〉a kind of nutritive black-bone chicken wolfberry fruit wine for nourishing blood, described prescription has following composition and ratio: Gallus Domesticus: Fructus Lycii: Lentinus Edodes: Fructus Jujubae: Arillus Longan, Radix Angelicae Sinensis, Fructus Amomi, Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Pericarpium Citri Reticulatae, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Codonopsis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Chuanxiong=1: 0.3～0.5: 0.05～0.1: 0.02～0.05: 0.002～0.005; (2), extraction is the above grain neutral spirits of wine degree 55 degree with Chinese liquor, consumption is: Gallus Domesticus: Chinese liquor=1: 30～40, water and Chinese liquor extraction successively reprocessed and formed behind the prescription.The present invention is molten to fill blood, spleen invigorating lung, liver and kidney tonifying, coordination of daoyin and respiration, blood circulation promoting and blood stasis dispelling be in one, not only is fit to healthy people's drink-service, especially is fit to blood deficiency, deficiency of both the heart and spleen, deficiency of both the liver and kidney, various anemia, cancer and multiple chronic and takes.
5,＜and application number〉93120022＜denomination of invention〉beautifying health oral liquid and cream＜applicant〉Dai Mingchang, eastbound village＜the digest in end of the bridge town, Yongjia County, Zhejiang Province〉the present invention relates to a kind of Chinese medicinal food of using: the composition of its raw material (weight) is: precious cream of the beauty treatment of a kind of special beauty functions of taking that Arillus Longan 5-10% Colla Corii Asini 0.5-2% Semen Juglandis 10-20% Fructus Lycii 10-15% Fructus Jujubae (enucleation) 10-20% Radix Polygoni Multiflori Preparata 5-10% Semen Sesami Nigrum 10-15% Margarita powder 0.2-0.8% Mel 25-35%, composition are processed into through scientific formula and oral liquid.Have fill blood, improve looks face, defying age, improve the body immunity effect.Adhere to every day taking on a small quantity, more than 45 days, can make the effect of the ruddy health of skin, delicate gloss and crease-resistant and black hair.
6,＜application number〉97107444＜denomination of invention〉a kind of tonic wine and preparation method thereof＜applicant〉Kangda Building Material Industry (Group) Corp., Sichuan, No. 1＜the digest in prestige glass road, city, Weiyuan County, Sichuan Province〉the invention discloses a kind of tonic wine and preparation method thereof, it is characterized in that: composition comprises: Radix Ginseng 10-12 gram Zaocys 9-11 gram Radix Polygoni Multiflori 9-12 cron eye 7.5-11 gram crystal sugar 2 gram Sorghum vulgare Pers. Wines 500 gram mineral waters 110 are restrained and are equipped with technology and are: A, raw material is handled a, after the Radix Polygoni Multiflori is fried 80 ℃-150 ℃ with Zhu Sha with big fire with the Zhu Sha parch, putting into the Radix Polygoni Multiflori continues to stir-fry, behind Radix Polygoni Multiflori parching to brown, take out the Radix Polygoni Multiflori, brush away Zhu Sha above the Radix Polygoni Multiflori with hairbrush, be broken into fritter with hammering, b, with Radix Ginseng, Zaocys, Arillus Longan is cut into slices or saves or be broken into graininess, lamellar is long for 30-60m m, 10-30mm is thick, nodular is that 50-100mm is long, granular diameter is 10-30mm, B, raw material after the infuse extracting juice will be handled is put into the container of sealing, after soaking 30-40 days with the high-quality Sorghum vulgare Pers. Wine of 56-60 degree, wine sucking-off after will soaking with leather hose or wine pump, filter with 70-120 purpose filter cloth, the high-quality Sorghum vulgare Pers. Wine that adds the 50-60 degree then again continues to soak 30-40 days, wine sucking-off after reuse leather hose or wine pump will soak, extracting juice filters with the 70-120 purpose, main processes is that raw material is handled, soak extracting juice, blend, the seasoning aging, test package, it is pure and mild that the present invention has comfortable taste, the color and luster sense organ is good, advantage of low manufacturing cost, the energy YIN nourishing and YANG strengthening, promote health, be rich in multiple nutrient the human body beneficial.
7,＜application number〉97119951＜denomination of invention〉tonic liquid＜applicant〉Zhou Kaiwei, 16 groups＜inventor of Xinfu District good fortune people street, Fushun City, Liaoning Province 17 committee〉Zhou Kaiwei＜digest〉the invention belongs to a kind of health product, be the nutrient that lacks easily at people and the regulation mechanism of medicine, be equipped with that corresponding Chinese herbal medicine makes, its main component is by Fructus Lycii, Formica fusca, Rhizoma Curculiginis, Cortex Acanthopancis, Arillus Longan, Herba Cistanches, a few flavor Chinese herbal medicine of Radix Polygoni Multiflori and Chinese liquor are formed, the percentage by weight of each component is: with Chinese liquor is 100% component, and other proportioning of respectively distinguishing the flavor of Chinese herbal medicine is respectively: Fructus Lycii 4-5%; Formica fusca 3-3.5%; Rhizoma Curculiginis 2.5-3%; Cortex Acanthopancis 2.4-2.8%; Arillus Longan 2-2.4%; Herba Cistanches 2.4-2.8%; Radix Polygoni Multiflori 4-4.4%.This fluid infusion have foster the spirit of nobility enrich blood, support that essence is reinforced the kidney, body-building and tonifying yang, adjusting physiological equilibrium's function.
