CN113975222A - Wash-free hand sanitizer and preparation method thereof - Google Patents
Wash-free hand sanitizer and preparation method thereof Download PDFInfo
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- CN113975222A CN113975222A CN202111484566.2A CN202111484566A CN113975222A CN 113975222 A CN113975222 A CN 113975222A CN 202111484566 A CN202111484566 A CN 202111484566A CN 113975222 A CN113975222 A CN 113975222A
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- hand sanitizer
- diatom
- solution
- ethanol
- peg
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- 238000002360 preparation method Methods 0.000 title abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 88
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000008367 deionised water Substances 0.000 claims abstract description 27
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 27
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 26
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 17
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 16
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 15
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003899 bactericide agent Substances 0.000 claims abstract description 14
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- 125000005456 glyceride group Chemical group 0.000 claims abstract description 14
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 14
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims abstract description 14
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 14
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims abstract description 13
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- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 12
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 9
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 4
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 9
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- 238000000034 method Methods 0.000 claims description 4
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- 238000007789 sealing Methods 0.000 description 6
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
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- XEFAJZOBODPHBG-UHFFFAOYSA-N 1-phenoxyethanol Chemical compound CC(O)OC1=CC=CC=C1 XEFAJZOBODPHBG-UHFFFAOYSA-N 0.000 description 1
- CXIISRLRZRAKST-UHFFFAOYSA-N 29‐(4‐nonylphenoxy)‐3,6,9,12,15,18,21,24,27‐ nonaoxanonacosan‐1‐ol Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 CXIISRLRZRAKST-UHFFFAOYSA-N 0.000 description 1
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 1
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a no-clean hand sanitizer and a preparation method thereof, wherein the no-clean hand sanitizer comprises the following components in percentage by weight: 1-2% of diatom; 65-75% of ethanol; 0.003 to 0.325 percent of bactericide; 9-14% of a humectant; 2-4.8% of auxiliary agent and the balance of deionized water. Wherein the bactericide is selected from one or two of methyl hydroxybenzoate and p-chloro-m-dimethylphenol; the humectant is selected from one or more of sodium hyaluronate, propylene glycol and glycerin; the auxiliary agent is selected from one or more of aloe vera leaf juice, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, disodium EDTA and phenoxyethanol. The washing-free hand sanitizer provided by the invention has the antibacterial and sterilizing effects by adding the diatom extract. Meanwhile, the diatom contains rich natural high-quality protein, so that the hydrogel is stable in structure and not sticky, particularly, the damage of alcohol to the skin caused by washing-free is avoided, and hands are not injured after long-term use.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a no-clean hand sanitizer and a preparation method thereof.
Background
The existing no-clean gel hand disinfectant mainly adopts volatile alcohols as a solvent, and ethanol and isopropanol are used most in consideration of the requirements of safety and nontoxicity.
The foreign research considers that the alcohol disinfectant has reliable and rapid action and good tolerance, the optimal ethanol disinfection concentration is 75%, but when the ethanol content is too high, the alcohol disinfectant has strong pungent smell and is difficult to be accepted by consumers. The ethanol content of the existing hand-washing-free disinfectant is generally 55-65%, but the low-concentration ethanol has poor sterilization effect and needs to be compounded with other bactericides.
Therefore, the prior art has defects and needs to be improved and developed.
Disclosure of Invention
The invention aims to solve the technical problems that the no-clean hand sanitizer and the preparation method thereof are provided aiming at solving the problems that the no-clean hand sanitizer in the prior art has irritation to skin and poor sterilization effect.
The technical scheme adopted by the invention for solving the technical problem is as follows:
in a first aspect, a no-clean hand sanitizer comprises, by weight: 1-2% of diatom; 65-75% of ethanol; the balance being deionized water.
Optionally, the wash-free hand sanitizer further comprises: 0.003 to 0.325 percent of bactericide; 9-14% of a humectant; 2 to 4.8 percent of auxiliary agent.
Optionally, the no-clean hand sanitizer, wherein the bactericide is one or more selected from quaternary ammonium salt, methyl hydroxybenzoate and p-chloro-m-dimethylphenol.
Optionally, the leave-on hand sanitizer, wherein the moisturizer is selected from the group consisting of sodium hyaluronate, propylene glycol and glycerin.
Optionally, the leave-in hand sanitizer is a combination of one or more of aloe vera leaf juice, acrylic acid/C10-30 alkanol acrylate crosspolymer, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, disodium EDTA, and phenoxyethanol.
