CN113355229A - Temperature control sliding table based on chip detection - Google Patents
Temperature control sliding table based on chip detection Download PDFInfo
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- CN113355229A CN113355229A CN202110760990.9A CN202110760990A CN113355229A CN 113355229 A CN113355229 A CN 113355229A CN 202110760990 A CN202110760990 A CN 202110760990A CN 113355229 A CN113355229 A CN 113355229A
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- 238000001514 detection method Methods 0.000 title claims abstract description 112
- 230000007246 mechanism Effects 0.000 claims abstract description 72
- 238000010438 heat treatment Methods 0.000 claims description 42
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- 238000000034 method Methods 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 11
- 230000017525 heat dissipation Effects 0.000 description 19
- 239000011159 matrix material Substances 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 9
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- 125000006850 spacer group Chemical group 0.000 description 7
- 238000005057 refrigeration Methods 0.000 description 6
- 230000003321 amplification Effects 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 230000008878 coupling Effects 0.000 description 4
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- 238000007789 sealing Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
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- 238000006073 displacement reaction Methods 0.000 description 1
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- 238000012806 monitoring device Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
The invention relates to a temperature control sliding table based on chip detection, which comprises a driving mechanism, a connecting shaft, a screw rod and a temperature control module, wherein the temperature control module comprises a temperature control adapter plate and a temperature control device, one end of the connecting shaft is connected with an output shaft of the driving mechanism, the other end of the connecting shaft is connected with the screw rod, the temperature control module is arranged on the screw rod, a chip to be detected is arranged on the temperature control adapter plate, the temperature control device is arranged below the temperature control adapter plate, the driving mechanism drives the screw rod to rotate through the connecting shaft, and then the temperature control module arranged on the screw rod is driven, so that the chip to be detected on the temperature control module moves to a preset position. The real-time position of the temperature control module is detected, the stepping motor is controlled through the control mechanism according to the actual distance between the real-time position and the preset position, and the driving mechanism is used for driving the temperature control module to move to the preset position.
Description
Technical Field
The invention relates to the field of nucleic acid detection, in particular to a temperature control sliding table based on chip detection.
Background
In nucleic acid detection, an equipment for nucleic acid detection, including carousel, filtering mechanism, supporting platform, collimation light source mechanism, processing unit and image acquisition mechanism, wherein, the carousel is provided with the revolving stage along the level to setting up, its downside, and the carousel is rotatory on the revolving stage, and the revolving stage is connected with step motor, and it is rotatory through step motor drive carousel, promptly, rotates through step motor drive revolving stage, and the revolving stage drives the carousel rotation, and the carousel downside is placed and is waited to detect the chip.
The collimating light source mechanism is arranged along the horizontal direction and connected with the middle part of the supporting platform, the collimating light source mechanism is positioned right above the middle part of the turntable, and the collimating light source mechanism is used for emitting exciting light beams. The image acquisition mechanism is arranged along the vertical direction and is connected with the upper end of the supporting platform in a sliding way. The light filtering mechanism is arranged on the upper side surface of the turntable, a plurality of light filtering mechanisms are annularly arranged along the circumferential direction of the upper side surface of the turntable, the collimated light source mechanism and the image acquisition mechanism are vertically intersected with the light filtering mechanism, and the light filtering mechanism, the image acquisition mechanism and the central axis of the chip to be detected are superposed; the light filtering mechanism is used for reflecting light with required preset wavelength to the chip to be detected at the lower end after the exciting light beam of the collimation light source mechanism passes through, and transmitting the fluorescence emitted by the chip to be detected to the image acquisition mechanism at the upper end; the image acquisition mechanism is used for acquiring image data of the chip to be detected. The processing unit is electrically connected with the image acquisition mechanism and used for receiving the image data and outputting a detection result of the chip to be detected according to the image data.
According to the analysis, when nucleic acid detection is carried out, the chip to be detected needs to be arranged at a preset position, namely the light filtering mechanism, the image acquisition mechanism and the position where the central axes of the chip to be detected coincide, but when nucleic acid detection is not carried out, the chip to be detected needs to be arranged in the chip groove, then the chip groove is moved to the preset position to be detected, the chip to be detected is usually moved in a manual mode, the chip to be detected is manually moved to the preset position, and the determined position precision is low.
Disclosure of Invention
Therefore, the invention provides a temperature control sliding table based on chip detection, which can automatically feed a solid gene chip and automatically heat the chip.
In order to achieve the above object, the present invention provides a temperature controlled sliding table based on chip detection, including: actuating mechanism, connecting axle, lead screw and temperature control module, temperature control module includes control by temperature change keysets and temperature control unit, the one end of connecting axle is connected actuating mechanism's output shaft, the other end is connected the lead screw, temperature control module sets up on the lead screw, it is in to wait to detect the chip setting on the control by temperature change keysets, temperature control unit arranges in the below of control by temperature change keysets, actuating mechanism passes through the connecting axle drives the lead screw rotates, and then drives and set up control by temperature change module on the lead screw, so that it removes to predetermine the position to wait to detect the chip on the temperature control module.
Further, the temperature control sliding table based on chip detection further comprises a temperature control module connecting piece, wherein the temperature control module connecting piece comprises an object stage and a longitudinal connecting piece; the utility model discloses a vertical connecting piece, including the lead screw, control by temperature change module, objective table, slide, longitudinal connecting piece, temperature control module, the lead screw is connected with the lead screw, temperature control module sets up on the objective table, the top of longitudinal connecting piece with objective table fixed connection, the outside of lead screw still is provided with a supporting bench, be provided with the slide on the supporting bench, the lower surface of objective table be provided with slide complex slide rail, longitudinal connecting piece drives the objective table is in remove in the slide.
Furthermore, the lower end of the support table is also provided with a running stop mechanism for preventing the temperature control module from being separated from the screw rod in the moving process.
Further, the driving mechanism comprises a stepping motor and a control circuit, a temperature sensor is arranged below the chip to be detected, the control circuit is respectively connected with the stepping motor and the temperature control device, the stepping motor is connected with the connecting shaft, the control circuit is used for controlling the stepping motor, when the temperature control module is located at a non-preset position, the control circuit controls the stepping motor to move to a first position in an accelerating mode, the first position is 5-10mm away from the preset position, and then the control circuit controls the stepping motor to move to the preset position slowly.
