CN1255177C - Heat-clearing and toxicant-eliminating preparation and preparation method - Google Patents
Heat-clearing and toxicant-eliminating preparation and preparation method Download PDFInfo
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- CN1255177C CN1255177C CN 03103991 CN03103991A CN1255177C CN 1255177 C CN1255177 C CN 1255177C CN 03103991 CN03103991 CN 03103991 CN 03103991 A CN03103991 A CN 03103991A CN 1255177 C CN1255177 C CN 1255177C
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Abstract
The present invention relates to a preparation for clearing heat and removing toxicity, and the preparation method of the preparation. In the present invention, baical skullcap root, forsythia fruit, isatis root, gypsum, herba agastachis, common anemarrhena rhizome, rehmannia root, curcuma root, calamus and uncaria are used as raw materials to be prepared into oral liquid through the steps of immersion, distillation, decoction, filtration, concentration, even mixing, separate packing and sterilization. The preparation of the present invention has the functions of clearing heat, removing toxicity, eliminating turbid pathogen with aromatics, regulating qi, alleviating pain, calming the liver, stopping endogenous wind, cooling blood, nourishing yin, promoting salivation, quenching thirst, etc., and has the double effect of resisting viruses and bacteria. The preparation of the present invention has the advantages of unique formula and obvious curative effect, and is used as a preparation for treating diseases, such as respiratory tract infection, influenza, fever, epidemic parotitis, viral encephalitis, etc.
Description
Technical field
The invention belongs to the biological medicine technology field, relate to a kind of natural Chinese medicines compound preparation, particularly relate to a kind of antipyretic-detoxicant preparation that is used for the treatment of antibacterial or viral infection and preparation method thereof, in particular for pure natural antipyretic-detoxicant preparation of treatment upper respiratory tract infection, influenza, heating, mumps and viral encephalitis and preparation method thereof.
Background technology
Upper respiratory tract infection, influenza, mumps and viral encephalitis etc. are common clinical, frequently-occurring disease, and be very easily popular because of it, and that often gives society and people healthyly causes very big harm.Viral encephalitis particularly, as treat untimelyly, can jeopardize patient's life at any time.
This type of disease of treatment does not still have specific medicament at present, in addition, and antiviral drugs multivalence lattice costliness, and certain toxic and side effects is arranged again.Can cause the change of reversibility anemia and liver injury and liver function as virazole; Interferon can cause heating, headache, leucocytes reduction, thrombocytopenia and anemia.Moreover; patient to bacterial infection; the sensitivity that is difficult to clear and definite its pathogenesis and relative medicine again, nosetiology it be unclear that and under the situation about can not clarify a diagnosis in addition, drug resistance and toxic and side effects and anaphylaxis etc. that regular meeting causes clinical antibiotic abuse to produce then.Like thatly all effectively use antibiotic and brought certain difficulty to us.In addition the untoward reaction of these chemicalses is more and more serious, and the therapeutic effect of existing other natural drugs is not ideal enough.Therefore, seek the clinical application of the above-mentioned disease of a kind of effective treatment, become a problem of being badly in need of solution of medical technical field.
Goal of the invention
Purpose of the present invention is exactly in order to inherit and excavate Chinese medicine precious legacy, under Chinese medical theory instructs, in conjunction with clinical experience for many years, with the natural Chinese medicines is raw material, fully use modern science and technology, develop a kind of efficient, low toxicity, taking convenience and cheap natural Chinese medicines thermochromic compound detoxicating preparation, and therefore overcome existing problem and shortage in the prior art, be used for the treatment of upper respiratory tract infection, influenza, heating, mumps and viral encephalitis.
Another object of the present invention just provides the preparation method of this antipyretic-detoxicant preparation.
Technical scheme
Solution of the present invention is based on pathogenetic understanding and the Therapeutic Principle of motherland's medical science to upper respiratory tract infection, influenza, heating, mumps and viral encephalitis, achieve with reference to modern pharmacological research, select the pure natural plant medicine for use, carry out reasonable formula and preparation the present invention according to theory of Chinese medical science.