8,＜and application number〉93110081＜denomination of invention〉medicine with intelligence increasing and brain tonic function＜applicant〉Jiangxi Huiren Pharmaceutical Co., Ltd, No. 31＜digest in GaoXin Development Area torch street, Nanchang City, Jiangxi Province〉medicine with intelligence increasing and brain tonic function relates to promoting intelligence and strengthening brain Chinese medicine.The key component of medicine of the present invention is Radix Polygoni Multiflori 325-425g, Semen Platycladi 150-200g, Arillus Longan 100-150g, Rhizoma Polygonati 325-425g, Fructus Ligustri Lucidi 325-425g, Fructus Mori 325-425g, Semen Nelumbinis 150-200g, Radix Polygalae 150-200g.The present invention is to have tangible invigorating heart and kidney, nourish blood and transfer the effect of liver, nourishing the brain and improving intelligence through pharmacodynamics, toxicology and stability experiment, clinical verification, through clinical observation treatment MR total effective rate 82%, and treatment MBD total effective rate 96%.
9,＜and application number〉94102628＜denomination of invention〉energy oral liquid compounding method＜applicant〉Chen Changyi, No. 27 mailbox＜digests of Shaanxi Province's Hanzhong City〉the invention belongs to the oral Chinese medicine preparation that a kind of middle-aged and old health keeps fit.Be after Chinese medicines such as Chinese medicine Radix Polygoni Multiflori, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Angelicae Sinensis, the Cortex Eucommiae, Semen Nelumbinis, Herba Cistanches, Radix Panacis Quinquefolii, Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Lignum Aquilariae Resinatum, Radix Saposhnikoviae, Arillus Longan, Semen Juglandis, the Radix Astragali, Herba Epimedii, Caulis Spatholobi, Fructus Alpiniae Oxyphyllae, Fructus Amomi, Massa Medicata Fermentata, Semen Cuscutae are prepared by a certain percentage, mix to take extract.The energy oral liquid has good YIN nourishing and YANG strengthening, QI invigorating and in, brain-strengthening is soothed the spirit, the effect of black beard and hair, bone and muscle strengthening, bright eyes, damp skin, life lengthening.Through the clinical observation in more than 20 years, health-care effect was fine, and without any side effects.
Recognize from above-mentioned open source literature, foster the spirit of nobility at present enrich blood, the Chinese medicine of YIN nourishing, tonify deficiency, the kidney invigorating or health product, drink formula be complicated, the effective ingredient that has can not be given full play of, only be its manufacturing process or continue to use in the past outmoded way, perhaps with edible steeping in wine bubble, carry out perhaps that simple water is carried and decoction obtains, product quality is wayward.
Summary of the invention
The purpose of this invention is to provide a kind ofly to blood deficiency, it is with strong points, evident in efficacy to have a sleepless night, and prescription is uncomplicated, and raw material sources are easier to, volume of production big, low price, product effective ingredient and stability is more easy to control, the Chinese patent medicine and the production method of easy detection.
The main active of its raw material of blood tonic preparation of the present invention is Radix Polygoni Multiflori and Arillus Longan, and it is to be made by the raw material of following parts by weight:
Radix Polygoni Multiflori 4-10 part, Arillus Longan 3-7 part.
Described Radix Polygoni Multiflori is without the Radix Polygoni Multiflori dry tablet of making, and also claims Radix Polygoni Multiflori, Radix Polygoni Multiflori.
Described Arillus Longan is that the fresh fruit Arillus Longan is not added the sun-dried dry product that obtains of any additives.