Optionally, the leave-on hand sanitizer, wherein the particle size of the diatom is 1-100 μm.
Optionally, the wash-free hand sanitizer has a pH of 6.0 to 8.0.
In a second aspect, a method for preparing a no-clean hand sanitizer as described above comprises: mixing diatom, ethanol and deionized water to obtain the no-clean hand sanitizer.
Optionally, the preparation method of the no-clean hand sanitizer comprises the following steps:
dispersing the diatom and the auxiliary agent in the deionized water, and standing overnight to obtain a solution A;
mixing the bactericide, the humectant and ethanol to obtain a solution B;
and mixing the liquid A and the liquid B, and adjusting the pH to 6.0-8.0 to obtain the no-clean hand sanitizer.
Optionally, the preparation method of the no-clean hand sanitizer comprises the following steps:
adding diatom, aloe barbadensis leaf juice and acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer into deionized water accounting for 35% of the total weight of the no-clean hand sanitizer, and standing overnight to obtain a solution A;
adding ethanol accounting for 30% of the washing-free hand sanitizer, and then adding p-chloro-m-dimethylphenol, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, EDTA disodium, phenoxyethanol and methyl hydroxybenzoate to obtain a solution B;
and adding the solution B into the solution A, adding the balance of ethanol, uniformly stirring, sequentially adding propylene glycol, glycerol, essence, triethanolamine, the balance of deionized water and a pH value regulator until the pH value is 6.0-8.0 to obtain the no-clean hand sanitizer.
Has the advantages that: according to the disposable hand sanitizer provided by the invention, the diatom is dispersed in the disposable hand sanitizer taking alcohol as a substrate, so that the antibacterial effect is cooperated, the trouble that the skin is dry and easy to crack after long-term use of alcohol can be avoided, the skin of the hands is moistened, and the hands are always kept wet.
Drawings
FIG. 1 is an electron micrograph of diatoms provided by an embodiment of the present invention;
FIG. 2 is a schematic diagram of bacteria capture by a porous silicon shell structure provided in an embodiment of the present invention;
fig. 3 is a comparative graph of the sterilization effect provided by the embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer and clearer, the present invention is further described in detail by referring to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the units indicating the content of the raw materials are all in parts by mass. Other raw materials and reagents not specifically mentioned in the present invention are those generally used in the art.
In the invention, the diatom is a precursor of diatomite/mud and petroleum, is a micron-sized unicellular plant, cannot be seen by naked eyes, but is a treasure. The diatom is used as a natural biological material, is rich in fatty acid (such as HTA, palmitoleic acid, stearic acid, remenic acid, EPA and the like), polar lipid (such as glycolipid and the like) and steroid (such as 24-methylenoholestrol and the like) with certain antibacterial property, has the functions of sterilization and antibiosis, and has great potential in the aspect of biological medicine. Natural diatoms contain one third of frustules, one third of diatomic lipids and one third of diatomic proteins.
Referring to fig. 1, the diatom may be diatom extract, and the diatom extract is obtained by separating natural diatom from water and sintering to obtain diatom shells, wherein the outer layer of the diatom shells is siliceous and the inner layer is pectic substance. The silicon casing component is amorphous silicon dioxide, and the silicon casing has the advantages of various shapes, unique structure, uniform pore system, no color, transparency, strong adsorbability, compatibility with a silicon processing technology and the like. The diatom siliceous materials of different species have different shapes, including circular, oval, rectangular, kidney-shaped, triangular, needle-shaped, rhombic and other shapes, and the surfaces of the diatom siliceous materials are provided with micropores which are regularly arranged, so that the diatom siliceous materials have a strong adsorption function.
Illustratively, the particle size of the diatoms used in the formulation may be 1 μm to 5 μm, 5 μm to 10 μm, 10 μm to 20 μm, 20 μm to 30 μm, 30 μm to 40 μm, 40 μm to 50 μm, 50 μm to 60 μm, 60 μm to 70 μm, 70 μm to 80 μm, 80 μm to 90 μm, 90 μm to 100 μm. The proportion of addition may be 1-2%.
In the invention, the methylparaben is also called methylparaben, and can be compatible with other components in a formula of the no-clean hand sanitizer, such as diatom, ethanol and deionized water, so that the effects of sterilization and corrosion prevention can be achieved. The p-chloro-m-dimethylphenol (PCMX) and the 4-chloro-3, 5-dimethylphenol have good stability under common storage conditions, cannot be inactivated, and have good killing effects on gram-positive and gram-negative bacteria and mold.