Belong to traditional Chinese medical science diseases caused by exogenous pathogenic factor excess-heat according to above-mentioned disease more, clinical or see fever with chills, headache, dry pharynx, or see excess syndrome, the heat syndrome of pathogenic factor heat-transformation fire-transformation such as high fever, excessive thirst flushed complexion, coma, tic.So the present invention is based on clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body.The Gypsum Fibrosum of square Radix Scutellariae, Fructus Forsythiae, Radix Isatidis and clearing away heat-fire with heat-clearing and toxic substances removing, removing pathogenic heat from blood and toxic substance from the body, the Rhizoma Anemarrhenae, the Radix Rehmanniae etc. are elder generation to plunge calorific potential, consider the easy impairment of YIN of intenseness of heat simultaneously, and the merit of the clearing away heat and promoting production of body fluid of this type of medicine of dual-purpose can prevent cloudy liquid loss again.Also used Radix Curcumae, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis in the side, with the circulation of qi promoting arresting convulsion of having one's ideas straightened out, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., Herba Pogostemonis eliminating turbid pathogen with aromatics in addition can effectively be prevented and treated the unconsciousness and delirium of hot telepathy battalion and the infantile convulsion of liver-wind caused by excessive heat and twitch.Add sugarcane (in vain) sugar simultaneously with flavoring, in order to taking.The preparation technology that the present invention in addition implemented has further improved the utilization rate of medicine, has also prevented the volatilization and the loss of effective ingredient simultaneously.
Below in conjunction with pharmaceutical formulation the present invention is done a narration.
Thermal detoxification preparation of the present invention is made (consumption is a weight portion) by following component:
Radix Scutellariae 5-7 part Fructus Forsythiae 10-14 part Radix Isatidis 22-26 part Gypsum Fibrosum 18-22 part Herba Pogostemonis 10-14 part
Rhizoma Anemarrhenae 6-8 part Radix Rehmanniae 8-12 part Radix Curcumae 4-6 part Rhizoma Acori Graminei 6-8 part Ramulus Uncariae Cum Uncis 4-6 part
The optimum weight proportioning of thermal detoxification preparation of the present invention is:
12 parts of 20 portions of Herba Pogostemoniss of 24 parts of Gypsum Fibrosum of 12 parts of Radix Isatidis of 6 parts of Fructus Forsythiaes of Radix Scutellariae
4.8 parts of 7.2 parts of Ramulus Uncariae Cum Uncis of 4.8 portions of Rhizoma Acori Gramineis of 9.6 portions of Radix Curcumaes of 72 parts of Radix Rehmanniae of the Rhizoma Anemarrhenae
The pharmacological action of the drug component in the thermal detoxification preparation of the present invention is:
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, stomach, large intestine channel.The merit that heat clearing and damp drying, eliminating fire and detoxication, hemostasis are arranged.Its pharmacological research shows: anti-microbial effect is arranged, its decoct is external to have different inhibitory action to staphylococcus aureus, meningococcus etc., the staphylococcus that penicillin is developed immunity to drugs also has certain inhibitory action, and influenza virus PR8 strain is in vitro also had certain inhibitory action.
Fructus Forsythiae: bitter in the mouth, cold nature.Return lung, the heart, gallbladder meridian.The effect that heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation are arranged.Its pharmacological research shows: antibiotic, resisiting influenza virus and antiinflammatory, Detoxication are arranged.
Radix Isatidis: bitter in the mouth, cold in nature.GUIXIN, stomach warp.Energy heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving more are good at detoxicating and resolving stagnation of pathogens, and the resisting pathogenic microbes effect is arranged.
Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold.Attach to the lung and stomach meridians.The merit that tool clearing away heat-fire, relieving restlessness are quenched the thirst.Its pharmacological research shows: effects such as analgesic, spasmolytic, antiinflammatory are arranged, can obviously strengthen the phagocytic activity of macrophage., resisiting influenza virus and antiinflammatory, Detoxication.
Herba Pogostemonis: acrid in the mouth, tepor.Return spleen, stomach, lung meridian.Energy removing dampness expelling summer-heat, preventing or arresting vomiting.Candida albicans, Cryptococcus histolyticus, staphylococcus aureus, Staphylococcus albus etc. all there is inhibitory action.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature.Return lung, stomach, kidney channel.Clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect are arranged, can resisting pathogenic microbes, the tool refrigeration function.
Radix Curcumae: the acrid in the mouth hardship, cold in nature.GUIXIN, liver, gallbladder meridian.Energy promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, removing heat from blood clear away heart-fire.Modern pharmacological research shows: antiinflammatory, analgesia and antibacterial action are arranged.
The Radix Rehmanniae: sweet-bitter flavor, cold in nature.GUIXIN, liver, kidney channel.Energy clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature.GUIXIN, stomach warp.But resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach have anticonvulsant action.