In this medicine technological process of production, the method that multiflower knotweed tuber prepared employing is new and aging method that need not be traditional, 2,3,5,4 '-tetrahydroxystilbene-β-D-glycoside the main effective ingredient of Radix Polygoni Multiflori has three kinds:, content can be the leading indicator of control of quality up to 1.2%; Phospholipid, wherein lecithin is up to about 3.7%; The hydroxyanthraquinone compounds, content reaches 1.1%.Stilbene is a water solublity, phospholipid all has very big dissolubility in non-polar solven and water, anthraquinone compounds conjunction type water soluble and free type indissoluble, the effect of Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata and toxicity difference are very big, be since Radix Polygoni Multiflori Preparata behind long-time hyperpyrexia, variation has taken place in chemical constituent, be transformed into the free type anthraquinone of indissoluble as easily molten combined anthraquinone, so Radix Polygoni Multiflori has the discharge function Radix Polygoni Multiflori Preparata then not have, on the other hand, the toxicity of Radix Polygoni Multiflori Preparata is than the obvious reduction of Radix Polygoni Multiflori, and tonic effect is obviously strengthened, therefore Radix Polygoni Multiflori Preparata focuses on and enriches blood, and Radix Polygoni Multiflori focuses on and invigorates blood circulation.The multiflower knotweed tuber prepared usefulness of Chinese medicine is boiled in a covered pot over a slow fire the steaming method, promptly in Radix Polygoni Multiflori, add decoction of black soybean (Semen sojae atricolor 10kg, it is an amount of to add water, boiled about 4 hours, the about 15kg of extractive, bean dregs added decocting in water about 3 hours again, the about 10kg of extractive, merge the about 25kg of decoction of black soybean), after the stirring, put in the jar and obturage, put the steaming and decocting of kettle internal heating more than 32 hours, nine steam nine shines, and the inside and outside sepia that all shows is pitch-black shinny.The high temperature and high pressure method of exploitation of innovation of the present invention will be given birth to (doing) Radix Polygoni Multiflori section (or pulverizing), behind water infiltration, put in the steam pressure cooker, and logical steam makes temperature reach 118 ℃ to 124 ℃, and 6 to 10 hours finish to take out use, can get effect same.Through research repeatedly for many years, comparative control, animal pharmacodynamics, pharmacology, toxicology test obtain the proof optimum efficiency, and overlong time, temperature are too high, curative effect is reduced, and the time are too short, temperature is low excessively, does not also obtain the Radix Polygoni Multiflori Preparata curative effect and removes toxicity.Through research repeatedly, therefrom selected medicament composing prescription, invent finally that a kind of good effect, prescription simplify, control easily that technological process and quality, stable effective ingredients are good, power consumption less, low price, raw material sources enrich, be suitable for that modernization industry is produced, technology advanced person's feasible Chinese patent medicine.
Radix Polygoni Multiflori and Arillus Longan can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia and other Chinese medicine handbook.In order to understand the mechanism that the present invention treats disease, existing effect to the Chinese medicine of respectively distinguishing the flavor of in the prescription, method for making and the effect in prescription are described below:
Arillus Longan is called Arillus Longan in Guangxi, invigorating the heart and spleen, nourishing blood to tranquillize the mind.Be used for insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.Radix Polygoni Multiflori system usefulness, invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Be used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void: hyperlipidemia.Two medicines share, and the blood-enriching qi-invigorating and the effect of calming the nerves obviously strengthen, and the effect of falling cholesterol in the blood, improving cholesterol (HDL-C) in the blood high density lipoprotein is arranged.
Though the Chinese medicine preparation of open source literature report also has Radix Polygoni Multiflori and Arillus Longan, for seeing both separately as the content of blood tonic preparation, and the manufacture method of Radix Polygoni Multiflori is to adopt new method fully, thereby more can make full use of its effective ingredient.
Diseases such as above-mentioned prescription can be treated QI and blood deficiency, severe palpitation, forgetful insomnia for institute of traditional Chinese medicine, had a dizzy spell, fatigue and weakness, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, hyperlipidemia, patients is fried in shallow oil soup and is taken; Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make any dosage form on the pharmaceuticss such as capsule, granule, oral liquid, tablet, concrete production method is as follows:
1. the production method of oral liquid:
1.. get Radix Polygoni Multiflori (red, living, as to do) and thinly slice or pulverize,, put in the container, put in the steam pressure cooker with water infiltration a few hours (4-6), logical steam, the control temperature is at 118 ℃ to 124 ℃, and the persistent period is 6-10 hour, and the taking-up cooling is stand-by.2.. Radix Polygoni Multiflori Preparata, Arillus Longan, quantitatively after, put in the medicine boiler, add 5-8 times of water, heated and boiled is extracted, 2-3 hour.Take out medicinal liquid, medicinal residues add suitable quantity of water again, and heated and boiled is extracted, 1-2 hour.Take out medicinal liquid, extracted twice liquid is merged.Extracting solution A liquid in the middle of getting.
3.. heating concentrates.A liquid is put in the concentration pan, and heating concentrates, and takes out cooling, extracting solution B liquid in the middle of getting.
4.. ethanol precipitation.Be added in the B liquid with 95% ethanol, the ratio (volume) of 95% ethanol and B liquid is 3: 1.Mix.Put and left standstill under 4-8 ℃ 24 hours.Filter (going precipitation).Extracting solution C liquid in the middle of getting.
5. reclaim ethanol.C liquid is put in the alcohol recovering device, and steam heated reclaims ethanol.Take out recovery liquid, heating concentrates, and takes out cooling, gets medicinal liquid D liquid.
