CN113109582A - Sample extractor and sample extraction method - Google Patents
Sample extractor and sample extraction method Download PDFInfo
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- CN113109582A CN113109582A CN202110380201.9A CN202110380201A CN113109582A CN 113109582 A CN113109582 A CN 113109582A CN 202110380201 A CN202110380201 A CN 202110380201A CN 113109582 A CN113109582 A CN 113109582A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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Abstract
The present disclosure provides a sample extractor and a sample extraction method, which solve the technical problem of difficult sample extraction operation in the prior art. The utility model provides a sample extractor, includes the body, the body has sample chamber, runner and reaction chamber, the sample chamber pass through the runner with the reaction chamber communicates with each other, the body still has the reagent chamber, the reagent chamber with the reaction chamber communicates with each other, the runner with be provided with between the sample chamber and prevent that the medium in the runner from flowing back extremely the check valve in sample chamber, wherein, the body has presses the region, operates press regional messenger sample chamber and the medium in the reagent chamber gets into simultaneously the reaction chamber. The scheme makes the sample extraction operation very convenient, and reduces the labor intensity of operators. In addition, the present disclosure provides a method for extracting a sample, by which the extraction efficiency of the sample is greatly improved.
Description
Technical Field
The present disclosure relates to the field of sample extraction technologies, and in particular, to a sample extractor and a sample extraction method.
Background
The sample extraction means that the sample collected on the sample collector is extracted to be processed in the next process. The common sample collector comprises a cotton swab, the cotton swab comprises a rod body and a cotton swab head arranged at the end part of the rod body, the cotton swab head is in contact with a mucous membrane of a human body or body fluid to adsorb a sample, and the sample is collected at the cotton swab head. Generally, a sample cannot be directly analyzed and measured, the sample can be measured and analyzed only by dissolving the sample in a reagent, and the process of dissolving the sample on a cotton swab head in the reagent is sample extraction.
In the prior art, sample extraction is generally performed by using a test tube, specifically, a certain amount of reagent is stored in the test tube, and then a swab head is immersed in the reagent in the test tube to complete sample extraction. After the sample is extracted, the sample in the test tube needs to be injected into an analysis instrument to complete analysis and measurement. This operation makes the sample extraction very inconvenient, reducing the efficiency of sample extraction.
Disclosure of Invention
In a first aspect, the present disclosure provides a sample extractor, which solves the technical problem of difficulty in sample extraction operation in the prior art.
Some embodiments adopted to solve the above technical problems include:
the utility model provides a sample extractor, includes the body, the body has sample chamber, runner and reaction chamber, the sample chamber pass through the runner with the reaction chamber communicates with each other, the body still has the reagent chamber, the reagent chamber with the reaction chamber communicates with each other, the runner with be provided with between the sample chamber and prevent that the medium in the runner from flowing back extremely the check valve in sample chamber, wherein, the body has presses the region, operates press regional messenger sample chamber and the medium in the reagent chamber gets into simultaneously the reaction chamber.
In the practical application process, different reagents are preset in the sampling cavity and the reagent cavity, the sampling cavity is arranged in the sample collector, then, the region is pressed through the operation, different media in the sampling cavity and the reagent cavity can enter the reaction cavity to react, the scheme enables the sample extraction operation to be very convenient, and the labor intensity of operators is reduced.
Preferably, the body is made of the same soft film, wherein a separation strip is formed on the body in a hot-pressing mode, and a cavity surrounded by the body and divided by the separation strip forms the sampling cavity, the reaction cavity and the flow channel.
In this scheme, the body is made by same piece soft film to form the parting strip through the hot pressing mode on soft film, body simple structure easily processes.
In addition, the body is made of a soft film, and the whole body has pressing capacity, so that the sample extraction operation is facilitated. For example, the medium in the body may be made to flow by any pressing method when pressing the body.
Meanwhile, the body is made of a soft film, so that the space enclosed by the body is easy to form vacuum, air is prevented from entering the space enclosed by the body, and air pollution to the sample is further avoided. When the medium enters the reaction cavity, the medium can completely enter the sampling cavity, and the dosage of the reagent is saved.
Preferably, the body is provided with a spacer made of the same material as the body, and the spacer is provided in a space surrounded by the body and divides the space surrounded by the body to form the reagent chamber.
In this scheme, the spacer is the same with the material of body, and the spacer easily with this body coupling, reduced the processing cost of sample extractor.
Preferably, the spacer is arranged in a space enclosed by the body in a hot pressing mode, and an opening communicated with the outside is formed in one end, far away from the reaction cavity, of the reagent cavity.