Ramulus Uncariae Cum Uncis: sweet in the mouth, cold nature.Return liver, pericardium channel.Energy relieving spasm by subduing liver-wind, heat clearing away suppressing the hyperactive liver.Calmness and anticonvulsant action are arranged.
Full medicine share, and complements each other, and has both strengthened the therapeutic effect of single medicine, has reduced side effect again, therefore can play effects such as heat-clearing and toxic substances removing, eliminating turbid pathogen with aromatics, promoting the circulation of QI to relieve pain, suppressing the hyperactive liver to relieve the wind syndrome, removing heat from blood yin nourishing, promoting the production of body fluid to quench thirst very soon.Pharmacological research shows that antipyretic-detoxicant preparation has antiviral, antibacterium double effect, can strengthen and promote the phagocytic function of leukocyte and macrophage, human body immunity improving power.
The antipyretic-detoxicant preparation of the present invention especially preparation method of oral liquid is:
1, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis were soaked 1 hour in the side of getting, and added thermal distillation, collected distillate;
2, the same Radix Scutellariae of medicine residue, Radix Isatidis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, the Radix Rehmanniae, the Radix Curcumae of getting after above-mentioned steps 1 is distilled mixes, and soaks 1 hour, and heating decocts 2 times, and each 2 hours, merge 2 times decocting liquid, filter, gained filtrate is concentrated, static 48 hours.
3, get above-mentioned steps 2 filtering and concentrating liquid, draw supernatant, add that sugarcane (in vain) is candy to boil 10 minutes, filter to get filtrate;
4, above-mentioned steps 3 filtrates and step 1 distillate are merged mixing, adjust capacity with distilled water, packing behind the mixing, it is standby to sterilize.
Antipyretic-detoxicant preparation oral liquid of the present invention promptly can be used for clinical practice after quality inspection is qualified.
The using method of antipyretic-detoxicant preparation oral liquid of the present invention is:
Oral: as to look the state of an illness 30-60ml every day 2 times at every turn, shake up decoction being taken warmly.Coloclysis is followed the doctor's advice.
Antipyretic-detoxicant preparation of the present invention can also be prepared into powder, pill, electuary, capsule and unguentum according to conventional method except being prepared into above-mentioned oral liquid formulation, also can get the above-mentioned raw materials medicine and take as Chinese herbs decoction by proportioning.The various dosage forms of the invention described above are preferably made QINGRE JIEDU KOUFUYE, so that take.
Technique effect
Antipyretic-detoxicant preparation of the present invention shows to have following advantage through clinical use result:
1, the present invention drink, carry, convenient transportation, be applicable to that men and women, old young patient take.
2, determined curative effect of the present invention, have no side effect, be applicable to that respiratory tract infection, influenza, heating, mumps and viral encephalitis patient take.
3, the antiviral of the alternative costliness of the present invention, anti-bacterial drug can effectively be avoided the drug resistance and the toxic and side effects of Western medicine.
4, to prepare raw material sources extensive, economical and practical in the present invention.
5, mature preparation process of the present invention, reliable in quality is implemented easily.
In order further to show the therapeutic effect of antipyretic-detoxicant preparation of the present invention, the present invention is since in February, 2000, and through system's clinical observation of 506 routine patients, its result is as follows:
One, clinical application cases number: see Table 1
Table 1: clinical application cases number
| The sick kind | The example number | 1-3 year | 4-6 year | 7-8 year | 9-12 year |
| Upper respiratory tract infection | 180 | 30 | 50 | 40 | 60 |
| Chickenpox | 28 | 4 | 10 | 8 | 6 |
| Parotitis | 50 | 2 | 12 | 24 | 12 |
| Viral encephalitis | 248 | 30 | 60 | 100 | 58 |
Two, diagnostic criteria:
Chickenpox: 1, popular medical history and contact history.2, generate heat or do not have heat.3, pimple, herpes, incrustation.4, leukopenia.5, the companioned with headache that has, nauseating.
(2) parotitis: 1, popular medical history and contact history.2, heating.3, with the ear-lobe be center anthorisma, tenderness, not red, calm innervation.4, the normal or reduction of leukocyte.5, the patient who has is with central nervous system's symptom.
(3) viral encephalitis: 1, the sense of going up forerunner medical history is arranged.2, headache, vomiting.3, lassitude or drowsiness.4, the pathologic reflex positive.5, electroencephalogram is based on the SO slow wave.6, cerebrospinal fluid changes, and cell number is light, moderate increases, and classification is based on mononuclear cell.