Further, this control by temperature change slip table based on chip detects still including first heating circuit and second heating circuit, first heating circuit with second heating circuit respectively with the temperature control module is connected, first heating circuit is used for with temperature control device heats to first temperature, second heating circuit is used for with temperature control device heats to operating temperature, first temperature with operating temperature differs 1-5 degrees, works as temperature control module is in not predetermine the position to when the first position removes, starts first heating circuit will temperature control device heats to first temperature, works as temperature control module by the first position to when predetermineeing the position and remove, start second heating circuit, will temperature control device heats to operating temperature.
Furthermore, a through hole and a connecting bulge are arranged on the temperature control adapter plate, the through hole is used for accommodating a chip to be detected, the connecting bulge is arranged at one end of the temperature control adapter plate, the connecting bulge is provided with a connecting hole, and the other end of the temperature control adapter plate is provided with a lock hole; the temperature control module further comprises a chip pressing device, one end of the chip pressing device is provided with a connecting lug, the connecting lug is matched with a connecting hole in the connecting protrusion to realize the movable connection of the temperature control connecting plate and the chip pressing device, the other end of the chip pressing device is provided with a spring bolt, and the lock hole is connected with the spring bolt to lock the temperature control connecting plate and the chip pressing device.
Further, this control by temperature change slip table based on chip detects still includes the chip spacer, the chip spacer sets up in the through-hole, it arranges in to wait to detect the chip on the preset position of chip spacer.
Furthermore, an elastic bulge is arranged on the inner wall of the lock hole, a barb is arranged on the lock tongue, and the barb is hooked with the elastic bulge.
Further, this control by temperature change slip table based on chip detects still includes the shell, the shell sets up the outside of connecting axle.
Furthermore, the temperature control adapter plate and the chip pressing device are both square.
Compared with the prior art, the temperature control module has the advantages that the real-time position of the temperature control module is detected, the stepping motor is controlled through the control mechanism according to the actual distance between the real-time position and the preset position, and the driving mechanism is used for driving the temperature control module to move to the preset position.
Further, through increasing the accurate control procedure to temperature control device, owing to adopt step motor, the mode through accurate control can be realized, accelerates the rotational speed through control circuit control step motor and makes temperature control device move to the primary importance with higher speed, when temperature control module is about to reach the preset position, in order to guarantee to fix a position accurately, carries out the deceleration to temperature control device to press close gradually and preset the position.
Drawings
Fig. 1 is a schematic cross-sectional structure diagram of a temperature control slide table based on chip detection according to an embodiment of the present invention;
fig. 2 is a schematic top view of a temperature control slide table based on chip detection according to an embodiment of the present invention;
fig. 3 is a schematic perspective view of a temperature control slide table based on chip detection according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a temperature control module in a temperature control slide table based on chip detection according to an embodiment of the present invention;
fig. 5 is a schematic view of an explosion structure of a temperature control module in a temperature control slide table based on chip detection according to an embodiment of the present invention.
Detailed Description
In order that the objects and advantages of the invention will be more clearly understood, the invention is further described below with reference to examples; it should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only for explaining the technical principle of the present invention, and do not limit the scope of the present invention.
It should be noted that in the description of the present invention, the terms of direction or positional relationship indicated by the terms "upper", "lower", "left", "right", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, which are only for convenience of description, and do not indicate or imply that the device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Referring to fig. 1-3, a temperature-controlled slide table based on chip detection according to an embodiment of the present invention is applied to nucleic acid detection, where a sample in a chip to be detected performs a fluorescence reaction under irradiation of excitation light, and nucleic acid information of the sample is obtained according to the fluorescence reaction. The temperature control sliding table based on chip detection provided by the embodiment of the invention comprises a driving mechanism 100, a connecting shaft 200, a screw rod 300 and a temperature control module 400, wherein the temperature control module 400 comprises a temperature control adapter plate 401 and a temperature control device 402, one end of the connecting shaft 200 is connected with an output shaft of the driving mechanism 100, the other end of the connecting shaft is connected with the screw rod 300, the temperature control module 400 is arranged on the screw rod 300, a chip 500 to be detected is arranged on the temperature control adapter plate 401, the temperature control device 402 is arranged below the temperature control adapter plate 401, the driving mechanism 100 drives the screw rod 300 to rotate through the connecting shaft 200, and then the temperature control module 400 arranged on the screw rod 300 is driven, so that the chip 500 to be detected on the temperature control module 400 moves to a preset position.
Specifically, the driving mechanism 100 may include a stepping motor, the stepping motor is used to rotate to drive a connecting shaft 200 connected thereto, the connecting shaft 200 drives a lead screw 300 to rotate, the power output of the stepping motor is sequentially transmitted to drive a temperature control module 400, the temperature control module 400 and the lead screw 300 are screwed, the connecting shaft 200 is respectively fixedly connected with the output shaft of the stepping motor and the lead screw 300 to transmit the power output, when the lead screw 300 rotates around the central shaft thereof, under the effect of the external thread of the screw 300 and the internal thread of the temperature control module 400, the temperature control module 400 moves along the screw 300, the chip 500 to be detected is arranged in the temperature control module 400, the movement of the chip 500 to be detected is realized, the stepping motor can calculate the revolution number of the stepping motor according to the distance between the actual position and the preset position, the corresponding revolution number is further determined, and the chip 500 to be detected is moved to the preset position. The driving mechanism may further include a control mechanism for controlling the stepping motor to rotate, stop, perform calculations, and the like, so as to precisely control the temperature control module 400, so that the temperature control module 400 moves to a specified position along the lead screw 300, and perform subsequent nucleic acid reactions and detections.
According to the temperature control sliding table based on chip detection provided by the embodiment of the invention, the real-time position of the temperature control module is detected, the stepping motor is controlled through the control mechanism according to the actual distance between the real-time position and the preset position, and the driving mechanism is used for driving the temperature control module to move to the preset position.
