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CN113490493A - 治疗脂肪性肝病和/或脂肪性肝炎的方法 - Google Patents

治疗脂肪性肝病和/或脂肪性肝炎的方法 Download PDF

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CN113490493A
CN113490493A CN202080017129.7A CN202080017129A CN113490493A CN 113490493 A CN113490493 A CN 113490493A CN 202080017129 A CN202080017129 A CN 202080017129A CN 113490493 A CN113490493 A CN 113490493A
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CN113490493B (zh
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姜媛媛
仲伟婷
赵焰平
王红军
赵静
李晶
刘伟娜
周丽莹
刘亚男
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Beijing Tide Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/415—1,2-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN202080017129.7A 2019-03-01 2020-02-26 治疗脂肪性肝病和/或脂肪性肝炎的方法 Active CN113490493B (zh)

Applications Claiming Priority (3)

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CN2019076688 2019-03-01
CNPCT/CN2019/076688 2019-03-01
PCT/CN2020/076723 WO2020177587A1 (zh) 2019-03-01 2020-02-26 治疗脂肪性肝病和/或脂肪性肝炎的方法

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US (1) US20220378743A1 (zh)
EP (1) EP3932404A4 (zh)
JP (1) JP7565292B2 (zh)
KR (1) KR20210137086A (zh)
CN (1) CN113490493B (zh)
AU (1) AU2020230574A1 (zh)
BR (1) BR112021017354A2 (zh)
CA (1) CA3132228A1 (zh)
IL (1) IL285989A (zh)
WO (1) WO2020177587A1 (zh)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
AU2021332886A1 (en) * 2020-08-31 2023-05-11 Beijing Tide Pharmaceutical Co., Ltd. Salt of rho-associated protein kinase inhibitor, solid form of the salt, preparation method for same, and uses thereof
CN113135900B (zh) * 2021-03-12 2022-05-24 中山大学 吲哚嘧啶类化合物及其合成方法和应用
JP2024533528A (ja) * 2021-09-18 2024-09-12 ベイジン タイド ファーマシューティカル カンパニー リミテッド Ｒｈｏ関連タンパク質キナーゼ阻害剤の固体形態又はその溶媒和物、調製方法及びその使用
IL312855A (en) * 2021-11-16 2024-07-01 Beijing Tide Pharmaceutical Co Ltd ROCK2 inhibitor nanocrystalline preparation and method for its preparation
US20240109868A1 (en) * 2022-08-29 2024-04-04 Miracure Biotechnology Limited Ep300/cbp modulator, preparation method therefor and use thereof

Citations (2)

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WO2019001572A1 (zh) * 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho 相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
WO2019000682A1 (zh) * 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途

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WO2012040499A2 (en) * 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
WO2016004254A1 (en) * 2014-07-01 2016-01-07 The Regents Of The University Of California Combined modulation of ire1

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2019001572A1 (zh) * 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho 相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
WO2019000682A1 (zh) * 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途

Non-Patent Citations (1)

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Title
HU HUANG等: "Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 128, no. 12, pages 5334 - 5350 *

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KR20210137086A (ko) 2021-11-17
JP7565292B2 (ja) 2024-10-10
CN113490493B (zh) 2024-10-29
WO2020177587A1 (zh) 2020-09-10
TW202045497A (zh) 2020-12-16
CA3132228A1 (en) 2020-09-10
EP3932404A4 (en) 2022-11-30
IL285989A (en) 2021-10-31
AU2020230574A1 (en) 2021-10-28
BR112021017354A2 (pt) 2021-11-16
US20220378743A1 (en) 2022-12-01
JP2022522486A (ja) 2022-04-19
EP3932404A1 (en) 2022-01-05

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