6.. remove tannin.Add an amount of 3-5% edible Gelatinum oxhide solution in D liquid, the limit edged stirs, and tangible white casse occurs, till not continuing to increase to muddiness.Put in 4 ℃ of-8 ℃ of refrigerators (or in cold house), left standstill 16-24 hour, cross the elimination precipitation.Get filtrate E liquid.
7.. the ethanol redeposition.Add 95% ethanol in E liquid, E liquid and 95% alcoholic acid ratio are 1: 3.Mix.Put in 4 to 8 ℃ of refrigerators or the cold house, left standstill 16 to 24 hours.Take out and filter, go precipitation.Get filtrate F liquid.
8.. reclaim ethanol.F liquid is put in the alcohol recovering device, and steam heated reclaims ethanol.Suitably heating is concentrated with medicinal liquid, gets medicinal liquid G liquid.
9.. get adjuvants such as G liquid and an amount of syrup and mixes, fill, sterilization must the finished product oral liquid.
2. the production method of capsule:
1.. the same oral liquid of technological process such as multiflower knotweed tuber prepared, extract drugs, purification.Get G liquid.G liquid is condensed into fluid extract, and spray drying gets intermediate products dried cream powder H.
2.. get H and appropriate amount of auxiliary materials mixing, granulate, encapsulated, packing, packing gets the finished capsule product agent.
3. the production method of granule:
1.. the same capsule of technology such as multiflower knotweed tuber prepared, extract drugs, purification, powder H gets dry extract.
2.. get H and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets the finished particle agent.
4. the production method of tablet:
1.. multiflower knotweed tuber prepared, extract drugs, the same capsule of purifying process, fluid extract.
2.. get fluid extract and appropriate amount of auxiliary materials mixing, granulate, tabletting, packing gets finished tablet.
Instructions of taking:
Oral liquid, every day 2-3 time, each 10ml; Capsule, every day 2-3 time, each 2, every 0.5 gram; Granule, every day 2-3 time, each 1 bag, every bag 7 gram; Tablet every day 2-3 time, each 2-3 sheet, every 0.3 gram.
The present invention compared with the prior art, its outstanding substantive distinguishing features and obvious improvement is:
1. the present invention's preferred above-mentioned Chinese medicine under Chinese medical theory instructs, in addition the science compatibility is made, and cooperatively interacts, learn from other's strong points to offset one's weaknesses, synergism, qi and blood tonifying, the tranquillizing and allaying excitement effect strengthens.Simultaneously, the medication negligible amounts helps controlling effective ingredient and product stability.
2. this medicine Radix Polygoni Multiflori Preparata has adopted brand-new novel preparation method, i.e. high temperature and high pressure method.With traditional method relatively, its advantage be short, power consumption of time less, the efficient height, curative effect does not change, and more can make full use of its effective ingredient, is suitable for big production of modernized Chinese medicine industry.This seminar was applied to the big production of industry in 1993 in this method that begins one's study in 1988, used proof through for many years, and efficient of the present invention and curative effect are all remarkable.Be advanced commercial production flow process, workable, be fit to modern chemical industry sparetime university and produce.
3. through experiment and clinical verification, the present invention has the effect of invigorating the heart and spleen, benefiting QI and nourishing blood, is applicable to QI and blood deficiency, severe palpitation, forgetful insomnia, has a dizzy spell, disease such as fatigue and weakness, and clinical total effective rate is higher, (reaching 94.2%).
4. from the angle analysis of modern medicine, the present invention has raising hemoglobin (Hb) and erythrocyte number, reduces serum total cholesterol (T-Ch), improves cholesterol level in the serum high-density LP, improves SOD vigor in hepatic tissue and the blood.
5. raw material is easy to get, the prescription science, and production technology advanced person, workable.Moderate product price is fit to suitability for industrialized production.
6. according to each Effective Components of Chinese Herb character and preparation requirement, adopt that water is carried, precipitate with ethanol, gelatin remove malicious composition in producing, the production technology of corresponding sterilizing methods, thereby finished product keeps the higher effective composition, and not perishable, long shelf-life.
7. product studies on acute toxicity of the present invention and long term toxicity research and clinical trial prove, are safe by intending with using the daily dose and the course of treatment product of the present invention.
The specific embodiment
Below be embodiments of the invention:
Embodiment one:
Take by weighing following Chinese medicine ingredients (unit: g) Radix Polygoni Multiflori 4, Arillus Longan 3,
1. its production stage is: get Radix Polygoni Multiflori (red, dried) sheet 5g, use water infiltration 6 hours, put in the container, put in the steam pressure cooker, heat logical steam, temperature transfers to 120 ℃, continues 6 hours, and taking-up is cooled off, and gets Radix Polygoni Multiflori Preparata.
2. get above Radix Polygoni Multiflori Preparata, Arillus Longan adds 5-8 times of water, and heated and boiled was extracted 2-3 hour, and the medicinal liquid that falls comes out, and adds suitable quantity of water again, continues heated and boiled and extracts 2 hours.Pour out medicinal liquid, with medicinal liquid merging last time.Get medicinal liquid A liquid.
