CN1274584A - Application of photosynthetic bacteria as medical health article and its production process and product - Google Patents
Application of photosynthetic bacteria as medical health article and its production process and product Download PDFInfo
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- CN1274584A CN1274584A CN99107591A CN99107591A CN1274584A CN 1274584 A CN1274584 A CN 1274584A CN 99107591 A CN99107591 A CN 99107591A CN 99107591 A CN99107591 A CN 99107591A CN 1274584 A CN1274584 A CN 1274584A
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- rhodospirillum
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Abstract
Athiorhodaceae spawn of rhodospirillum in Rholdospirillaceae is inoculated and cultured to prepare culture liquid of live preparation with Athiorhodaceae bacteria content of 100-120 mega per ml. The culture liquid is deactivated at 120-125 deg.c to produce deactivated preparation, and is mixed with coagulant, filtered, and low-temperature dried to obtain bacteria powder, which is capsulized. The product is applied as health article for resisting senility, resisting cancer, strenthening immunity, lowering blood lipoid, etc.
Description
The present invention relates to the application of a kind of photosynthetic bacteria and as the manufacture method of Medicines and Health Product and made Medicines and Health Product.
Photosynthetic bacteria (Photosynthesis bacteria PSB) is a kind of of hydrosphere microorganism, extensively be distributed in each corners such as ocean, lake, rivers, paddy field, mud, soil, be distributed in the lonely layer of water, carry out the photosynthesis of non-oxygen-production and synthetic idiotrophic material.Photosynthetic bacteria is divided four section: Rhodospirillaceae (red non-sulfur bacteria), Chromatiaceae (red sulfur bacteria), Chlorobiaceae (green sulfur bacteria) Chlorolexaceae (sliding thread green sulfur bacteria).So far separate the known photosynthetic bacteria that obtains and relate to totally 4 sections, 22 genus, 61 kinds.At present also few for the Application and Development of photosynthetic bacteria.
The purpose of this invention is to provide of a kind of application of a kind of photosynthetic bacteria as Medicines and Health Product, and provide as the manufacture method of Medicines and Health Product and made Medicines and Health Product, but this Medicines and Health Product defying age, cancer-resisting, enhancing immunity, lowering blood-fat and reducing weight, resisting fatigue, increase intelligence and the treatment Peptic Ulcers.
To achieve these goals, the present invention takes following technical scheme: a kind of photosynthetic bacteria is as the application of Medicines and Health Product, the red non-sulfur rhodospirillum kind that belongs to Rhodospirillaceae, Rhodospirillum is through inoculated and cultured, make active bacteria formulation or sterilization preparation or capsule, as defying age, cancer-resisting, enhancing immunity, lowering blood-fat and reducing weight, resisting fatigue, increase the application of Medicines and Health Product of intelligence and treatment Peptic Ulcers.The non-sulfur rhodospirillum of redness used in the present invention kind is externally to provide by Shanghai east wind ecological Studies are disclosed.
The method of the red non-sulfur rhodospirillum kind active bacteria formulation of making of the present invention comprises the steps:
(1) prepare culture medium according to the following number of weight ratio,
Sugar 190-200 part
Potassium dihydrogen phosphate 4.5-5 part
Sodium hydrogen phosphate 4.5-5 part
Carbamide 4.5-5 part
Water soluble starch 4.5-5 part
Peptone 1.7-1.9 part
Carnis Bovis seu Bubali cream 1.7-1.9 part
Sal 1.9-2.1 part
Maltodextrin 46-49 part
Aminoacids complex 1-1.1 part
Three phosphorus, three adenosine 0.18-0.22 parts
Vitamin D 1.9-2.1 part
Sodium carbonate 1.9-2.1 part
Tocopherol 0.9-1.1 part
Phosphatidase 11 .9-2.1 part
Distilled water 2955-3005 part
(2) in above-mentioned culture medium, connect the strain of the red non-sulfur rhodospirillum of people 60-90 parts by weight, under the illumination sufficient condition, cultivated 7-15 days, and to reach the every milliliter of non-sulfur rhodospirillum of redness content be the culture fluid of hundred million of 1-1.2, promptly be made for red non-sulfur rhodospirillum kind active bacteria formulation.
The method of the red non-sulfur rhodospirillum kind sterilization preparation of making of the present invention, this method are also to comprise the steps: on the basis that makes above-mentioned culture fluid
(3) with above-mentioned red non-sulfur rhodospirillum kind culture fluid at 120-125 ℃ of following deactivation 10-20 minute, promptly be made for red non-sulfur rhodospirillum kind sterilization preparation.