Three, using method:
Oral: as to look the state of an illness 30-60ml every day 2 times at every turn, shake up decoction being taken warmly.Coloclysis is followed the doctor's advice.
In addition, merge the central nervous system symptom, award 20% mannitol, the intracranial pressure anti symptom treatment falls in hormone for viral encephalitis and parotitis.
Four, efficacy determination:
Cure: symptom and sign disappear, and it is normal that routine blood test and cerebrospinal fluid recover.
Take a turn for the better: heat is moved back, and symptom, sign take a turn for the better, and it is normal that routine blood test recovers.
Do not heal (invalid): symptom and sign do not have improvement.
Five, therapeutic effect:
1,506 routine patient's clinical treatment effective percentage: see Table 2
Table 2:506 example patient clinical treatment effective percentage
| The sick kind | The example number | Cure | Take a turn for the better | Invalid | Total effective rate (%) | Cure rate (%) |
| Upper respiratory tract infection | 180 | 151 | 25 | 4 | 978 | 83.9 |
| Chickenpox | 28 | 26 | 2 | 0 | 1000 | 929 |
| Parotitis | 50 | 43 | 6 | 1 | 980 | 860 |
| Viral encephalitis | 248 | 221 | 21 | 6 | 976 | 891 |
| Add up to | 506 | 441 | 54 | 11 | 978 | 872 |
2, to the therapeutic effect of viral encephalitis: see Table 3
Table 3: antipyretic-detoxicant preparation is to the therapeutic effect of viral encephalitis
| Cardinal symptom | Persistent period (my god) | The t value | The P value | |||
| Treatment group (135 example) | Matched group (115 example) | |||||
| Heating | 194±105 | n＝135 | 448±266 | n＝115 | 524 | P＜0.01 |
| Headache | 198±107 | n＝123 | 3.92±278 | n＝103 | 4.23 | P＜0.01 |
| Vomiting | 197±110 | n＝116 | 396±272 | n＝92 | 348 | P＜0.01 |
| Disturbance of consciousness | 1.68±054 | n＝77 | 2.08±065 | n＝61 | 2.46 | 001＜P＜005 |
| Twitch | 0.97±0.56 | n＝93 | 201±054 | n＝69 | 3.07 | P＜0.01 |
Annotate: statistical procedures adopts two sample mean t check.
3, model case
Case 1: Chen, woman, 12 years old, first visit on November 21 in 2000.Patient's heating, pharyngalgia, cough, lossless, 38.9 ℃ of body temperature, companioned with headache dizziness, vexed xerostomia, yellow urine, big dry stool, red tongue with yellow fur, rapid pulse, leukocyte 11 * 10
9/ L, neutrophilic granulocyte 90%.Examine and be upper respiratory tract infection, give antipyretic-detoxicant preparation, each 40ml, every day 2 times.In heat on the 2nd move back, sweating, calm pulse, all diseases alleviate, the check routine blood test recovers normal after 2 days, recovery from illness after 3 days.
Case 2: Wang, man, 11 years old, the first visit on the 18th of calendar year 2001 December.Patient's headache, pharyngalgia, heating hospital admission over 3 days, metopodynia is bowed and is increased the weight of for work before the headache.38 ℃ of body temperature, infant spirit is poor, pharyngeal fair blood, antiadoncus, two pulmonary respiration sounds are thick.Examination of cerebrospinal fluid: numeration of leukocyte 2 * 10
6/ L, lymphocyte 73%, neutrophilic granulocyte 7%, the quantitative 380mg/L of cerebrospinal fluid protein.Be diagnosed as viral encephalitis, give antipyretic-detoxicant preparation, each 50ml gives anti symptom treatment every day 2 times simultaneously, and temperature recovery is normal after 1 day, and medication is had a headache after 3 days and disappeared, and in high spirits, all diseases are known flat.
Case 3: Xing, man, 4 years old, first visit on May 26 in 1998.It is 2 big that the patient generates heat, bilateral parotid gland swelling and pain, poor appetite, dry pharynx pain.39.5 ℃ of body temperature, the bilateral parotid gland are the center anthorisma with the ear-lobe, and the surface is not red, touch a tender spot obviously.Two submaxillary gland silght enlargements, no purulent secretion.Be diagnosed as mumps.Give antipyretic-detoxicant preparation, each 60ml, every day 2 times.After heat on the 2nd is moved back, and swelling of parotid gland obviously alleviates, and swelling and ache after taking medicine 4 days disappears.