3. heating concentrates.A liquid is placed in the concentration pan, and heating concentrates, to an amount of volume.Must extract concentrated solution B liquid.
4. ethanol precipitation.With 95% ethanol and B liquid by volume (3 to 1) mix, stir, put in 4-8 refrigerator or the icehouse and placed 24 hours.Cross the elimination precipitation.Get extracting solution C liquid.
5. reclaim ethanol.C liquid is put in the alcohol recovering device heating recovery ethanol.Take out medicinal liquid, heating concentrates.Get D liquid.
6. in D liquid, add 3%-5% edible Gelatinum oxhide solution.The limit edged stirs, occur tangible white opacity,, till not continuing to increase to white.Put in 4 ℃ to the 8 ℃ refrigerators, left standstill 16-24 hour.Cross the elimination precipitation.Get filtrate E liquid.
7. add 95% ethanol in E liquid, ethanol and E liquid are in 3 to 1 ratios.Stir, put in 4 ℃ of-8 ℃ of refrigerators, left standstill 16 to 24 hours.Cross the elimination precipitation, get filtrate F liquid.
8. reclaim ethanol.F liquid is put in the alcohol recovering device heating recovery ethanol.Medicinal liquid heats concentrated, gets G liquid, adds an amount of and adjuvant of syrup, and fill is sealed, and sterilization gets finished product " head's oral liquid " (having another name called " black round blood enriching capsule ").
Embodiment two:
Take by weighing following Chinese medicine ingredients: (unit: g)
The Radix Polygoni Multiflori 6 Arillus Longans 4
Its technological process of production is:
1. the process of preparing Chinese medicine of Radix Polygoni Multiflori, whole extract drugs, purification etc. are pressed oral liquid, get G liquid.Heating is condensed into fluid extract, spray drying, and powder H gets dry extract.
2. get dried cream powder H, mix, granulate with appropriate amount of auxiliary materials, encapsulated, get finished product with In Aluminium Foil Packing, name of product is " head's blood enriching capsule ".(having another name called " crow circle blood enriching capsule ")
Embodiment three;
Take by weighing following Chinese medicine ingredients: (unit: g)
The Radix Polygoni Multiflori 8 Arillus Longans 5
Its technological process of production is:
1. the process of preparing Chinese medicine of Radix Polygoni Multiflori, whole extract drugs, technologies such as purification are by head's blood enriching capsule, and powder H gets dry extract.
2. get dried cream powder H, mix, granulate with appropriate amount of auxiliary materials, packing, pack finished product, every bag of 7g, name of product is " head enrich blood granule " (having another name called " crow circle blood enriching capsule ").
Embodiment four:
Take by weighing following Chinese medicine ingredients: (unit: g)
Radix Polygoni Multiflori 9 Arillus Longans 6
Its technological process of production is:
1. polygonum multiflorum processing technology, all extract drugs, purification are pressed oral liquid.Get G liquid.
2. G liquid is condensed into the extractum shape.Mix with adjuvants such as Mel or brown sugar, make pill, packing, the pill name of product is " head enrich blood ball " (having another name called " crow circle blood enriching capsule ").
Embodiment five:
Take by weighing following Chinese medicine ingredients: (unit: g)
Radix Polygoni Multiflori 10 Arillus Longans 7
Its technological process of production is:
1. polygonum multiflorum processing technology, all extract drugs, purification are pressed oral liquid.Get G liquid.
2. G liquid is condensed into the extractum shape.Mix with adjuvant, tabletting, packing, getting the finished product name of product is " head's antanemic tablet " (having another name called " crow circle blood enriching capsule ").
Below be clinical research report of the present invention:
Medicine of the present invention entrusts provincial three tame hospitals (the People's Hospital, Guangxi district, first, second attached institute of Colleges Of Traditional Chinese Medicine Of Guangxi) to carry out clinical verification work, and job step and experimental result are as follows:
Clinical data
One, physical data:
Treatment group and matched group 210 examples, 70 examples are observed by one attached institute of Colleges Of Traditional Chinese Medicine Of Guangxi, and 70 examples are observed by two attached institutes, and 70 examples are observed by the People's Hospital, Guangxi district.
The object of observation of being included in is Chinese medical discrimination and belongs to syndrome of deficiency of both heart and spleen patient or deficiency of both QI and blood patient, and treatment is organized 120 examples (each 60 example of deficiency of both the heart and spleen and deficiency of both QI and blood) and used head's oral liquid.Matched group 90 examples (syndrome of deficiency of both heart and spleen 60 examples, deficiency of both QI and blood 30 examples) are used one Hundred Years Oral Liquid.Treatment group and matched group sex, age distribution there are no significant difference (P＞0.05).(seeing Table 1).
Two, diagnostic criteria:
(1), tcm diagnosis standard:
1, syndrome of deficiency of both heart and spleen: severe palpitation, insomnia and dreamful sleep, forgetful, the food poor appetite is few, the spleen-distension, diarrhea, fatigue and weakness, pale and tender tongue, thready and weak pulse.