The capsular method of the red non-sulfur rhodospirillum kind of making of the present invention, this method are also to comprise the steps: on the basis that makes above-mentioned culture fluid
(3) in above-mentioned red non-sulfur rhodospirillum kind culture fluid, the proportioning that adds 3-5 gram coagulant by every liter of culture fluid adds coagulant, after filtration, and under 55 ℃ of-59 ℃ of temperature dry 25-30 minute, promptly be made for the mycopowder of red non-sulfur rhodospirillum kind, and dress people capsule.Coagulant adopts calcium sulfate.
The red non-sulfur rhodospirillum kind active bacteria formulation of made of the present invention, wherein, the content of the red non-sulfur rhodospirillum kind viable bacteria in the non-sulfur rhodospirillum of the described redness kind active bacteria formulation is hundred million/milliliter of 1-1.2.
The red non-sulfur rhodospirillum kind sterilization preparation of made of the present invention, wherein, the content of the red non-sulfur rhodospirillum in the non-sulfur rhodospirillum of the described redness kind sterilization preparation is hundred million/milliliter of 1-1.2.
In order to satisfy people's oral taste, can in active bacteria formulation, sterilization preparation, add an amount of seasoning material, directly fill.
The red non-sulfur rhodospirillum kind capsule of made of the present invention, wherein, the content of the red non-sulfur rhodospirillum in the non-sulfur rhodospirillum of the described redness kind capsule is hundred million of 1-1.2/gram.
The red non-sulfur rhodospirillum kind mycopowder of made of the present invention, contain in its per 100 grams:
The composition unit content
Crude protein % 65.45
Smart fatty % 7.16
Soluble sugar % 20.31
Crude fibre % 2.78
Ash % 4.28
VB1 mg/g 12
VB6 mg/g 5
VB12 mg/g 12
Nicotinic acid mg/g 125
Pantothenic acid mg/g 30
Folic acid mg/g 60
Biotin mg/g 65
In this albumen of 65.45%, basic protein and be that (more than 20000) of macromolecule just contain 38.81% wherein, biotin has exceeded 4 times and 2 times more than than the 1.5mg/g of the Radix Astragali and the 2.8mg/g of Radix Ginseng, and high molecular basic protein is the vital balanced source of human body atomic group.
In addition, red non-sulfur rhodospirillum kind contains active trace element, and this takes effect especially for replenishing trace element necessary in the human body.
It is as follows that the non-sulfur rhodospirillum of redness of the present invention kind is applied to the effect of medicines and health protection aspect:
1, be applied to the defying age aspect: the applicant carries out mice existence test, get 50 of purebred mices, random packet, raising is under 25 ℃ room temperature, the Mus feedstuff with routine is fed in the irradiation that keeps lamp every day, gives red non-sulfur rhodospirillum kind active bacteria formulation group and matched group with identical condition, add up its dead Mus number every day, up to whole natural deaths.The result all obviously is better than matched group for red non-sulfur rhodospirillum kind active bacteria formulation group average life and maximum life span; The concentration determination of mice tail tendon hydroxyproline, prove that also red non-sulfur rhodospirillum kind active bacteria formulation has obvious anti-aging effects, the antidotal dominant mechanism of red non-sulfur rhodospirillum kind active bacteria formulation is that red non-sulfur rhodospirillum kind can be eliminated human body cell senescence-factor-superoxide radical and hydroxyl radical free radical reaches more than 90%.
2, be applied to the cancer-resisting aspect: applicant's laboratory research shows that red non-sulfur rhodospirillum kind suppresses laboratory animal lactic acid dehydrogenase and isozyme thereof, rising body hydrogen peroxide enzyme and activity.The excessive generation of the generation of tumor and free radical has closely related, reduces the generation of free radical, and keeping interior oxidation of body and antioxidative balance is the reasonable approach that prophylaxis of tumours takes place, and catalase is one of main enzyme of removing in the body free radical.Catalase mainly is present in liver and the erythrocyte, and content is less in brain, the heart and the skeletal muscle.Bringing out the commitment of cancer, the animal serum catalase activity promptly begins to descend, and cancer forms the back, and it actively further descends, and uses red non-sulfur rhodospirillum kind preparation or capsule effectively after the treatment, enzymatic activity progressively returns to normal level, and cancerous cell is effectively suppressed.