As can be understood by those skilled in the art, a chip to be detected is disposed in the temperature control module 400, and in the practical application process, the temperature control module 400 moves to the preset position, and actually the chip to be detected moves to the preset position, and since the relative positions of the temperature control module 400 and the chip to be detected 500 are fixed, the chip to be detected 500 also reaches the preset position when the temperature control module 400 moves to the preset position. In the experiment of nucleic acid detection, the predetermined position of the chip 500 to be detected is just below the filter mechanism. When the chip 500 to be detected is moved to a predetermined position, the related nucleic acid detection is performed. It can be understood by those skilled in the art that, during the nucleic acid amplification reaction, the temperature control device in the temperature control module 400 needs to be heated, during the actual operation, the heating can be started during the movement of the temperature control module 400 to the preset position, and when the temperature control module moves to the preset position, the temperature of the chip to be detected reaches the reaction temperature, so that the amplification reaction can be directly performed, the detection time is shortened, and the chip detection efficiency is improved.
Specifically, as an alternative embodiment, the chip 500 to be detected is placed in the temperature control module 400 at a non-preset position, then the step motor needs to control the chip 500 to be detected in the temperature control module to move horizontally to the preset position under the action of the control circuit, the driving mechanism includes a step motor and a control circuit, a temperature sensor is disposed below the chip 500 to be detected, the control circuit is connected to the step motor for controlling the rotation speed and the switch of the step motor, the control circuit is further connected to a temperature control device for controlling and changing the real-time temperature of the chip to be detected, the temperature sensor is used for sensing the real-time temperature of the chip to be detected, when the temperature control module is at the non-preset position, the control circuit controls the step motor to move to a first position at an accelerated speed, the first position is 5-10mm away from the preset position, and then the control circuit controls the stepping motor to slowly move to a preset position.
In the temperature control sliding table based on chip detection provided by the embodiment of the invention, by adding an accurate control program to the temperature control device, the temperature control sliding table can be realized in an accurate control mode by adopting the stepping motor, the stepping motor is controlled by the control circuit to accelerate the rotating speed so as to accelerate the temperature control device to move to the first position, and when the temperature control module is about to reach the preset position, the speed of the temperature control device is reduced and the temperature control device is gradually close to the preset position in order to ensure accurate positioning. The first position sets up near presetting the position, and specific distance can be 5mm, can also be 10mm, can also be 7 or 8mm, moves to presetting the position through accelerateing to be close to behind the first position deceleration again, and cooperation step motor can shorten temperature control device and move the accurate control of in-process, shortens temperature control device and moves to presetting the time of position, shortens check-out time.
On the basis of above-mentioned embodiment, treat that to detect the chip and carry out temperature control's temperature control device includes the heating plate, the refrigeration piece, fin and refrigeration fan, control by temperature change keysets 401 sets up in temperature control device's top, the heating plate, the refrigeration piece, fin and refrigeration fan set gradually the downside at control by temperature change keysets 401, the heating plate is used for waiting to detect on the control by temperature change keysets to heat the chip, the heating plate is the better sheetmetal of heat conductivility, the refrigeration piece is used for treating and detects the chip and cools down, the fin is used for carrying out timely heat dissipation to temperature control device, the refrigeration fan is used for carrying out outside timely discharge temperature control device to the heat that gives off. In the embodiment of the present invention, the heating sheet is further connected to a first heating circuit and a second heating circuit, the first heating circuit and the second heating circuit are respectively connected to the temperature control module, the first heating circuit is configured to heat the temperature control device to a first temperature, the second heating circuit is configured to heat the temperature control device to a working temperature, a difference between the first temperature and the working temperature is 1-5 degrees, when the temperature control module is in a non-preset position and moves to the first position, the first heating circuit is started to heat the temperature control device to the first temperature, and when the temperature control module moves from the first position to the preset position, the second heating circuit is started to heat the temperature control device to the working temperature.
According to the temperature control sliding table based on chip detection provided by the embodiment of the invention, the copper drum position and the temperature are matched, so that the chip to be detected reaches the working temperature when reaching the preset position, and the chip to be detected can directly carry out the next amplification reaction when reaching the preset position, thus the heating time is saved, the whole experiment process is not wasted much time, the experiment process is more efficient, and the time is saved.
Specifically, the temperature control sliding table based on chip detection provided by the embodiment of the present invention further includes a temperature control module connector 600, where the temperature control module connector 600 includes an object stage 601 and a longitudinal connector 602; vertical connecting piece 602 with lead screw 300 is connected, temperature control module 400 sets up on the objective table 601, the top of vertical connecting piece 602 with objective table 601 fixed connection, the outside of lead screw 300 still is provided with a supporting bench 301, be provided with slide 302 on the supporting bench 301, the lower surface of objective table 601 be provided with slide 302 complex slide rail, vertical connecting piece 602 drives objective table 601 is in remove in the slide 302.
According to the temperature control sliding table based on chip detection provided by the embodiment of the invention, the temperature control device is arranged on the objective table 601 by arranging the temperature control module connecting piece 600, the objective table is of a planar platform structure, the longitudinal connecting piece 602 drives the objective table 601 to move in the slide way 302, and the slide way arranged on the lower surface of the objective table 601 is matched with the slide way 302 on the support table 301, so that the temperature control module slides on the screw rod, the resistance is reduced, the speed is increased or the movement is accelerated, and the temperature control sliding table moves along the slide way, so that the position deviation is not easy to occur, the position deviation in the moving process is reduced, and the stability of a chip to be detected is influenced.
The lower end of the support platform 301 is further provided with a running-stopping mechanism for preventing the temperature control module 400 from being separated from the screw rod 300 in the moving process. Those skilled in the art can understand that a plurality of travel switches can be disposed at the lower end of the supporting platform 301, the travel stop structure can be a travel switch, so that the temperature control module 400 can only move back and forth on the screw rod, the travel stop switch is detachable, when the temperature control module needs to be detached from the screw rod, the travel stop switch can be detached, the temperature control module is detached from the screw rod by one end of the screw rod through the control of the stepping motor, the travel switches can be disposed at the two ends of the screw rod in practical application, the travel switches can respectively detect and control each position of the chip to be detected on the screw rod, and the chip structure can be stopped and adjusted at any time.