2, deficiency of both QI and blood: deficiency of QI with disinclination to talk, weak spontaneous perspiration, pale complexion, palpitation and insomnia, have a dizzy spell, pale tongue with white fur, thready and weak pulse.
(2), Western medicine diagnose standard: the doctor trained in Western medicine disease that assertive evidence relates to is with reference to " clinical disease diagnosis is according to curing the improvement standard " observational technique
Observe 210 examples altogether, be divided into 2 groups at random, wherein 120 examples are organized in treatment, use head's oral liquid, and each 10ml, serve on for 4 weeks at every day 3 times.Matched group 90 examples, the one Hundred Years Oral Liquid that Pharmaceutical Factory of Guangxi Traditional Chinese Medicine College produces, each 15ml, serve on for 4 weeks at every day 3 times.Routine is made detailed physical examination to the experimenter before the test, meets case choice criteria person and promptly includes the object of observation in.Weekly with examining 1 time, inquire the situation of taking medicine, the record state of an illness and side effect after the test.The deficiency of both QI and blood person routine of all having a blood test before and after testing.With card point-score evaluation therapeutic effect.The curative effect judgement is made by the observer.Viewing duration is without other drug.
Therapeutic outcome
One, efficacy assessment standard:
1, cure in the recent period: primary symptom disappears, and the witness integration reduces more than 91%.
2, produce effects: primary symptom is improved 2 grades, and the witness integration reduces 61-90%.
3, effective: primary symptom is improved 1 grade, and the witness integration reduces 31-60%.
4, invalid: primary symptom does not have improvement, and the witness integration reduces below 30%.
Two, therapeutic outcome:
1, to the influence of various symptoms: see Table 2.After from table, can finding out treatment group and two kinds of disease patient treatments of matched group, the various witness integrations equal highly significant (P＜0.01) that descends, point out two kinds of medicines to syndrome of deficiency of both heart and spleen palpitation and insomnia, forgetful, poor appetite, abdominal distention loose stool, to the fatigue and weakness of deficiency of both QI and blood, have a dizzy spell, the symptom effect of having clear improvement such as palpitation and insomnia.
2, compare before and after the physico-chemical examination: see Table 2.All be significantly increased after from table, can finding out two groups of patient's peripheral blood Hb, RBC treatments, point out two groups of medicines all can obviously improve human blood Hb and RBC content.
3, two groups of curative effects relatively: see Table 3.120 examples are organized in treatment, and total effective rate is 94.2%, matched group 90 examples, and total effective rate is 94.4%.Two groups of curative effect differences are checked nonsignificance (P＞0.05) with Ri di analytic process.
Side effect
Obvious adverse reaction and toxic and side effects all do not take place at viewing duration in two groups of patients.
Model case
Example 1. Huangs, the women, 45 years old, because of shortness of breath and palpitation is gone to a doctor half a year.The conscious severe palpitation over the past half year of patient, with insomnia, forgetful, diet minimizing, abdominal part distending pain, anorexia, loose stool, one day twice, it was weak to work.
Check: ordinary circumstance still can, the lung abdomen is looked into no abnormal, body of the tongue is light red, white and thin fur, thready and weak pulse.Electrocardiogram is normal.Tcm diagnosis: cardiopalmus (deficiency of both the heart and spleen).Western medicine diagnose: climacteric syndrome.Give the head oral liquid treatment, each 10ml, every day 3 times.Symptoms such as the 1 week back abdominal distention, food poor appetite of taking medicine is few, loose stool are clearly better.Taking medicine, have a sleepless night in 2 all backs, cardiopalmus alleviates.Can normally fall asleep after 3 weeks, stool changes into shape, every day 1 time.After 4 weeks, except that still have slight cardiopalmus, forgetful, all the other each diseases disappear.Efficacy evaluation: produce effects.
Example 2. thunders, the male, 40 years old, dizzy because of the back of having blood in stool, went to a doctor in weak two months.The patient is in hospital because of separating tarry stools two months ago.Examine and be upper gastrointestinal hemorrhage.Having blood in stool after treatment disappearance recovery from illness is left hospital.But be still dizzy weak, obvious when standing with crouching of a specified duration especially after leaving hospital.With severe palpitation, the lazy speech of breathing hard, sweating while acting.Check: complexion is pale slightly, and the cardiopulmonary abdomen is checked no abnormality seen.Pale tongue, white and thin fur, thready and weak pulse.Peripheral blood Hb100g/L, RBC3.4 * 10
12/ L.Tcm diagnosis: dizzy (QI and blood deficiency).Western medicine diagnose: hemorrhagic anemia.Give the head oral liquid treatment.Each 10ml, every day 3 times.The 1 week back spontaneous perspiration transference cure of taking medicine, all the other sxs.3 week backs except that still having slight severe palpitation, transference cures such as weak, dizzy, deficiency of QI with disinclination to talk.After finishing the course of treatment, peripheral blood check: Hb120g/L, RBC4.0 * 10
12/ L.Efficacy evaluation: produce effects.