3, be applied to the enhancing immunity aspect: the applicant adopts the various experimental techniques of nonspecific immunity, humoral immunization and cellular immunization to observe.Nonspecific immunity has been tested immune organ weight method, thymus and splenocyte counting, peripheral blood cells counting; Humoral immunization has been tested hemolysin mensuration; Cellular immunization has been tested the periphery blood T lymphocyte counting, and lymphocyte transformation test proves that red non-sulfur rhodospirillum kind has the activity of regulating immunity (particularly raise immunity).
4, be applied to the lowering blood-fat and reducing weight aspect: the applicant studies show that, red non-sulfur rhodospirillum kind can reduce the ester content of T-CHOL and total glycerol in the serum, increases HPL content, reduces LPL content, reduces atherogenic index, improves the activity of LCAT.Red non-sulfur rhodospirillum kind preparation or capsule for treating obesity, adopt the high protein food of biological value, improve the body fat oxidizing process, employ the fat that accumulates, reduce accumulating of fat, red non-sulfur rhodospirillum kind is rich in the active substance that can stop fat and cholesterol absorption simultaneously, has physiological regulation function, is comparatively ideal diet food.
5, be applied to motion and resisting fatigue aspect: the applicant discovers, the tired mechanism that takes place, be that energy substance is exhausted on the one hand, on the one hand be to be that the acidic metabolite of representative is when the anoxia muscular work with lactic acid, concentration increases greatly, when the more important thing is strenuous exercise tissue because of ischemia and blood again filling can produce a large amount of free radicals.Free radical is the high activity molecule, and histiocyte is had certain destruction.Free radical can change the fine structure of sarcoplasmic reticulum, can also directly influence Ca
2+--Mg
2+--the dehydrogenation of ATP enzyme, make the function reduction of sarcoplasmic reticulum, cause Ca in the endochylema
2+Concentration raise the Ca of high concentration in the endochylema
2+Can bring out mitochondrion to Ca
2+Huge uptake, Ca in the mitochondrion
2+Bulk deposition can suppress Cellular respiration, cause the hydrogenation phosphorylation to take off coupling connection, ATP resynthesis speed is descended greatly, muscular work energy supply deficiency causes fatigue at last.Red non-sulfur rhodospirillum kind can be replenished big energy, removes the acid product that internal metabolism is piled up, and eliminates free radical, and the zoopery antifatigue effect is remarkable, is optimal anti-fatigue effect food and motion food of new generation.
6, Ying Yu increases the intelligence aspect: the normal function of brain depends on the cranial nerve cell and the neurotransmitter synthetic and the secretion capacity thereof of sufficient amount.The applicant studies show that red non-sulfur rhodospirillum kind is mainly that to the influence of intelligence its many active substances are precursors of some neurotransmitteies, also is the bioactive substance of nervous system development and functional activity.By the passive avoidance conditioned reflex test of animal, as diving tower method, darkness avoidance test; With main avoidance conditioning experiment, as experimentatioies such as shuttle box, maze methods, red non-sulfur rhodospirillum kind has and significantly increases the intelligence function.
Red non-sulfur rhodospirillum kind is carried out following test aspect toxicity:
1, LD50 is measured in acute toxicity test, and the red non-sulfur rhodospirillum kind LD50 dosage of result may intake more than 300 times greater than human body.
2, short-term feeding trial is not found any toxic action.
The active bacteria formulation of red non-sulfur rhodospirillum kind and capsular sanitary inspection and physicochemical identification are as follows:
1, hygiology physical and chemical inspection index:
The red non-sulfur rhodospirillum kind of the red non-sulfur rhodospirillum of project
Plant active bacteria formulation dry powder capsule
Lead does not detect
Arsenic does not detect
Record does not detect that other pollutant do not detect 2, microbiological indicator
Red non-sulfur rhodospirillum kind active bacteria formulation
Total plate count＜100
Coliform＜10
Toadstool does not detect
Yeast does not detect
Pathogenic bacterium do not detect 3, physicochemical property is differentiated (red non-sulfur rhodospirillum kind dry powder) item characteristic conclusion pH value 9.5 alkaline molecular weight 25000 macromole electrophoresis 4 boundary multiple proteins and amino
The acid dissolving is water insoluble, be slightly soluble in the ethanol ether, the calcination of benzene macromolecule protein has the protein stink, blackening protein stabilization no change in air is nonhygroscopic, and it is salty to be easy to deposit certainly 48 hours fluoroscopic examination blue light-emitting alkalescence biotin mouthfeels, no impurity taste alkalescence is smelt the normal trace element iron content of odorlessness, zinc, manganese, sulfur, the calcium various trace elements
Embodiment is by following weight preparation culture medium
195.2 kilograms of sugar
4.76 kilograms of potassium dihydrogen phosphates
4.76 kilograms of sodium hydrogen phosphates
4.76 kilograms in carbamide
4.76 kilograms of water soluble starchs
1.8 kilograms of peptones
1.8 kilograms of Carnis Bovis seu Bubali creams
2 kilograms of Sal
47.6 kilograms of maltodextrins
0.9 kilogram of aminoacids complex
0.2 kilogram of three phosphorus, three adenosine
2 kilograms of vitamin D
2 kilograms of sodium carbonate
1 kilogram of tocopherol
The phosphatidase 12 kilogram
3000 kilograms in water
Connect 90 kilograms of non-sulfur rhodospirillum of redness of people kind, under the illumination sufficient condition, cultivated 7-15 days, it is qualified reaching hundred million of the every milliliter of non-sulfur rhodospirillum of redness content 1-1.2.