In this scheme, the spacer passes through hot pressing mode and body coupling, and the spacer is easily processed with the body, has reduced the manufacturing cost of sample extractor. The arrangement of the mouth part can conveniently discharge the air in the reagent cavity, and then the reagent can be conveniently filled into the reagent cavity.
Preferably, the body is provided with a closure clip closing the mouth.
In this scheme, seal the setting of pressing from both sides and can make things convenient for closed oral area, avoided the medium leakage in the reagent intracavity effectively.
Preferably, the reagent cavity and the communication part of the flow channel and the reaction cavity are at least partially overlapped.
In this scheme, the medium in the reagent chamber and the medium in the runner have great area of contact when getting into the reaction chamber, and then make the medium in the reagent chamber and the medium misce bene in the runner.
Preferably, the flow channel comprises a first portion communicating with the sampling chamber and a second portion communicating with the reaction chamber, the first portion communicating with the second portion, and the second portion being at least partially disposed to overlap with the reagent chamber.
The arrangement mode of sample chamber, runner and reagent chamber is reasonable in this scheme, has reduced the volume of sample extractor, and then has widened the range of application of sample extractor.
Preferably, the first portion is arranged perpendicular to the second portion.
The arrangement mode of sampling cavity and runner is reasonable in this scheme, has further reduced the volume of sample extractor.
In a second aspect, the present disclosure provides a sample extraction method, which solves the technical problem of low sample extraction efficiency in the prior art.
The technical scheme adopted for solving the technical problems comprises the following steps:
a method of extracting a sample, comprising a sample extractor disclosed in the first aspect, the method comprising the steps of:
presetting a first reagent in the sampling cavity;
presetting a second reagent in the reagent cavity;
placing a sample collector into the sampling cavity;
applying a first force to allow the medium in the sampling cavity to enter the flow channel;
and applying a second acting force to enable the medium in the flow channel and the reagent cavity to simultaneously enter the reaction cavity.
In the practical application process, the sample and the reagent can be injected into the reaction cavity for reaction by applying the acting force twice, so that the extraction efficiency of the sample is greatly improved, and the labor intensity of operators is reduced. In addition, the medium in the reagent cavity and the medium in the flow channel simultaneously enter the reaction cavity, so that the medium in the reagent cavity and the medium in the flow channel are uniformly mixed in the reaction cavity, the uniform mixing of the medium in the reaction cavity is favorable for subsequent analysis and detection, and the extraction efficiency of the sample is further improved.
Preferably, when the medium in the reagent chamber and the medium in the flow channel simultaneously enter the reaction chamber, a contact width between the medium in the reagent chamber and the medium in the flow channel is not smaller than a width of the flow channel.
In this scheme, the medium in the runner has great area of contact with the medium in the reagent chamber in the reaction chamber, and under the effect of molecular force, the medium misce bene in the reaction chamber has improved the extraction efficiency of sample.
Drawings
For purposes of explanation, several embodiments of the disclosed technology are set forth in the following figures. The following drawings are incorporated herein and constitute a part of the detailed description. In some instances, well-known structures and components are shown in block diagram form in order to avoid obscuring the concepts of the disclosed subject technology.
Fig. 1 is a front view of a first aspect of the present disclosure.
FIG. 2 is a cross-sectional view taken along line A-A of FIG. 1.
Fig. 3 is an enlarged view of fig. 2 at B.
Fig. 4 is an isometric view of a first aspect of the present disclosure.
Shown in the figure:
1. body, 2, sample chamber, 3, runner, 301, first part, 302, second part, 4, reaction chamber, 5, reagent chamber, 6, check valve, 7, parting bead, 8, spacer, 9, seal and press from both sides.
Detailed Description
The specific embodiments illustrated below are intended as descriptions of various configurations of the presently disclosed subject technology and are not intended to represent the only configurations in which the presently disclosed subject technology may be practiced. Specific embodiments include specific details for the purpose of providing a thorough understanding of the presently disclosed subject matter technology. It will be apparent, however, to one skilled in the art that the disclosed subject matter technology is not limited to the specific details shown herein and may be practiced without these specific details.