As shown in fig. 4 and 5, a through hole 4011 and a connecting protrusion 4012 are arranged on the temperature control adapter plate 401, the through hole 4011 is used for accommodating a chip 500 to be detected, the connecting protrusion 4012 is arranged at one end of the temperature control adapter plate 401, the connecting protrusion 4011 is provided with a connecting hole 4013, and the other end of the temperature control adapter plate 401 is provided with a locking hole 4014; temperature control module 400 still includes chip closing device 403, the one end of chip closing device 403 is provided with engaging lug 4031, engaging lug 4031 with connecting hole 4013 cooperation on connecting protrusion 4012 realizes temperature control connecting plate 401 with chip closing device 403's swing joint, chip closing device 403's the other end is provided with spring bolt 4032, lockhole 4014 with spring bolt 4032 connects, is used for the locking temperature control connecting plate 401 with chip closing device 403. The chip detection device further comprises a chip positioning sheet 404, wherein the chip positioning sheet 404 is arranged in the through hole 4011, and the chip 500 to be detected is arranged at a preset position of the chip positioning sheet 404. An elastic protrusion 4015 is arranged on the inner wall of the lock hole 4014, a barb 4033 is arranged on the lock tongue 4032, and the barb 4033 is hooked with the elastic protrusion 4015.
Specifically, the temperature control sliding table based on chip detection provided by the embodiment of the invention can be applied to a biochip detection device, the temperature control adapter plate 401 is a square plate with a certain thickness, the through hole 4011 is formed in the temperature control adapter plate 401, the through hole 4011 accommodates a chip to be detected, in order to further stabilize the chip to be detected in the through hole 4011, the temperature control sliding table based on chip detection provided by the embodiment of the invention can further comprise a chip positioning plate 404, the chip to be detected is placed on the chip positioning plate 404, and the chip positioning plate 404 can fix the position of the chip to be detected, so as to prevent the chip to be detected from moving in the through hole 4011. Those skilled in the art can understand that one end of the chip pressing device 403 is provided with a connecting lug 4031, and the connecting lug 4031 is matched with a connecting hole 4013 on a connecting bump 4012 to realize the movable connection between the temperature control connecting plate 1 and the chip pressing device 403.
Specifically, the connecting hole 4013 on the connecting protrusion 4012 is a circular hole, the connecting protrusion 4012 is a semi-cylinder, the circular hole is arranged in the axial direction of the semi-cylinder, and the connecting lug 4031 is provided with a corresponding structure which is connected with the connecting hole 4013 in a matched manner, so as to connect the connecting lug 4031 and the connecting hole 4013. A strain gauge (not shown in the figure) is arranged on a side plate of the chip pressing device, and the strain gauge is arranged to detect a stress change between the temperature control adapter plate 401 and the chip pressing device 403 after the chip pressing device 403 and the temperature control adapter plate 401 are pressed, but those skilled in the art can understand that the stress change between the temperature control adapter plate 401 and the chip pressing device 403 can reflect the tightness of the chip to be detected in the accommodating space, and can also know some physical defects of the temperature control adapter plate 401 and/or the chip pressing device 403.
According to the temperature control sliding table based on chip detection provided by the embodiment of the invention, the temperature control adapter plate and the chip pressing device are locked through the matched connection of the lock tongue and the lock hole, and the strain gauge is arranged on the side plate of the chip pressing device, so that the stress change between the temperature control adapter plate and the chip pressing device can be detected, the sealing condition between the temperature control adapter plate and the chip pressing device is further obtained, the influence of the environment on a chip to be detected is reduced under the condition that the sealing state is good, and the reaction time of amplification reaction is shortened.
The chip pressing device 403 in the temperature control sliding table based on chip detection provided by the embodiment of the invention comprises a chip pressing plate, a pressure spring and a chip pressing cover, wherein a strain gauge is arranged on a side plate of the chip pressing cover, the pressure spring is arranged between the chip pressing plate and the chip pressing cover, the chip pressing plate is arranged in the chip pressing cover, when the temperature control sliding table is used, the chip pressing cover is opened, a chip to be detected is aligned to a chip positioning plate 404, the chip pressing device is buckled, the chip pressing plate can be pressed close to the upper surface of the chip in the buckling process, the chip pressing plate is pressed to press the chip to be detected by the elastic force of the pressure spring, a soft connection effect is generated, the bottom of the chip to be detected is tightly connected with the temperature control device, meanwhile, all contact parts are made of plastic, and heat loss is reduced after the chip pressing device 403 is buckled.
According to the temperature control sliding table based on chip detection provided by the embodiment of the invention, the connection between the chip pressing device 403 and the temperature control adapter plate 401 is softer through the arrangement of the pressure spring, the impact of the chip pressing device 403 on the temperature control adapter plate 401 is reduced through the buffer action of the pressure spring in the pressing process, and the physical damage of the chip pressing device 403 and the temperature control adapter plate 401 is reduced.
It can be understood that if the environment of the chip to be detected is open, the temperature control of the chip becomes extremely difficult, and the progress of the amplification reaction is affected when the preset temperature standard is not reached later. Therefore, it is important to ensure that the environment of the chip to be detected is closed, in the embodiment of the present invention, the chip to be detected is arranged in the through hole of the temperature control adapter plate, the temperature control adapter plate and the chip pressing device are pressed to close the chip to be detected, and in the practical application process, the lower side of the temperature control adapter plate is the temperature control device, so that the pressing between the temperature control adapter plate and the chip pressing device is concerned by the embodiment of the present invention.
The temperature control sliding table based on chip detection provided by the embodiment of the invention further comprises a shell 201, wherein the shell 201 is arranged outside the connecting shaft 200. Because the connecting shaft 200 is driven by the stepping motor to rotate continuously, the rotating shaft may rotate at an accelerated speed or rotate at a uniform speed or rotate at a decelerated speed, in the rotating process, the rotating shaft can be protected by arranging the shell, the connecting shaft can be ensured to rotate smoothly, and the connecting shaft cannot be influenced by the external environment.
