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CN113166246A - 一种抗体及其用途 - Google Patents

一种抗体及其用途 Download PDF

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Publication number
CN113166246A
CN113166246A CN201980076474.5A CN201980076474A CN113166246A CN 113166246 A CN113166246 A CN 113166246A CN 201980076474 A CN201980076474 A CN 201980076474A CN 113166246 A CN113166246 A CN 113166246A
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seq
sequence
antibody
cdr
heavy chain
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CN113166246B (zh
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田海军
邓俗俊
赵春霞
李虹
刘登念
龙虎
王成
肖亮
薛彤彤
王晶翼
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Konasi Pharmaceutical Co ltd
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Konasi Pharmaceutical Co ltd
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract

涉及疾病治疗领域，具体而言，涉及抗CLDN18.2的抗体或其抗原结合片段，编码它们的核酸分子，制备它们的方法。所述抗CLDN18.2抗体或其抗原结合片段对CLDN18.2具有高特异性和高亲和力，能够有效结合CLDN18.2并介导杀伤CLDN18.2表达细胞。因此，进一步涉及包含所述抗体或其抗原结合片段的药物组合物，以及其在制备药物中的用途，所述药物用于预防和/或治疗肿瘤。

Description

PCT国内申请，说明书已公开。

Claims (32)

  1. PCT国内申请，权利要求书已公开。
CN201980076474.5A 2018-12-28 2019-12-19 一种抗体及其用途 Active CN113166246B (zh)

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CN2018116175358 2018-12-28
CN201811617535 2018-12-28
PCT/CN2019/126495 WO2020135201A1 (zh) 2018-12-28 2019-12-19 一种抗体及其用途

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US (1) US20230192840A1 (zh)
EP (1) EP3904386A4 (zh)
JP (1) JP7562528B2 (zh)
KR (1) KR20210109520A (zh)
CN (1) CN113166246B (zh)
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Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN113687085A (zh) * 2021-08-27 2021-11-23 复旦大学附属中山医院 一种评估实体肿瘤Claudin18.2蛋白表达的方法和应用
CN113801231A (zh) * 2021-08-20 2021-12-17 四川大学华西医院 抗dog-1抗体或其抗原结合片段及其用途
CN115947851A (zh) * 2022-12-19 2023-04-11 华润生物医药有限公司 结合cldn18.2的抗体及其用途
CN116267016A (zh) * 2021-10-19 2023-06-20 宝船生物医药科技(上海)有限公司 抗cd47-cldn18.2双特异性抗体及其用途
WO2023241629A1 (zh) * 2022-06-15 2023-12-21 中山康方生物医药有限公司 抗cldn18.2抗体、其药物组合物及用途
WO2024067612A1 (zh) * 2022-09-29 2024-04-04 南京博望医药科技有限公司 抗密蛋白18.2的抗体
WO2024146419A1 (zh) * 2023-08-10 2024-07-11 北京百普赛斯生物科技股份有限公司 一种Claudin-18.2特异性抗体及其应用

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SG11202108398YA (en) 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
AU2021270940A1 (en) * 2020-05-15 2022-12-15 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Antibody drug conjugate, preparation method therefor and use thereof
CN111704669B (zh) * 2020-07-13 2022-05-13 北京凯因科技股份有限公司 一种用于治疗晚期胃癌的抗cldn18全人源化抗体
JP2023544140A (ja) * 2020-09-28 2023-10-20 エルピサイエンス（スーチョウ）・バイオファーマ，リミテッド 新規の抗クローディン１８抗体
CN114437221B (zh) * 2020-11-05 2023-08-01 北京天广实生物技术股份有限公司 一种癌症检测抗体及其用途
WO2022122709A1 (en) 2020-12-07 2022-06-16 Sotio Biotech A.S. Antibody-drug conjugates based on humanized cldn18.2 antibodies
CN114617961B (zh) * 2020-12-10 2022-12-02 北京东方百泰生物科技股份有限公司 一种抗lag-3单克隆抗体的注射制剂
CA3199830A1 (en) 2020-12-23 2022-06-30 Lukas BAMMERT Tumor-specific claudin 18.2 antibody-drug conjugates
CN115109154A (zh) * 2021-03-17 2022-09-27 三优生物医药(上海)有限公司 一种靶向cldn18.2的抗体或其抗原结合片段及其应用
KR20230135653A (ko) * 2021-05-08 2023-09-25 레메젠 코, 리미티드 항-클라우딘 18.2 항체 및 이의 항체-약물 접합체
CN115611983A (zh) * 2021-07-14 2023-01-17 三优生物医药(上海)有限公司 Cldn18.2结合分子及其用途
AU2022416272A1 (en) * 2021-12-17 2024-07-18 Fortvita Biologics (Singapore) Pte. Ltd. Antibody-drug conjugate targeting claudin18.2
WO2024020236A2 (en) * 2022-07-22 2024-01-25 The United States Government, As Represented By The Secretary Of The Army Monoclonal antibodies that interfere with iron uptake
WO2024074145A1 (zh) * 2022-10-08 2024-04-11 盛禾(中国)生物制药有限公司 一种结合baffr和cd3的双特异性抗体及其应用
CN117106081B (zh) * 2023-09-28 2024-05-07 北京凯祥弘康生物科技有限公司 一种抗nfl蛋白的捕获抗体

Citations (3)

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