In the invention, the ALOE vera (ALOE BARBADENSIS) leaf juice, namely the ALOE vera leaf juice, has the effects of resisting bacteria, diminishing inflammation and preserving moisture.
Acrylic acid/C10-30 alkanol acrylate crosspolymers were used as thickeners. The PEG-40 hydrogenated castor oil has skin moisturizing effect, and can uniformly disperse oily substances in the formula in deionized water.
The non-ionic emulsifier nonyl phenol polyether-10, NONOXYNOL-10, is miscible with water at any ratio, and can well mix oily substances in the no-clean hand sanitizer with deionized water.
PEG-6 caprylic/capric glycerides are hydrophilic emollient esters, and play a role in locking lipid components in the no-wash hand sanitizer and improving the softness of skin.
Phenoxyethanol belongs to aromatic ether alcohol, namely ethylene glycol monophenyl ether and phenyl cellosolve (2-phenoxyethaneol), and has a molecular formula C8H10O2Phenoxyethanol is colorless slightly viscous oily liquid, slightly fragrant, astringent, slightly soluble in water, basically insoluble in mineral oil, and can be mixed with acetone, ethanol and ethanolThe glycerin is mixed arbitrarily. Has broad antibacterial activity as antiseptic, is effective against various gram-negative and gram-positive bacteria and yeast, and has weak inhibitory effect on skin indigenous flora.
In the embodiment, diatom with biological activity is dispersed in ethanol, and ethanol is used as a main bactericide for sterilization, so that the biological activity of the diatom is used for avoiding the damage of the ethanol to the skin, namely, the diatom can effectively sterilize and protect the skin. Meanwhile, the problems that carbomer contained in the formula is very sticky after being used, cannot be dried quickly, feels dirtier and is high in production cost are solved.
Based on the same inventive concept, the invention also provides a preparation method of the no-clean hand sanitizer, which comprises the following steps: mixing diatom, ethanol and deionized water to obtain the no-clean hand sanitizer.
Specifically, diatom, ethanol and deionized water are weighed according to the proportion, and the diatom and the ethanol are added into the deionized water under the condition of stirring. The proportion of the diatom can be 1% and 2%, the proportion of the ethanol can be 65%, 70% and 75%, and the balance is deionized water. The diatom is pretreated diatom, the pretreatment is sintering, the pore structure of the kieselguhr can be guaranteed to be dredged through sintering, and most of the pore structures of the kieselguhr are not communicated. After pretreatment, the dredging of the pore structure of the diatom is ensured, the good adsorption performance of the diatom can be better kept, and when the wash-free hand sanitizer is used, bacteria are adsorbed and adsorbed in the gaps (as shown in figure 2), so that the physical sterilization effect is realized.
In this embodiment, the no-clean hand sanitizer further includes an auxiliary bactericide such as methyl hydroxybenzoate, p-chloroxylenol, and a quaternary ammonium salt bactericide, wherein the quaternary ammonium salt is also called quaternary ammonium salt, and is a compound generated by replacing four hydrogen atoms in ammonium ions with hydroxyl groups, and has a general formula of R4NX, and the quaternary ammonium salt has similar properties to inorganic salts, is easily soluble in water, and is conductive in aqueous solution. The quaternary ammonium salt has a sterilization function and is used as a disinfectant, and the sterilization principle is as follows: quaternary ammonium salt dissociates quaternary ammonium cation in water, the cell wall of the bacteria surface has negative charge, the positive charge in the quaternary ammonium salt molecule has strong adsorption effect on the bacteria, and the positive charge penetrates the surface of the bacteria and enters the cell membrane through the functions of penetration and diffusion, so that cell damage and cell internal metabolite coenzyme leakage are caused, the semi-penetration effect of the cell membrane is hindered, the cell membrane further penetrates the inside of the cell, the cell enzyme is passivated, the protease cannot be generated, the protein is denatured, and the purpose of killing the bacteria cell is achieved.
Illustratively, the quaternary ammonium salt is selected from one or more of didecyldimethyl ammonium chloride, didecyldimethyl ammonium bromide, benzalkonium chloride, benzalkonium bromide. It is to be understood that the quaternary ammonium salt may be a single type of quaternary ammonium salt or a mixture of several types of quaternary ammonium salts.
Moisturizing emollient such as propylene glycol, glycerin, ALOE BARBADENSIS (ALOE BARBADENSIS) leaf juice, thickening agent such as acrylic acid/C10-30 alkanol acrylate crosspolymer, pH adjusting agent such as triethanolamine, cosolvent such as PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, preservative such as phenoxyethanol, and chelating agent such as disodium EDTA, etc.