Specifically, the temperature control sliding table device based on chip detection comprises a supporting table 301, a sliding block, a temperature control module connecting piece 600, a driving mechanism 100, a temperature control module 400 and a control unit, wherein the supporting table 301 is arranged along the horizontal direction, and the lower side surface of the supporting table is connected with a bottom plate of the chip detection device.
Specifically, a coupling protrusion is provided on a lower edge of a side portion of the support table 301, the coupling protrusion is provided in a horizontal direction, and the coupling protrusion and the bottom plate are integrally connected by a bolt.
Specifically, a first end of the support stage 301 is provided with a first cavity and a second end of the support stage 301 is provided with a second cavity. The first cavity is a hollow structure arranged near the first end of the support table 301, and the first cavity is a square or L-shaped groove structure. The second cavity is a hollow structure disposed near the second end of the supporting platform 301, and is a receiving space for receiving components.
Specifically, the slider is provided inside the support base 301 and slides in the installation direction of the support base 301. Particularly, the slider sets up in first cavity, has seted up a plurality of slides that set up side by side on the interior bottom surface of first cavity, and the slide sets up along the direction that sets up of brace table 301, and the slider card is established in the slide, and the slider slides in first cavity along the direction that sets up of slide.
Specifically, a sliding plate is arranged on the upper side surface of the support platform 301, the sliding plate is arranged right above the first cavity, two sliding rails are arranged on the upper side surface of the sliding plate side by side, and the sliding rails are arranged along the arrangement direction of the support platform 301. The underside of the temperature control module connector 600 is slidably connected to the slide rail.
Specifically, the slider is a U type structure, and the slider sets up the slide under, and the slide card is established in the open end of slider. That is, an accommodating space is provided between the slide plate and the support platform 301, and the accommodating space is a first cavity. The temperature control module connecting piece 600 is arranged on the upper side of the first end of the supporting table 301 along the horizontal direction and is connected with the sliding block, and the temperature control module connecting piece 600 and the sliding block move synchronously.
Specifically, the two opposite edges of the lower side surface of the temperature control module connecting piece 600 are connected with the upper ends of the two edge plates at the opening end of the sliding block respectively, the temperature control module connecting piece 600 is connected with the sliding block through a first bolt, and the sliding plate is clamped between the temperature control module connecting piece 600 and the sliding block.
Specifically, the driving mechanism 100 is disposed at an end of the second end of the supporting platform 301, and is connected to the slider, and the driving mechanism 100 is configured to drive the slider to drive the temperature control module connecting member 600 to slide, that is, the driving mechanism 100 provides a driving force to drive the slider to slide in the first cavity.
Specifically, the driving mechanism 100 is electrically connected to a control mechanism of the chip monitoring apparatus, and the control mechanism of the chip monitoring apparatus is configured to supply power to the driving mechanism 100 and control the operation of the driving mechanism 100.
Specifically, the drive mechanism 100 includes a drive motor, a coupling, and a lead screw. Specifically, a driving motor is disposed at an end of the second end of the support stage 301, and the driving motor is preferably a servo motor. The driving motor and the temperature control module connecting member 600 are respectively disposed at two opposite ends of the supporting stage 301.
Specifically, the coupler is arranged in the second cavity along the horizontal direction, and the driving end of the driving motor is connected with one end of the coupler; the screw rod is arranged in the first cavity along the horizontal direction and is arranged between the slide way and the slide rail 214; the first end of the coupler is connected with a driving motor, the second end of the coupler is connected with a lead screw, and the driving motor drives the lead screw to rotate through the coupler; the slider is established on the lead screw, and the lead screw is used for driving the slider and slides in first cavity under driving motor's drive.
It can be seen that the driving mechanism 100 is arranged to automatically drive the chip to be detected to move to the position to be detected, so that the problems of low efficiency and inaccurate detection position when the chip is manually moved to the position to be detected are solved.
Specifically, the temperature control module 400 is connected with the temperature control module connecting member 600 and moves synchronously with the temperature control module connecting member 600, a chip to be detected is clamped in the temperature control module 400, and the temperature control module 400 is used for controlling the temperature change of the chip 3 to be detected; the through-hole has been seted up along vertical direction in the middle part of side on the temperature control module 400 to expose and set up and wait to detect the chip in its inside, actuating mechanism 100 drive slider slides in a supporting bench 301 is inside, and the slider passes through temperature control module connecting piece 600 and drives temperature control module 400 and slide to chip detection device's downside, so that chip detection device treats and detects the chip.
Specifically, one side of the temperature control module connector 600 close to the chip monitoring device is provided with a protrusion connecting plate, and the protrusion connecting plate is a protrusion structure arranged on the side wall of the temperature control module connector 600. The temperature control module 400 is coupled to the bump tab, and preferably, the temperature control module 400 is coupled to the bump tab by a second bolt.
Particularly, temperature control module 400 includes control by temperature change keysets 401, chip spacer 404, chip pressure strip 403 and chip gland, control by temperature change keysets 401's downside edge is connected with control by temperature change module connecting piece 600, and with control by temperature change module connecting piece 600 synchronous motion, control by temperature change keysets 401's middle part is seted up flutedly, chip spacer 404 card is established in the recess, the through-hole has been seted up at chip spacer 404 middle part, it passes through-hole and recess bottom surface contact to wait to detect the chip, control by temperature change keysets 401 is used for treating and detects the chip and heat, chip spacer 404 is used for treating and detects the chip and fix a position.
Specifically, the chip pressing plate 403 is disposed above the chip positioning plate 404, the lower side surface of the chip pressing plate 403 contacts with the chip to be detected, and the chip card to be detected is disposed between the chip positioning plate 404 and the chip pressing plate 403.
Specifically, the upper side of the chip pressing plate 403 is connected with the lower side of the chip pressing cover through a pressure spring, one side edge of the chip pressing cover is rotatably connected with the upper side of the temperature control adapter plate 401, the other side of the chip pressing cover is clamped with the temperature control adapter plate 401, and the chip pressing cover is used for arranging the chip card to be detected on the temperature control adapter plate 401; a first unthreaded hole is formed in the middle of the chip pressing plate 403, and a second unthreaded hole is formed in the middle of the chip pressing cover so as to expose the upper side surface of the chip to be detected.