Referring to fig. 1 to 4, a sample extractor comprises a body 1, wherein the body 1 is provided with a sampling cavity 2, a flow channel 3 and a reaction cavity 4, the sampling cavity 2 is communicated with the reaction cavity 4 through the flow channel 3, the body 1 is further provided with a reagent cavity 5, the reagent cavity 5 is communicated with the reaction cavity 4, a one-way valve 6 for preventing a medium in the flow channel 3 from flowing back to the sampling cavity 2 is arranged between the flow channel 3 and the sampling cavity 2, the body 1 is provided with a pressing area, and the pressing area is operated to enable the medium in the sampling cavity 2 and the medium in the reagent cavity 5 to simultaneously enter the reaction cavity 4.
In the actual use process, a certain amount of reagent is stored in the sampling cavity 2, a certain amount of reagent is preset in the reagent cavity 5, and the reagent preset in the reagent cavity 5 is different from the reagent preset in the sampling cavity 2. Typically, subsequent analysis, detection, etc. of the sample will require mixing with different reagents. Therefore, in addition to the need to quickly take out the sample from the sample collector, the need to improve the efficiency of sample extraction also needs to quickly mix the sample with different reagents uniformly, and to shorten the waiting time for analysis and detection.
Since the sampling chamber 2 and the reagent chamber 5 are pre-filled with different reagents, the sampling chamber 2 and the reagent chamber 5 should be conveniently sealed during a specific operation process to avoid sample contamination. Specifically, the reagent chamber 5 should be sealed after the sample collector is placed in the sampling chamber 2.
In the process of sample extraction, the pressing area is operated to extrude the medium in the flow channel 3 and the reagent cavity 5 into the reaction cavity 4, the medium in the reagent cavity 5 and the medium in the flow channel 3 simultaneously enter the reaction cavity 4, so that the medium in the flow channel 3 and the medium in the reagent cavity 5 can be uniformly mixed in the reaction cavity 4, and the mixing is mixing under the action of molecular force. When the medium is in micron-sized thickness, the mixing of two different media can be realized under the action of molecular force.
Through the introduction, the technical scheme provided by the disclosure greatly improves the sample extraction efficiency and reduces the labor intensity of operators. In addition, the media in the flow channel 3 and the reagent cavity 5 can completely enter the reaction cavity 4, so that the cost is saved, and the labor intensity of operators is reduced.
The one-way valve 6 has the capability of one-way conduction and is small in size. Specifically, the check valve 6 may be a membrane valve, wherein the membrane valve includes two thin films, a valve cavity is formed between the two thin films, the sampling cavity 2 is communicated with the valve cavity, the flow channel 3 is communicated with the valve cavity, and simultaneously, the medium in the flow channel 3 is also distributed on the outer sides of the two thin films, when the flow channel 3 is extruded, the medium in the flow channel 3 can extrude the two thin films, and at this time, the valve cavity is closed. Therefore, the membrane valve has the capability of one-way conduction.
The one-way valve 6 can be replaced by other structures with one-way conduction capability. However, in consideration of the volume of the body 1 and the manufacturing cost, the check valve 6 is preferably a simple-structure, low-cost membrane valve.
In some embodiments, the body 1 is made of the same soft film, wherein the body 1 is formed with a separation strip 7 by a hot pressing method, and a cavity enclosed by the body 1 and divided by the separation strip 7 forms the sampling cavity 2, the reaction cavity 4 and the flow channel 3.
The body 1 is provided with a spacer 8, the spacer 8 is the same as the body 1 in material, the spacer 8 set up in the space that body 1 encloses to cut apart the space that body 1 encloses forms reagent chamber 5.
The spacer 8 is arranged in a space enclosed by the body 1 in a hot pressing mode, and one end of the reagent cavity 5 far away from the reaction cavity 4 is provided with an opening communicated with the outside.
The flexible film may be made of any material that does not chemically react with the reagent. In the actual production process, the soft film is firstly folded in half, an open space is formed at the moment, then the spacer 8 is placed in the open space, and finally the body 1 can be formed by closing the open position of the open space through a hot pressing process. Specifically, the hot pressing process melts or partially melts the soft film, and then the melted soft film is cooled to form corresponding spaces, which are separated from each other. For example, a flow channel 3, a reagent chamber 5, a reaction chamber 4, and a sampling chamber 2, etc. are formed. The process parameters of the hot pressing process are different according to the difference of the soft film, and are not limited in detail here. The body can be made of transparent plate materials, and therefore, structures such as isolating strips in the attached drawings are replaced by lines.
In some embodiments, the body 1 is provided with a closure clip 9 closing the mouth.
The reagent cavity 5, the communication part of the flow channel 3 and the reaction cavity 4 are at least partially overlapped.