Embodiment
Embodiment 1:
Take by weighing raw material by following proportioning:
Radix Scutellariae 6 gram Fructus Forsythiaes 12 gram Radix Isatidis 24 gram Gypsum Fibrosum 20 gram Herba Pogostemoniss 12 grams
The Rhizoma Anemarrhenae 72 gram Radix Rehmanniae 96 gram Radix Curcumaes 48 gram Rhizoma Acori Gramineis 7.2 gram Ramulus Uncariae Cum Uncis 4.8 grams
Its production method is:
1, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis were soaked 1 hour in the side of getting, and added thermal distillation, collected the about 20ml of distillate;
2, the same Radix Scutellariae of medicine residue, Radix Isatidis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, the Radix Rehmanniae, the Radix Curcumae of getting after above-mentioned steps 1 is distilled mixes, and soaks 1 hour, and heating decocts 2 times, and each 2 hours, merge 2 times decocting liquid, filter, gained filtrate is concentrated into 80ml, static 48 hours.
3, get above-mentioned steps 2 filtering and concentrating liquid, draw supernatant, add that sugarcane (in vain) is candy to boil 10 minutes, filter to get filtrate;
4, above-mentioned steps 3 filtrates and step 1 distillate are merged mixing, adjust capacity to 100ml with distilled water, packing behind the mixing, it is standby to sterilize.
Embodiment 2:
Take by weighing raw material by following proportioning:
Radix Scutellariae 0.6kg Fructus Forsythiae 1.2kg Radix Isatidis 2.4kg Gypsum Fibrosum 2.0kg Herba Pogostemonis 1.2kg
Rhizoma Anemarrhenae 0.72kg Radix Rehmanniae 0.96kg Radix Curcumae 0.48kg Rhizoma Acori Graminei 0.72kg Ramulus Uncariae Cum Uncis 0.48kg
Its production method is:
1, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis were soaked 1 hour in the side of getting, and added thermal distillation, collected the about 2000ml of distillate;
2, the same Radix Scutellariae of medicine residue, Radix Isatidis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, the Radix Rehmanniae, the Radix Curcumae of getting after above-mentioned steps 1 is distilled mixes, and soaks 1 hour, and heating decocts 2 times, each 2 hours, merge 2 times decocting liquid, filter, gained filtrate is concentrated into 8000ml, static 48 hours.
3, get above-mentioned steps 2 filtering and concentrating liquid, draw supernatant, add that sugarcane (in vain) is candy to boil 10 minutes, filter to get filtrate;
4, above-mentioned steps 3 filtrates and step 1 distillate are merged mixing, adjust capacity to 10000ml with distilled water, packing behind the mixing, it is standby to sterilize.
Claims (4)
1, a kind of antipyretic-detoxicant preparation is characterized in that it being the preparation of being made by weight ratio by following pure natural medical raw material:
Radix Scutellariae 5-7 part Fructus Forsythiae 10-14 part Radix Isatidis 22-26 part Gypsum Fibrosum 18-22 part Herba Pogostemonis 10-14 part
Rhizoma Anemarrhenae 6-8 part Radix Rehmanniae 8-12 part Radix Curcumae 4-6 part Rhizoma Acori Graminei 6-8 part Ramulus Uncariae Cum Uncis 4-6 part
2, antipyretic-detoxicant preparation according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
12 parts of 20 portions of Herba Pogostemoniss of 24 parts of Gypsum Fibrosum of 12 parts of Radix Isatidis of 6 parts of Fructus Forsythiaes of Radix Scutellariae
4.8 parts of 7.2 parts of Ramulus Uncariae Cum Uncis of 4.8 portions of Rhizoma Acori Gramineis of 9.6 portions of Radix Curcumaes of 7.2 parts of Radix Rehmanniae of the Rhizoma Anemarrhenae
3, antipyretic-detoxicant preparation according to claim 1 and 2 is characterized in that described preparation is the above a dosage form of any pharmaceutics.
4, antipyretic-detoxicant preparation according to claim 3 is characterized in that described preparation is an oral liquid formulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03103991 CN1255177C (en) | 2003-02-16 | 2003-02-16 | Heat-clearing and toxicant-eliminating preparation and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03103991 CN1255177C (en) | 2003-02-16 | 2003-02-16 | Heat-clearing and toxicant-eliminating preparation and preparation method |
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| CN1437990A CN1437990A (en) | 2003-08-27 |
| CN1255177C true CN1255177C (en) | 2006-05-10 |
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| CN105477207A (en) * | 2016-01-04 | 2016-04-13 | 刘雷 | Traditional Chinese medicine for treating mumps |
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