Specifically, the middle part of the groove is provided with a light sensor, the through hole in the middle part of the chip positioning sheet 404 is arranged opposite to the first unthreaded hole and the second unthreaded hole in the middle parts of the chip pressing plate 403 and the chip pressing cover, and the light sensor is arranged opposite to the through hole, the first unthreaded hole and the second unthreaded hole and is exposed on the upper part of the chip pressing cover through the through hole, the first unthreaded hole and the second unthreaded hole.
Particularly, the light sensor is electrically connected with the control unit, and the light sensor is used for detecting whether to place in the groove and wait to detect the chip.
Specifically, an edge of the temperature control interposer 401 is connected to the temperature control module connector 600, preferably, the temperature control interposer 401 is connected to the temperature control module connector 600 by a second bolt.
Specifically, a resistance wire is arranged inside the temperature control adapter plate 401, and the resistance wire is used for heating the temperature control adapter plate 401 to adjust the temperature thereof.
Specifically, a protruding connecting portion is arranged on one side, close to the protruding connecting plate, of a groove of the temperature control adapter plate 401, a connecting hole is formed in the middle of the protruding connecting portion, a clamping groove is formed in one side, away from the protruding connecting plate, of the groove of the temperature control adapter plate 401, a concave portion is formed in the middle of one edge of the chip pressing cover, a buckle is arranged on the lower side of the middle of the other edge of the chip pressing cover, the protruding connecting portion and the concave portion are arranged oppositely, the protruding connecting portion and the concave portion are rotatably connected together through a connecting shaft, and the connecting shaft penetrates through the connecting hole; the clamping groove and the buckle are oppositely arranged and are connected in a clamping mode, so that the chip pressing cover is connected with the temperature control adapter plate in a clamping mode.
Particularly, be provided with micro-gap switch on the interior bottom surface of draw-in groove, micro-gap switch is connected with the control unit electricity, and micro-gap switch-on when draw-in groove and buckle are connected, and micro-gap switch disconnection when draw-in groove and buckle disconnection to can detect the state of opening and shutting of chip gland.
Specifically, the control unit is electrically connected to the driving mechanism 100 and the temperature control module 400, and is configured to obtain position information of the temperature control module 400 in real time, and output a position control instruction to the driving mechanism 100 to adjust the position of the temperature control module 400, so that the temperature control module 400 drives the chip to be detected to move to a preset detection position; the control unit is further configured to collect temperature information of the temperature control module 400 in real time, control the temperature of the temperature control module 400 in real time, and output a temperature control instruction to the temperature control module 400, so that the chip to be detected is within a preset detection temperature range.
It can be seen that, by setting the control unit to control the driving mechanism 100 and the temperature control module 400, and acquiring the position information of the temperature control module 400 and the temperature information of the temperature control module 400 in real time, by controlling the position of the temperature control module 400, it is determined that the chip to be detected is at the preset detection position, by controlling the temperature of the temperature control module 400, the chip to be detected is within the preset detection temperature range, and by controlling the driving mechanism 100 and the temperature control module 400 in real time, the chip to be detected can be detected within the preset temperature range, so as to improve the detection efficiency; meanwhile, the driving mechanism 100 and the temperature control module 400 are automatically controlled in real time, so that the position control accuracy and the temperature control efficiency of the chip to be detected are improved.
Specifically, the temperature control sliding table device further comprises a heat dissipation unit, the heat dissipation unit is arranged right below the temperature control module 400 and is in contact with the temperature control module 400, and the heat dissipation unit is used for dissipating heat of the temperature control module 400 so that the temperature of the temperature control module 400 is within a preset temperature range; the heat dissipation unit is electrically connected with the control module, and the control module is used for controlling the working state of the heat dissipation unit;
it can be seen that, this embodiment dispels the heat to temperature control module 400 through setting up the radiating element, can make to wait to detect the chip and be in predetermineeing detection temperature range, has not only guaranteed the accuracy of testing result, has still improved temperature control efficiency.
Specifically, a plurality of travel switches are uniformly arranged on the lower edge of the support table 301, which is far away from one side wall of the turntable, and the travel switches are arranged opposite to the slide block to detect and control the translation position of the slide block, so as to determine the translation position of the chip to be detected.
Specifically, a drag chain is disposed on one side of the support platform 301 close to the turntable, and the drag chain and the slider are connected together through a bolt.
Specifically, the control unit is a single chip microcomputer or a PLC.
It can be seen that by providing the support stage 301 and connecting it to the chip inspection device, to fix the support stage 301 to the base plate of the chip inspection device, a sliding block is arranged in the support platform 301, a temperature control module connecting piece 600 is arranged on the sliding block, a temperature control module 400 is arranged on the temperature control module connecting piece 600, a chip to be detected is clamped in the temperature control module 400, the driving mechanism 100 drives the slide block to drive the temperature control module 400 to move to a preset detection position of the chip detection device, and the chip to be detected is aligned with the image acquisition unit and the filtering mechanism of the chip detection device, so as to acquire the image information of the chip to be detected, detect the image information and simultaneously, when the chip to be detected is detected, the chip is heated to a preset working temperature through the temperature control module 400, so that image information of the chip in a working temperature environment can be collected and detected. It can be seen that the chip is heated by the temperature control module 400, the working temperature of the chip is simulated, and the microscopic examination of the chip is carried out, so that the detection efficiency of the chip can be improved, and the accuracy of the quality of the chip in the microscopic examination is greatly improved.
Specifically, the control unit includes a control module, a control matrix a (P, T) is set in the control module, where P is a position matrix of the temperature control module 400, and T is a temperature matrix of the temperature control module 400, and the control module is further configured to output a position control instruction and a temperature control instruction according to the control matrix a (P, T). The control module is used for setting the control matrix to control the displacement and heating operation of the temperature control sliding table device, so that the control efficiency can be greatly improved.
Specifically, the control module is further configured to set a position matrix P (P1, P2, p3... pn) of the temperature control module 400, and set a temperature matrix T (T1, T2, t3... tn) of the temperature control module 400, where P1, P2, p3... pn respectively represent different positions of the temperature control module 400, and T1, T2, t3... tn respectively represent different temperatures of the temperature control module 400. It can be understood that the temperature of the temperature control module 400 is the temperature of the chip to be detected, and the position of the temperature control module 400 is the position of the chip to be detected.