Above-mentioned culture fluid adding seasoning material is an amount of, and directly fill is active bacteria formulation; Or with above-mentioned culture fluid 120 ℃ of deactivations, it is an amount of to add seasoning material, fill is sterilization preparation.Or with above-mentioned culture fluid adding 3-5 kilogram coagulant calcium sulfate, after the filtration, under 58 ℃ of temperature, dry 25 minutes, promptly get red non-sulfur rhodospirillum kind dry powder, directly incapsulate, every capsules weighs 0.5 gram.
Claims (7)
1, a kind of photosynthetic bacteria is as the application of Medicines and Health Product, the red non-sulfur rhodospirillum kind that belongs to Rhodospirillaceae, Rhodospirillum is through inoculated and cultured, make active bacteria formulation or sterilization preparation or capsule, as defying age, cancer-resisting, enhancing immunity, lowering blood-fat and reducing weight, resisting fatigue, increase the application of Medicines and Health Product of intelligence and treatment Peptic Ulcers.
2, make the method for the described Medicines and Health Product of claim 1, it is characterized in that: this method comprises the steps:
(1) prepare culture medium according to the following number of weight ratio,
Sugar 190-200 part
Potassium dihydrogen phosphate 4.5-5 part
Sodium hydrogen phosphate 4.5-5 part
Carbamide 4.5-5 part
Water soluble starch 4.5-5 part
Peptone 1.7-1.9 part
Carnis Bovis seu Bubali cream 1.7-1.9 part
Sal 1.9-2.1 part
Maltodextrin 46-49 part
Aminoacids complex 1-1.1 part
Three phosphorus, three adenosine 0.18-0.22 parts
Vitamin D 1.9-2.1 part
Sodium carbonate 1.9-2.1 part
Tocopherol 0.9-1.1 part
Phosphatidase 11 .9-2.1 part
Distilled water 2955-3005 part
(2) strain of the red non-sulfur rhodospirillum of access 60-90 parts by weight in above-mentioned culture medium, under the illumination sufficient condition, cultivated 7-15 days, and to reach the every milliliter of non-sulfur rhodospirillum of redness content be the culture fluid of hundred million of 1-1.2, promptly be made for red non-sulfur rhodospirillum kind active bacteria formulation.
3, the method for making Medicines and Health Product according to claim 2 is characterized in that: this method also comprises the steps:
(3) with above-mentioned red non-sulfur rhodospirillum kind culture fluid at 120-125 ℃ of following deactivation 10-20 minute, promptly be made for red non-sulfur rhodospirillum kind sterilization preparation.
4, the method for making Medicines and Health Product according to claim 2 is characterized in that: this method also comprises the steps:
(3) in above-mentioned red non-sulfur rhodospirillum kind culture fluid, the proportioning that adds 3-5 gram coagulant by every liter of culture fluid adds coagulant, after filtration, and under 55 ℃ of-59 ℃ of temperature dry 25-30 minute, promptly be made for the mycopowder of red non-sulfur rhodospirillum kind, and incapsulate.
5, the red non-sulfur rhodospirillum kind active bacteria formulation of making of the method for claim 2, it is characterized in that: the content of the red non-sulfur rhodospirillum kind viable bacteria in the non-sulfur rhodospirillum of the described redness kind active bacteria formulation is hundred million/milliliter of 1-1.2.