Brief summary
Above data prompting:
1, head's oral liquid has the effect of mind calming spleen invigorating, invigorating qi and benefiting blood, can be used for impairment caused by overstrain heart spleen, insufficiency of vital energy and blood institute to severe palpitation, insomnia and dreamful sleep, fatigue and weakness, disease such as have a dizzy spell.
2, head's oral liquid can improve hemoglobin and erythrocyte content in the blood of human body.
3, this organizes 120 examples, total effective rate 94.2%, and the one Hundred Years Oral Liquid that curative effect and Colleges Of Traditional Chinese Medicine Of Guangxi pharmaceutical factory produce does not have significant difference.
4, this product is safe and reliable, and 120 examples are not found obvious adverse reaction and toxic and side effects at viewing duration.
Table 1. treatment group and matched group sex (example), and the age (X ± SD) relatively
| The treatment group | Matched group | |||||
| The man | The woman | Age | The man | The woman | Age | |
| The deficiency of both the heart and spleen QI and blood deficiency | 26 23 | 34 37 | 45.28±11.79 46.37±12.93 | 30 10 | 30 20 | 46.77±11.40 42.20±11.50 |
Two groups of sexes, age ratio, the P value is all＞0.05
Witness integration and physico-chemical examination comparison before and after table 2 treatment (X ± SD)
| The treatment group | Matched group | |||||
| n | Before the treatment | After the treatment | n | Before the treatment | After the treatment | |
| Syndrome of deficiency of both heart and spleen: the forgetful poor abdominal distension loose stool syndrome of deficiency of both qi and blood of receiving of palpitation and insomnia: the weak pale complexion palpitation and insomnia of deficiency of QI with disinclination to talk Hb (g/L) RBC (10/L) that has a dizzy spell | 51 56 57 37 34 41 57 60 53 51 42 54 60 60 | 2.69±1.13 3.40±0.93 2.63±1.00 2.32±1.07 1.76±1.36 1.76±0.97 3.32±1.00 1.43±0.97 2.03±0.91 2.94±1.03 2.34±1.19 3.98±0.95 108.52±14.72 3.56±0.39 | 1.01±0.77 1.20±0.94 1.52±0.86 0.70±0.70 0.54±0.73 0.50±0.66 1.17±0.72 1.63±0.94 1.51±0.82 0.67±0.77 0.91±0.88 1.79±0.68 117.33±13.8 3.84±0.31 | 54 53 58 53 39 37 27 58 29 28 20 30 30 30 | 3.10±1.20 3.30±0.97 3.02±1.05 2.88±1.03 1.98±1.27 1.99±0.67 3.50±0.85 4.33±0.92 3.40±1.07 2.90±1.13 2.47±1.47 4.73±0.93 100.20±10.19 3.32±0.40 | 1.20±0.87 1.27±0.79 1.63±0.90 0.70±0.68 0.61±0.69 0.54±0.61 1.00±1.10 1.67±1.09 1.23±0.83 0.63±0.03 1.02±0.96 2.07±0.94 114.27±10.19 3.03±0.46 |
Table 3 treatment group and matched group curative effect relatively (Ridit) are analyzed
| n | Recovery from illness | Produce effects | Effectively | Invalid | R | U | P | |
| Syndrome of deficiency of both heart and spleen treatment group control group syndrome of deficiency of both qi and blood treatment group control group total effects treatment group control group | 60 60 60 30 120 90 | 3 6 2 4 5 10 | 25 31 32 13 57 44 | 29 21 22 10 51 31 | 3 2 4 3 7 5 | 0.4582 0.5418 0.4930 0.5141 0.4760 0.5321 | 1.5862 0.3269 1.3937 | ＞0.05 ＞0.05 ＞0.05 |
The clinical research director:
The one attached combination of Chinese and Western medicine associate chief physician Zhou Wenguang of institute of Colleges Of Traditional Chinese Medicine Of Guangxi
Each clinical director:
The one attached associate chief physician Zhou Deli of institute of Colleges Of Traditional Chinese Medicine Of Guangxi
The two attached associate chief physician He Hui of institute of Colleges Of Traditional Chinese Medicine Of Guangxi
The associate chief physician Liu Qingfen of the People's Hospital, Guangxi district
Experimentation:
Head's oral liquid is to the influence of white mice HDL-C and LCAT
(research worker: Zhang Shuqiu, Huang Yunzhong, Lu Caizhen, Li Min)
Animal: white mice, the Kunming kind, body weight 18-22g, health, 66 mices are divided into three groups: test one group, test two groups, matched group.
Medication: test one group and measure 8 times, two groups by the adult and measure 2 multiple dose administrations, irritate stomach, once a day by the adult.Continuous 30 days.Matched group is irritated distilled water, equal volume.