Specifically, the support table 301 is provided with a plurality of stroke switches, the control module is electrically connected to the stroke switches, and position data after the slider contacts each stroke switch is obtained by obtaining electrical signals of each stroke switch, so that a position matrix P (P1, P2, p3... pn) is set in the control module, where P1 is electrical signal data of a first stroke switch, P2 is electrical signal data of a second stroke switch, P3 is electrical signal data of a third stroke switch, and pn is electrical signal data of an nth stroke switch.
Specifically, a temperature sensor is arranged on the temperature control adapter plate 401 to collect temperature information of the chip to be detected in the temperature control adapter plate 401. The temperature sensor is arranged in a groove of the temperature control adapter plate 401 and is electrically connected with the control module. The temperature information of the chip to be detected at different moments is collected through the control module, so that a temperature matrix T (T1, T2, t3... tn) is set in the control module, wherein T1 is the temperature information of the chip to be detected at a first moment, T2 is the temperature information of the chip to be detected at a second moment, T3 is the temperature information of the chip to be detected at a third moment, and tn is the temperature information of the chip to be detected at an nth moment.
Specifically, the control module is further configured to output a first pre-heating control command after detecting that the chip detection device is powered on. Specifically, when the chip detection device is powered on, the control module is powered on to start working, and outputs a first pre-heating control command to the temperature control module 400, so that the resistance wires in the temperature control module 400 are powered on to start heating the temperature control adapter plate 401. Through carrying out first preheating to temperature control module 400, can make temperature control module 400 keep at certain temperature range to after will waiting to detect the chip and place in temperature control module 400, reduce heating time, thereby improve detection efficiency.
Specifically, the control module sets the first preheating matrix k1(tm0, tmn, tm1), where tm0 represents the initial temperature of the chip to be detected, tmn represents the temperature of the chip to be detected at the nth time when the first preheating is performed, tm1 represents the upper limit temperature when the first preheating is performed, and tm0< tmn < tm 1. Specifically, the preset detection temperature range of the chip to be detected is 90-100 ℃, wherein the upper limit temperature of the first preheating is 50 ℃, and then tm1 is 50. It is understood that the heating temperature of the first preheating ranges from 0 to 50 ℃.
It can be seen that the invention can greatly improve the control efficiency by arranging the control module, setting the control matrix and controlling the position and the detection temperature of the chip to be detected according to the control matrix. Meanwhile, the control module outputs a first preheating instruction to the temperature control module 400, so that the temperature control module 400 performs preheating operation of the chip placing position to be detected before placing the chip to be detected, detection time after placing the chip can be shortened, and heating efficiency is improved.
Specifically, the control module is further configured to set a first heat dissipation matrix S1 and a second heat dissipation matrix S2, and output a first heat dissipation command according to the first heat dissipation matrix S1 when the chip inspection apparatus starts to perform a chip inspection operation; when the chip detection device finishes the chip detection operation, a second heat dissipation instruction is output according to the second heat dissipation matrix S2.
Specifically, the control unit further includes a position detection module, where the position detection module is configured to detect whether the chip to be detected is located at a preset detection position, and when the chip to be detected is not located at the preset detection position, the detection module outputs a position adjustment instruction to the driving mechanism 100 to adjust the chip to be detected to the preset detection position; when the chip to be detected is at the preset detection position, the detection module outputs a continuous heating instruction to the temperature control module 400, so that the chip to be detected is kept within the preset detection temperature range.
Specifically, the position detection module is electrically connected with the travel switches, and the position of the chip to be detected is determined by collecting electric signals of the travel switches. Specifically, a travel switch is arranged at a preset detection position of the chip to be detected, and after the travel switch outputs an electric signal, the chip to be detected is determined to reach the preset detection position, so that the driving motor is turned off, and the chip to be detected is heated to a preset detection temperature, so that chip detection is performed. The preset detection position of the chip to be detected can be determined by setting the stroke of the servo motor.
Specifically, the control unit further comprises a judging module, wherein the judging module is used for outputting a detection instruction to the chip detection device after detecting that the chip to be detected reaches a preset detection position and is within a preset detection temperature range, so that the chip detection device detects the chip to be detected.
Specifically, the judging module outputs a detection instruction to the chip detection device after detecting that the module to be detected meets the position and temperature conditions, so that the chip detection device collects image information of the chip to be detected, and the chip to be detected is subjected to microscopic examination.
Specifically, the judging module is further configured to output a reverse movement instruction after the chip detection device completes detection of the chip to be detected, so that the chip to be detected moves to the initial position. Namely, after the chip detection is completed, the driving motor is rotated reversely, so that the chip to be detected returns to the initial position to take out the chip for the detection of the next chip.
Specifically, the judging module is further configured to output a trigger signal to the control module after outputting the reverse movement instruction, so that the control module outputs a second heat dissipation instruction to the heat dissipation unit. The judging module is electrically connected with an image acquisition mechanism of the chip detection device, when the image acquisition mechanism acquires image information, a completion signal is output, the judging module outputs a trigger signal according to the completion signal, the control module outputs a second heat dissipation instruction to the heat dissipation unit after receiving the trigger signal, and the heat dissipation unit dissipates heat of the chip which is detected, so that the chip to be detected is recovered to normal temperature.
It can be seen that through dispelling the heat to the chip that accomplishes the detection, can be quick wait to detect the quick normal atmospheric temperature that resumes of chip, be convenient for change next chip and detect to improve chip detection efficiency, can detect more chips in the short time.