6, the red non-sulfur rhodospirillum kind sterilization preparation of making of the method for claim 3, it is characterized in that: the content of the red non-sulfur rhodospirillum in the non-sulfur rhodospirillum of the described redness kind sterilization preparation is hundred million/milliliter of 1-1.2.
7, the red non-sulfur rhodospirillum kind capsule of making of the method for claim 4, it is characterized in that: the content of the red non-sulfur rhodospirillum in the non-sulfur rhodospirillum of the described redness kind capsule is hundred million of 1-1.2/gram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN99107591A CN1274584A (en) | 1999-05-21 | 1999-05-21 | Application of photosynthetic bacteria as medical health article and its production process and product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN99107591A CN1274584A (en) | 1999-05-21 | 1999-05-21 | Application of photosynthetic bacteria as medical health article and its production process and product |
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| CN1274584A true CN1274584A (en) | 2000-11-29 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827301A1 (en) * | 2001-07-13 | 2003-01-17 | Blue Energy Laboratoire | Enriching photosynthetic microorganisms with biologically active molecules, useful for delivering pharmaceuticals, by incubating cells in presence of the molecules |
| NL1022153C2 (en) * | 2002-12-12 | 2004-06-15 | Tno | Cholesterol lowering preparation, food supplement and food and methods for the preparation thereof. |
| WO2018229223A1 (en) | 2017-06-15 | 2018-12-20 | Ezcol B.V. | Ldl-cholesterol-lowering cell extract and food supplement |
| WO2023009000A1 (en) | 2021-07-29 | 2023-02-02 | Semilla Health B.V. | Poultry feed for lowering cholesterol level in egg yolks |
-
1999
- 1999-05-21 CN CN99107591A patent/CN1274584A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827301A1 (en) * | 2001-07-13 | 2003-01-17 | Blue Energy Laboratoire | Enriching photosynthetic microorganisms with biologically active molecules, useful for delivering pharmaceuticals, by incubating cells in presence of the molecules |
| NL1022153C2 (en) * | 2002-12-12 | 2004-06-15 | Tno | Cholesterol lowering preparation, food supplement and food and methods for the preparation thereof. |
| WO2004052380A1 (en) * | 2002-12-12 | 2004-06-24 | Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno | Cholesterol-lowering preparation, food supplement and foodstuff, and methods for preparing same |
| JP2006513176A (en) * | 2002-12-12 | 2006-04-20 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | Cholesterol-reducing preparations, food supplements and foods, and methods for their production |
| US7749513B2 (en) | 2002-12-12 | 2010-07-06 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Methods of using a cholesterol-lowering preparation, food supplement and foodstuff |
| JP4814524B2 (en) * | 2002-12-12 | 2011-11-16 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | Preparations that lower cholesterol |
| EP3189845A1 (en) * | 2002-12-12 | 2017-07-12 | ezCol B.V. | Cholesterol-lowering preparation, food supplement and foodstuff, and methods preparing same |
| WO2018229223A1 (en) | 2017-06-15 | 2018-12-20 | Ezcol B.V. | Ldl-cholesterol-lowering cell extract and food supplement |
| JP2020524500A (en) * | 2017-06-15 | 2020-08-20 | エズコル ビー．ヴイ． | LDL-cholesterol lowering cell extract and food supplement |
| US11026981B2 (en) | 2017-06-15 | 2021-06-08 | Ezcol B.V. | LDL-cholesterol-lowering cell extract and food supplement |
| WO2023009000A1 (en) | 2021-07-29 | 2023-02-02 | Semilla Health B.V. | Poultry feed for lowering cholesterol level in egg yolks |
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Free format text: CORRECT: APPLICANT; FROM: ZHONGWEI HUAMEI PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD BEIJING TO: HONGDIKANGHUA BIO-ENGINEERING TECHNOLOGY CO LTD, BEIJING |
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Address after: 100086 Beijing city Haidian District zhichunli sigma apartment block B room 1705 Applicant after: Hongdikanghua Bio-Engineering Technology Co Ltd, Beijing Address before: The 100054 Beijing Fengtai District right outside the West No. ten Applicant before: Zhongwei Huamei Medicine Technology Development Co., Ltd., Beijing |
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Owner name: JIAHUA BIOLOGICAL TECHNOLOGY ( SHANDONG ) CO., LT Free format text: FORMER OWNER: HONGDIKANGHUA BIO-ENGINEERING TECHNOLOGY CO LTD, BEIJING Effective date: 20030327 |
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