The hand-washing-free liquid soap provided by the invention is further explained by specific preparation examples.
Example 1
Weighing 1g of diatom, 65g of ethanol and 34g of deionized water, and uniformly stirring and mixing to obtain the no-clean hand sanitizer, wherein the particle size of the diatom is 1-5 microns.
Example 2
Weighing 10g of diatom and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, uniformly stirring, and standing overnight to obtain solution A, wherein the particle size of the diatom is 1-5 microns;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and sealing and storing for later use.
And pouring the solution B into the solution A, adding 455g of ethanol, stirring uniformly, and then sequentially adding 10g of propylene glycol, the rest of water and a pH value regulator until the pH value is 6.0 to obtain the no-clean hand sanitizer.
Example 3
Weighing 10g of diatom, 10g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 1-5 μm;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and hermetically storing for later use.
And pouring the liquid B into the liquid A, adding 455g of ethanol, stirring uniformly, and then sequentially adding 10g of propylene glycol, 80g of glycerol, 1.5g of triethanolamine, the rest water and a pH value regulator until the pH value is 6.0 to obtain the no-clean hand sanitizer.
Example 4
Weighing 10g of diatom, 10g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 1-5 μm;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 2.0g of nonylphenol polyether-10, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and sealing and storing for later use.
And pouring the liquid B into the liquid A, adding 455g of ethanol, uniformly stirring, and sequentially adding 10g of propylene glycol, 80g of glycerol, 1.5g of essence, 1.5g of triethanolamine, residual water and a pH value regulator until the pH value is 6.0 to obtain the no-clean hand sanitizer.
Example 5
Weighing 15g of diatom, 15g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 5-10 μm;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 2.0g of nonylphenol polyether-10, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and sealing and storing for later use.
And pouring the liquid B into the liquid A, adding 455g of ethanol, uniformly stirring, and sequentially adding 10g of propylene glycol, 80g of glycerol, 1.5g of essence, 1.5g of triethanolamine, residual water and a pH value regulator until the pH value is 7.0 to obtain the no-clean hand sanitizer.
Example 6
Weighing 15g of diatom, 15g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 5-10 μm;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 2.0g of nonylphenol polyether-10, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and sealing and storing for later use.
And pouring the liquid B into the liquid A, adding 455g of ethanol, uniformly stirring, and sequentially adding 10g of propylene glycol, 80g of glycerol, 1.5g of essence, 1.5g of triethanolamine, residual water and a pH value regulator until the pH value is 8.0 to obtain the no-clean hand sanitizer.
Example 7
Weighing 10g of diatom, 10g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 1-5 μm;
adding 225g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 2.0g of nonylphenol polyether-10, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare a solution B, and sealing and storing for later use.
And pouring the liquid B into the liquid A, adding 525g of ethanol, stirring uniformly, and then sequentially adding 10g of propylene glycol, 1.5g of essence, 1.5g of triethanolamine, residual water and a pH value regulator until the pH value is 6.0 to obtain the no-clean hand sanitizer.
Example 8
Weighing 15g of diatom, 15g of aloe barbadensis leaf juice and 10g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, adding into 350g of deionized water, stirring uniformly, and standing overnight to obtain solution A, wherein the particle size of diatom is 100 μm;
adding 195g of ethanol, 0.75g of chloro-m-dimethylphenol, 1.5g of PEG-40 hydrogenated castor oil, 2.0g of nonylphenol polyether-10, 1.5g of PEG-6 caprylic/capric glycerides, 1.5g of disodium EDTA, 10g of phenoxyethanol and 2.5g of methylparaben into the solution A, mixing and dissolving until the solution is clear to prepare solution B, and sealing and storing for later use.
And pouring the liquid B into the liquid A, adding 455g of ethanol, uniformly stirring, and sequentially adding 10g of propylene glycol, 80g of glycerol, 1.5g of essence, 1.5g of triethanolamine, residual water and a pH value regulator until the pH value is 6.0 to obtain the no-clean hand sanitizer.
The experiment of the sterilization comparison text by using the no-clean hand sanitizer prepared in the embodiment 3 shows that the experimental result is shown in fig. 3, and the best sterilization effect of the no-clean hand sanitizer prepared in the embodiment of the invention can reach 100%.