In the above embodiment, when the chip to be detected is to be detected, the temperature control module 400 starts to perform the first preheating operation after the chip detection device is powered on; after detecting that the chip to be detected is placed in the temperature control module 400, performing a second preheating operation on the chip to be detected; meanwhile, the driving mechanism 100 starts to work, and heats the chip to be detected while moving the chip to be detected to a preset detection position; after the chip to be detected reaches the preset detection position, continuously heating the chip to be detected to a preset detection temperature; in the heating process, if the temperature of the chip to be detected exceeds a preset detection temperature, starting a heat dissipation unit to perform a first heat dissipation operation; when the chip to be detected reaches the preset detection position and is within the preset detection temperature range, the chip detection device acquires images of the chip to be detected so as to detect the chip. After chip detection device accomplished the chip and detected, control by temperature change module 400 reverse motion to wait to detect the chip and carry to the initial position, so that change next chip and detect, simultaneously, after accomplishing the detection, the radiating element dispels the heat completely to the chip, so that the quick replacement chip.
Therefore, the chip microscopic examination operation can be rapidly and conveniently carried out by the embodiment. In addition, the temperature control module 400 is arranged to heat the chip, and the working temperature of the chip is simulated to perform microscopic examination of the chip, so that the detection efficiency of the chip can be improved, and the accuracy of the quality of the chip during microscopic examination is greatly improved.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of the present invention is obviously not limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can fall into the protection scope of the invention.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention; various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The utility model provides a control by temperature change slip table based on chip detects which characterized in that includes: a driving mechanism, a connecting shaft, a screw rod and a temperature control module, wherein,
the temperature control module comprises a temperature control adapter plate and a temperature control device, one end of the connecting shaft is connected with an output shaft of the driving mechanism, the other end of the connecting shaft is connected with the screw rod, the temperature control module is arranged on the screw rod, the chip to be detected is arranged on the temperature control adapter plate, and the temperature control device is arranged below the temperature control adapter plate;
the driving mechanism drives the screw rod to rotate through the connecting shaft, and then drives the temperature control module arranged on the screw rod, so that the chip to be detected on the temperature control module moves to a preset position.
2. The temperature control sliding table based on chip detection according to claim 1, further comprising a temperature control module connecting piece, wherein the temperature control module connecting piece comprises an object stage and a longitudinal connecting piece; the longitudinal connecting piece is connected with the screw rod, the temperature control module is arranged on the objective table, the top end of the longitudinal connecting piece is fixedly connected with the objective table,
the outside of lead screw still is provided with a supporting bench, be provided with the slide on the supporting bench, the lower surface of objective table be provided with slide complex slide rail, longitudinal connecting piece drives the objective table is in remove in the slide.
3. The temperature control sliding table based on chip detection as claimed in claim 2, wherein a moving and stopping mechanism is further arranged at the lower end of the supporting table to prevent the temperature control module from being separated from the screw rod in the moving process.
4. The temperature control sliding table based on chip detection according to claim 3, wherein the driving mechanism comprises a stepping motor and a control circuit, a temperature sensor is arranged below the chip to be detected, the control circuit is connected with the stepping motor and the temperature control device respectively, the stepping motor is connected with the connecting shaft, the control circuit is used for controlling the stepping motor, when the temperature control module is in a non-preset position, the control circuit controls the stepping motor to move to a first position in an accelerating manner, the first position is 5-10mm away from the preset position, and then the control circuit controls the stepping motor to move to the preset position slowly.
5. The temperature control sliding table based on chip detection according to claim 4, further comprising a first heating circuit and a second heating circuit, wherein the first heating circuit and the second heating circuit are respectively connected to the temperature control module, the first heating circuit is configured to heat the temperature control device to a first temperature, the second heating circuit is configured to heat the temperature control device to a working temperature, a difference between the first temperature and the working temperature is 1-5 degrees, when the temperature control module is at a non-preset position and moves to the first position, the first heating circuit is started to heat the temperature control device to the first temperature, and when the temperature control module moves from the first position to the preset position, the second heating circuit is started to heat the temperature control device to the working temperature.
6. The temperature control sliding table based on chip detection according to claim 3, wherein a through hole and a connecting protrusion are arranged on the temperature control adapter plate, the through hole is used for accommodating a chip to be detected, the connecting protrusion is arranged at one end of the temperature control adapter plate, the connecting protrusion is provided with a connecting hole, and the other end of the temperature control adapter plate is provided with a lock hole; the temperature control module further comprises a chip pressing device, one end of the chip pressing device is provided with a connecting lug, the connecting lug is matched with a connecting hole in the connecting protrusion to realize the movable connection of the temperature control connecting plate and the chip pressing device, the other end of the chip pressing device is provided with a spring bolt, and the lock hole is connected with the spring bolt to lock the temperature control connecting plate and the chip pressing device.
7. The temperature control sliding table based on chip detection according to claim 5, further comprising a chip positioning plate, wherein the chip positioning plate is arranged in the through hole, and the chip to be detected is arranged at a preset position of the chip positioning plate.
8. The temperature control sliding table based on chip detection as claimed in claim 5, wherein an elastic protrusion is arranged on the inner wall of the lock hole, a barb is arranged on the lock tongue, and the barb is hooked with the elastic protrusion.
9. The temperature control sliding table based on chip detection according to any one of claims 1 to 8, further comprising a housing, wherein the housing is arranged outside the connecting shaft.
10. The temperature control sliding table based on chip detection according to claim 9, wherein the temperature control adapter plate and the chip pressing device are both square.
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CN114803428A (en) * | 2022-04-29 | 2022-07-29 | 深圳格芯集成电路装备有限公司 | Test equipment and test method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019144717A1 (en) * | 2018-01-23 | 2019-08-01 | 深圳市瀚海基因生物科技有限公司 | Bearing module, nucleic acid loading device and application |
CN111349545A (en) * | 2020-03-13 | 2020-06-30 | 北京中科生仪科技有限公司 | A portable chip clamping device for nucleic acid amplification appearance |
-
2021
- 2021-07-06 CN CN202110760990.9A patent/CN113355229A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019144717A1 (en) * | 2018-01-23 | 2019-08-01 | 深圳市瀚海基因生物科技有限公司 | Bearing module, nucleic acid loading device and application |
CN111349545A (en) * | 2020-03-13 | 2020-06-30 | 北京中科生仪科技有限公司 | A portable chip clamping device for nucleic acid amplification appearance |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114803428A (en) * | 2022-04-29 | 2022-07-29 | 深圳格芯集成电路装备有限公司 | Test equipment and test method thereof |
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Application publication date: 20210907 |