The flow channel 3 comprises a first part 301 communicated with the sampling cavity 2 and a second part 302 communicated with the reaction cavity 4, wherein the first part 301 is communicated with the second part 302, and the second part 302 is at least partially overlapped with the reagent cavity 5.
The first portion 301 is arranged perpendicular to the second portion 302.
The sealing clip 9 may be a common clip in the prior art, and the sealing clip 9 may preferably be a plastic clip because of its advantages of low cost and long service life. In addition, the plastic clip is not easy to cause chemical reaction of the medium, and can prevent the sample from being polluted.
In practical application, the space for placing the sample in the device for analyzing and detecting the sample is limited, so the volume of the body 1 should not be too large, and the volume of the body 1 should be reduced as much as possible in the design to realize the miniaturization of the analyzing and detecting device.
Referring to fig. 3, the volume of the body 1 is effectively reduced by the reasonable arrangement of the flow channel 3 and the reagent chamber 5. In addition, the reagent cavity 5 and the communication part of the flow channel 3 and the reaction cavity 4 are at least partially overlapped, so that the contact area of the medium in the reagent cavity 5 and the medium in the flow channel 3 in the reaction cavity 4 is increased, the medium in the flow channel 3 and the medium in the reaction cavity 4 are easy to mix, and the sample extraction efficiency is further improved.
The sample chamber 2 should have certain sealing characteristics in the introduction to avoid the medium leakage in the sample chamber 2, however, the sample chamber 2 should possess the opening, so that the sample collector can be put into the sample chamber 2, therefore, the body 1 should still set up the seal, with open or closed sample chamber 2.
The sealing body is a sealing cover arranged on the body 1. The sealing cover is a structure externally arranged on the body 1, specifically, the sealing cover can comprise a mouth part and a cover body, the mouth part is arranged on the body 1, and the cover body can be fixed on the mouth part through threads to realize sealing. The scheme can meet the functional requirements of the sealing body.
Another embodiment of the seal is: the sealing body is a seal arranged on the body 1. The structure formed on the seal body 1 does not need an external structure. Specifically, the sampling cavity 2 is provided with an opening, and after the cotton swab is placed in the sampling cavity 2, the film sheets on both sides of the opening are closed in a hot pressing mode to form a seal.
For example, when the seal is used as a sealing body, a structure such as a heat sealing machine can be built in the instrument, so that the seal is formed in the instrument.
In a second aspect, a method for extracting a sample includes a sample extractor according to the first aspect, and includes the following steps:
a first reagent is preset in the sampling cavity 2;
a second reagent is preset in the reagent cavity 5, and the reagent cavity 5 is closed after the second reagent is preset in the reagent cavity 5 so as to avoid the leakage of the second reagent in the reagent cavity 5;
placing a sample collector into the sampling cavity 2, closing the sampling cavity 2 after the sample collector is placed in the sampling cavity 2 to prevent the first medium in the sampling cavity 2 from leaking, wherein the sampling cavity 2 is normally closed by heat sealing, and for the heat sealing, reference is made to the description of the sealing body in the first aspect;
applying a first force to make the medium in the sampling cavity 2 enter the flow channel 3;
and applying a second acting force to enable the medium in the flow channel 3 and the reagent cavity 5 to simultaneously enter the reaction cavity 4.
Usually, the first force and the second force can be applied manually or automatically by a force application mechanism. When the first acting force and the second acting force are applied by an automatic force application mode, the force application mechanism can be a structure which outputs linear motion, such as an electromagnet or a linear motor. The first acting force can be formed by an electromagnet, namely the electromagnet adsorbs the armature to extrude the body 1, so that the medium in the sampling cavity 2 enters the flow channel 3. The second acting force can adopt a linear motor as a power source to extrude the medium in the flow channel 3 and the reagent cavity 5 into the reaction cavity 4.
In some embodiments, when the medium in the reagent chamber 5 and the medium in the flow channel 3 enter the reaction chamber 4 simultaneously, the contact width of the medium in the reagent chamber 5 and the medium in the flow channel 3 is not less than the width of the flow channel 3.
In the technical scheme of the disclosure, the body 1 is made of a soft film, and the soft film has the soft characteristic, and in addition, the amount of the reagent preset in the reagent chamber 5 is small, so that the medium in the reagent chamber 5 cannot automatically enter the reaction chamber 4 on the premise of not applying an acting force. Therefore, it is necessary to simultaneously introduce the medium in the flow channel 3 and the reagent chamber 5 into the reaction chamber 4 by applying the second force.