Assay method:
Experiment finishes, and gets blood from eyeball, and separation of serum is measured cholesterol (HDL-C) and lecithin cholesterol acyltransferase (LCAT) activity in the high density lipoprotein.
Experimental result:
Table 1 experimental group and matched group HDL-C content is (unit: mmoL/L) relatively
| Group | The example number | HDL-C(X±SD) | The P value |
| Test one group and test two groups of matched groups (Mus) | 22 22 22 | 3.74±1.82 3.06±0.70 1.96±1.00 | P＜0.01 P＜0.01 |
| Matched group (people) | 22 | 1.33±0.71 |
Experimental group HDL-C is all apparently higher than matched group, (P＜0.01)
Table 2 mice serum LCAT specific activity is (mmol/mh
-1)
| Group | n | Unit of enzyme activity | The P value |
| The experimental group matched group | 21 21 | 8.45 4.13 | ＜0.01 |
Experimental group LCAT is apparently higher than matched group (P＜0.01).
Claims (2)
1, a kind of blood tonic preparation is characterized in that: it is to be made by the raw material of following parts by weight:
Radix Polygoni Multiflori 4-10 part, Arillus Longan 3-7 part;
Described Radix Polygoni Multiflori is without the Radix Polygoni Multiflori dry tablet of making;
Described Arillus Longan is that the fresh fruit Arillus Longan is not added the sun-dried dry product that obtains of any additives;
Described preparation is the amount ratio Arillus Longan height of Radix Polygoni Multiflori in use.
2, a kind of production method of blood tonic preparation as claimed in claim 1 is characterized in that: its production stage is:
(1) get Radix Polygoni Multiflori, use water infiltration 4-6 hour, put in the container, put in the steam pressure cooker, heat logical steam, temperature transfers to 118-124 ℃, continues 6-10 hour, takes out and cools off, and gets Radix Polygoni Multiflori Preparata;
(2) get above Radix Polygoni Multiflori Preparata, Arillus Longan adds 5-8 times of water, heated and boiled extraction 2-3 hour, and the medicinal liquid that falls comes out, and adds suitable quantity of water again, continues heated and boiled and extracts 2 hours, pours out medicinal liquid, and the medicinal liquid merging with last time gets medicinal liquid A liquid; Heating concentrates, and A liquid is placed in the concentration pan, and heating concentrates, and to an amount of volume, must extract concentrated solution B liquid;
(3) ethanol precipitation mixes by 3: 1 volume ratio with B liquid with 95% ethanol, stirs, and puts in 4-8 ℃ of refrigerator or the icehouse and places 24 hours, crosses the elimination precipitation; Get extracting solution C liquid;
(4) reclaim ethanol, C liquid is put in the alcohol recovering device heating recovery ethanol; Take out medicinal liquid, heating concentrates, and gets D liquid;
(5) add 3%-5% edible Gelatinum oxhide solution in D liquid, the limit edged stirs, and tangible white opacity occurs, till not continuing to increase to white, puts in 4 ℃ to the 8 ℃ refrigerators, leaves standstill 16-24 hour, crosses the elimination precipitation, gets filtrate E liquid; Add 95% ethanol in E liquid, ethanol and E liquid stir in 3 to 1 ratios, put in 4 ℃ of-8 ℃ of refrigerators, leave standstill 16 to 24 hours, cross elimination and precipitate, and get filtrate F liquid;
(6) reclaim ethanol, F liquid is put in the alcohol recovering device, heating recovery ethanol, the medicinal liquid heating concentrates, and gets G liquid, makes oral liquid; Or add appropriate amount of auxiliary materials, make capsule, tablet, granule and pharmaceutically available dosage form product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410013167 CN1287827C (en) | 2004-05-14 | 2004-05-14 | Blood-supplementing traditional Chinese medicine preparation and its production method |
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| CN101843891B (en) * | 2009-03-27 | 2012-06-06 | 哈药集团制药六厂 | Blood tonifying composition |
| CN102008647B (en) * | 2009-09-09 | 2011-12-14 | 刘皇琼 | Traditional Chinese medicine for treating lymphangioleiomyomatosis and preparation method thereof |
| CN102526316A (en) * | 2012-01-18 | 2012-07-04 | 张树球 | Chinese medicinal formulation for preventing and treating senile dementia and production method thereof |
| CN103315360B (en) * | 2013-06-21 | 2016-08-17 | 方希修 | Radix cynanchi bungei granule and preparation method thereof |
| CN103892274A (en) * | 2013-08-19 | 2014-07-02 | 周俊 | Method for preparing composite blood replenishing tablet from dry longan pulp |
| CN104623266A (en) * | 2014-12-08 | 2015-05-20 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine formula for enriching heart blood |
| CN108295233A (en) * | 2018-04-11 | 2018-07-20 | 丹阳市上古本真健康科技有限公司 | Chinese medicine of blood-supplementing blood-nourishing and preparation method thereof |
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