In summary, the invention discloses a no-clean hand sanitizer and a preparation method thereof, wherein the no-clean hand sanitizer comprises the following components in percentage by weight: 1-2% of diatom; 65-75% of ethanol; 0.003 to 0.325 percent of bactericide; 9-14% of a humectant; 2-4.8% of auxiliary agent and the balance of deionized water. Wherein the bactericide is selected from one or two of methyl hydroxybenzoate and p-chloro-m-dimethylphenol; the humectant is selected from one or more of sodium hyaluronate, propylene glycol and glycerin; the auxiliary agent is selected from one or more of aloe vera leaf juice, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, disodium EDTA and phenoxyethanol.
The washing-free hand sanitizer provided by the invention can effectively capture bacteria by adding the diatom extract and containing the porous silica shell structure, so that the bacteria are trapped in pores, and the effects of bacteriostasis and sterilization are achieved. Meanwhile, the diatom contains rich natural high-quality protein, so that the hydrogel has a stable structure, can effectively care the skin of hands, is not sticky, has comfortable smell and the like, particularly avoids the damage of alcohol to the skin without washing, and does not hurt hands after long-term use.
It is to be understood that the invention is not limited to the examples described above, but that modifications and variations may be effected thereto by those of ordinary skill in the art in light of the foregoing description, and that all such modifications and variations are intended to be within the scope of the invention as defined by the appended claims.
Claims (10)
1. The no-clean hand sanitizer is characterized by comprising the following components in percentage by weight: 1-2% of diatom; 65-75% of ethanol; the balance being deionized water.
2. The leave-in hand sanitizer according to claim 1, further comprising: 0.003 to 0.325 percent of bactericide; 9-14% of a humectant; 2 to 4.8 percent of auxiliary agent.
3. The leave-on hand sanitizer according to claim 2, wherein said bactericide is selected from the group consisting of one or more of methylparaben, p-chloroxylenol, and quaternary ammonium salts.
4. The leave-on hand sanitizer according to claim 2, wherein said humectant is selected from the group consisting of sodium hyaluronate, propylene glycol and glycerin, in combination, or a combination thereof.
5. The leave-in hand sanitizer according to claim 2, wherein said builder is selected from the group consisting of aloe vera leaf juice, acrylic/C10-30 alkanol acrylate crosspolymer, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, disodium EDTA, and phenoxyethanol in combination with one or more.
6. The leave-in hand sanitizer according to claim 1, wherein the diatoms have a particle size of from 1 to 100 μm.
7. A hands-free solution according to any of claims 1 to 6, wherein the pH of the solution is from 6.0 to 8.0.
8. A method of preparing a leave-in hand sanitizer according to claim 1 comprising: mixing diatom, ethanol and deionized water to obtain the no-clean hand sanitizer.
9. A method of preparing a leave-in hand sanitizer according to claim 8 comprising:
dispersing the diatom and the auxiliary agent in the deionized water, and standing overnight to obtain a solution A;
mixing the bactericide, the humectant and ethanol to obtain a solution B;
and mixing the liquid A and the liquid B, and adjusting the pH to 6.0-8.0 to obtain the no-clean hand sanitizer.
10. A method of preparing a leave-in hand sanitizer according to claim 9 comprising:
adding diatom, aloe barbadensis leaf juice and acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer into deionized water accounting for 35% of the total weight of the no-clean hand sanitizer, and standing overnight to obtain a solution A;
adding ethanol accounting for 30% of the washing-free hand sanitizer, and then adding p-chloro-m-dimethylphenol, PEG-40 hydrogenated castor oil, nonylphenol polyether-10, PEG-6 caprylic/capric glycerides, EDTA disodium, phenoxyethanol and methyl hydroxybenzoate to obtain a solution B;
and adding the solution B into the solution A, adding the balance of ethanol, uniformly stirring, sequentially adding propylene glycol, glycerol, essence, triethanolamine, the balance of deionized water and a pH value regulator until the pH value is 6.0-8.0 to obtain the no-clean hand sanitizer.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
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| CN107349139A (en) * | 2017-08-31 | 2017-11-17 | 白山市和硅藻科技有限公司 | A kind of diatomite hand cleanser and preparation method thereof |
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| CN1334719A (en) * | 1998-11-23 | 2002-02-06 | 宝洁公司 | Skin deodorizing and sanitizing compositions |
| CN107349139A (en) * | 2017-08-31 | 2017-11-17 | 白山市和硅藻科技有限公司 | A kind of diatomite hand cleanser and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
| CN116898742B (en) * | 2023-09-13 | 2023-12-22 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
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