The technical scheme provided by the disclosure can be applied to any sample extraction equipment, such as a fluorescent quantitative PCR instrument and other instruments.
While the subject matter of the present disclosure and its corresponding details have been described above, it is to be understood that the above description is only illustrative of some embodiments of the subject matter of the present disclosure and that some of the details may be omitted from the detailed description.
In addition, in some of the embodiments disclosed above, there is a possibility that a plurality of embodiments may be combined and implemented, and various combinations are not listed at length. The implementation embodiments can be freely combined according to the requirements when the technical personnel in the field carry out the implementation so as to obtain better application experience.
Other configurations of details or figures may be derived by those skilled in the art in practicing the presently disclosed subject matter, as well as figures, and it will be apparent that such details are within the scope of the presently disclosed subject matter and are covered by the presently disclosed subject matter without departing from the presently disclosed subject matter.
Claims (10)
1. A sample extractor, comprising: including body (1), body (1) has sample chamber (2), runner (3) and reaction chamber (4), sample chamber (2) through runner (3) with reaction chamber (4) communicate with each other, body (1) still has reagent chamber (5), reagent chamber (5) with reaction chamber (4) communicate with each other, runner (3) with be provided with between sample chamber (2) and prevent that the medium in runner (3) from flowing back to check valve (6) of sample chamber (2), wherein, body (1) has presses the region, operates press regional messenger sample chamber (2) and the medium in the reagent chamber (5) gets into simultaneously reaction chamber (4).
2. The sample extractor of claim 1, wherein: the body (1) is made of the same soft film, wherein the body (1) is provided with a separation strip (7) in a hot pressing mode, and the separation strip (7) divides a cavity surrounded by the body (1) to form the sampling cavity (2), the reaction cavity (4) and the flow channel (3).
3. The sample extractor of claim 2, wherein: the reagent box is characterized in that the body (1) is provided with a spacer (8), the spacer (8) is made of the same material as the body (1), the spacer (8) is arranged in a space surrounded by the body (1) and is used for dividing the space surrounded by the body (1) to form the reagent cavity (5).
4. The sample extractor of claim 3, wherein: the spacer (8) is arranged in a space surrounded by the body (1) in a hot-pressing mode, and one end of the reagent cavity (5) far away from the reaction cavity (4) is provided with an opening communicated with the outside.
5. The sample extractor of claim 4, wherein: the body (1) is provided with a sealing clip (9) for closing the opening.
6. The sample extractor of any of claims 1 to 5, wherein: the reagent cavity (5) and the communication part of the flow channel (3) and the reaction cavity (4) are at least partially overlapped.
7. The sample extractor of claim 6, wherein: the flow channel (3) comprises a first part (301) communicated with the sampling cavity (2) and a second part (302) communicated with the reaction cavity (4), the first part (301) is communicated with the second part (302), and the second part (302) is at least partially overlapped with the reagent cavity (5).
8. The sample extractor of claim 7, wherein: the first portion (301) is arranged perpendicular to the second portion (302).
9. A method of extracting a sample, comprising a sample extractor, characterized by: the sample extractor of any one of claims 1 to 8, the extraction method comprising the steps of:
presetting a first reagent in the sampling cavity (2);
a second reagent is preset in the reagent cavity (5);
placing a sample collector into the sampling cavity (2);
applying a first force to make the medium in the sampling cavity (2) enter the flow channel (3);
and applying a second acting force to enable the medium in the flow channel (3) and the reagent cavity (5) to simultaneously enter the reaction cavity (4).
10. The sample extractor of claim 9, wherein: when the medium in the reagent cavity (5) and the medium in the flow channel (3) enter the reaction cavity (4) simultaneously, the contact width of the medium in the reagent cavity (5) and the medium in the flow channel (3) is not less than the width of the flow channel (3).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110380201.9A CN113109582A (en) | 2021-04-08 | 2021-04-08 | Sample extractor and sample extraction method |
| PCT/CN2021/134983 WO2022213630A1 (en) | 2021-04-08 | 2021-12-02 | Sample extractor and sample extraction method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110380201.9A CN113109582A (en) | 2021-04-08 | 2021-04-08 | Sample extractor and sample extraction method |
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| CN113109582A true CN113109582A (en) | 2021-07-13 |
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| CN202110380201.9A Pending CN113109582A (en) | 2021-04-08 | 2021-04-08 | Sample extractor and sample extraction method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022213630A1 (en) * | 2021-04-08 | 2022-10-13 | 埃妥生物科技(杭州)有限公司 | Sample extractor and sample extraction method |
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